Septic serum induces glucocorticoid resistance and modifies the expression of glucocorticoid isoforms receptors: A prospective cohort study and in vitro experimental assay

Critical Care

Volumn 17, Issue 3, 2013, Pages

  Guerrero, Julia ^a,b   Gatica, Héctor A ^a   Rodríguez, Margarita ^b   Estay, Roberto ^b   Goecke, Irmgadt A ^a,b  

^a HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

corticosteroids; glucocorticoid receptor; glucocorticoid receptor beta; inflammation; sepsis; septic shock

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; TUMOR NECROSIS FACTOR ALPHA; GLUCOCORTICOID RECEPTOR; ISOPROTEIN;

ADULT; AGED; APACHE; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; HUMAN CELL; HYPOTENSION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOCOMPETENT CELL; IN VITRO STUDY; INTENSIVE CARE UNIT; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEPSIS; SEPTIC SERUM; SEPTIC SHOCK; SERUM; T LYMPHOCYTE; BLOOD; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; K562 CELL LINE; MIDDLE AGED; PHYSIOLOGY;

ADULT; AGED; COHORT STUDIES; DRUG RESISTANCE; FEMALE; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HUMANS; K562 CELLS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PROTEIN ISOFORMS; RECEPTORS, GLUCOCORTICOID; SEPSIS;

EID: 84878818465     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc12774     Document Type: Article

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