메뉴 건너뛰기




Volumn 69, Issue 6, 2014, Pages 725-735

Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: Evidence for a new erythropoietin/hemoglobin set point

Author keywords

Erythropoietin; Ferritin; Hepcidin; Testosterone

Indexed keywords

ANDROGEN; ERYTHROPOIETIN; HEMOGLOBIN; HEPCIDIN; TESTOSTERONE;

EID: 84896285751     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glt154     Document Type: Article
Times cited : (278)

References (44)
  • 2
    • 77954409942 scopus 로고    scopus 로고
    • Testosterone therapy inmen with androgen deficiency syndromes: An Endocrine Society clinicalpractice guideline
    • Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy inmen with androgen deficiency syndromes: an Endocrine Society clinicalpractice guideline. J Clin Endocrinol Metab. 2010;95:2536-2559.
    • (2010) J Clin Endocrinol Metab. , vol.95 , pp. 2536-2559
    • Bhasin, S.1    Cunningham, G.R.2    Hayes, F.J.3
  • 3
    • 29144469309 scopus 로고    scopus 로고
    • Adverse events associated withtestosterone replacement in middle-aged and older men: A meta-analysisof randomized, placebo-controlled trials
    • Calof OM, Singh AB, Lee ML, et al. Adverse events associated withtestosterone replacement in middle-aged and older men: a meta-analysisof randomized, placebo-controlled trials. J Gerontol A Biol SciMed Sci. 2005;60:1451-1457.
    • (2005) J Gerontol A Biol SciMed Sci. , vol.60 , pp. 1451-1457
    • Calof, O.M.1    Singh, A.B.2    Lee, M.L.3
  • 5
    • 0013850252 scopus 로고
    • Mechanism of testosterone action inerythropoiesis
    • Mirand EA, Gordon AS, Wenig J. Mechanism of testosterone action inerythropoiesis. Nature 1965;206(981):270-272.
    • (1965) Nature , vol.206 , Issue.981 , pp. 270-272
    • Mirand, E.A.1    Gordon, A.S.2    Wenig, J.3
  • 7
    • 79551583056 scopus 로고    scopus 로고
    • Hepcidin and disorders of iron metabolism
    • Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism. AnnuRev Med. 2011;62:347-360.
    • (2011) AnnuRev Med. , vol.62 , pp. 347-360
    • Ganz, T.1    Nemeth, E.2
  • 8
    • 75149116750 scopus 로고    scopus 로고
    • Trough serum testosterone predicts the development of polycythemiain hypogonadal men treated for up to 21 years with subcutaneous testosteronepellets
    • Ip FF, di Pierro I, Brown R, Cunningham I, Handelsman DJ, Liu PY.Trough serum testosterone predicts the development of polycythemiain hypogonadal men treated for up to 21 years with subcutaneous testosteronepellets. Eur J Endocrinol. 2010;162(2):385-390.
    • (2010) Eur J Endocrinol. , vol.162 , Issue.2 , pp. 385-390
    • Ip, F.F.1    Di Pierro, I.2    Brown, R.3    Cunningham, I.4    Handelsman, D.J.5    Liu, P.Y.6
  • 9
    • 61349136872 scopus 로고    scopus 로고
    • Testosterone actionon erythropoiesis does not require its aromatization to estrogen:insights from the testosterone and estrogen treatment of two aromatasedeficientmen
    • Rochira V, Zirilli L, Madeo B, Maffei L, Carani C. Testosterone actionon erythropoiesis does not require its aromatization to estrogen:insights from the testosterone and estrogen treatment of two aromatasedeficientmen. J Steroid Biochem Mol Biol. 2009;113:189-194.
    • (2009) J Steroid Biochem Mol Biol. , vol.113 , pp. 189-194
    • Rochira, V.1    Zirilli, L.2    Madeo, B.3    Maffei, L.4    Carani, C.5
  • 10
    • 84878730065 scopus 로고    scopus 로고
    • Is the haematopoietic effect oftestosterone mediated by erythropoietin? the results of a clinical trialin older men
    • Maggio M, Snyder PJ, Ceda GP, et al. Is the haematopoietic effect oftestosterone mediated by erythropoietin? The results of a clinical trialin older men. Andrology. 2013;1(1):24-28.
    • (2013) Andrology , vol.1 , Issue.1 , pp. 24-28
    • Maggio, M.1    Snyder, P.J.2    Ceda, G.P.3
  • 11
    • 0026494916 scopus 로고
    • Hypoxic inductionof the human erythropoietin gene: Cooperation between the promoterand enhancer, each of which contains steroid receptor responseelements
    • Blanchard KL, Acquaviva AM, Galson DL, Bunn HF. Hypoxic inductionof the human erythropoietin gene: cooperation between the promoterand enhancer, each of which contains steroid receptor responseelements. Mol Cell Biol. 1992;12:5373-5385.
    • (1992) Mol Cell Biol. , vol.12 , pp. 5373-5385
    • Blanchard, K.L.1    Acquaviva, A.M.2    Galson, D.L.3    Bunn, H.F.4
  • 12
    • 77957779215 scopus 로고    scopus 로고
    • Testosterone suppresses hepcidinin men: A potential mechanism for testosterone-induced erythrocytosis
    • Bachman E, Feng R, Travison T, et al. Testosterone suppresses hepcidinin men: a potential mechanism for testosterone-induced erythrocytosis.J Clin Endocrinol Metab. 2010;95:4743-4747.
    • (2010) J Clin Endocrinol Metab. , vol.95 , pp. 4743-4747
    • Bachman, E.1    Feng, R.2    Travison, T.3
  • 13
    • 77954421915 scopus 로고    scopus 로고
    • Adverse events associatedwith testosterone administration
    • Basaria S, Coviello AD, Travison TG, et al. Adverse events associatedwith testosterone administration. N Engl J Med. 2010;363:109-122.
    • (2010) N Engl J Med. , vol.363 , pp. 109-122
    • Basaria, S.1    Coviello, A.D.2    Travison, T.G.3
  • 14
    • 62149115641 scopus 로고    scopus 로고
    • A novel spreadsheet method for calculating the free serumconcentrations of testosterone, dihydrotestosterone, estradiol, estroneand cortisol: With illustrative examples from male and female populations
    • Mazer NA. A novel spreadsheet method for calculating the free serumconcentrations of testosterone, dihydrotestosterone, estradiol, estroneand cortisol: with illustrative examples from male and female populations.Steroids. 2009;74:512-519.
    • (2009) Steroids , vol.74 , pp. 512-519
    • Mazer, N.A.1
  • 16
    • 0033549052 scopus 로고    scopus 로고
    • The definition of anemia inolder persons
    • Izaks GJ, Westendorp RG, Knook DL. The definition of anemia inolder persons. JAMA. 1999;281:1714-1717.
    • (1999) JAMA , vol.281 , pp. 1714-1717
    • Izaks, G.J.1    Westendorp, R.G.2    Knook, D.L.3
  • 17
    • 0031589468 scopus 로고    scopus 로고
    • Effects of variousmodes of androgen substitution therapy on erythropoiesis
    • Jockenhovel F, Vogel E, Reinhardt W, Reinwein D. Effects of variousmodes of androgen substitution therapy on erythropoiesis. Eur J MedRes. 1997;2:293-298.
    • (1997) Eur J MedRes. , vol.2 , pp. 293-298
    • Jockenhovel, F.1    Vogel, E.2    Reinhardt, W.3    Reinwein, D.4
  • 18
  • 19
    • 76149135996 scopus 로고    scopus 로고
    • Effects of testosteroneon muscle strength, physical function, body composition,and quality of life in intermediate-frail and frail elderly men: A randomized,double-blind, placebo-controlled study
    • Srinivas-Shankar U, Roberts SA, Connolly MJ, et al. Effects of testosteroneon muscle strength, physical function, body composition,and quality of life in intermediate-frail and frail elderly men: a randomized,double-blind, placebo-controlled study. J Clin EndocrinolMetab. 2010;95:639-650.
    • (2010) J Clin EndocrinolMetab. , vol.95 , pp. 639-650
    • Srinivas-Shankar, U.1    Roberts, S.A.2    Connolly, M.J.3
  • 20
    • 77954394453 scopus 로고    scopus 로고
    • Clinicalreview 1: Adverse effects of testosterone therapy in adult men: Asystematic review and meta-analysis
    • Fernandez-Balsells MM, Murad MH, Lane M, et al. Clinicalreview 1: adverse effects of testosterone therapy in adult men: asystematic review and meta-analysis. J Clin Endocrinol Metab.2010;95:2560-2575.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2560-2575
    • Fernandez-Balsells, M.M.1    Murad, M.H.2    Lane, M.3
  • 21
    • 0025964392 scopus 로고
    • Circulating erythropoietinlevels after bone marrow transplantation: Inappropriate response toanemia in allogeneic transplants
    • Beguin Y, Clemons GK, Oris R, Fillet G. Circulating erythropoietinlevels after bone marrow transplantation: inappropriate response toanemia in allogeneic transplants. Blood. 1991;77:868-873.
    • (1991) Blood , vol.77 , pp. 868-873
    • Beguin, Y.1    Clemons, G.K.2    Oris, R.3    Fillet, G.4
  • 22
    • 0030976033 scopus 로고    scopus 로고
    • Serum transferrin receptor andits ratio to serum ferritin in the diagnosis of iron deficiency
    • Punnonen K, Irjala K, Rajamaki A. Serum transferrin receptor andits ratio to serum ferritin in the diagnosis of iron deficiency. Blood.1997;89:1052-1057.
    • (1997) Blood , vol.89 , pp. 1052-1057
    • Punnonen, K.1    Irjala, K.2    Rajamaki, A.3
  • 23
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia ofinflammation by inducing the synthesis of the iron regulatory hormonehepcidin
    • Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia ofinflammation by inducing the synthesis of the iron regulatory hormonehepcidin. J Clin Invest. 2004;113:1271-1276.
    • (2004) J Clin Invest. , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3
  • 24
    • 2342631195 scopus 로고    scopus 로고
    • Congenital disorderof oxygen sensing: Association of the homozygous Chuvash polycythemiaVHL mutation with thrombosis and vascular abnormalitiesbut not tumors
    • Gordeuk VR, Sergueeva AI, Miasnikova GY, et al. Congenital disorderof oxygen sensing: association of the homozygous Chuvash polycythemiaVHL mutation with thrombosis and vascular abnormalitiesbut not tumors. Blood. 2004;103:3924-3932.
    • (2004) Blood , vol.103 , pp. 3924-3932
    • Gordeuk, V.R.1    Sergueeva, A.I.2    Miasnikova, G.Y.3
  • 25
    • 0025134007 scopus 로고
    • Intacttransferrin receptors in human plasma and their relation to erythropoiesis
    • Huebers HA, Beguin Y, Pootrakul P, Einspahr D, Finch CA. Intacttransferrin receptors in human plasma and their relation to erythropoiesis.Blood. 1990;75:102-107.
    • (1990) Blood. , vol.75 , pp. 102-107
    • Huebers, H.A.1    Beguin, Y.2    Pootrakul, P.3    Einspahr, D.4    Finch, C.A.5
  • 26
    • 84878914192 scopus 로고    scopus 로고
    • Testosterone administration inhibitshepcidin transcription and is associated with increased iron incorporationinto red blood cells
    • Guo W, Bachman E, Li M, et al. Testosterone administration inhibitshepcidin transcription and is associated with increased iron incorporationinto red blood cells. Aging Cell 2013;12(2):280-291.
    • (2013) Aging Cell , vol.12 , Issue.2 , pp. 280-291
    • Guo, W.1    Bachman, E.2    Li, M.3
  • 27
    • 36349028180 scopus 로고    scopus 로고
    • Hemochromatosis: An endocrine liver disease
    • Pietrangelo A. Hemochromatosis: an endocrine liver disease.Hepatology. 2007;46(4):1291-1301.
    • (2007) Hepatology , vol.46 , Issue.4 , pp. 1291-1301
    • Pietrangelo, A.1
  • 28
    • 33745752870 scopus 로고    scopus 로고
    • Targeted disruptionof the hepcidin 1 gene results in severe hemochromatosis
    • Lesbordes-Brion JC, Viatte L, Bennoun M, et al. Targeted disruptionof the hepcidin 1 gene results in severe hemochromatosis. Blood.2006;108(4):1402-1405.
    • (2006) Blood , vol.108 , Issue.4 , pp. 1402-1405
    • Lesbordes-Brion, J.C.1    Viatte, L.2    Bennoun, M.3
  • 29
    • 2342440466 scopus 로고    scopus 로고
    • Disruption of ferroportin 1 regulationcauses dynamic alterations in iron homeostasis and erythropoiesis inpolycythaemia mice
    • Mok H, Jelinek J, Pai S, et al. Disruption of ferroportin 1 regulationcauses dynamic alterations in iron homeostasis and erythropoiesis inpolycythaemia mice. Development. 2004;131(8):1859-1868.
    • (2004) Development. , vol.131 , Issue.8 , pp. 1859-1868
    • Mok, H.1    Jelinek, J.2    Pai, S.3
  • 30
    • 0016733331 scopus 로고
    • Effects of testosterone and erythropoietin onerythroid colony formation in human bone marrow cultures
    • Moriyama Y, Fisher JW. Effects of testosterone and erythropoietin onerythroid colony formation in human bone marrow cultures. Blood.1975;45:665- 670.
    • (1975) Blood , vol.45 , pp. 665-670
    • Moriyama, Y.1    Fisher, J.W.2
  • 31
    • 0031829427 scopus 로고    scopus 로고
    • Blockade of thein vitro effects of testosterone and erythropoietin on Cfu-E and Bfu-Eproliferation by pretreatment of the donor rats with cyproterone andflutamide
    • Malgor LA, Valsecia M, Verges E, De Markowsky EE. Blockade of thein vitro effects of testosterone and erythropoietin on Cfu-E and Bfu-Eproliferation by pretreatment of the donor rats with cyproterone andflutamide. Acta Physiol Pharmacol Ther Latinoam. 1998;48:99-105.
    • (1998) Acta Physiol Pharmacol Ther Latinoam. , vol.48 , pp. 99-105
    • Malgor, L.A.1    Valsecia, M.2    Verges, E.3    De Markowsky, E.E.4
  • 32
    • 84872134149 scopus 로고    scopus 로고
    • Regulation of erythropoiesis by hypoxia-inducible factors
    • Haase VH. Regulation of erythropoiesis by hypoxia-inducible factors.Blood Rev. 2013;27(1):41-53.
    • (2013) Blood Rev. , vol.27 , Issue.1 , pp. 41-53
    • Haase, V.H.1
  • 33
    • 80053936422 scopus 로고    scopus 로고
    • Isolation and characterization of renal erythropoietin-producingcells from genetically produced anemia mice
    • Pan X, Suzuki N, Hirano I, Yamazaki S, Minegishi N, YamamotoM. Isolation and characterization of renal erythropoietin-producingcells from genetically produced anemia mice. PLoS One.2011;6(10):e25839.
    • (2011) PLoS on , vol.6 , Issue.10
    • Pan, X.1    Suzuki, N.2    Hirano, I.3    Yamazaki, S.4    Minegishi, N.5    Yamamoto, M.6
  • 35
    • 84862736353 scopus 로고    scopus 로고
    • 17β-Estradiol inhibitsiron hormone hepcidin through an estrogen responsive elementhalf-site
    • Yang Q, Jian J, Katz S, Abramson SB, Huang X. 17β-Estradiol inhibitsiron hormone hepcidin through an estrogen responsive elementhalf-site. Endocrinology. 2012;153(7):3170-3178.
    • (2012) Endocrinology. , vol.153 , Issue.7 , pp. 3170-3178
    • Yang, Q.1    Jian, J.2    Katz, S.3    Abramson, S.B.4    Huang, X.5
  • 36
    • 84863827034 scopus 로고    scopus 로고
    • Estrogen regulates hepcidinexpression via GPR30-BMP6-dependent signaling in hepatocytes
    • Ikeda Y, Tajima S, Izawa-Ishizawa Y, et al. Estrogen regulates hepcidinexpression via GPR30-BMP6-dependent signaling in hepatocytes.PLoS One. 2012;7(7):e40465.
    • (2012) PLoS One , vol.7 , Issue.7
    • Ikeda, Y.1    Tajima, S.2    Izawa-Ishizawa, Y.3
  • 37
    • 84868193427 scopus 로고    scopus 로고
    • Estrogen regulates iron homeostasisthrough governing hepatic hepcidin expression via an estrogenresponse element
    • Hou Y, Zhang S, Wang L, et al. Estrogen regulates iron homeostasisthrough governing hepatic hepcidin expression via an estrogenresponse element. Gene. 2012;511(2):398-403.
    • (2012) Gene. , vol.511 , Issue.2 , pp. 398-403
    • Hou, Y.1    Zhang, S.2    Wang, L.3
  • 38
    • 84900998679 scopus 로고    scopus 로고
    • Testosterone supplementation improves anemiain aging male mice
    • [Epubahead of print] PMID: 23974081
    • Guo W, Li M, Bhasin S. Testosterone supplementation improves anemiain aging male mice. J Gerontol A Biol Sci Med Sci. 2013. [Epubahead of print]. PMID: 23974081.
    • (2013) J Gerontol A Biol Sci Med Sci.
    • Guo, W.1    Li, M.2    Bhasin, S.3
  • 39
    • 0034016476 scopus 로고    scopus 로고
    • Haematocrit, viscosity, erythrocytesedimentation rate: Meta-analyses of prospective studies ofcoronary heart disease
    • Danesh J, Collins R, Peto R, Lowe GD. Haematocrit, viscosity, erythrocytesedimentation rate: meta-analyses of prospective studies ofcoronary heart disease. Eur Heart J. 2000;21(7):515-520.
    • (2000) Eur Heart J. , vol.21 , Issue.7 , pp. 515-520
    • Danesh, J.1    Collins, R.2    Peto, R.3    Lowe, G.D.4
  • 40
    • 76249112614 scopus 로고    scopus 로고
    • Optimal hematocrit for maximalexercise performance in acute and chronic erythropoietin-treatedmice
    • Schuler B, Arras M, Keller S, et al. Optimal hematocrit for maximalexercise performance in acute and chronic erythropoietin-treatedmice. Proc Natl Acad Sci USA. 2010;107:419-423.
    • (2010) Proc Natl Acad Sci USA. , vol.107 , pp. 419-423
    • Schuler, B.1    Arras, M.2    Keller, S.3
  • 41
    • 66849128251 scopus 로고    scopus 로고
    • High serumtestosterone levels are associated with excessive erythrocytosis inchronic mountain sickness in men
    • Gonzales GF, Gasco M, Tapia V, Gonzales-Castaneda C. High serumtestosterone levels are associated with excessive erythrocytosis inchronic mountain sickness in men. Am J Physiol Endocrinol Metab.2009;296(6):E1319-E1325.
    • (2009) Am J Physiol Endocrinol Metab. , vol.296 , Issue.6
    • Gonzales, G.F.1    Gasco, M.2    Tapia, V.3    Gonzales-Castaneda, C.4
  • 42
    • 77957957176 scopus 로고    scopus 로고
    • Why do women have similarerythropoietin levels to men but lower hemoglobin levels?
    • Murphy WG, Tong E, Murphy C. Why do women have similarerythropoietin levels to men but lower hemoglobin levels? Blood.2010;116:2821-2862.
    • (2010) Blood , vol.116 , pp. 2821-2862
    • Murphy, W.G.1    Tong, E.2    Murphy, C.3
  • 43
    • 4344575935 scopus 로고    scopus 로고
    • Interpretation of erythropoietinlevels in patients with various degrees of renal insufficiency and anemia
    • Fehr T, Ammann P, Garzoni D, et al. Interpretation of erythropoietinlevels in patients with various degrees of renal insufficiency and anemia.Kidney Int. 2004;66:1206-1211.
    • (2004) Kidney Int. , vol.66 , pp. 1206-1211
    • Fehr, T.1    Ammann, P.2    Garzoni, D.3
  • 44
    • 79959908260 scopus 로고    scopus 로고
    • Hypoxia: Adapting to high altitude bymutating EPAS-1 the gene encoding HIF-2α
    • van Patot MC, Gassmann M. Hypoxia: adapting to high altitude bymutating EPAS-1, the gene encoding HIF-2α. High Alt Med Biol.2011;12(2):157-167.
    • (2011) High Alt Med Biol. , vol.12 , Issue.2 , pp. 157-167
    • Van Patot, M.C.1    Gassmann, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.