The transferrin receptor: Role in health and disease

International Journal of Biochemistry and Cell Biology

Volumn 31, Issue 10, 1999, Pages 1111-1137

  Ponka, Prem ^a,b   Lok, Chun Nam ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FERRIC ION; IRON REGULATORY FACTOR; LYMPHOKINE; REPRESSOR PROTEIN; TRANSFERRIN; TRANSFERRIN RECEPTOR;

DISORDERS OF METAL METABOLISM; ENDOCYTOSIS; ERYTHROID CELL; HUMAN; HYPOXIA; IRON RESPONSIVE ELEMENT; IRON TRANSPORT; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RAT; RECEPTOR GENE; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0032830130     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(99)00070-9     Document Type: Article

References (185)

1. Kühn L.C., Schulman H.M., Ponka P. Iron-transferrin requirements and transferrin receptor expression in proliferating cells. Ponka P., Schulman H.M., Woodworth R.C. Iron Transport and Storage. 1990;149-191 CRC, Boca Raton, FL.
2. Testa U., Pelosi E., Peschle C. The transferrin receptor. Critical Reviews in Oncogenesis. 4:1993;241-276.
3. Richardson D.R., Ponka P. The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochimica et Biophysica Acta. 1331:1997;1-40.
4. Ponka P., Schulman H.M., Cox T.M. Iron metabolism in relation to heme synthesis. Dailey H.A. Biosynthesis of Heme and Chlorophylls. 1990;393-434 McGraw-Hill Publishing Company, New York.
5. Ponka P., Beaumont C., Richardson D.R. Function and regulation of transferrin and ferritin. Seminars in Hematology. 35:1998;35-54.
6. Neilands J.B. Siderophores: structure and function of microbial iron transport compounds. Journal of Biological Chemistry. 270:1995;26,723-26,726.
7. Bothwell T.A., Charlton R.W., Cook J.D., Finch C.A. Iron Metabolism in Man. 1979;Blackwell Scientific, Oxford.
8. Winzerling J.J., Law J.H. Comparative nutrition of iron and copper. Annual Review of Nutrition. 17:1997;501-526.
9. Jamroz R.C., Gasdaska J.R., Bradfield J.Y., Law J.H. Transferrin in a cockroach: molecular cloning, characterization and suppression by juvenile hormone. Proceedings of the National Academy of Sciences USA. 90:1993;1320-1324.
10. Gasdaska J.R., Law J.H., Bender C.J., Aisen P. Cockroach transferrin closely resembles vertebrate transferrins in its metal ion-binding properties: a spectroscopic study. Journal of Inorganic Biochemistry. 64:1996;247-258.
11. Bartfeld N.S., Law J.H. Isolation and molecular cloning of transferrin from the tobacco hornwork, Manduca sexta. Sequence similarity to the vertebrate transferrins. Journal of Biological Chemistry. 265:1990;21,684-21,691.
12. Yoshiga T., Hernandez V.P., Gallon A.M., Law J.H. Mosquito transferrin, an acute-phase protein that is up-regulated upon infection. Proceedings of the National Academy of Sciences USA. 94:1997;12,337-12,342.
13. Fisher M., Gokhman I., Pick U., Zamir A. A structurally novel transferrin-like protein accumulates in the plasma membrane of the unicellular green alga Dunaliella salina grown in high salinities. Journal of Biological Chemistry. 272:1997;1565-1570.
14. Fisher M., Zamir A., Pick U. Iron uptake by the halotolerant alga Dunaliella is mediated by a plasma membrane transferrrin. Journal of Biological Chemistry. 273:1998;17,553-17,558.
15. Jandl J.H., Inman J.K., Simmons R.L., Allen D.W. Transfer of iron from serum iron-binding protein to human reticulocytes. Journal of Clinical Investigation. 38:1959;161-185.
16. Hu H-Y.Y., Aisen P. Molecular characteristics of the transferrin-receptor complex of the rabbit reticulocyte. Journal of Supramolecular Structure. 8:1978;349-360.
17. Witt D.P., Woodworth R.C. Identification of the transferrin receptor of the rabbit reticulocyte. Biochemistry. 17:1978;438-448.
18. Ecarot-Charrier B., Grey V.L., Wilczynska A., Schulman H.M. Reticulocyte membrane transferrin receptors. Canadian Journal of Biochemistry. 53:1980;418-426.
19. Enns C.A., Sussman H.H. Physical characterization of the transferrin receptor in human placentae. Journal of Biological Chemistry. 255:1981;9820-9823.
20. Sutherland R., Delia D., Schneider C., Newman R., Kemshead J., Greaves M. Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin. Proceedings of the National Academy of Sciences USA. 78:1981;4515-4519.
21. Trowbridge I.S., Omary M.B. Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin. Proceedings of the National Academy of Sciences USA. 78:1981;3039-3043.
22. McClelland A., Kühn L.C., Ruddle F.H. The human transferrin receptor gene: Genomic organization and the complete primary structure of the receptor deduced from a cDNA sequence. Cell. 39:1984;267-274.
23. C. Schneider, M.J. Owen, D. Banville, J.G. Williams, Primary structure of human transferrin receptor deduced from the mRNA sequence. Nature (1984) 675-678.
24. Jing S., Trowbridge I.S. Identification of the intermolecular disulfide bonds of the human transferrin receptor and its lipid-attachment site. EMBO Journal. 6:1987;327-331.
25. Omary M.B., Trowbridge I.S. Biosynthesis of the human transferrin receptor in cultured cells. Journal of Biological Chemistry. 256:1981;12,888-12,892.
26. Hayes G.R., Enns C.A., Lucas J.J. Identification of the O-linked glycosylation site of the human transferrin receptor. Glycobiology. 2:1992;355-359.
27. Williams A.M., Enns C.A. Mutated transferrin receptor lacking asparagine-linked glycoprotein sites shows reduced functionality and an association with binding immunoglobulin protein. Journal of Biological Chemistry. 266:1991;17,648-17,654.
28. Rutledge E.A., Root B.J., Lucas J.J., Enns C.A. Elimination of the O-linked glycosylation site at Thr 104 results in the generation of a soluble human-transferrin recptor. Blood. 83:1994;580-586.
29. Buchegger F., Trowbridge I.S., Liu L.F., White S., Collawn J.F. Functional analysis of human/chicken transferrin receptor chimeras indicates that the carboxy-terminal region is important for ligand binding. European Journal of Biochemistry. 235:1996;9-17.
30. Zerial M., Melancon P., Schneider C., Garoff H. The transmembrane segment of the human transferrin receptor functions as a signal peptide. EMBO Journal. 5:1986;1543-1550.
31. Zerial M., Haylbroek D., Garoff H. Foreign transmembrane peptides replacing the internal signal sequence of transferrin receptor allow its translocation and membrane binding. Cell. 48:1987;147-155.
32. Jing S., Trowbridge I.S. Nonacylated human transferrin receptors are rapidly internalized and mediate iron uptake. Journal of Biological Chemistry. 265:1990;11,555-11,559.
33. Schneider C.R., Sutherland R., Newman R., Greaves M. Structural features of the cell surface receptor for transferrin that is recognized by the monoclonal antibody OKT9. Journal of Biological Chemistry. 257:1982;8516-8522.
34. Rothenberger S., Iacopetta B.J., Kühn L.C. Endocytosis of the transferrin receptor requires the cytoplasmic domain but not its phosphorylation site. Cell. 49:1987;423-431.
35. Cox T.M., O'Donnell M.W., Aisen P., London I.M. Hemin inhibits internalization of transferrin by reticulocytes and promotes phosphorylation of the membrane transferrin receptor. Proceedings of the National Academy of Sciences USA. 82:1985;5170-5174.
36. Alvarez E., Girones N., Davis R.J. A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis. Biochemical Journal. 267:1990;31-35.
37. Collawn J.F., Stangel M., Kühn L.A., Esekogwu V., Jing S.Q., Trowbridge I.S., Tainer J.A. Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis. Cell. 63:1990;1061-1072.
38. Collawn J.F., Lai A., Domingo D., Fitch M., Hatton S., Trowbridge I.S. YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis. Journal of Biological Chemistry. 268:1993;21,686-21,692.
39. Andrews N.C., Levy J.E. Iron is hot: an update on the pathophysiology of hemochromatosis. Blood. 92:1998;1845-1851.
40. Feder J.N., Gnirke A., Thomas W., Tsuchihashi Z., Ruddy D.A., Basava A., Dornishian F., Domingo R. Jr, Ellis M.C., Fullan A., Hinton L.M., Jones N.L., Kimmel B.E., Kronmal G.S., Lauer P., Lee V.K., Loeb D.B., Mapa F.A., McClelland E., Meyer N.C., Mintier G.A., Moeller N., Moore T., Morikang E., Prass C.E., Quintana L., Starnes S.M., Schatzman R.C., Brunke K.J., Drayna D.T., Risch N.J., Bacon B.R., Wolff R.K. A novel MHC class I-like gene is mutated in patients with hereditary hemochromatosis. Nature Genetics. 13:1996;399-408.
41. Parkkila S., Waheed A., Britton R.S., Bacon N.R., Zhou X.Y., Tomatsu S., Fleming R.E., Sly W.S. Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis. Proceedings of the National Academy of Sciences USA. 94:1997;13,198-13,202.
42. Feder J.N., Penny D.M., Irrinki A., Lee V.K., Lebron J.A., Watson N., Tsuchihashi Z., Sigal E., Bjorkman P.J., Schatzman R.C. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proceedings of the National Academy of Sciences USA. 95:1998;1472-1477.
43. Lebrón J.A., Bennett M.J., Vaughn D.E., Chirino A.J., Snow P.M., Mintier G.A., Feder J.N., Bjorkman P.J. Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell. 93:1998;111-123.
44. Gross C.N., Irrinki A., Feder J.N., Enns C.A. Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation. Journal of Biological Chemistry. 273:1998;22,068-22,074.
45. McLaren G.D., Nathanson M.H., Jacobs A., Trevett D., Thomson W. Regulation of intestinal iron absorption and mucosal iron kinetics in hereditary hemochromatosis. Journal of Laboratory and Clinical Medicine. 117:1991;390-401.
46. Fillet G., Beguin Y., Baldelli L. Model of reticuloendothelial iron metabolism in humans: abnormal behavior in idiopathic hemochromatosis and in inflammation. Blood. 74:1989;844-851.
47. Fuchs H., Lucken U., Tauber R., Engel A., Gessner R. Structural model of phospholipid-reconstituted human transferrin receptor derived by electron microscopy. Structure. 6:1998;1235-1243.
48. May W.S. Jr, Cuatrecasas P. Transferrin receptor: its biological significance. Journal of Membrane Biology. 88:1985;205-215.
49. Raso V., Basala M. A highly cytotoxic human transferrin-ricin A chain conjugate used to select receptor-modified cells. Journal of Biological Chemistry. 259:1984;1143-1149.
50. McGraw T.E., Greenfield L., Maxfield F.R. Functional expression of the human transferrin receptor cDNA in Chinese hamster ovary cells deficient in endogenous transferrin receptor. Journal of Cell Biology. 105:1987;207-214.
51. Chan R.Y., Ponka P., Schulman H.M. Transferrin-receptor-independent but iron-dependent proliferation of variant Chinese hamster ovary cells. Experimental Cell Research. 202:1992;326-336.
52. Young S.P., Bomford A., Williams R. The effect of the iron saturation of transferrin on its binding and uptake by rabbit reticulocytes. Biochemical Journal. 219:1984;505-510.
53. Baker E., Morgan E.H. Iron transport. Brock J.H., Halliday J.W., Pippard M.J., Powell L.W. Iron Metabolism in Health and Disease. 1994;63-95 W.B. Saunders Company Ltd.
54. Bali P.K., Zak O., Aisen P. A new role for the transferrin receptor in the release of iron from transferrin. Biochemistry. 30:1991;324-328.
55. Sipe D.M., Murphy R.F. Binding to cellular receptors results in increased iron release from transferrin at mildly acidic pH. Journal of Biological Chemistry. 266:1991;8002-8007.
56. Fleming M.D., Trenor C.C.I., Su M.A., Foernzler D., Beier D.R., Dietrich W.F., Andrews N.C. Microcytic anemia mice have a mutation in Nramp2, a candidate iron transporter. Nature Genetics. 16:1997;383-386.
57. Fleming M.D., Romano M.A., Garrick L.M., Garrick M.D., Andrews N.C. Anemia of the Belgrade rat is caused by a mutation in iron transporter protein Nramp2. Proceedings of the National Academy of Sciences USA. 95:1998;1148-1153.
58. Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., Boron W.F., Nussberger S., Gollan J.L., Hediger M.A. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 388:1997;482-488.
59. Young S.P., Bomford A. Interactive endocytosis of transferrin by K562 cells. Biochemical Journal. 298:1994;165-170.
60. Richardson D.R., Ponka P., Vyoral D. Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone. Examination of cytoplasmic and mitochondrial intermediates involved in iron metabolism. Blood. 87:1996;3477-3488.
61. Ponka P. Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells. Blood. 89:1997;1-25.
62. Jin M., Snider M.D. Role of microtubules in transferrin receptor transport from the cell surface to endosomes and the Golgi complex. Journal of Biological Chemistry. 268:1993;18,390-18,397.
63. Sakai T., Mizuno T., Miyamoto H., Kawasaki K. Two distinct kinds of tubular organelles involved in the rapid recycling and slow processing of endocytosed transferrin. Biochemical and Biophysical Research Communications. 242:1998;151-157.
64. Malorni W., Testa U., Rainaldi G., Tritarelli E., Peschle C. Oxidative stress leads to a rapid alteration of transferrin receptor intravesicular trafficking. Experimental Cell Research. 241:1998;102-116.
65. Levy J.E., Jin O., Fujiwara Y., Kuo F., Andrews N.C. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nature Genetics. 21:1999;396-399.
66. Copp A.J., Estibeiro J.P., Brook F.A., Downs K.M. Exogenous transferrin is taken up and localized by the neurulation-stage mouse embryo in vitro. Developmental Biology. 153:1992;312-323.
67. Larrick J.W., Hyman E.S. Acquired iron-deficiency anemia caused by an antibody against the transferrin receptor. New England Journal of Medicine. 311:1984;214-218.
68. Kühn J.C., McClelland A., Ruddle F.H. Gene transfer, expression and molecular cloning of the human transferrin receptor gene. Cell. 37:1984;95-103.
69. Enns C.A., Soumalainen H.A., Gebhardt J.E., Schroder J., Sussman J. Human transferrin receptor: expression of the receptor is assigned to chromosome 3. Proceedings of the National Academy of Sciences USA. 79:1982;3241-3245.
70. Goodfellow P.N., Banting G., Sutherland R., Greaves M., Solomon E., Poveys S. Expression of human transferrin receptor is controlled by a gene on chromosome 2. Somatic Cell Genetics. 8:1982;197-206.
71. Owen D., Kühn L.C. Noncoding 3′ sequences of the transferrin receptor gene are required for mRNA regulation by iron. EMBO Journal. 6:1987;1287-1293.
72. Evans P., Kemp J. Exon/intron structure of the human transferrin receptor gene. Gene. 199:1997;123-131.
73. Israeli R.S., Powell C.T., Fair W.R., Heston W.D. Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Cancer Research. 53:1993;227-230.
74. Van Landeghem G.F., Beckman L.E., Sikstrom C., Saha N., Kucinskas V., Beckman L. New DNA polymorphisms define ethnically distinct halotypes in the human transferrin receptor gene. Human Heredity. 48:1998;245-250.
75. Müllner E.W., Neupert B., Kühn L.C. A specific mRNA-binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA. Cell. 58:1989;373-382.
76. Casey J.L., Koeller D.M., Rawin V.R., Klausner R.D., Harford J.B. Iron regulation of transferrin receptor mRNA levels required iron-responsive elements and a rapid turnover determinants in the 3′ untranslated region of the mRNA. EMBO Journal. 8:1989;3693-3699.
77. Rao K., Harford J.B., Rouault T.A., McClelland A., Ruddle F.H., Klausner R.D. Transcriptional regulation by iron of the gene for the transferrin receptor. Molecular and Cellular Biology. 6:1986;236-240.
78. Casey J.L., Di Jeso B., Rao K., Klausner R.D., Harford J.B. Two genetic loci participate in the regulation by iron of the gene for the human transferrin receptor. Proceedings of the National Academy of Sciences USA. 85:1988;1787-1791.
79. Miskimins W.K., McClelland A., Roberts M.P., Ruddle F.H. Cell proliferation and expression of the transferrin receptor gene: promoter sequence homologies and protein interactions. Journal of Cell Biology. 103:1986;1781-1788.
80. Ouyang Q., Bommakanti M., Miskimins W.K. A mitogen-responsive promoter region that is synergistically activated through multiple signalling pathways. Molecular and Cellular Biology. 13:1993;1796-1804.
81. Hirsch S., Miskinins W.K. Mitogen induction of nuclear factors that interact with a delayed responsive region of the transferrin receptor gene promoter. Cell Growth and Differentiation. 6:1995;719-726.
82. Kronke M., Leonard W., Depper J.M., Greene W.C. Sequential expression of genes involved in human T lymphocyte growth and differentiation. Journal of Experimental Medicine. 161:1985;1593-1598.
83. Boumpas D.T., Anastassiou E.D., Tsokos G.C., Thyphronitis G., Balow J.E. Gene transcription during in vitro activation of human B lymphocytes with Staphylococcus aureus Cowan I strain. Journal of Immunology. 145:1990;2701-2705.
84. Seiser C., Texieira S., Kühn L.C. Interleukin-2-dependent transcriptional and post-transcriptional regulation of transferrin receptor mRNA. Journal of Biological Chemistry. 268:1993;13,074-13,080.
85. Beard P., Offord E., Paduwat N., Bruggmann H. SV40 activates transcription from the transferrin receptor promoter by inducing a factor which binds to the CRE/AP-1 recognition sequence. Nucleic Acids Research. 25:1991;7117-7123.
86. Trepel J.B., Colamonici O.R., Kelly K., Schwab G., Watt R.A., Sauville E.A., Jaffe E.A., Neckers L.M. Transcriptional inactivation of c-myc and the transferrin receptor in dibutyryl cyclic AMP-treated HL-60 cells. Molecular and Cellular Biology. 7:1987;2644-2648.
87. Alcantara O., Denham C.A., Phillips J.L., Boldt D.H. Transcriptional regulation of transferrin receptor expression by cultured lymphoblastoid T cells treated with phorbol esters. Journal of Immunology. 142:1989;1719-1725.
88. Lok C.N., Chan K.F., Loh T.T. Transcriptional regulation of transferrin receptor gene expression during phorbol ester-induced HL-60 cell differentiation. European Journal of Biochemistry. 236:1996;614-619.
89. Chan L.N., Gerhardt E.M. Transferrin receptor gene is hyperexpressed and transcriptionally regulated in differentiating erythroid cells. Journal of Biological Chemistry. 267:1992;8254-8259.
90. Chan R.Y.Y., Seiser C., Schulman H.M., Kühn L.C., Ponka P. Regulation of transferrin receptor mRNA expression: distinct regulatory features in erythroid cells. European Journal of Biochemistry. 220:1994;683-692.
91. Busfield S.J., Tilbrook P.A., Callus N.A., Spadaccini A., Kühn L., Klinken S.P. Complex regulation of transferrin receptors during erythropoietin-induced differentiation of J2E erythroid cells. European Journal of Biochemistry. 249:1997;77-84.
92. Casey J.L., Di Jeso B., Rao K.K., Rouault T.A., Klausner R.D., Harford J.B. Deletion analysis of the promoter region of the transferrin receptor gene. Nucleic Acids Research. 16:1988;629-646.
93. Roberts M.R., Han Y., Fienberg A., Hunihan L., Ruddle F.H. A DNA-binding activity, TRAC, specific for the TRA element of the transferrin receptor gene copurifies with the Ku autoantigen. Proceedings of the National Academy of Sciences USA. 91:1994;6354-6358.
94. Miskimins W.K., King F., Miskimins R. Phosphatidylinositol 3-kinase inhibitor wortmannin blocks mitogenic activation of the transferrin receptor gene promoter in late G1. Cell Growth and Differentiation. 8:1997;565-570.
95. Sieweke M.H., Tekotte J., Frampton J., Graf T. MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation. Cell. 85:1996;49-60.
96. Lok C.N., Ponka P. Analysis of transferrin receptor promoter activity in erythroid cells. Blood. 90:1997;7a.
97. Liebold E.A., Guo B. Iron-dependent regulation of ferritin and transferrin receptor expression by the iron-responsive element binding protein. Annual Review of Nutrition. 12:1992;345-368.
98. Theil E.C. Iron regulatory elements (IREs): a family of mRNA non-coding sequences. Biochemical Journal. 304:1994;1-11.
99. Klausner R.D., Rouault T.A., Harford J.B. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell. 72:1993;19-28.
100. Hentze M.W., Kühn L.C. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proceedings of the National Academy of Sciences USA. 93:1996;8175-8182.
101. Samaniego F., Chin J., Iwai K., Rouault T.A., Klausner R.D. Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function and post-translational regulation. Journal of Biological Chemistry. 269:1994;30,904-30,910.
102. Guo B., Phillips J.D., Yu Y., Leibold E.A. Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome. Journal of Biological Chemistry. 270:1995;21,645-21,651.
103. Iwai K., Klausner R.D., Rouault T.A. Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2. EMBO Journal. 14:1995;5350-5357.
104. Iwai K., Drake S.K., Wehr N.B., Weissman A.M., LaVaute T., Minato N., Klausner R.D., Levine R.L., Rouault T.A. Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins. Proceedings of the National Academy of Sciences. 95:1998;4924-4928.
105. Gunshin H., Rouault T., Rogers J., Allerson C., Gollan J.L., Hediger M.A. Regulation of the divalent cation transporter DCT1 at the mRNA level. FASEB Journal. 12:1998;A820.
106. Richardson D.R., Ponka P. Effects of nitrogen monoxide on cellular iron metabolism. Methods in Neurosciences. 31:1996;329-345.
107. Drapier J.C., Hirling H., Wietzerbin J., Kaldy P., Kühn L.C. Biosynthesis of nitric oxide activates iron regulatory factor in macrophages. EMBO Journal. 12:1993;3643-3649.
108. Weiss G., Goossen B., Doppler W., Fuchs D., Pantopoulos K., Werner-Felmayer G., Wachter H., Hentze M.W. Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway. EMBO Journal. 12:1993;3651-3657.
109. Richardson D.R., Neumannova V., Nagy E., Ponka P. The effect of redox-related species of nitrogen monoxide on transferrin and iron uptake and cellular proliferation of erythroleukemia (K562) cells. Blood. 86:1995;3211-3219.
110. Stamler J.S., Singel D.J., Loscalzo J. Biochemistry of nitric oxide and its redox-activated forms. Science. 258:1992;1898-1902.
111. Stamler J.S. Redox signaling: nitrosylation and related target interactions of nitric oxide. Cell. 78:1994;931-936.
112. Ponka P., Kim S. Control of transferrin receptor and ferritin expression via nitric oxide (NO)-mediated degradation of IRP-2. Nitric Oxide. 2:1998;104.
113. Schalinske K.L., Blemings K.P., Steffen D.W., Chen O.S., Eisenstein R.S. Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line. Proceedings of the National Academy of Sciences USA. 94:1997;10,681-10,686.
114. Martins E.A., Robalinho R.L., Meneghini R. Oxidative stress induces activation of a cytosolic protein responsible for control of iron uptake. Archives of Biochemistry and Biophysics. 316:1995;128-134.
115. Pantopoulos K., Hentze M.W. Rapid responses to oxidative stress mediated by iron regulatory protein. EMBO Journal. 14:1995;2917-2924.
116. 2) control mammalian iron metabolism by different pathways. Molecular and Cellular Biology. 16:1996;3781-3788.
117. Pantopoulos K., Mueller S., Atzberger A., Ansorge W., Stremmel W., Hentze M.W. Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress. Journal of Biological Chemistry. 272:1997;9802-9808.
118. Pantopoulos K., Hentze M.W. Activation of iron regulatory protein-1 by oxidative stress in vitro. Proceedings of the National Academy of Sciences USA. 95:1998;10,559-10,563.
119. Jordan A., Reichard P. Ribonucleotide reductases. Annual Review of Biochemistry. 67:1998;71-98.
120. Fava R.A., Comeau R.D., Woodworth R.C. Specific membrane receptors for diferric-transferrin in cultured rat skeletal myocytes and chick-embryo cardiac myocytes. Bioscience Reports. 1:1981;377-385.
121. Holmes S.D., Bucci L.R., Lipschultz L.I., Smith R.G. Transferrin binds specifically to pachytene spermatocytes. Endocrinology. 113:1983;1916-1918.
122. Gatter K.C., Brown G., Trowbridge I.S., Woolston R.E., Mason D.Y. Transferrin receptors in human tissues: their distribution and possible clinical relevance. Journal of Clinical Pathology. 36:1983;539-545.
123. Siel C., Bicknell D., Cairne G., Robinson J., Lam G., Greaves M. Changes in cell surface antigen expression during hematopoietic differentiation. Blood. 60:1982;703-713.
124. Lesley J., Hyman R., Schulte R., Trotter J. Expression of transferrin receptor on murine hematopoietic progenitors. Cellular Immunology. 83:1984;14-25.
125. Iacopetta B.J., Morgan E.G., Yeoh G.C.T. Transferrin receptors and iron uptake during erythroid cell development. Biochimica et Biophysica Acta. 687:1982;204-210.
126. Sawyer S.T., Krantz S.B. Transferrin receptor number, synthesis, and endocytosis during erythropoietin-induced maturation of Friend virus-infected erythroid cells. Journal of Biological Chemistry. 261:1986;9187-9195.
127. Callus B.A., Busfield S.J., Rossi E., Tilbrook P.A., Chappell D., Morgan E.H., Klinken S.P. Haemoglobin synthesis in erythropoietin-stimulated J2E cells does not require increased numbers of transferrin receptors. European Journal of Biochemistry. 250:1997;459-466.
128. Hu H.Y., Gardner J., Aisen P., Skoultchi A.I. Inducibility of transferrin receptors of Friend erythroleukemia cells. Science. 197:1977;559-561.
129. Wilczynska A., Schulman H.M. Friend erythroleukemia cell membrane transferrin receptors. Canadian Journal of Biochemistry. 58:1980;935-940.
130. Laskey J.D., Ponka P., Schulman H.M. Control of heme synthesis during Friend cell differentiation: role of iron and transferrin. Journal of Cellular Physiology. 129:1986;185-192.
131. Rapoport S.M. The Reticulocyte. 1986;CRC, Boca Raton, FL.
132. Pan B.T., Blostein R., Johnstone R.M. Loss of the transferrin receptor during the maturation of sheep reticulocytes in vitro. An immunological approach. Biochemical Journal. 210:1983;37-47.
133. Orkin S.H. GATA-binding transcription factors in hematopoietic cells. Blood. 80:1992;575-581.
134. Chan L-N.L., Shao J.Y. Transcriptional regulation of the transferrin receptor gene in differentiating erythroid cells. Blood. 82:1993;458a.
135. Janknecht R., Nordheim A. Gene regulation by Ets proteins. Biochimica et Biophysica Acta. 1155:1993;346-356.
136. Gubin A.N., Njoroge J.M., Bouffard G.G., Miller J.L. Gene expression in proliferating human erythroid cells. Genomics. 59:1999;168-177.
137. Weiss G., Houston T., Kastner S., Johrer K., Grunenwald K., Brock J.H. Regulation of cellular iron metabolism by erythropoietin: activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cells. Blood. 89:1997;680-687.
138. Ponka P., Nagy E., Zhang A-S, Koury M.J. Regulation of transferrin receptor expression in erythroid cells: erythropoietin does not affect iron-regulatory proteins. Blood. 90:(1):1997;6a.
139. Pelicci P.G., Tabilio A., Thomopoulos P., Titeux M., Vainchenker W., Rochant J., Testa U. Hemin regulates the expression of transferrin receptors in human hematopoietic cell lines. FEBS Letters. 145:1982;350-354.
140. Rouault T., Rao K., Harford J.B., Mattia E., Klausner R.D. Hemin, chelatable iron and the regulation of transferrin receptor biosynthesis. Journal of Biological Chemistry. 260:1985;14,862-14,866.
141. Mascotti D.P., Rup D., Thach R.E. Regulation of iron metabolism: translational effects mediated by iron, heme and cytokines. Annual Review of Nutrition. 15:1995;239-261.
142. Eisenstein R.S., Garcia-Mayol D., Pettingell W., Munro H.N. Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron. Proceedings of the National Academy of Sciences USA. 88:1991;688-692.
143. Cox T.M., O'Donnell M.W., Aisen P., London I.M. Biosynthesis of the transferrin receptor in rabbit reticulocytes. Journal of Clinical Investigation. 76:1985;2144-2150.
144. Grdisa M., Mathew A., Johnstone R.M. Expression and loss of the transferrin receptor in growing and differentiating HD3 cells. Journal of Cellular Physiology. 155:1993;349-357.
145. Battistini A., Coccia E-M., Marziali G., Bulgarini D., Scalzo S., Fiorucci G., Romeo G., Affabris E., Testa U., Rossi G.B., Peschle C. Intracellular heme coordinately modulates globin chain synthesis, transferrin receptor numbers, and ferritin content in differentiating Friend erythroleukemia cells. Blood. 78:1991;2098-2103.
146. Hradilek A., Fuchs O., Neuwirt J. Inhibition of heme synthesis decreases transferrin receptor expression in mouse erythroleukemia cells. Journal of Cellular Physiology. 150:1992;327-333.
147. Lok C.N., Ponka P. Role of heme in transferrin receptor expression in erythroid cells. Blood. 90:(1):1997;6a.
148. P. Ponka, Cell biology of heme, American Journal of Medical Sciences (in press).
149. London I.M., Levin D.H., Matts R.L., Thomas N.S.B., Petryshyn R., Chan J.J. Regulation of protein synthesis. Boyer P.D. The Enzymes. vol. 18:1987;359-380 Academic, New York.
150. Testa U., Petrini M., Quaranta M.T., Pelosi-Testa E., Mastroberardino G., Camagna A., Boccoli G., Sargiacomo M., Isacchi G., Cozzi A., Arosio P., Peschle C. Iron up-modulates the expression of transferrin receptors during monocyte-macrophage maturation. Journal of Biological Chemistry. 264:1989;13,181-13,187.
151. Testa U., Kühn L., Petrini M., Quaranta M.T., Pelosi E., Peschle C. Differential regulation of iron regulatory element-binding protein(s) in cell extracts of activated lymphocytes versus monocytes-macrophages. Journal of Biological Chemistry. 266:1991;3925-3930.
152. Hamilton T.A., Gray P.W., Adams D.O. Expression of the transferrin receptor on murine peritoneal macrophages is modulated by in vitro treatment with interferon gamma. Cellular Immunology. 89:1984;478-488.
153. Byrd T.F., Horowitz M.A. Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. Journal of Clinical Investigation. 83:1989;1457-1465.
154. MacKicking J., Xie Q-W., Nathan C. Nitric oxide and macrophage function. Annual Review of Immunology. 15:1997;323-350.
155. Galbraith R.M., Galbraith G.M. Expression of transferrin receptors on mitogen-stimulated human peripheral blood lymphocytes: relation to cellular activation and related metabolic events. Immunology. 133:1983;703-710.
156. Neckers L.M., Cossman J. Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2. Proceedings of the National Academy of Sciences USA. 80:1983;3494-3498.
157. Neckers L.M., Yenokida G., James S.P. The role of the transferrin receptor in human B lymphocyte activation. Journal of Immunology. 133:1984;2437-2441.
158. Futran J., Kemp J.D., Field E.H., Vora A., Ashman R.F. Transferrin receptor synthesis is an early event in B cell activation. Journal of Immunology. 143:1989;787-792.
159. Teixeira S., Kühn L.C. Post-transcriptional regulation of the transferrin receptor and 4F2 antigen heavy chain mRNA during growth activation of spleen cells. European Journal of Biochemistry. 202:1991;819-826.
160. Brock J.H., Stevenson J. Replacement of transferrin in serum-free cultures of mitogen-stimulated mouse lymphocytes by a lipophilic iron chelator. Immunological Letters. 15:1987;23-25.
161. Laskey J., Webb I., Schulman H.M., Ponka P. Evidence that transferrin supports cell proliferation by supplying iron for DNA synthesis. Experimental Cell Research. 176:1988;87-95.
162. Brekelmans P., van Soest P., Leenen P.J., van Ewijk W. Inhibition of proliferation and differentiation during early T cell development by anti-transferrin receptor antibody. European Journal of Immunology. 24:1994;2896-2902.
163. Manger B., Weiss A., Hardy K.J., Stobo J.D. A transferrin receptor antibody represents one signal for the induction of IL 2 production by a human T cell line. Journal of Immunology. 136:1986;532-538.
164. Cano E., Pizarro A., Redondo J.M., Sanchez-Madrid F., Bernabeu C., Fresno M. Induction of T cell activation by monoclonal antibodies specific for the transferrin receptor. European Journal of Immunology. 20:1990;765-770.
165. Pan B.T., Johnstone R.M. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell. 33:1983;967-978.
166. Pan B.T., Teng K., Wu C., Adam M., Johnstone R.M. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. Journal of Cell Biology. 101:1985;942-948.
167. Ahn J., Johnstone R.M. Origin of a soluble truncated transferrin receptor. Blood. 81:1993;2442-2451.
168. Johnstone R.M. Cleavage of the transferrin receptor by human granulocytes: differential proteolysis of the exosome-bound TfR. Journal of Cellular Physiology. 168:1996;333-345.
169. Cook J.D., Skikne B.S., Baynes R.D. Serum transferrin receptor. Annual Review of Medicine. 44:1993;63-74.
170. Thorstensen K., Romslo I. The transferrin receptor: its diagnostic value and its potential as therapeutic target. Scandinavian Journal of Clinical and Laboratory Investigation. 53:(215):1993;113-120.
171. Ahluwalia N. Diagnostic utility of serum transferrin receptors measurement in assessing iron status. Nutritional Review. 56:1998;133-141.
172. Shih Y.J., Baynes R.D., Hudson B.G., Flowers C.H., Skikne B.S., Cook J.D. Serum transferrin receptor is a truncated form of tissue receptor. Journal of Biological Chemistry. 265:1990;19,077-19,081.
173. Ferguson B.J., Skikne B.S., Simpson K.M., Baynes R.D., Cook J.D. Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. Journal of Laboratory and Clinical Medicine. 119:1992;385-390.
174. Aisen P. Transferrin, the transferrin receptor, and the uptake of iron by cells. Sigel S., Sigel H. Metal Ions in Biological Systems. vol. 35:1998;585-631 Marcel Dekker Inc, New York.
175. Cox T.M., Ponka P., Schulman H.M. Erythroid cell iron metabolism and heme synthesis. Ponka P., Schulman H.M., Woodworth R.D. Iron Transport and Storage. 1990;163-279 CRC, Boca Raton, Florida.
176. Bastin J.M., Jones M., O'Callaghan C.A., Shimanski L., Mason D.Y., Townsend A.R.M. Kupffer cell staining by an HFE-specific monoclonal antibody: implications for hereditary haemochromatosis. British Journal of Hematology. 103:1998;931-941.
177. Dubljevic V., Sali A., Goding J.W. A conserved RGD (Arg=Gly-Asp) motif in the transferrin receptor is required for binding to transferrin. Biochemical Journal. 341:1999;11-14.
178. Roy C.N., Penny D.M., Feder J.N., Enns C.A. The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells. Journal of Biological Chemistry. 274:1999;9022-9028.
179. Salter-Cid L., Brunmark A., Li Y., Leturco D., Peterson P.A., Jackson M.R., Yang Y. Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: Implications for cellular iron homeostasis. Proceedings of the National Academy of Science USA. 96:1999;5434-5439.
180. Waheed A., Parkkila S., Saarnio J., Fleming R.E., Zhou X.Y., Tomatsu S., Britton R.S., Bacon B.R., Sly W.S. Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proceedings of the National Academy of Science USA. 96:1999;1579-1584.
181. Zuk P.A., Elferink L.A. Rab15 mediates an early endocytic event in Chinese hamster ovary cells. Journal of Biological Chemistry. 274:1999;22303-22312.
182. Kawabata H., Yang R., Hirama T., Vuong P.T., Kawano S., Gombart A.F., Koeffler H.P. Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. Journal of Biological Chemistry. 274:1999;20826-20832.
183. Lok C.N., Ponka P. Identification of a hypoxia response element in the transferrin receptor gene. Journal of Biological Chemistry. 274:1999;24147-24152.
184. Kaur C., Ling E.A. Increased expression of transferrin receptors and iron in amoeboid microglial cells in postnatal rats following an exposure to hypoxia. Neuroscience Letters. 262:1999;183-186.
185. S. Kim, P. Ponka, Control of transferrin receptor expression via nitric oxide-mediated modulation of iron-regulatory protein 2, Journal of Biological Chemistry 274 (1999) in press.