The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice

Haematologica

Volumn 98, Issue 3, 2013, Pages 444-447

  Casanovas, Guillem ^a,b,c   Spasić, Maja Vujić ^a,b   Casu, Carla ^d   Rivella, Stefano ^d   Strelau, Jens ^e   Unsicker, Klaus ^f   Muckenthaler, Martina U ^a,b  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b Molecular Medicine Partnership Unit   (Germany)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e UNIVERSITY OF HEIDELBERG   (Germany)

^f UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; BONE MORPHOGENETIC PROTEIN; CYTOKINE; GROWTH DIFFERENTIATION FACTOR 15; HEMOGLOBIN; HEPCIDIN; MESSENGER RNA; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; IRON;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ERYTHROBLAST; ERYTHROCYTE COUNT; ERYTHROPOIESIS; FEMALE; HEMATOLOGICAL PARAMETERS; HOMEOSTASIS; IRON HOMEOSTASIS; MALE; MOUSE; NONHUMAN; PHLEBOTOMY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RETROBULBAR HEMORRHAGE; ANIMAL; BLOOD; BONE MARROW; GENETICS; KNOCKOUT MOUSE; LIVER; MEAN CORPUSCULAR VOLUME; METABOLISM; SPLEEN;

ANIMALS; BONE MARROW; ERYTHROCYTE INDICES; FEMALE; GROWTH DIFFERENTIATION FACTOR 15; HEPCIDINS; HOMEOSTASIS; IRON; LIVER; MALE; MICE; MICE, KNOCKOUT; PHLEBOTOMY; RNA, MESSENGER; SPLEEN;

EID: 84871223663     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2012.069807     Document Type: Article

References (26)

1. Andrews NC. Forging a field: the golden age of iron biology. Blood. 2008;112(2):219-30.
2. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306(5704):2090-3.
3. Ramey G, Deschemin JC, Durel B, Canonne-Hergaux F, Nicolas G, Vaulont S. Hepcidin targets ferroportin for degradation in hepatocytes. Haematologica. 2010; 95(3):501-4.
4. Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, Lee YT, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007;13(9):1096-101.
5. Finkenstedt A, Bianchi P, Theurl I, Vogel W, Witcher DR, Wroblewski VJ, et al. Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency. Br J Haematol. 2009;144(5):789-93.
6. Casanovas G, Swinkels DW, Altamura S, Schwarz K, Laarakkers CM, Gross HJ, et al. Growth differentiation factor 15 in patients with congenital dyserythropoietic anaemia (CDA) type II. J Mol Med. 2011;89(8):811-6.
7. Tamary H, Shalev H, Perez-Avraham G, Zoldan M, Levi I, Swinkels DW, et al. Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I. Blood. 2008;112(13):5241-4.
8. Bottner M, Suter-Crazzolara C, Schober A, Unsicker K. Expression of a novel member of the TGF-beta superfamily, growth/differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues. Cell Tissue Res. 1999;297(1):103-10.
9. Bottner M, Laaff M, Schechinger B, Rappold G, Unsicker K, Suter-Crazzolara C. Characterization of the rat, mouse, and human genes of growth/differentiation factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1). Gene. 1999;237(1):105-11.
10. Ago T, Sadoshima J. GDF15, a cardioprotective TGF-beta superfamily protein. Circ Res. 2006;98(3):294-7.
11. Xu J, Kimball TR, Lorenz JN, Brown DA, Bauskin AR, Klevitsky R, et al. GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res. 2006;98(3): 342-50.
12. Strelau J, Sullivan A, Bottner M, Lingor P, Falkenstein E, Suter-Crazzolara C, et al. Growth/differentiation factor-15/macrophage inhibitory cytokine-1 is a novel trophic factor for midbrain dopaminergic neurons in vivo. J Neurosci. 2000;20 (23):8597-603.
13. Johnen H, Lin S, Kuffner T, Brown DA, Tsai VW, Bauskin AR, et al. Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nat Med. 2007;13(11):1333-40.
14. Strelau J, Strzelczyk A, Rusu P, Bendner G, Wiese S, Diella F, et al. Progressive postnatal motoneuron loss in mice lacking GDF-15. J Neurosci. 2009;29(43):13640-8.
15. Torrance JD, Bothwell TH. A simple technique for measuring storage iron concentrations in formalinised liver samples. S Afr J Med Sci. 1968;33(1):9-11.
16. Vujic Spasic M, Kiss J, Herrmann T, Galy B, Martinache S, Stolte J, et al. Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metabolism. 2008;7(2):173-8.
17. Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 2002;30(9):e36.
18. Hata A, Lagna G, Massague J, Hemmati, Brivanlou A. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 1998;12(2):186-97.
19. Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003;113(6):685-700.
20. Mleczko-Sanecka K, Casanovas G, Ragab A, Breitkopf K, Muller A, Boutros M, et al. SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. Blood. 2009;115(13):2657-65.
21. Oelgeschlager M, Larrain J, Geissert D, De Robertis EM. The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling. Nature. 2000;405(6788):757-63.
22. Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, Bhupatiraju A, et al. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood. 2009; 114(1):181-6.
23. Walter PB, Harmatz P, Vichinsky E. Iron metabolism and iron chelation in sickle cell disease. Acta Haematologica. 2009;122(2-3):174-83.
24. Gardenghi S, Marongiu MF, Ramos P, Guy E, Breda L, Chadburn A, et al. Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. Blood. 2007;109(11):5027-35.
25. Ginzburg Y, Rivella S. b-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism. Blood. 2011;118(16):4321-30.
26. Parrow NL, Gardenghi S, Ramos P, Casu C, Grady RW, Anderson ER, et al. Decreased hepcidin expression in murine b-thalassemia is associated with suppression of Bmp/Smad signaling. Blood. 2012;119(13): 3187-9.