메뉴 건너뛰기




Volumn 8, Issue 1, 2017, Pages 126-136

Regulation of the iron homeostatic hormone hepcidin

Author keywords

Anemia; Erythropoiesis; Hepcidin; Inflammation; Iron

Indexed keywords

CATION TRANSPORT PROTEIN; HEPCIDIN; IRON; METAL TRANSPORTING PROTEIN 1;

EID: 85011308989     PISSN: 21618313     EISSN: 21565376     Source Type: Journal    
DOI: 10.3945/an.116.013961     Document Type: Article
Times cited : (307)

References (134)
  • 1
    • 84885768132 scopus 로고    scopus 로고
    • Systemic iron homeostasis
    • Ganz T. Systemic iron homeostasis. Physiol Rev 2013;93:1721-41.
    • (2013) Physiol Rev , vol.93 , pp. 1721-1741
    • Ganz, T.1
  • 2
    • 0033599057 scopus 로고    scopus 로고
    • Disorders of iron metabolism
    • Andrews NC. Disorders of iron metabolism. N Engl J Med 1999;341: 1986-95.
    • (1999) N Engl J Med , vol.341 , pp. 1986-1995
    • Andrews, N.C.1
  • 3
    • 0032830130 scopus 로고    scopus 로고
    • The transferrin receptor: role in health and disease
    • Ponka P, Lok CN. The transferrin receptor: role in health and disease. Int J Biochem Cell Biol 1999;31:1111-37.
    • (1999) Int J Biochem Cell Biol , vol.31 , pp. 1111-1137
    • Ponka, P.1    Lok, C.N.2
  • 4
    • 84866007988 scopus 로고    scopus 로고
    • Macrophages and systemic iron homeostasis
    • Ganz T. Macrophages and systemic iron homeostasis. J Innate Immun 2012;4:446-53.
    • (2012) J Innate Immun , vol.4 , pp. 446-453
    • Ganz, T.1
  • 6
    • 84928963582 scopus 로고    scopus 로고
    • Iron-deficiency anemia
    • Camaschella C. Iron-deficiency anemia. N Engl J Med 2015;372:1832-43.
    • (2015) N Engl J Med , vol.372 , pp. 1832-1843
    • Camaschella, C.1
  • 7
    • 39749110624 scopus 로고    scopus 로고
    • Oxidative stress and iron homeostasis: mechanistic and health aspects
    • Galaris D, Pantopoulos K. Oxidative stress and iron homeostasis: mechanistic and health aspects. Crit Rev Clin Lab Sci 2008;45:1-23.
    • (2008) Crit Rev Clin Lab Sci , vol.45 , pp. 1-23
    • Galaris, D.1    Pantopoulos, K.2
  • 8
    • 24044540417 scopus 로고    scopus 로고
    • Iron, oxidative stress and human health
    • Puntarulo S. Iron, oxidative stress and human health. Mol Aspects Med 2005;26:299-312.
    • (2005) Mol Aspects Med , vol.26 , pp. 299-312
    • Puntarulo, S.1
  • 11
    • 0035960677 scopus 로고    scopus 로고
    • Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
    • Heitzer T, Schlinzig T, Krohn K, Meinertz T, Munzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001;104:2673-8.
    • (2001) Circulation , vol.104 , pp. 2673-2678
    • Heitzer, T.1    Schlinzig, T.2    Krohn, K.3    Meinertz, T.4    Munzel, T.5
  • 13
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 1993;262:689-95.
    • (1993) Science , vol.262 , pp. 689-695
    • Coyle, J.T.1    Puttfarcken, P.2
  • 14
    • 65949121134 scopus 로고    scopus 로고
    • Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options
    • Uttara B, Singh AV, Zamboni P, Mahajan RT. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol 2009;7:65-74.
    • (2009) Curr Neuropharmacol , vol.7 , pp. 65-74
    • Uttara, B.1    Singh, A.V.2    Zamboni, P.3    Mahajan, R.T.4
  • 15
    • 33646727321 scopus 로고    scopus 로고
    • The ins and outs of iron homeostasis
    • Donovan A, Roy CN, and Andrews NC. The ins and outs of iron homeostasis. Physiology 2006;21:115-23.
    • (2006) Physiology , vol.21 , pp. 115-123
    • Donovan, A.1    Roy, C.N.2    Andrews, N.C.3
  • 17
    • 0034733635 scopus 로고    scopus 로고
    • A novel mammalian iron-regulated protein involved in intracellular iron metabolism
    • Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 2000;275: 19906-12.
    • (2000) J Biol Chem , vol.275 , pp. 19906-19912
    • Abboud, S.1    Haile, D.J.2
  • 20
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001;276:7806-10.
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 22
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001;276:7811-9.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5    Brissot, P.6    Loreal, O.7
  • 24
    • 50949102412 scopus 로고    scopus 로고
    • Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network
    • Muckenthaler MU, Galy B, Hentze MW. Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Ann Rev Nutr 2008;28:197-213.
    • (2008) Ann Rev Nutr , vol.28 , pp. 197-213
    • Muckenthaler, M.U.1    Galy, B.2    Hentze, M.W.3
  • 25
    • 84876883321 scopus 로고    scopus 로고
    • Iron-responsive miR-485-3p regulates cellular iron homeostasis by targeting ferroportin
    • Sangokoya C, Doss JF, Chi JT. Iron-responsive miR-485-3p regulates cellular iron homeostasis by targeting ferroportin. PLoS Genet 2013; 9:e1003408.
    • (2013) PLoS Genet , vol.9
    • Sangokoya, C.1    Doss, J.F.2    Chi, J.T.3
  • 28
    • 84886991697 scopus 로고    scopus 로고
    • Manipulation of the hepcidin pathway for therapeutic purposes
    • Fung E, Nemeth E. Manipulation of the hepcidin pathway for therapeutic purposes. Haematologica 2013;98:1667-76.
    • (2013) Haematologica , vol.98 , pp. 1667-1676
    • Fung, E.1    Nemeth, E.2
  • 30
    • 79551583056 scopus 로고    scopus 로고
    • Hepcidin and disorders of iron metabolism
    • Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism. Ann Rev Med 2011;62:347-60.
    • (2011) Ann Rev Med , vol.62 , pp. 347-360
    • Ganz, T.1    Nemeth, E.2
  • 36
    • 0032716978 scopus 로고    scopus 로고
    • The hereditary hemochromatosis gene (HFE): a MHC class I-like gene that functions in the regulation of iron homeostasis
    • Feder JN. The hereditary hemochromatosis gene (HFE): a MHC class I-like gene that functions in the regulation of iron homeostasis. Immunol Res 1999;20:175-85.
    • (1999) Immunol Res , vol.20 , pp. 175-185
    • Feder, J.N.1
  • 38
    • 60649103774 scopus 로고    scopus 로고
    • Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression
    • Gao J, Chen J, Kramer M, Tsukamoto H, Zhang AS, Enns CA. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab 2009;9:217-27.
    • (2009) Cell Metab , vol.9 , pp. 217-227
    • Gao, J.1    Chen, J.2    Kramer, M.3    Tsukamoto, H.4    Zhang, A.S.5    Enns, C.A.6
  • 40
    • 84875649042 scopus 로고    scopus 로고
    • Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway
    • Enns CA, Ahmed R, Wang J, Ueno A, Worthen C, Tsukamoto H, Zhang AS. Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway. PLoS One 2013;8:e60534.
    • (2013) PLoS One , vol.8
    • Enns, C.A.1    Ahmed, R.2    Wang, J.3    Ueno, A.4    Worthen, C.5    Tsukamoto, H.6    Zhang, A.S.7
  • 41
    • 84929492922 scopus 로고    scopus 로고
    • Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?
    • Rausa M, Pagani A, Nai A, Campanella A, Gilberti ME, Apostoli P, Camaschella C, Silvestri L. Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload? PLoS One 2015;10: e0122696.
    • (2015) PLoS One , vol.10
    • Rausa, M.1    Pagani, A.2    Nai, A.3    Campanella, A.4    Gilberti, M.E.5    Apostoli, P.6    Camaschella, C.7    Silvestri, L.8
  • 42
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003;113:685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 48
    • 46749158788 scopus 로고    scopus 로고
    • Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
    • Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 2008;111:5195-204.
    • (2008) Blood , vol.111 , pp. 5195-5204
    • Xia, Y.1    Babitt, J.L.2    Sidis, Y.3    Chung, R.T.4    Lin, H.Y.5
  • 49
    • 84866928814 scopus 로고    scopus 로고
    • Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs)
    • Wu Q, Sun CC, Lin HY, Babitt JL. Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS One 2012;7:e46307.
    • (2012) PLoS One , vol.7
    • Wu, Q.1    Sun, C.C.2    Lin, H.Y.3    Babitt, J.L.4
  • 50
    • 84977090495 scopus 로고    scopus 로고
    • Effects of testosterone on erythropoiesis in a female mouse model of anemia of inflammation
    • Guo W, Schmidt PJ, Fleming MD, Bhasin S. Effects of testosterone on erythropoiesis in a female mouse model of anemia of inflammation. Endocrinology 2016;157:2937-46.
    • (2016) Endocrinology , vol.157 , pp. 2937-2946
    • Guo, W.1    Schmidt, P.J.2    Fleming, M.D.3    Bhasin, S.4
  • 51
    • 34447137331 scopus 로고    scopus 로고
    • Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
    • Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest 2007;117:1933-9.
    • (2007) J Clin Invest , vol.117 , pp. 1933-1939
    • Babitt, J.L.1    Huang, F.W.2    Xia, Y.3    Sidis, Y.4    Andrews, N.C.5    Lin, H.Y.6
  • 52
    • 33745898241 scopus 로고    scopus 로고
    • Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6
    • Truksa J, Peng H, Lee P, Beutler E. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci USA 2006; 103:10289-93.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 10289-10293
    • Truksa, J.1    Peng, H.2    Lee, P.3    Beutler, E.4
  • 59
    • 84907266506 scopus 로고    scopus 로고
    • BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism
    • Mayeur C, Leyton PA, Kolodziej SA, Yu B, Bloch KD. BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism. Blood 2014;124:2116-23.
    • (2014) Blood , vol.124 , pp. 2116-2123
    • Mayeur, C.1    Leyton, P.A.2    Kolodziej, S.A.3    Yu, B.4    Bloch, K.D.5
  • 62
    • 84958811849 scopus 로고    scopus 로고
    • Effect of erythropoietin, iron deficiency and iron overload on liver matriptase-2 (TMPRSS6) protein content in mice and rats
    • Frýdlová J, Prikryl P, Truksa J, Falke LL, Du X, Gurieva I, Vokurka M, Krijt J. Effect of erythropoietin, iron deficiency and iron overload on liver matriptase-2 (TMPRSS6) protein content in mice and rats. PLoS One 2016;11:e0148540.
    • (2016) PLoS One , vol.11
    • Frýdlová, J.1    Prikryl, P.2    Truksa, J.3    Falke, L.L.4    Du, X.5    Gurieva, I.6    Vokurka, M.7    Krijt, J.8
  • 64
    • 56449096622 scopus 로고    scopus 로고
    • The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin
    • Silvestri L, Pagani A, Nai A, De Domenico I, Kaplan J, Camaschella C. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab 2008;8:502-11.
    • (2008) Cell Metab , vol.8 , pp. 502-511
    • Silvestri, L.1    Pagani, A.2    Nai, A.3    De Domenico, I.4    Kaplan, J.5    Camaschella, C.6
  • 67
    • 84867411483 scopus 로고    scopus 로고
    • Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage
    • Enns CA, Ahmed R, Zhang AS. Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage. J Biol Chem 2012;287:35104-17.
    • (2012) J Biol Chem , vol.287 , pp. 35104-35117
    • Enns, C.A.1    Ahmed, R.2    Zhang, A.S.3
  • 68
    • 84974653224 scopus 로고    scopus 로고
    • Neogenin facilitates the induction of hepcidin expression by hemojuvelin in the liver
    • Zhao N, Maxson JE, Zhang RH, Wahedi M, Enns CA, Zhang AS. Neogenin facilitates the induction of hepcidin expression by hemojuvelin in the liver. J Biol Chem 2016;291:12322-35.
    • (2016) J Biol Chem , vol.291 , pp. 12322-12335
    • Zhao, N.1    Maxson, J.E.2    Zhang, R.H.3    Wahedi, M.4    Enns, C.A.5    Zhang, A.S.6
  • 69
    • 84941588340 scopus 로고    scopus 로고
    • Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin
    • Goh JB, Wallace DF, Hong W, Subramaniam VN. Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin. Sci Rep 2015;5:13986.
    • (2015) Sci Rep , vol.5 , pp. 13986
    • Goh, J.B.1    Wallace, D.F.2    Hong, W.3    Subramaniam, V.N.4
  • 70
    • 77957964766 scopus 로고    scopus 로고
    • Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis
    • Ryan JD, Ryan E, Fabre A, Lawless MW, Crowe J. Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis. Hepatology 2010;52:1266-73.
    • (2010) Hepatology , vol.52 , pp. 1266-1273
    • Ryan, J.D.1    Ryan, E.2    Fabre, A.3    Lawless, M.W.4    Crowe, J.5
  • 72
    • 4043156591 scopus 로고
    • The copper and non-hemoglobinous iron contents of the blood serum in disease
    • Locke A, Main ER, Rosbash DO. The copper and non-hemoglobinous iron contents of the blood serum in disease. J Clin Invest 1932;11:527-42.
    • (1932) J Clin Invest , vol.11 , pp. 527-542
    • Locke, A.1    Main, E.R.2    Rosbash, D.O.3
  • 73
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004;113:1271-6.
    • (2004) J Clin Invest , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5    Pedersen, B.K.6    Ganz, T.7
  • 74
    • 14744278436 scopus 로고    scopus 로고
    • Anemia of chronic disease
    • Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005;352:1011-23.
    • (2005) N Engl J Med , vol.352 , pp. 1011-1023
    • Weiss, G.1    Goodnough, L.T.2
  • 76
    • 84940737023 scopus 로고    scopus 로고
    • Hepcidin and host defense against infectious diseases
    • Michels K, Nemeth E, Ganz T, Mehrad B. Hepcidin and host defense against infectious diseases. PLoS Pathog 2015;11:e1004998.
    • (2015) PLoS Pathog , vol.11
    • Michels, K.1    Nemeth, E.2    Ganz, T.3    Mehrad, B.4
  • 77
    • 79955958017 scopus 로고    scopus 로고
    • Hepcidin and iron regulation, 10 years later
    • Ganz T. Hepcidin and iron regulation, 10 years later. Blood 2011;117: 4425-33.
    • (2011) Blood , vol.117 , pp. 4425-4433
    • Ganz, T.1
  • 81
    • 84960984139 scopus 로고    scopus 로고
    • TLR stimulation dynamically regulates heme and iron export gene expression in macrophages
    • Philip M, Chiu EY, Hajjar AM, Abkowitz JL. TLR stimulation dynamically regulates heme and iron export gene expression in macrophages. J Immunol Res 2016:4039038.
    • (2016) J Immunol Res
    • Philip, M.1    Chiu, E.Y.2    Hajjar, A.M.3    Abkowitz, J.L.4
  • 82
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003;101:2461-3.
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 83
    • 84892956031 scopus 로고    scopus 로고
    • Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6
    • Rodriguez R, Jung CL, Gabayan V, Deng JC, Ganz T, Nemeth E, Bulut Y. Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6. Infect Immun 2014;82:745-52.
    • (2014) Infect Immun , vol.82 , pp. 745-752
    • Rodriguez, R.1    Jung, C.L.2    Gabayan, V.3    Deng, J.C.4    Ganz, T.5    Nemeth, E.6    Bulut, Y.7
  • 84
    • 35348850734 scopus 로고    scopus 로고
    • Hematopoietic cytokine receptor signaling
    • Baker SJ, Rane SG, Reddy EP. Hematopoietic cytokine receptor signaling. Oncogene 2007;26:6724-37.
    • (2007) Oncogene , vol.26 , pp. 6724-6737
    • Baker, S.J.1    Rane, S.G.2    Reddy, E.P.3
  • 85
    • 33750522675 scopus 로고    scopus 로고
    • Jaks and cytokine receptors-an intimate relationship
    • Haan C, Kreis S, Margue C, Behrmann I. Jaks and cytokine receptors-an intimate relationship. Biochem Pharmacol 2006;72:1538-46.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1538-1546
    • Haan, C.1    Kreis, S.2    Margue, C.3    Behrmann, I.4
  • 86
    • 0030804219 scopus 로고    scopus 로고
    • The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs)
    • Pellegrini S, Dusanter-Fourt I. The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs). Eur J Biochem 1997;248(3):615-33.
    • (1997) Eur J Biochem , vol.248 , Issue.3 , pp. 615-633
    • Pellegrini, S.1    Dusanter-Fourt, I.2
  • 91
    • 84864053080 scopus 로고    scopus 로고
    • Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling
    • Besson-Fournier C, Latour C, Kautz L, Bertrand J, Ganz T, Roth MP, Coppin H. Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood 2012;120:431-9.
    • (2012) Blood , vol.120 , pp. 431-439
    • Besson-Fournier, C.1    Latour, C.2    Kautz, L.3    Bertrand, J.4    Ganz, T.5    Roth, M.P.6    Coppin, H.7
  • 92
    • 33750402400 scopus 로고    scopus 로고
    • Activin B can signal through both ALK4 and ALK7 in gonadotrope cells
    • Bernard DJ, Lee KB, and Santos MM. Activin B can signal through both ALK4 and ALK7 in gonadotrope cells. Reprod Biol Endocrinol 2006;4:52.
    • (2006) Reprod Biol Endocrinol , vol.4 , pp. 52
    • Bernard, D.J.1    Lee, K.B.2    Santos, M.M.3
  • 94
    • 84960540727 scopus 로고    scopus 로고
    • Activin B induces noncanonical SMAD1/5/8 signaling via BMP type I receptors in hepatocytes: evidence for a role in hepcidin induction by inflammation in male mice
    • Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL. Activin B induces noncanonical SMAD1/5/8 signaling via BMP type I receptors in hepatocytes: evidence for a role in hepcidin induction by inflammation in male mice. Endocrinology 2016;157:1146-62.
    • (2016) Endocrinology , vol.157 , pp. 1146-1162
    • Canali, S.1    Core, A.B.2    Zumbrennen-Bullough, K.B.3    Merkulova, M.4    Wang, C.Y.5    Schneyer, A.L.6    Pietrangelo, A.7    Babitt, J.L.8
  • 97
    • 13844307889 scopus 로고    scopus 로고
    • Regulation of hepcidin transcription by interleukin-1 and interleukin-6
    • Lee P, Peng H, Gelbart T, Wang L, Beutler E. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci USA 2005;102:1906-10.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1906-1910
    • Lee, P.1    Peng, H.2    Gelbart, T.3    Wang, L.4    Beutler, E.5
  • 99
    • 84939520941 scopus 로고    scopus 로고
    • Analysis of IL-22 contribution to hepcidin induction and hypoferremia during the response to LPS in vivo
    • Wallace DF, Subramaniam VN. Analysis of IL-22 contribution to hepcidin induction and hypoferremia during the response to LPS in vivo. Int Immunol 2015;27:281-7.
    • (2015) Int Immunol , vol.27 , pp. 281-287
    • Wallace, D.F.1    Subramaniam, V.N.2
  • 101
    • 77953525651 scopus 로고    scopus 로고
    • Oncostatin M is a potent inducer of hepcidin, the iron regulatory hormone
    • Chung B, Verdier F, Matak P, Deschemin JC, Mayeux P, Vaulont S. Oncostatin M is a potent inducer of hepcidin, the iron regulatory hormone. FASEB J 2010;24:2093-103.
    • (2010) FASEB J , vol.24 , pp. 2093-2103
    • Chung, B.1    Verdier, F.2    Matak, P.3    Deschemin, J.C.4    Mayeux, P.5    Vaulont, S.6
  • 102
    • 73449106764 scopus 로고    scopus 로고
    • Oncostatin M and leukemia inhibitory factor increase hepcidin expression in hepatoma cell lines
    • Kanda J, Uchiyama T, Tomosugi N, Higuchi M, Uchiyama T, Kawabata H. Oncostatin M and leukemia inhibitory factor increase hepcidin expression in hepatoma cell lines. Int J Hematol 2009;90:545-52.
    • (2009) Int J Hematol , vol.90 , pp. 545-552
    • Kanda, J.1    Uchiyama, T.2    Tomosugi, N.3    Higuchi, M.4    Uchiyama, T.5    Kawabata, H.6
  • 103
    • 35848934560 scopus 로고    scopus 로고
    • Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells
    • Chung B, Matak P, McKie AT, Sharp P. Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells. J Nutr 2007;137:2366-70.
    • (2007) J Nutr , vol.137 , pp. 2366-2370
    • Chung, B.1    Matak, P.2    McKie, A.T.3    Sharp, P.4
  • 104
    • 0018843419 scopus 로고
    • The molecular biology of mammalian hemoglobin synthesis
    • Smith DW. The molecular biology of mammalian hemoglobin synthesis. Ann Clin Lab Sci 1980;10:116-22.
    • (1980) Ann Clin Lab Sci , vol.10 , pp. 116-122
    • Smith, D.W.1
  • 105
    • 0028049495 scopus 로고
    • Regulators of iron balance in humans
    • Finch C. Regulators of iron balance in humans. Blood 1994;84:1697-702.
    • (1994) Blood , vol.84 , pp. 1697-1702
    • Finch, C.1
  • 106
    • 84875321185 scopus 로고    scopus 로고
    • Iron metabolism: interactions with normal and disordered erythropoiesis
    • Ganz T, Nemeth E. Iron metabolism: interactions with normal and disordered erythropoiesis. Cold Spring Harb Perspect Med 2012;2:a011668.
    • (2012) Cold Spring Harb Perspect Med , vol.2
    • Ganz, T.1    Nemeth, E.2
  • 107
    • 84979022072 scopus 로고    scopus 로고
    • Regulation of hepcidin by erythropoiesis: the story so far
    • Pasricha SR, McHugh K, Drakesmith H. Regulation of hepcidin by erythropoiesis: the story so far. Ann Rev Nutr 2016;36:417-34.
    • (2016) Ann Rev Nutr , vol.36 , pp. 417-434
    • Pasricha, S.R.1    McHugh, K.2    Drakesmith, H.3
  • 109
    • 33845245942 scopus 로고    scopus 로고
    • Suppression of hepcidin during anemia requires erythropoietic activity
    • Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood 2006;108: 3730-5.
    • (2006) Blood , vol.108 , pp. 3730-3735
    • Pak, M.1    Lopez, M.A.2    Gabayan, V.3    Ganz, T.4    Rivera, S.5
  • 110
    • 84875253909 scopus 로고    scopus 로고
    • Erythropoietin stimulation decreases hepcidin expression through hematopoietic activity on bone marrow cells in mice
    • Sasaki Y, Noguchi-Sasaki M, Yasuno H, Yorozu K, Shimonaka Y. Erythropoietin stimulation decreases hepcidin expression through hematopoietic activity on bone marrow cells in mice. Int J Hematol 2012;96:692-700.
    • (2012) Int J Hematol , vol.96 , pp. 692-700
    • Sasaki, Y.1    Noguchi-Sasaki, M.2    Yasuno, H.3    Yorozu, K.4    Shimonaka, Y.5
  • 113
  • 116
    • 84903578007 scopus 로고    scopus 로고
    • Identification of erythroferrone as an erythroid regulator of iron metabolism
    • Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet 2014;46:678-84.
    • (2014) Nat Genet , vol.46 , pp. 678-684
    • Kautz, L.1    Jung, G.2    Valore, E.V.3    Rivella, S.4    Nemeth, E.5    Ganz, T.6
  • 117
    • 84908144096 scopus 로고    scopus 로고
    • Erythroferrone contributes to recovery from anemia of inflammation
    • Kautz L, Jung G, Nemeth E, Ganz T. Erythroferrone contributes to recovery from anemia of inflammation. Blood 2014;124:2569-74.
    • (2014) Blood , vol.124 , pp. 2569-2574
    • Kautz, L.1    Jung, G.2    Nemeth, E.3    Ganz, T.4
  • 118
    • 84944930727 scopus 로고    scopus 로고
    • Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of beta-thalassemia
    • Kautz L, Jung G, Du X, Gabayan V, Chapman J, NasoffM, Nemeth E, Ganz T. Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of beta-thalassemia. Blood 2015;126: 2031-7.
    • (2015) Blood , vol.126 , pp. 2031-2037
    • Kautz, L.1    Jung, G.2    Du, X.3    Gabayan, V.4    Chapman, J.5    Nasoff, M.6    Nemeth, E.7    Ganz, T.8
  • 120
    • 84863531503 scopus 로고    scopus 로고
    • Inhibition of hepcidin transcription by growth factors
    • Goodnough JB, Ramos E, Nemeth E, Ganz T. Inhibition of hepcidin transcription by growth factors. Hepatology 2012;56:291-9.
    • (2012) Hepatology , vol.56 , pp. 291-299
    • Goodnough, J.B.1    Ramos, E.2    Nemeth, E.3    Ganz, T.4
  • 124
    • 84870566647 scopus 로고    scopus 로고
    • Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis
    • Liu Q, DavidoffO, Niss K, Haase VH. Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. J Clin Invest 2012;122:4635-44.
    • (2012) J Clin Invest , vol.122 , pp. 4635-4644
    • Liu, Q.1    Davidoff, O.2    Niss, K.3    Haase, V.H.4
  • 125
    • 84862148400 scopus 로고    scopus 로고
    • Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis
    • Mastrogiannaki M, Matak P, Mathieu JR, Delga S, Mayeux P, Vaulont S, Peyssonnaux C. Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis. Haematologica 2012;97:827-34.
    • (2012) Haematologica , vol.97 , pp. 827-834
    • Mastrogiannaki, M.1    Matak, P.2    Mathieu, J.R.3    Delga, S.4    Mayeux, P.5    Vaulont, S.6    Peyssonnaux, C.7
  • 126
    • 84878914192 scopus 로고    scopus 로고
    • Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells
    • GuoW, Bachman E, Li M, Roy CN, Blusztajn J, Wong S, Chan SY, Serra C, Jasuja R, Travison TG, et al. Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells. Aging Cell 2013;12:280-91.
    • (2013) Aging Cell , vol.12 , pp. 280-291
    • Guo, W.1    Bachman, E.2    Li, M.3    Roy, C.N.4    Blusztajn, J.5    Wong, S.6    Chan, S.Y.7    Serra, C.8    Jasuja, R.9    Travison, T.G.10
  • 127
    • 84893655780 scopus 로고    scopus 로고
    • Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin
    • Latour C, Kautz L, Besson-Fournier C, Island ML, Canonne-Hergaux F, Loreal O, Ganz T, Coppin H, Roth MP. Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin. Hepatology 2014;59:683-94.
    • (2014) Hepatology , vol.59 , pp. 683-694
    • Latour, C.1    Kautz, L.2    Besson-Fournier, C.3    Island, M.L.4    Canonne-Hergaux, F.5    Loreal, O.6    Ganz, T.7    Coppin, H.8    Roth, M.P.9
  • 129
    • 84862736353 scopus 로고    scopus 로고
    • 17beta-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site
    • Yang Q, Jian J, Katz S, Abramson SB, Huang X. 17beta-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site. Endocrinology 2012;153:3170-8.
    • (2012) Endocrinology , vol.153 , pp. 3170-3178
    • Yang, Q.1    Jian, J.2    Katz, S.3    Abramson, S.B.4    Huang, X.5
  • 130
    • 84868193427 scopus 로고    scopus 로고
    • Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element
    • Hou Y, Zhang S, Wang L, Li J, Qu G, He J, Rong H, Ji H, Liu S. Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element. Gene 2012;511:398-403.
    • (2012) Gene , vol.511 , pp. 398-403
    • Hou, Y.1    Zhang, S.2    Wang, L.3    Li, J.4    Qu, G.5    He, J.6    Rong, H.7    Ji, H.8    Liu, S.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.