Upregulation of hepcidin by interleukin-1β in human hepatoma cell lines

Hepatology Research

Volumn 33, Issue 3, 2005, Pages 198-205

  Inamura, Junki ^a   Ikuta, Katsuya ^a   Jimbo, Junko ^a   Shindo, Motohiro ^a   Sato, Kazuya ^a   Torimoto, Yoshihiro ^a   Kohgo, Yutaka ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Anemia of chronic disease (ACD); Hepcidin; HuH 7 cells; Interleukin 1 (IL 1 ); Interleukin 6 (IL 6); Iron metabolism

Indexed keywords

HEPCIDIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA;

ANEMIA; ARTICLE; CELL STIMULATION; CELL STRAIN HEPG2; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; IRON METABOLISM; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

EID: 29144437865     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hepres.2005.08.005     Document Type: Article

References (52)

1. P. Aisen C. Enns M. Wessling-Resnick Chemistry and biology of eukaryotic iron metabolism Int J Biochem Cell Biol 33 2001 940-959
2. N.C. Andrews Disorders of iron metabolism N Engl J Med 341 1999 1986-1995
3. J.N. Feder A. Gnirke W. Thomas et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis Nat Genet 13 1996 399-408
4. A. Hattori S. Wakusawa H. Hayashi et al. AVAQ 594-597 deletion of the TfR2 gene in a Japanese family with hemochromatosis Hepatol Res 26 2003 154-156
5. A. Pietrangelo Non-HFE hemochromatosis Hepatology 39 2004 21-29
6. G.R. Lee The anemia of chronic disease Semin Hematol 20 1983 61-80
7. R.T. Means Jr. Advances in the anemia of chronic disease Int J Hematol 70 1999 7-12
8. C.H. Park E.V. Valore A.J. Waring T. Ganz Hepcidin, a urinary antimicrobial peptide synthesized in the liver J Biol Chem 276 2001 7806-7810
9. A. Krause S. Neitz H.-J. Mägert et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity FEBS Lett 480 2000 147-150
10. C. Pigeon G. Ilyin B. Courselaud et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload J Biol Chem 276 2001 7811-7819
11. G. Nicolas M. Bennoun I. Devaux et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice Proc Natl Acad Sci USA 98 2001 8780-8785
12. G. Nicolas M. Bennoun A. Porteu et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin Proc Natl Acad Sci USA 99 2002 4596-4601
13. R.E. Fleming W.S. Sly Hepcidin: A putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease Proc Natl Acad Sci USA 98 2001 8160-8162
14. H. Shike X. Lauth M.E. Westerman et al. Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge Eur J Biochem 269 2002 2232-2237
15. G. Nicolas C. Chauvet L. Viatte et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation J Clin Invest 110 2002 1037-1044
16. D.A. Weinstein C.N. Roy M.D. Fleming M.F. Loda J.I. Wolfsdorf N.C. Andrews Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease Blood 100 2002 3776-3781
17. E. Nemeth E.V. Valore M. Territo G. Schiller A. Lichtenstein T. Ganz Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein Blood 101 2003 2461-2463
18. V.R. Gordeuk P. Prithviraj T. Dolinar G.M. Brittenham Interleukin 1 administration in mice produces hypoferremia despite neutropenia J Clin Invest 82 1988 1934-1938
19. X. Alvarez-Hernández J. Licéaga I.C. McKay J.H. Brock Induction of hypoferremia and modulation of macrophage iron metabolism by tumor necrosis factor Lab Invest 61 1989 319-322
20. M. Kobune Y. Kohgo J. Kato E. Miyazaki Y. Niitsu Interleukin-6 enhances hepatic transferrin uptake and ferritin expression in rats Hepatology 19 1994 1468-1475
21. M. Jongen-Lavrencic H.R. Peeters H. Rozemuller et al. IL-6-induced anaemia in rats: Possible pathogenetic implications for anemia observed in chronic inflammations Clin Exp Immunol 103 1996 328-334
22. E. Nemeth S. Rivera V. Gabayan et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin J Clin Invest 113 2004 1271-1276
23. P. Lee H. Peng T. Gelbart E. Beutler The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and β2-microglobulin-deficient hepatocytes Proc Natl Acad Sci USA 101 2004 9263-9265
24. P. Lee H. Peng T. Gelbart L. Wang E. Beutler Regulation of hepcidin transcription by interleukin-1 and interleukin-6 Proc Natl Acad Sci USA 102 2005 1906-1910
25. H. Nakabayashi K. Taketa K. Miyano T. Yamane J. Saito Growth of human hepatoma cell lines with differentiated functions in chemically defined medium Cancer Res 42 1982 3858-3863
26. I. Doi M. Namba J. Sato Establishment and some biological characteristics of human hepatoma cell lines Gann 66 1975 385-392
27. D.P. Aden A. Fogel S. Plotkin I. Damjanov B.B. Knowles Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line Nature 282 1979 615-616
28. F. Orii T. Ashida M. Nomura et al. Quantitative analysis for human glucocorticoid receptor α/β mRNA in IBD Biochem Biophys Res Commun 296 2002 1286-1294
29. H. Kohda M. Ono Y. Torimoto et al. Induction of interleukin 6 production by interleukin 1 and tumor necrosis factor in human hepatoma cells Gastroenterol Jpn 27 1992 685
30. A.H. Laftah B. Ramesh R.J. Simpson et al. Effect of hepcidin on intestinal iron absorption in mice Blood 103 2004 3940-3944
31. S. Yamaji P. Sharp B. Ramesh S.K. Srai Inhibition of iron transport across human intestinal epithelial cells by hepcidin Blood 104 2004 2178-2180
32. E. Nemeth M.S. Tuttle J. Powelson et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Science 306 2004 2090-2093
33. D.M. Frazer S.J. Wilkins E.M. Becker et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats Gastroenterology 123 2002 835-844
34. K.-Y. Yeh M. Yeh J. Glass Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat Am J Physiol Gastrointest Liver Physiol 286 2004 G385-G394
35. T. Ganz Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation Blood 102 2003 783-788
36. S.G. Gehrke H. Kulaksiz T. Herrmann et al. Expression of hepcidin in hereditary hemochromatosis: Evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron Blood 102 2003 371-376
37. M. Fahmy S.P. Young Modulation of iron metabolism in monocyte cell line U937 by inflammatory cytokines: Changes in transferrin uptake, iron handling and ferritin mRNA Biochem J 296 1993 175-181
38. A. Djeha J.-L. Pérez-Arellano S.L. Hayes et al. Cytokine-mediated regulation of transferrin synthesis in mouse macrophages and human T lymphocytes Blood 85 1995 1036-1042
39. S.Y. Ryu K.S. Jeong B.N. Kang et al. Modulation of transferrin synthesis, transferrin receptor expression, iNOS expression and NO production in mouse macrophages by cytokines, either alone or in combination Anticancer Res 20 2000 3331-3338
40. J.F. Telfer J.H. Brock Proinflammatory cytokines increase iron uptake into human monocytes and synovial fibroblasts from patients with rheumatoid arthritis Med Sci Monit 10 2004 BR91-BR95
41. M.C. di Patti T. Persichini V. Mazzone F. Polticelli M. Colasanti G. Musci Interleukin-1β up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis Neurosci Lett 363 2004 182-186
42. J.T. Rogers K.R. Bridges G.P. Durmowicz J. Glass P.E. Auron H.N. Munro Translational control during the acute phase response: Ferritin synthesis in response to interleukin-1 J Biol Chem 265 1990 14572-14578
43. M. Hirayama Y. Kohgo H. Kondo et al. Regulation of iron metabolism in HepG2 cells: A possible role for cytokines in the hepatic deposition of iron Hepatology 18 1993 874-880
44. D.J. Piñero J. Hu B.M. Cook R.C. Scaduto Jr. J.R. Connor Interleukin-1β increases binding of the iron regulatory protein and the synthesis of ferritin by increasing the labile iron pool Biochim Biophys Acta 1497 2000 279-288
45. J.A. Eastgate J.A. Symons N.C. Wood F.M. Grinlinton F.S. di Giovine G.W. Duff Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis Lancet 332 1988 706-709
46. M.L. Wellby J.A. Kennedy K. Pile B.S. True P. Barreau Serum interleukin-6 and thyroid hormones in rheumatoid arthritis Metabolism 50 2001 463-467
47. G. Baffet T.A. Braciak R.G. Fletcher J. Gauldie G.H. Fey W. Northemann Autocrine activity of interleukin 6 secreted by hepatocarcinoma cell lines Mol Biol Med 8 1991 141-156
48. K. Utsumi Y. Takai T. Tada S. Ohzeki H. Fujiwara T. Hamaoka Enhanced production of IL-6 in tumor-bearing mice and determination of cells responsible for its augmented production J Immunol 145 1990 397-403
49. M. Lotz B.L. Zuraw D.A. Carson F.R. Jirik Hepatocytes produce interleukin-6 Ann N Y Acad Sci 557 1989 509-511
50. C. Gabay I. Kushner Acute-phase proteins and other systemic responses to inflammation N Engl J Med 340 1999 448-454
51. H. Moshage Cytokines and the hepatic acute phase response J Pathol 181 1997 257-266
52. B. Courselaud C. Pigeon Y. Inoue et al. C/EBPα regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism: Cross-talk between C/EBP pathway and iron metabolism J Biol Chem 277 2002 41163-41170