-
1
-
-
33746909869
-
Regulation of iron acquisition and iron distribution in mammals
-
Ganz T, Nemeth E. Regulation of iron acquisition and iron distribution in mammals. Biochim Biophys Acta. 2006;1763:690-699.
-
(2006)
Biochim Biophys Acta
, vol.1763
, pp. 690-699
-
-
Ganz, T.1
Nemeth, E.2
-
2
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090-2093.
-
(2004)
Science
, vol.306
, pp. 2090-2093
-
-
Nemeth, E.1
Tuttle, M.S.2
Powelson, J.3
-
3
-
-
0036791486
-
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
-
Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002;110:1037-1044.
-
(2002)
J Clin Invest
, vol.110
, pp. 1037-1044
-
-
Nicolas, G.1
Chauvet, C.2
Viatte, L.3
-
4
-
-
0035896581
-
Anew mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
-
Pigeon C, Ilyin G, Courselaud B, et al. Anew mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 2001;276:7811-7819.
-
(2001)
J Biol Chem
, vol.276
, pp. 7811-7819
-
-
Pigeon, C.1
Ilyin, G.2
Courselaud, B.3
-
5
-
-
20244388240
-
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
-
Roetto A, Papanikolaou G, Politou M, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet. 2003;33:21-22.
-
(2003)
Nat Genet
, vol.33
, pp. 21-22
-
-
Roetto, A.1
Papanikolaou, G.2
Politou, M.3
-
6
-
-
9144252017
-
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
-
Papanikolaou G, Samuels ME, Ludwig EH, et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 2004;36:77-82.
-
(2004)
Nat Genet
, vol.36
, pp. 77-82
-
-
Papanikolaou, G.1
Samuels, M.E.2
Ludwig, E.H.3
-
7
-
-
13544250486
-
Hepcidin is decreased in TFR2 hemochromatosis
-
Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C. Hepcidin is decreased in TFR2 hemochromatosis. Blood. 2005;105:1803-1806.
-
(2005)
Blood
, vol.105
, pp. 1803-1806
-
-
Nemeth, E.1
Roetto, A.2
Garozzo, G.3
Ganz, T.4
Camaschella, C.5
-
8
-
-
37049024131
-
Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis
-
Piperno A, Girelli D, Nemeth E, et al. Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood. 2007;110:4096-4100.
-
(2007)
Blood
, vol.110
, pp. 4096-4100
-
-
Piperno, A.1
Girelli, D.2
Nemeth, E.3
-
9
-
-
33646370235
-
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
-
Babitt JL, Huang FW, Wrighting DM, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006;38:531-539.
-
(2006)
Nat Genet
, vol.38
, pp. 531-539
-
-
Babitt, J.L.1
Huang, F.W.2
Wrighting, D.M.3
-
10
-
-
34447137331
-
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
-
Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest. 2007;117:1933-1939.
-
(2007)
J Clin Invest
, vol.117
, pp. 1933-1939
-
-
Babitt, J.L.1
Huang, F.W.2
Xia, Y.3
Sidis, Y.4
Andrews, N.C.5
Lin, H.Y.6
-
11
-
-
33646337674
-
Iron metabolism meets signal transduction
-
Anderson GJ, Frazer DM. Iron metabolism meets signal transduction. Nat Genet. 2006;38:503-504.
-
(2006)
Nat Genet
, vol.38
, pp. 503-504
-
-
Anderson, G.J.1
Frazer, D.M.2
-
12
-
-
33644876815
-
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
-
Wang RH, Li C, Xu X, et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2005;2:399-409.
-
(2005)
Cell Metab
, vol.2
, pp. 399-409
-
-
Wang, R.H.1
Li, C.2
Xu, X.3
-
13
-
-
33745898241
-
Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6
-
Truksa J, Peng H, Lee P, Beutler E. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci U S A. 2006;103:10289-10293.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 10289-10293
-
-
Truksa, J.1
Peng, H.2
Lee, P.3
Beutler, E.4
-
14
-
-
0036182842
-
Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains
-
Dupic F, Fruchon S, Bensaid M, et al. Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains. Gastroenterology. 2002;122:745-751.
-
(2002)
Gastroenterology
, vol.122
, pp. 745-751
-
-
Dupic, F.1
Fruchon, S.2
Bensaid, M.3
-
15
-
-
33745752870
-
Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis
-
Lesbordes-Brion JC, Viatte L, Bennoun M, et al. Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Blood. 2006;108:1402-1405.
-
(2006)
Blood
, vol.108
, pp. 1402-1405
-
-
Lesbordes-Brion, J.C.1
Viatte, L.2
Bennoun, M.3
-
16
-
-
33645241407
-
The RIN: An RNA integrity number for assigning integrity values to RNAmeasurements
-
Schroeder A, Mueller O, Stocker S, et al. The RIN: an RNA integrity number for assigning integrity values to RNAmeasurements. BMC Mol Biol (http://www.biomedcentral.com/bmcmolbiol/). 2006;7:3.
-
BMC Mol Biol
-
-
Schroeder, A.1
Mueller, O.2
Stocker, S.3
-
17
-
-
84870532154
-
-
Accessed June 30, 2008
-
National Center for Biotechnology Information. Gene Expression Omnibus. http://www.ncbi.nlm.nih.gov/geo/. Accessed June 30, 2008.
-
Gene Expression Omnibus
-
-
-
20
-
-
24644519314
-
Significance analysis of time course microarray experiments
-
Storey JD, Xiao W, Leek JT, Tompkins RG, Davis RW. Significance analysis of time course microarray experiments. Proc Natl Acad Sci U S A. 2005;102:12837-12842.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 12837-12842
-
-
Storey, J.D.1
Xiao, W.2
Leek, J.T.3
Tompkins, R.G.4
Davis, R.W.5
-
21
-
-
0036838570
-
Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice
-
Dupic F, Fruchon S, Bensaid M, et al. Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice. Gut. 2002;51:648-653.
-
(2002)
Gut
, vol.51
, pp. 648-653
-
-
Dupic, F.1
Fruchon, S.2
Bensaid, M.3
-
22
-
-
37549047172
-
Effects of iron loading on muscle: Genome-wide mRNA expression profiling in the mouse
-
Rodriguez A, Hilvo M, Kytomaki L, et al. Effects of iron loading on muscle: genome-wide mRNA expression profiling in the mouse. BMC Genomics (http://www.biomedcentral.com/bmcgenomics). 2007;8:379.
-
BMC Genomics
-
-
Rodriguez, A.1
Hilvo, M.2
Kytomaki, L.3
-
23
-
-
10744226568
-
Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice
-
Courselaud B, Troadec MB, Fruchon S, et al. Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice. Blood Cells Mol Dis. 2004;32:283-289.
-
(2004)
Blood Cells Mol Dis
, vol.32
, pp. 283-289
-
-
Courselaud, B.1
Troadec, M.B.2
Fruchon, S.3
-
25
-
-
0038005018
-
-
Genome Biol
-
Dennis G Jr, Sherman BT, Hosack DA, et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. (http://genomebiology.com). 2003;4:P3.
-
DAVID: Database for Annotation, Visualization, and Integrated Discovery
-
-
Dennis Jr, G.1
Sherman, B.T.2
Hosack, D.A.3
-
26
-
-
33847716712
-
Negative regulation of TGF-beta receptor/Smad signal transduction
-
Itoh S, ten Dijke P. Negative regulation of TGF-beta receptor/Smad signal transduction. Curr Opin Cell Biol. 2007;19:176-184.
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 176-184
-
-
Itoh, S.1
ten Dijke, P.2
-
27
-
-
0037085441
-
Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter
-
Korchynskyi O, ten Dijke P. Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J Biol Chem. 2002;277:4883-4891.
-
(2002)
J Biol Chem
, vol.277
, pp. 4883-4891
-
-
Korchynskyi, O.1
ten Dijke, P.2
-
28
-
-
0035191859
-
Math6, a bHLH gene expressed in the developing nervous system, regulates neuronal versus glial differentiation
-
Inoue C, Bae SK, Takatsuka K, Inoue T, Bessho Y, Kageyama R. Math6, a bHLH gene expressed in the developing nervous system, regulates neuronal versus glial differentiation. Genes Cells. 2001;6:977-986.
-
(2001)
Genes Cells
, vol.6
, pp. 977-986
-
-
Inoue, C.1
Bae, S.K.2
Takatsuka, K.3
Inoue, T.4
Bessho, Y.5
Kageyama, R.6
-
29
-
-
34548825938
-
Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4
-
Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007;110:2182-2189.
-
(2007)
Blood
, vol.110
, pp. 2182-2189
-
-
Lin, L.1
Valore, E.V.2
Nemeth, E.3
Goodnough, J.B.4
Gabayan, V.5
Ganz, T.6
-
30
-
-
26444509876
-
BMP-6 inhibits growth of mature human B cells: Induction of Smad phosphorylation and upregulation of Id1
-
Kersten C, Sivertsen EA, Hystad ME, Forfang L, Smeland EB, Myklebust JH. BMP-6 inhibits growth of mature human B cells: induction of Smad phosphorylation and upregulation of Id1. BMC Immunol (http://www.biomedcentral.com/bmcimmunol/) . 2005;6:9.
-
BMC Immunol
-
-
Kersten, C.1
Sivertsen, E.A.2
Hystad, M.E.3
Forfang, L.4
Smeland, E.B.5
Myklebust, J.H.6
-
31
-
-
0036910425
-
Two major Smad pathways in TGF-beta superfamily signalling
-
Miyazawa K, Shinozaki M, Hara T, Furuya T, Miyazono K. Two major Smad pathways in TGF-beta superfamily signalling. Genes Cells. 2002;7:1191-1204.
-
(2002)
Genes Cells
, vol.7
, pp. 1191-1204
-
-
Miyazawa, K.1
Shinozaki, M.2
Hara, T.3
Furuya, T.4
Miyazono, K.5
-
32
-
-
37249010753
-
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
-
Yu PB, Hong CC, Sachidanandan C, et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008;4:33-41.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 33-41
-
-
Yu, P.B.1
Hong, C.C.2
Sachidanandan, C.3
-
33
-
-
46749158788
-
Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
-
Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood. 2008;111:5195-5204.
-
(2008)
Blood
, vol.111
, pp. 5195-5204
-
-
Xia, Y.1
Babitt, J.L.2
Sidis, Y.3
Chung, R.T.4
Lin, H.Y.5
-
34
-
-
2342510407
-
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
-
Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113:1271-1276.
-
(2004)
J Clin Invest
, vol.113
, pp. 1271-1276
-
-
Nemeth, E.1
Rivera, S.2
Gabayan, V.3
-
35
-
-
39649115776
-
The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression
-
Schmidt PJ, Toran PT, Giannetti AM, Bjorkman PJ, Andrews NC. The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. Cell Metab. 2008;7:205-214.
-
(2008)
Cell Metab
, vol.7
, pp. 205-214
-
-
Schmidt, P.J.1
Toran, P.T.2
Giannetti, A.M.3
Bjorkman, P.J.4
Andrews, N.C.5
-
36
-
-
0035984569
-
Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation
-
Rosendahl A, Pardali E, Speletas M, Ten Dijke P, Heldin CH, Sideras P. Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am J Respir Cell Mol Biol. 2002;27:160-169.
-
(2002)
Am J Respir Cell Mol Biol
, vol.27
, pp. 160-169
-
-
Rosendahl, A.1
Pardali, E.2
Speletas, M.3
Ten Dijke, P.4
Heldin, C.H.5
Sideras, P.6
-
37
-
-
0033584854
-
Regulation of Smad7 promoter by direct association with Smad3 and Smad4
-
Nagarajan RP, Zhang J, Li W, Chen Y. Regulation of Smad7 promoter by direct association with Smad3 and Smad4. J Biol Chem. 1999;274:33412-33418.
-
(1999)
J Biol Chem
, vol.274
, pp. 33412-33418
-
-
Nagarajan, R.P.1
Zhang, J.2
Li, W.3
Chen, Y.4
-
38
-
-
0042347689
-
Id proteins in development, cell cycle and cancer
-
Ruzinova MB, Benezra R. Id proteins in development, cell cycle and cancer. Trends Cell Biol. 2003;13:410-418.
-
(2003)
Trends Cell Biol
, vol.13
, pp. 410-418
-
-
Ruzinova, M.B.1
Benezra, R.2
-
39
-
-
0037088678
-
Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation
-
Jogi A, Persson P, Grynfeld A, Pahlman S, Axelson H. Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. J Biol Chem. 2002;277:9118-9126.
-
(2002)
J Biol Chem
, vol.277
, pp. 9118-9126
-
-
Jogi, A.1
Persson, P.2
Grynfeld, A.3
Pahlman, S.4
Axelson, H.5
-
40
-
-
0030611757
-
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
-
Nakao A, Afrakhte M, Moren A, et al. Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature. 1997;389:631-635.
-
(1997)
Nature
, vol.389
, pp. 631-635
-
-
Nakao, A.1
Afrakhte, M.2
Moren, A.3
-
41
-
-
33745188200
-
Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells
-
Valdimarsdottir G, Goumans MJ, Itoh F, Itoh S, Heldin CH, ten Dijke P. Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells. BMC Cell Biol (http://www.biomedcentral.com/bmccellbiol). 2006;7:16.
-
BMC Cell Biol
-
-
Valdimarsdottir, G.1
Goumans, M.J.2
Itoh, F.3
Itoh, S.4
Heldin, C.H.5
ten Dijke, P.6
-
42
-
-
33747006700
-
Smad7 promotes and enhances skeletal muscle differentiation
-
Kollias HD, Perry RL, Miyake T, Aziz A, McDermott JC. Smad7 promotes and enhances skeletal muscle differentiation. Mol Cell Biol. 2006;26:6248-6260.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 6248-6260
-
-
Kollias, H.D.1
Perry, R.L.2
Miyake, T.3
Aziz, A.4
McDermott, J.C.5
-
43
-
-
33845477874
-
Cis and trans regulation of hepcidin expression by upstream stimulatory factor
-
Bayele HK, McArdle H, Srai SK. Cis and trans regulation of hepcidin expression by upstream stimulatory factor. Blood. 2006;108:4237-4245.
-
(2006)
Blood
, vol.108
, pp. 4237-4245
-
-
Bayele, H.K.1
McArdle, H.2
Srai, S.K.3
|