메뉴 건너뛰기




Volumn 511, Issue 2, 2012, Pages 398-403

Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element

Author keywords

Estrogen; Estrogen response element; Hepcidin; Iron; Ovariectomy

Indexed keywords

ESTROGEN; HEMOGLOBIN; HEPCIDIN; IRON;

EID: 84868193427     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2012.09.060     Document Type: Article
Times cited : (159)

References (44)
  • 1
    • 63449103712 scopus 로고    scopus 로고
    • BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
    • Andriopoulos B., et al. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat. Genet. 2009, 41:482-487.
    • (2009) Nat. Genet. , vol.41 , pp. 482-487
    • Andriopoulos, B.1
  • 2
    • 0042622257 scopus 로고    scopus 로고
    • Dragon ERE Finder version 2: a tool for accurate detection and analysis of estrogen response elements in vertebrate genomes
    • Bajic V.B., et al. Dragon ERE Finder version 2: a tool for accurate detection and analysis of estrogen response elements in vertebrate genomes. Nucleic Acids Res. 2003, 31:3605-3607.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 3605-3607
    • Bajic, V.B.1
  • 3
    • 84870031929 scopus 로고    scopus 로고
    • Liver fat accumulation may be dissociated from adiposity gain in ovariectomized rats
    • [Electronic publication ahead of print]
    • Cote I., et al. Liver fat accumulation may be dissociated from adiposity gain in ovariectomized rats. Climacteric 2012, [Electronic publication ahead of print]. 10.3109/13697137.2011.637650.
    • (2012) Climacteric
    • Cote, I.1
  • 4
    • 0037174609 scopus 로고    scopus 로고
    • C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism
    • Courselaud B., et al. C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J. Biol. Chem. 2002, 277:41163-41170.
    • (2002) J. Biol. Chem. , vol.277 , pp. 41163-41170
    • Courselaud, B.1
  • 5
    • 20444416123 scopus 로고    scopus 로고
    • The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
    • Donovan A., et al. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 2005, 1:191-200.
    • (2005) Cell Metab. , vol.1 , pp. 191-200
    • Donovan, A.1
  • 6
    • 79959517566 scopus 로고    scopus 로고
    • Serum hepcidin: reference ranges and biochemical correlates in the general population
    • Galesloot T.E., et al. Serum hepcidin: reference ranges and biochemical correlates in the general population. Blood 2011, 117:e218-e225.
    • (2011) Blood , vol.117
    • Galesloot, T.E.1
  • 7
    • 0041672570 scopus 로고    scopus 로고
    • Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
    • Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003, 102:783-788.
    • (2003) Blood , vol.102 , pp. 783-788
    • Ganz, T.1
  • 8
    • 4344600507 scopus 로고    scopus 로고
    • Hepcidin in iron metabolism
    • Ganz T. Hepcidin in iron metabolism. Curr. Opin. Hematol. 2004, 11:251-254.
    • (2004) Curr. Opin. Hematol. , vol.11 , pp. 251-254
    • Ganz, T.1
  • 9
    • 14544298717 scopus 로고    scopus 로고
    • Hepcidin-a regulator of intestinal iron absorption and iron recycling by macrophages
    • Ganz T. Hepcidin-a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract. Res. Clin. Haematol. 2005, 18:171-182.
    • (2005) Best Pract. Res. Clin. Haematol. , vol.18 , pp. 171-182
    • Ganz, T.1
  • 10
    • 79551583056 scopus 로고    scopus 로고
    • Hepcidin and disorders of iron metabolism
    • Ganz T., Nemeth E. Hepcidin and disorders of iron metabolism. Annu. Rev. Med. 2011, 62:347-360.
    • (2011) Annu. Rev. Med. , vol.62 , pp. 347-360
    • Ganz, T.1    Nemeth, E.2
  • 11
    • 84861355868 scopus 로고    scopus 로고
    • Hepcidin and iron homeostasis
    • Ganz T., Nemeth E. Hepcidin and iron homeostasis. Biochim. Biophys. Acta 2012, 1823:1434-1443.
    • (2012) Biochim. Biophys. Acta , vol.1823 , pp. 1434-1443
    • Ganz, T.1    Nemeth, E.2
  • 12
    • 29044450387 scopus 로고    scopus 로고
    • Bone mineral density in men with genetic hemochromatosis and HFE gene mutation
    • Guggenbuhl P., et al. Bone mineral density in men with genetic hemochromatosis and HFE gene mutation. Osteoporos. Int. 2005, 16:1809-1814.
    • (2005) Osteoporos. Int. , vol.16 , pp. 1809-1814
    • Guggenbuhl, P.1
  • 13
    • 79960281508 scopus 로고    scopus 로고
    • Bone status in a mouse model of genetic hemochromatosis
    • Guggenbuhl P., et al. Bone status in a mouse model of genetic hemochromatosis. Osteoporos. Int. 2011, 22:2313-2319.
    • (2011) Osteoporos. Int. , vol.22 , pp. 2313-2319
    • Guggenbuhl, P.1
  • 14
    • 79751538029 scopus 로고    scopus 로고
    • Bone disease and skeletal complications in patients with beta thalassemia major
    • Haidar R., Musallam K.M., Taher A.T. Bone disease and skeletal complications in patients with beta thalassemia major. Bone 2011, 48:425-432.
    • (2011) Bone , vol.48 , pp. 425-432
    • Haidar, R.1    Musallam, K.M.2    Taher, A.T.3
  • 15
    • 0035813112 scopus 로고    scopus 로고
    • The multifaceted mechanisms of estradiol and estrogen receptor signaling
    • Hall J.M., Couse J.F., Korach K.S. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J. Biol. Chem. 2001, 276:36869-36872.
    • (2001) J. Biol. Chem. , vol.276 , pp. 36869-36872
    • Hall, J.M.1    Couse, J.F.2    Korach, K.S.3
  • 16
    • 84863827034 scopus 로고    scopus 로고
    • Estrogen regulates hepcidin expression via GPR30-BMP6-dependent signaling in hepatocytes
    • Ikeda Y., et al. Estrogen regulates hepcidin expression via GPR30-BMP6-dependent signaling in hepatocytes. PLoS One 2012, 7:e40465.
    • (2012) PLoS One , vol.7
    • Ikeda, Y.1
  • 17
    • 62049085382 scopus 로고    scopus 로고
    • Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation
    • Ishii K.A., et al. Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat. Med. 2009, 15:259-266.
    • (2009) Nat. Med. , vol.15 , pp. 259-266
    • Ishii, K.A.1
  • 18
    • 80052408372 scopus 로고    scopus 로고
    • Effect of immune stress on body weight regulation is altered by ovariectomy in female rats
    • Iwasa T., et al. Effect of immune stress on body weight regulation is altered by ovariectomy in female rats. J. Reprod. Immunol. 2011, 91:41-47.
    • (2011) J. Reprod. Immunol. , vol.91 , pp. 41-47
    • Iwasa, T.1
  • 19
    • 70449129929 scopus 로고    scopus 로고
    • Iron and menopause: does increased iron affect the health of postmenopausal women?
    • Jian J., Pelle E., Huang X. Iron and menopause: does increased iron affect the health of postmenopausal women?. Antioxid. Redox Signal. 2009, 11:2939-2943.
    • (2009) Antioxid. Redox Signal. , vol.11 , pp. 2939-2943
    • Jian, J.1    Pelle, E.2    Huang, X.3
  • 20
    • 0026777433 scopus 로고
    • Increased osteoclast development after estrogen loss: mediation by interleukin-6
    • Jilka R.L., et al. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 1992, 257:88-91.
    • (1992) Science , vol.257 , pp. 88-91
    • Jilka, R.L.1
  • 21
    • 0035878743 scopus 로고    scopus 로고
    • Estrogen receptor interaction with estrogen response elements
    • Klinge C.M. Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res. 2001, 29:2905-2919.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 2905-2919
    • Klinge, C.M.1
  • 22
    • 38349131338 scopus 로고    scopus 로고
    • Iron genes, iron load and risk of Alzheimer's disease
    • Lehmann D.J., et al. Iron genes, iron load and risk of Alzheimer's disease. J. Med. Genet. 2006, 43:e52.
    • (2006) J. Med. Genet. , vol.43
    • Lehmann, D.J.1
  • 23
    • 33745405978 scopus 로고    scopus 로고
    • Age-associated iron accumulation in bone: implications for postmenopausal osteoporosis and a new target for prevention and treatment by chelation
    • Liu G., Men P., Kenner G.H., Miller S.C. Age-associated iron accumulation in bone: implications for postmenopausal osteoporosis and a new target for prevention and treatment by chelation. Biometals 2006, 19:245-251.
    • (2006) Biometals , vol.19 , pp. 245-251
    • Liu, G.1    Men, P.2    Kenner, G.H.3    Miller, S.C.4
  • 24
    • 36048955045 scopus 로고    scopus 로고
    • The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation
    • Liu S., et al. The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. J. Clin. Invest. 2007, 117:3296-3305.
    • (2007) J. Clin. Invest. , vol.117 , pp. 3296-3305
    • Liu, S.1
  • 25
    • 39349116031 scopus 로고    scopus 로고
    • Therapeutic effects of an oral chelator targeting skeletal tissue damage in experimental postmenopausal osteoporosis in rats
    • Liu G., Men P., Kenner G.H., Miller S.C. Therapeutic effects of an oral chelator targeting skeletal tissue damage in experimental postmenopausal osteoporosis in rats. Hemoglobin 2008, 32:181-190.
    • (2008) Hemoglobin , vol.32 , pp. 181-190
    • Liu, G.1    Men, P.2    Kenner, G.H.3    Miller, S.C.4
  • 26
    • 43449094715 scopus 로고    scopus 로고
    • Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice
    • Liu S., Suragani R.N., Han A., Zhao W., Andrews N.C., Chen J.J. Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice. Haematologica 2008, 93:753-756.
    • (2008) Haematologica , vol.93 , pp. 753-756
    • Liu, S.1    Suragani, R.N.2    Han, A.3    Zhao, W.4    Andrews, N.C.5    Chen, J.J.6
  • 27
    • 80053308050 scopus 로고    scopus 로고
    • CdSe quantum dot (QD)-induced morphological and functional impairments to liver in mice
    • Liu W., et al. CdSe quantum dot (QD)-induced morphological and functional impairments to liver in mice. PLoS One 2011, 6:e24406.
    • (2011) PLoS One , vol.6
    • Liu, W.1
  • 28
    • 69349098846 scopus 로고    scopus 로고
    • Ovariectomy and estrogen treatment modulate iron metabolism in rat adipose tissue
    • Mattace Raso G., et al. Ovariectomy and estrogen treatment modulate iron metabolism in rat adipose tissue. Biochem. Pharmacol. 2009, 78:1001-1007.
    • (2009) Biochem. Pharmacol. , vol.78 , pp. 1001-1007
    • Mattace Raso, G.1
  • 29
    • 70349282987 scopus 로고    scopus 로고
    • Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures
    • Messer J.G., Kilbarger A.K., Erikson K.M., Kipp D.E. Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures. Bone 2009, 45:972-979.
    • (2009) Bone , vol.45 , pp. 972-979
    • Messer, J.G.1    Kilbarger, A.K.2    Erikson, K.M.3    Kipp, D.E.4
  • 30
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E., et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J. Clin. Invest. 2004, 113:1271-1276.
    • (2004) J. Clin. Invest. , vol.113 , pp. 1271-1276
    • Nemeth, E.1
  • 31
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004, 306:2090-2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1
  • 32
    • 33845245942 scopus 로고    scopus 로고
    • Suppression of hepcidin during anemia requires erythropoietic activity
    • Pak M., Lopez M.A., Gabayan V., Ganz T., Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood 2006, 108:3730-3735.
    • (2006) Blood , vol.108 , pp. 3730-3735
    • Pak, M.1    Lopez, M.A.2    Gabayan, V.3    Ganz, T.4    Rivera, S.5
  • 33
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park C.H., Valore E.V., Waring A.J., Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J. Biol. Chem. 2001, 276:7806-7810.
    • (2001) J. Biol. Chem. , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 34
    • 67349105361 scopus 로고    scopus 로고
    • Mechanisms of estrogen signaling and gene expression via GPR30
    • Prossnitz E.R., Maggiolini M. Mechanisms of estrogen signaling and gene expression via GPR30. Mol. Cell. Endocrinol. 2009, 308:32-38.
    • (2009) Mol. Cell. Endocrinol. , vol.308 , pp. 32-38
    • Prossnitz, E.R.1    Maggiolini, M.2
  • 35
    • 84861842156 scopus 로고    scopus 로고
    • Quantum dots impair macrophagic morphology and the ability of phagocytosis by inhibiting the Rho-associated kinase signaling
    • Qu G., et al. Quantum dots impair macrophagic morphology and the ability of phagocytosis by inhibiting the Rho-associated kinase signaling. Nanoscale 2012, 4:2239-2244.
    • (2012) Nanoscale , vol.4 , pp. 2239-2244
    • Qu, G.1
  • 36
    • 79953757053 scopus 로고    scopus 로고
    • Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice
    • Ramos E., et al. Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology 2011, 53:1333-1341.
    • (2011) Hepatology , vol.53 , pp. 1333-1341
    • Ramos, E.1
  • 37
    • 11244346967 scopus 로고    scopus 로고
    • Enhanced marrow adipogenesis and bone resorption in estrogen-deprived rats treated with the PPARgamma agonist BRL49653 (rosiglitazone)
    • Sottile V., Seuwen K., Kneissel M. Enhanced marrow adipogenesis and bone resorption in estrogen-deprived rats treated with the PPARgamma agonist BRL49653 (rosiglitazone). Calcif. Tissue Int. 2004, 75:329-337.
    • (2004) Calcif. Tissue Int. , vol.75 , pp. 329-337
    • Sottile, V.1    Seuwen, K.2    Kneissel, M.3
  • 38
    • 0028785711 scopus 로고
    • FDA guidelines and animal models for osteoporosis
    • Thompson D.D., Simmons H.A., Pirie C.M., Ke H.Z. FDA guidelines and animal models for osteoporosis. Bone 1995, 17:125S-133S.
    • (1995) Bone , vol.17
    • Thompson, D.D.1    Simmons, H.A.2    Pirie, C.M.3    Ke, H.Z.4
  • 39
  • 40
    • 33750610853 scopus 로고    scopus 로고
    • Iron loading: a risk factor for osteoporosis
    • Weinberg E.D. Iron loading: a risk factor for osteoporosis. Biometals 2006, 19:633-635.
    • (2006) Biometals , vol.19 , pp. 633-635
    • Weinberg, E.D.1
  • 41
    • 58149512144 scopus 로고    scopus 로고
    • Role of iron in osteoporosis
    • Weinberg E.D. Role of iron in osteoporosis. Pediatr. Endocrinol. Rev. 2008, 6(Suppl. 1):81-85.
    • (2008) Pediatr. Endocrinol. Rev. , vol.6 , Issue.SUPPL. 1 , pp. 81-85
    • Weinberg, E.D.1
  • 42
    • 70449529421 scopus 로고    scopus 로고
    • Excess iron inhibits osteoblast metabolism
    • Yamasaki K., Hagiwara H. Excess iron inhibits osteoblast metabolism. Toxicol. Lett. 2009, 191:211-215.
    • (2009) Toxicol. Lett. , vol.191 , pp. 211-215
    • Yamasaki, K.1    Hagiwara, H.2
  • 43
    • 79958807411 scopus 로고    scopus 로고
    • Inhibitory effects of iron on bone morphogenetic protein 2-induced osteoblastogenesis
    • Yang Q., Jian J., Abramson S.B., Huang X. Inhibitory effects of iron on bone morphogenetic protein 2-induced osteoblastogenesis. J. Bone Miner. Res. 2011, 26:1188-1196.
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 1188-1196
    • Yang, Q.1    Jian, J.2    Abramson, S.B.3    Huang, X.4
  • 44
    • 84862736353 scopus 로고    scopus 로고
    • 17beta-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site
    • Yang Q., Jian J., Katz S., Abramson S.B., Huang X. 17beta-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site. Endocrinology 2012, 153:3170-3178.
    • (2012) Endocrinology , vol.153 , pp. 3170-3178
    • Yang, Q.1    Jian, J.2    Katz, S.3    Abramson, S.B.4    Huang, X.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.