-
1
-
-
0035896581
-
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
-
Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., and Loréal, O. (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276, 7811-7819
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 7811-7819
-
-
Pigeon, C.1
Ilyin, G.2
Courselaud, B.3
Leroyer, P.4
Turlin, B.5
Brissot, P.6
Loréal, O.7
-
2
-
-
0035896642
-
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
-
Park, C. H., Valore, E. V., Waring, A. J., and Ganz, T. (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J. Biol. Chem. 276, 7806-7810
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 7806-7810
-
-
Park, C.H.1
Valore, E.V.2
Waring, A.J.3
Ganz, T.4
-
3
-
-
0035902605
-
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
-
DOI 10.1073/pnas.151179498
-
Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., and Vaulont, S. (2001) Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc. Natl. Acad. Sci. U.S.A. 98, 8780-8785 (Pubitemid 32678104)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.15
, pp. 8780-8785
-
-
Nicolas, G.1
Bennoun, M.2
Devaux, I.3
Beaumont, C.4
Grandchamp, B.5
Kahn, A.6
Vaulont, S.7
-
4
-
-
0036791486
-
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
-
Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., and Vaulont, S. (2002) The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Invest. 110, 1037-1044
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1037-1044
-
-
Nicolas, G.1
Chauvet, C.2
Viatte, L.3
Danan, J.L.4
Bigard, X.5
Devaux, I.6
Beaumont, C.7
Kahn, A.8
Vaulont, S.9
-
5
-
-
0038662619
-
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
-
DOI 10.1182/blood-2002-10-3235
-
Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., and Ganz, T. (2003) Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101, 2461-2463 (Pubitemid 36857598)
-
(2003)
Blood
, vol.101
, Issue.7
, pp. 2461-2463
-
-
Nemeth, E.1
Valore, E.V.2
Territo, M.3
Schiller, G.4
Lichtenstein, A.5
Ganz, T.6
-
6
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
DOI 10.1126/science.1104742
-
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., and Kaplan, J. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306, 2090-2093 (Pubitemid 40007660)
-
(2004)
Science
, vol.306
, Issue.5704
, pp. 2090-2093
-
-
Nemeth, E.1
Tuttle, M.S.2
Powelson, J.3
Vaughn, M.D.4
Donovan, A.5
Ward, D.M.6
Ganz, T.7
Kaplan, J.8
-
7
-
-
34250865977
-
The molecular mechanism of hepcidin-mediated ferroportin down-regulation
-
DOI 10.1091/mbc.E07-01-0060
-
De Domenico, I., Ward, D. M., Langelier, C., Vaughn, M. B., Nemeth, E., Sundquist, W. I., Ganz, T., Musci, G., and Kaplan, J. (2007) The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol. Biol. Cell 18, 2569-2578 (Pubitemid 47025722)
-
(2007)
Molecular Biology of the Cell
, vol.18
, Issue.7
, pp. 2569-2578
-
-
De Domenico, I.1
Ward, D.M.2
Langelier, C.3
Vaughn, M.B.4
Nemeth, E.5
Sundquist, W.I.6
Ganz, T.7
Musci, G.8
Kaplan, J.9
-
8
-
-
33750133047
-
Regulation of iron metabolism by hepcidin
-
Nemeth, E., and Ganz, T. (2006) Regulation of iron metabolism by hepcidin. Annu. Rev. Nutr. 26, 323-342
-
(2006)
Annu. Rev. Nutr.
, vol.26
, pp. 323-342
-
-
Nemeth, E.1
Ganz, T.2
-
9
-
-
33745743014
-
Hepcidin and iron-loading anemias
-
Nemeth, E., and Ganz, T. (2006) Hepcidin and iron-loading anemias. Haematologica 91, 727-732 (Pubitemid 44014536)
-
(2006)
Haematologica
, vol.91
, Issue.6
, pp. 727-732
-
-
Nemeth, E.1
Ganz, T.2
-
10
-
-
33646370235
-
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
-
Babitt, J. L., Huang, F. W., Wrighting, D. M., Xia, Y., Sidis, Y., Samad, T. A., Campagna, J. A., Chung, R. T., Schneyer, A. L., Woolf, C. J., Andrews, N. C., and Lin, H. Y. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat. Genet. 38, 531-539
-
(2006)
Nat. Genet.
, vol.38
, pp. 531-539
-
-
Babitt, J.L.1
Huang, F.W.2
Wrighting, D.M.3
Xia, Y.4
Sidis, Y.5
Samad, T.A.6
Campagna, J.A.7
Chung, R.T.8
Schneyer, A.L.9
Woolf, C.J.10
Andrews, N.C.11
Lin, H.Y.12
-
11
-
-
34447137331
-
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
-
DOI 10.1172/JCI31342
-
Babitt, J. L., Huang, F. W., Xia, Y., Sidis, Y., Andrews, N. C., and Lin, H. Y. (2007) Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J. Clin. Invest. 117, 1933-1939 (Pubitemid 47036327)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.7
, pp. 1933-1939
-
-
Babitt, J.L.1
Huang, F.W.2
Xia, Y.3
Sidis, Y.4
Andrews, N.C.5
Lin, H.Y.6
-
12
-
-
63449103712
-
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
-
Andriopoulos, B., Jr., Corradini, E., Xia, Y., Faasse, S. A., Chen, S., Grgurevic, L., Knutson, M. D., Pietrangelo, A., Vukicevic, S., Lin, H. Y., and Babitt, J. L. (2009) BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat. Genet. 41, 482-487
-
(2009)
Nat. Genet.
, vol.41
, pp. 482-487
-
-
Andriopoulos Jr., B.1
Corradini, E.2
Xia, Y.3
Faasse, S.A.4
Chen, S.5
Grgurevic, L.6
Knutson, M.D.7
Pietrangelo, A.8
Vukicevic, S.9
Lin, H.Y.10
Babitt, J.L.11
-
13
-
-
63449122819
-
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
-
Meynard, D., Kautz, L., Darnaud, V., Canonne-Hergaux, F., Coppin, H., and Roth, M. P. (2009) Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat. Genet. 41, 478-481
-
(2009)
Nat. Genet.
, vol.41
, pp. 478-481
-
-
Meynard, D.1
Kautz, L.2
Darnaud, V.3
Canonne-Hergaux, F.4
Coppin, H.5
Roth, M.P.6
-
14
-
-
48549096566
-
Intriguing extracellular regulation of BMP signaling
-
Bier, E. (2008) Intriguing extracellular regulation of BMP signaling. Dev. Cell 15, 176-177
-
(2008)
Dev. Cell
, vol.15
, pp. 176-177
-
-
Bier, E.1
-
15
-
-
67651043722
-
Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells
-
Tanno, T., Porayette, P., Sripichai, O., Noh, S. J., Byrnes, C., Bhupatiraju, A., Lee, Y. T., Goodnough, J. B., Harandi, O., Ganz, T., Paulson, R. F., and Miller, J. L. (2009) Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood 114, 181-186
-
(2009)
Blood
, vol.114
, pp. 181-186
-
-
Tanno, T.1
Porayette, P.2
Sripichai, O.3
Noh, S.J.4
Byrnes, C.5
Bhupatiraju, A.6
Lee, Y.T.7
Goodnough, J.B.8
Harandi, O.9
Ganz, T.10
Paulson, R.F.11
Miller, J.L.12
-
16
-
-
0033789235
-
Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila
-
Conley, C. A., Silburn, R., Singer, M. A., Ralston, A., Rohwer-Nutter, D., Olson, D. J., Gelbart, W., and Blair, S. S. (2000) Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila. Development 127, 3947-3959
-
(2000)
Development
, vol.127
, pp. 3947-3959
-
-
Conley, C.A.1
Silburn, R.2
Singer, M.A.3
Ralston, A.4
Rohwer-Nutter, D.5
Olson, D.J.6
Gelbart, W.7
Blair, S.S.8
-
17
-
-
0043133835
-
BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation
-
DOI 10.1128/MCB.23.16.5664-5679.2003
-
Moser, M., Binder, O., Wu, Y., Aitsebaomo, J., Ren, R., Bode, C., Bautch, V. L., Conlon, F. L., and Patterson, C. (2003) BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol. Cell. Biol. 23, 5664-5679 (Pubitemid 36951331)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.16
, pp. 5664-5679
-
-
Moser, M.1
Binder, O.2
Wu, Y.3
Aitsebaomo, J.4
Ren, R.5
Bode, C.6
Bautch, V.L.7
Conlon, F.L.8
Patterson, C.9
-
18
-
-
34548151204
-
BMPER is a conserved regulator of hematopoietic and vascular development in zebrafish
-
DOI 10.1016/j.yjmcc.2007.05.008, PII S0022282807010474
-
Moser, M., Yu, Q., Bode, C., Xiong, J. W., and Patterson, C. (2007) BMPER is a conserved regulator of hematopoietic and vascular development in zebrafish. J. Mol. Cell. Cardiol. 43, 243-253 (Pubitemid 47304444)
-
(2007)
Journal of Molecular and Cellular Cardiology
, vol.43
, Issue.3
, pp. 243-253
-
-
Moser, M.1
Yu, Q.2
Bode, C.3
Xiong, J.-W.4
Patterson, C.5
-
19
-
-
33645542833
-
Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation
-
Rentzsch, F., Zhang, J., Kramer, C., Sebald, W., and Hammerschmidt, M. (2006) Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation. Development 133, 801-811
-
(2006)
Development
, vol.133
, pp. 801-811
-
-
Rentzsch, F.1
Zhang, J.2
Kramer, C.3
Sebald, W.4
Hammerschmidt, M.5
-
20
-
-
10744233059
-
Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins
-
DOI 10.1016/j.bbrc.2004.01.048
-
Binnerts, M. E., Wen, X., Canté-Barrett, K., Bright, J., Chen, H. T., Asundi, V., Sattari, P., Tang, T., Boyle, B., Funk, W., and Rupp, F. (2004) Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins. Biochem. Biophys. Res. Commun. 315, 272-280 (Pubitemid 38183104)
-
(2004)
Biochemical and Biophysical Research Communications
, vol.315
, Issue.2
, pp. 272-280
-
-
Binnerts, M.E.1
Wen, X.2
Cante-Barrett, K.3
Bright, J.4
Chen, H.-T.5
Asundi, V.6
Sattari, P.7
Tang, T.8
Boyle, B.9
Funk, W.10
Rupp, F.11
-
21
-
-
0037111732
-
Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease
-
DOI 10.1182/blood-2002-04-1260
-
Weinstein, D. A., Roy, C. N., Fleming, M. D., Loda, M. F., Wolfsdorf, J. I., and Andrews, N. C. (2002) Inappropriate expression of hepcidin is associated with iron refractory anemia. Implications for the anemia of chronic disease. Blood 100, 3776-3781 (Pubitemid 35303951)
-
(2002)
Blood
, vol.100
, Issue.10
, pp. 3776-3781
-
-
Weinstein, D.A.1
Roy, C.N.2
Fleming, M.D.3
Loda, M.F.4
Wolfsdorf, J.I.5
Andrews, N.C.6
-
22
-
-
0033861745
-
A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
-
McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., Hediger, M. A., Hentze, M. W., and Simpson, R. J. (2000) A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol. Cell 5, 299-309 (Pubitemid 30628088)
-
(2000)
Molecular Cell
, vol.5
, Issue.2
, pp. 299-309
-
-
McKie, A.T.1
Marciani, P.2
Rolfs, A.3
Brennan, K.4
Wehr, K.5
Barrow, D.6
Miret, S.7
Bomford, A.8
Peters, T.J.9
Farzaneh, F.10
Hediger, M.A.11
Hentze, M.W.12
Simpson, R.J.13
-
23
-
-
0035710746
-
-ΔΔCT method
-
DOI 10.1006/meth.2001.1262
-
Livak, K. J., and Schmittgen, T. D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) Method. Methods 25, 402-408 (Pubitemid 34164012)
-
(2001)
Methods
, vol.25
, Issue.4
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
24
-
-
67349204418
-
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD
-
Casanovas, G., Mleczko-Sanecka, K., Altamura, S., Hentze, M.W., and Muckenthaler, M. U. (2009) Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD. J. Mol. Med. 87, 471-480
-
(2009)
J. Mol. Med.
, vol.87
, pp. 471-480
-
-
Casanovas, G.1
Mleczko-Sanecka, K.2
Altamura, S.3
Hentze, M.W.4
Muckenthaler, M.U.5
-
25
-
-
0037244116
-
Human hepatocyte isolation and relationship of cell viability to early graft function
-
Mitry, R. R., Hughes, R. D., Aw, M. M., Terry, C., Mieli-Vergani, G., Girlanda, R., Muiesan, P., Rela, M., Heaton, N. D., and Dhawan, A. (2003) Human hepatocyte isolation and relationship of cell viability to early graft function. Cell Transplant. 12, 69-74 (Pubitemid 36397317)
-
(2003)
Cell Transplantation
, vol.12
, Issue.1
, pp. 69-74
-
-
Mitry, R.R.1
Hughes, R.D.2
Aw, M.M.3
Terry, C.4
Mieli-Vergani, G.5
Girlanda, R.6
Muiesan, P.7
Rela, M.8
Heaton, N.D.9
Dhawan, A.10
-
26
-
-
78751558997
-
Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice
-
Bartnikas, T. B., Andrews, N. C., and Fleming, M. D. (2011) Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. Blood 117, 630-637
-
(2011)
Blood
, vol.117
, pp. 630-637
-
-
Bartnikas, T.B.1
Andrews, N.C.2
Fleming, M.D.3
-
27
-
-
48549097726
-
Crossveinless-2 Is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning
-
Ambrosio, A. L., Taelman, V. F., Lee, H. X., Metzinger, C. A., Coffinier, C., and De Robertis, E. M. (2008) Crossveinless-2 Is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning. Dev. Cell 15, 248-260
-
(2008)
Dev. Cell
, vol.15
, pp. 248-260
-
-
Ambrosio, A.L.1
Taelman, V.F.2
Lee, H.X.3
Metzinger, C.A.4
Coffinier, C.5
De Robertis, E.M.6
-
28
-
-
34547117636
-
Von Willebrand factor type C domain-containing proteins regulate bone morphogenetic protein signaling through different recognition mechanisms
-
DOI 10.1074/jbc.M700456200
-
Zhang, J. L., Huang, Y., Qiu, L. Y., Nickel, J., and Sebald, W. (2007) von Willebrand factor type C domain-containing proteins regulate bone morphogenetic protein signaling through different recognition mechanisms. J. Biol. Chem. 282, 20002-20014 (Pubitemid 47100074)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.27
, pp. 20002-20014
-
-
Zhang, J.-L.1
Huang, Y.2
Qiu, L.-Y.3
Nickel, J.4
Sebald, W.5
-
29
-
-
43049116191
-
Crystal Structure Analysis Reveals How the Chordin Family Member Crossveinless 2 Blocks BMP-2 Receptor Binding
-
DOI 10.1016/j.devcel.2008.02.017, PII S1534580708001172
-
Zhang, J. L., Qiu, L. Y., Kotzsch, A., Weidauer, S., Patterson, L., Hammerschmidt, M., Sebald, W., and Mueller, T. D. (2008) Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding. Dev. Cell 14, 739-750 (Pubitemid 351622617)
-
(2008)
Developmental Cell
, vol.14
, Issue.5
, pp. 739-750
-
-
Zhang, J.-l.1
Qiu, L.-y.2
Kotzsch, A.3
Weidauer, S.4
Patterson, L.5
Hammerschmidt, M.6
Sebald, W.7
Mueller, T.D.8
-
30
-
-
10244255021
-
Regulation of transferrin receptor 2 protein levels by transferrin
-
DOI 10.1182/blood-2004-06-2481
-
Robb, A., and Wessling-Resnick, M. (2004) Regulation of transferrin receptor 2 protein levels by transferrin. Blood 104, 4294-4299 (Pubitemid 39620185)
-
(2004)
Blood
, vol.104
, Issue.13
, pp. 4294-4299
-
-
Robb, A.1
Wessling-Resnick, M.2
-
31
-
-
0033231035
-
Importance of anemia and transferrin levels in the regulation of intestinal iron absorption in hypotransferrinemic mice
-
Raja, K. B., Pountney, D. J., Simpson, R. J., and Peters, T. J. (1999) Importance of anemia and transferrin levels in the regulation of intestinal iron absorption in hypotransferrinemic mice. Blood 94, 3185-3192 (Pubitemid 29512727)
-
(1999)
Blood
, vol.94
, Issue.9
, pp. 3185-3192
-
-
Raja, K.B.1
Pountney, D.J.2
Simpson, R.J.3
Peters, T.J.4
-
32
-
-
33644772206
-
Animal models with enhanced erythropoiesis and iron absorption
-
DOI 10.1016/j.bbadis.2005.12.007, PII S092544390500205X
-
Latunde-Dada, G. O., McKie, A. T., and Simpson, R. J. (2006) Animal models with enhanced erythropoiesis and iron absorption. Biochim. Biophys. Acta 1762, 414-423 (Pubitemid 43344302)
-
(2006)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1762
, Issue.4
, pp. 414-423
-
-
Latunde-Dada, G.O.1
McKie, A.T.2
Simpson, R.J.3
|