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Volumn 63, Issue 12, 2014, Pages 1951-1959

Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB

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EID: 84894730959     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2013-305317     Document Type: Article
Times cited : (127)

References (50)
  • 2
    • 0015293961 scopus 로고
    • The response of W-W v and Sl-Sl d anaemic mice to haemopoietic stimuli
    • Harrison DE, Russell ES. The response of W-W v and Sl-Sl d anaemic mice to haemopoietic stimuli. Br J Haematol 1972;22:155-68.
    • (1972) Br J Haematol , vol.22 , pp. 155-168
    • Harrison, D.E.1    Russell, E.S.2
  • 3
    • 35148888161 scopus 로고    scopus 로고
    • Life with oxygen
    • Semenza GL. Life with oxygen. Science 2007;318:62-4.
    • (2007) Science , vol.318 , pp. 62-64
    • Semenza, G.L.1
  • 5
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas G, Bennoun M, Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 2001;98:8780-5.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3
  • 6
    • 77954249308 scopus 로고    scopus 로고
    • Two to tango: Regulation of Mammalian iron metabolism
    • Hentze MW, Muckenthaler MU, Galy B, et al. Two to tango: regulation of Mammalian iron metabolism. Cell 2010;142:24-38.
    • (2010) Cell , vol.142 , pp. 24-38
    • Hentze, M.W.1    Muckenthaler, M.U.2    Galy, B.3
  • 7
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001;276:7811-19.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3
  • 8
    • 78649634981 scopus 로고    scopus 로고
    • Hepcidin in human iron disorders: Therapeutic implications
    • Pietrangelo A. Hepcidin in human iron disorders: therapeutic implications. J Hepatol 2012;54:173-81.
    • (2012) J Hepatol , vol.54 , pp. 173-181
    • Pietrangelo, A.1
  • 9
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004;306:2090-3.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3
  • 10
    • 67149084949 scopus 로고    scopus 로고
    • Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: Diagnostic and therapeutic implications
    • Theurl I, Aigner E, Theurl M, et al. Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications. Blood 2009;113:5277-86.
    • (2009) Blood , vol.113 , pp. 5277-5286
    • Theurl, I.1    Aigner, E.2    Theurl, M.3
  • 11
    • 33644876815 scopus 로고    scopus 로고
    • A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
    • Wang RH, Li C, Xu X, et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2005;2:399-409.
    • (2005) Cell Metab , vol.2 , pp. 399-409
    • Wang, R.H.1    Li, C.2    Xu, X.3
  • 12
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    • Babitt JL, Huang FW, Wrighting DM, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 2006;38:531-9.
    • (2006) Nat Genet , vol.38 , pp. 531-539
    • Babitt, J.L.1    Huang, F.W.2    Wrighting, D.M.3
  • 13
    • 67349204418 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD
    • Casanovas G, Mleczko-Sanecka K, Altamura S, et al. Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD. J Mol Med (Berl) 2009;87:471-80.
    • (2009) J Mol Med (Berl) , vol.87 , pp. 471-480
    • Casanovas, G.1    Mleczko-Sanecka, K.2    Altamura, S.3
  • 14
    • 33845985236 scopus 로고    scopus 로고
    • STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
    • Verga Falzacappa MV, Vujic Spasic M, Kessler R, et al. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 2007;109:353-8.
    • (2007) Blood , vol.109 , pp. 353-358
    • Verga Falzacappa, M.V.1    Vujic Spasic, M.2    Kessler, R.3
  • 15
    • 33846212344 scopus 로고    scopus 로고
    • STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo
    • Pietrangelo A, Dierssen U, Valli L, et al. STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology 2007;132:294-300.
    • (2007) Gastroenterology , vol.132 , pp. 294-300
    • Pietrangelo, A.1    Dierssen, U.2    Valli, L.3
  • 16
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through STAT3
    • Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood 2006;108:3204-9.
    • (2006) Blood , vol.108 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 17
    • 68949220321 scopus 로고    scopus 로고
    • ER stress controls iron metabolism through induction of hepcidin
    • Vecchi C, Montosi G, Zhang K, et al. ER stress controls iron metabolism through induction of hepcidin. Science 2009;325:877-80.
    • (2009) Science , vol.325 , pp. 877-880
    • Vecchi, C.1    Montosi, G.2    Zhang, K.3
  • 18
    • 79960223299 scopus 로고    scopus 로고
    • GATA-4 transcription factor regulates hepatic hepcidin expression
    • Island ML, Fatih N, Leroyer P, et al. GATA-4 transcription factor regulates hepatic hepcidin expression. Biochem J 2011;437:477-82.
    • (2011) Biochem J , vol.437 , pp. 477-482
    • Island, M.L.1    Fatih, N.2    Leroyer, P.3
  • 19
    • 54349098472 scopus 로고    scopus 로고
    • New and old players in the hepcidin pathway
    • Camaschella C, Silvestri L. New and old players in the hepcidin pathway. Haematologica 2008;93:1441-4.
    • (2008) Haematologica , vol.93 , pp. 1441-1444
    • Camaschella, C.1    Silvestri, L.2
  • 20
    • 79551583056 scopus 로고    scopus 로고
    • Hepcidin and disorders of iron metabolism
    • Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism. Annu Rev Med 2010;62:347-60.
    • (2010) Annu Rev Med , vol.62 , pp. 347-360
    • Ganz, T.1    Nemeth, E.2
  • 21
    • 78449290415 scopus 로고    scopus 로고
    • The struggle for iron - A metal at the host-pathogen interface
    • Nairz M, Schroll A, Sonnweber T, et al. The struggle for iron - a metal at the host-pathogen interface. Cell Microbiol 2011;12:1691-702.
    • (2011) Cell Microbiol , vol.12 , pp. 1691-1702
    • Nairz, M.1    Schroll, A.2    Sonnweber, T.3
  • 22
  • 23
    • 34447120059 scopus 로고    scopus 로고
    • Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
    • Peyssonnaux C, Zinkernagel AS, Schuepbach RA, et al. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest 2007;117:1926-32.
    • (2007) J Clin Invest , vol.117 , pp. 1926-1932
    • Peyssonnaux, C.1    Zinkernagel, A.S.2    Schuepbach, R.A.3
  • 24
    • 0026072341 scopus 로고
    • Cell-type-speci fic and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice
    • Semenza GL, Koury ST, Nejfelt MK, et al. Cell-type-speci fic and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. Proc Natl Acad Sci USA 1991;88:8725-9.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8725-8729
    • Semenza, G.L.1    Koury, S.T.2    Nejfelt, M.K.3
  • 25
    • 33947095427 scopus 로고    scopus 로고
    • ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3
    • Choi SO, Cho YS, Kim HL, et al. ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3. Biochem Biophys Res Commun 2007;356:312-17.
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 312-317
    • Choi, S.O.1    Cho, Y.S.2    Kim, H.L.3
  • 26
    • 40949120506 scopus 로고    scopus 로고
    • 2-Oxoglutarate-dependent oxygenases control hepcidin gene expression
    • Braliou GG, Verga Falzacappa MV, Chachami G, et al. 2-Oxoglutarate-dependent oxygenases control hepcidin gene expression. J Hepatol 2008;48:801-10.
    • (2008) J Hepatol , vol.48 , pp. 801-810
    • Braliou, G.G.1    Verga Falzacappa, M.V.2    Chachami, G.3
  • 27
    • 79955132381 scopus 로고    scopus 로고
    • Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling
    • Chaston TB, Matak P, Pourvali K, et al. Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling. Am J Physiol Cell Physiol 2011;300:C888-95.
    • (2011) Am J Physiol Cell Physiol , vol.300 , pp. C888-C895
    • Chaston, T.B.1    Matak, P.2    Pourvali, K.3
  • 28
    • 79953108427 scopus 로고    scopus 로고
    • Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: Data from the HIGHCARE project
    • Piperno A, Galimberti S, Mariani R, et al. Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood 2010;117:2953-9.
    • (2010) Blood , vol.117 , pp. 2953-2959
    • Piperno, A.1    Galimberti, S.2    Mariani, R.3
  • 29
    • 84856072239 scopus 로고    scopus 로고
    • Regulation of hepcidin expression at high altitude
    • Talbot NP, Lakhal S, Smith TG, et al. Regulation of hepcidin expression at high altitude. Blood 2011;119:857-60.
    • (2011) Blood , vol.119 , pp. 857-860
    • Talbot, N.P.1    Lakhal, S.2    Smith, T.G.3
  • 30
    • 84888287262 scopus 로고    scopus 로고
    • Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers
    • Goetze O, Schmitt J, Spliethoff K, et al. Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers. Hepatology 2013;58:2153-62.
    • (2013) Hepatology , vol.58 , pp. 2153-2162
    • Goetze, O.1    Schmitt, J.2    Spliethoff, K.3
  • 31
    • 80052647221 scopus 로고    scopus 로고
    • Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats
    • Theurl I, Schroll A, Sonnweber T, et al. Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood 2011;118: 4977-84.
    • (2011) Blood , vol.118 , pp. 4977-4984
    • Theurl, I.1    Schroll, A.2    Sonnweber, T.3
  • 32
    • 34147145982 scopus 로고    scopus 로고
    • Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1
    • Ludwiczek S, Theurl I, Muckenthaler MU, et al. Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Nat Med 2007;13:448-54.
    • (2007) Nat Med , vol.13 , pp. 448-454
    • Ludwiczek, S.1    Theurl, I.2    Muckenthaler, M.U.3
  • 33
    • 78751698162 scopus 로고    scopus 로고
    • Erythropoietin contrastingly affects bacterial infection and experimental colitis by inhibiting nuclear factor-kappaB-inducible immune pathways
    • Nairz M, Schroll A, Moschen AR, et al. Erythropoietin contrastingly affects bacterial infection and experimental colitis by inhibiting nuclear factor-kappaB-inducible immune pathways. Immunity 2011;34:61-74.
    • (2011) Immunity , vol.34 , pp. 61-74
    • Nairz, M.1    Schroll, A.2    Moschen, A.R.3
  • 34
    • 84883469904 scopus 로고    scopus 로고
    • Erythropoietin and engineered innate repair activators
    • Brines M, Cerami A. Erythropoietin and engineered innate repair activators. Methods Mol Biol 2013;982:1-11.
    • (2013) Methods Mol Biol , vol.982 , pp. 1-11
    • Brines, M.1    Cerami, A.2
  • 35
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and infl ammation
    • Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and infl ammation. J Clin Invest 2002;110:1037-44.
    • (2002) J Clin Invest , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3
  • 36
    • 77952980768 scopus 로고    scopus 로고
    • Thiazolidinediones prevent PDGF-BB-induced CREB depletion in pulmonary artery smooth muscle cells by preventing upregulation of casein kinase 2 alpha' catalytic subunit
    • Garat CV, Crossno JT Jr, Sullivan TM, et al. Thiazolidinediones prevent PDGF-BB-induced CREB depletion in pulmonary artery smooth muscle cells by preventing upregulation of casein kinase 2 alpha' catalytic subunit. J Cardiovasc Pharmacol 2010;55:469-80.
    • (2010) J Cardiovasc Pharmacol , vol.55 , pp. 469-480
    • Garat, C.V.1    Crossno, J.T.2    Sullivan, T.M.3
  • 37
    • 84867087464 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
    • Schito L, Rey S, Tafani M, et al. Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells. Proc Natl Acad Sci USA 2012;109:E2707-16.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. E2707-E2716
    • Schito, L.1    Rey, S.2    Tafani, M.3
  • 38
    • 0037174609 scopus 로고    scopus 로고
    • C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism
    • Courselaud B, Pigeon C, Inoue Y, et al. C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J Biol Chem 2002;277:41163-70.
    • (2002) J Biol Chem , vol.277 , pp. 41163-41170
    • Courselaud, B.1    Pigeon, C.2    Inoue, Y.3
  • 39
    • 84863531503 scopus 로고    scopus 로고
    • Inhibition of hepcidin transcription by growth factors
    • Goodnough JB, Ramos E, Nemeth E, et al. Inhibition of hepcidin transcription by growth factors. Hepatology 2012;56:291-9.
    • (2012) Hepatology , vol.56 , pp. 291-299
    • Goodnough, J.B.1    Ramos, E.2    Nemeth, E.3
  • 40
    • 77949707023 scopus 로고    scopus 로고
    • Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin
    • Ashby DR, Gale DP, Busbridge M, et al. Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin. Haematologica 2009;95:505-8.
    • (2009) Haematologica , vol.95 , pp. 505-508
    • Ashby, D.R.1    Gale, D.P.2    Busbridge, M.3
  • 41
    • 69249217850 scopus 로고    scopus 로고
    • Alterations of systemic and muscle iron metabolism in human subjects treated with low-dose recombinant erythropoietin
    • Robach P, Recalcati S, Girelli D, et al. Alterations of systemic and muscle iron metabolism in human subjects treated with low-dose recombinant erythropoietin. Blood 2009;113:6707-15.
    • (2009) Blood , vol.113 , pp. 6707-6715
    • Robach, P.1    Recalcati, S.2    Girelli, D.3
  • 42
    • 0031018874 scopus 로고    scopus 로고
    • Regulation of cellular iron metabolism by erythropoietin: Activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cells
    • Weiss G, Houston T, Kastner S, et al. Regulation of cellular iron metabolism by erythropoietin: activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cells. Blood 1997;89:680-7.
    • (1997) Blood , vol.89 , pp. 680-687
    • Weiss, G.1    Houston, T.2    Kastner, S.3
  • 43
    • 33845245942 scopus 로고    scopus 로고
    • Suppression of hepcidin during anemia requires erythropoietic activity
    • Pak M, Lopez MA, Gabayan V, et al. Suppression of hepcidin during anemia requires erythropoietic activity. Blood 2006;108:3730-5.
    • (2006) Blood , vol.108 , pp. 3730-3735
    • Pak, M.1    Lopez, M.A.2    Gabayan, V.3
  • 44
    • 84870566647 scopus 로고    scopus 로고
    • Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis
    • Liu Q, Davidoff O, Niss K, et al. Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. J Clin Invest 2012;122:4635-44.
    • (2012) J Clin Invest , vol.122 , pp. 4635-4644
    • Liu, Q.1    Davidoff, O.2    Niss, K.3
  • 45
    • 34948904750 scopus 로고    scopus 로고
    • High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
    • Tanno T, Bhanu NV, Oneal PA, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med 2007;13:1096-101.
    • (2007) Nat Med , vol.13 , pp. 1096-1101
    • Tanno, T.1    Bhanu, N.V.2    Oneal, P.A.3
  • 46
    • 77949889342 scopus 로고    scopus 로고
    • Erythropoietin accelerates smooth muscle cell-rich vascular lesion formation in mice through endothelial cell activation involving enhanced PDGF-BB release
    • Janmaat ML, Heerkens JL, de Bruin AM, et al. Erythropoietin accelerates smooth muscle cell-rich vascular lesion formation in mice through endothelial cell activation involving enhanced PDGF-BB release. Blood 2010;115:1453-60.
    • (2010) Blood , vol.115 , pp. 1453-1460
    • Janmaat, M.L.1    Heerkens, J.L.2    De Bruin, A.M.3
  • 47
    • 2942676788 scopus 로고    scopus 로고
    • The PDGF family: Four gene products form five dimeric isoforms
    • Fredriksson L, Li H, Eriksson U. The PDGF family: four gene products form five dimeric isoforms. Cytokine Growth Factor Rev 2004;15:197-204.
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 197-204
    • Fredriksson, L.1    Li, H.2    Eriksson, U.3
  • 48
    • 82855164013 scopus 로고    scopus 로고
    • Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo
    • Theurl I, Schroll A, Nairz M, et al. Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo. Haematologica 2011;96:1761-9.
    • (2011) Haematologica , vol.96 , pp. 1761-1769
    • Theurl, I.1    Schroll, A.2    Nairz, M.3
  • 49
    • 79953121575 scopus 로고    scopus 로고
    • Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2
    • Wallace DF, McDonald CJ, Ostini L, et al. Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2. Blood 2011;117:2960-6.
    • (2011) Blood , vol.117 , pp. 2960-2966
    • Wallace, D.F.1    McDonald, C.J.2    Ostini, L.3
  • 50
    • 63449086727 scopus 로고    scopus 로고
    • Function of the hemochromatosis protein HFE: Lessons from animal models
    • Pantopoulos K. Function of the hemochromatosis protein HFE: Lessons from animal models. World J Gastroenterol 2008;14:6893-901.
    • (2008) World J Gastroenterol , vol.14 , pp. 6893-6901
    • Pantopoulos, K.1


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