Bmp6 expression in murine liver non parenchymal cells: A mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Rausa, Marco ^a,b   Pagani, Alessia ^a,b   Nai, Antonella ^a,b   Campanella, Alessandro ^a,b   Gilberti, Maria Enrica ^c   Apostoli, Pietro ^c   Camaschella, Clara ^a,b   Silvestri, Laura ^a,b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; FERRITIN; FERRITIN L; FERROPORTIN; HEPCIDIN; MESSENGER RNA; UNCLASSIFIED DRUG; APOFERRITIN; BMP6 PROTEIN, MOUSE; HFE2 PROTEIN, MOUSE; IRON; IRON INTAKE; MATRIPTASE 2; MEMBRANE PROTEIN; SERINE PROTEINASE; TFRC PROTEIN, MOUSE; TRANSFERRIN RECEPTOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOCRINE EFFECT; BMP6 GENE; CELL ISOLATION; CONTROLLED STUDY; GENE; GENE CONTROL; GENE EXPRESSION; IN VIVO STUDY; IRON DEFICIENCY; IRON KINETICS; IRON OVERLOAD; IRON TRANSPORT; LIVER CELL; MALE; MOUSE; NON PARENCHYMAL CELL; NONHUMAN; PARACRINE SIGNALING; TFR1 GENE; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; GENETICS; IRON DEFICIENCY ANEMIA; IRON INTAKE; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHARMACOLOGY;

MURINAE; MUS;

ANEMIA, IRON-DEFICIENCY; ANIMALS; APOFERRITINS; BONE MORPHOGENETIC PROTEIN 6; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HEPATOCYTES; HEPCIDINS; IRON; IRON OVERLOAD; IRON, DIETARY; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, TRANSFERRIN; RNA, MESSENGER; SERINE ENDOPEPTIDASES;

EID: 84929492922     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0122696     Document Type: Article

References (29)

1. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093. PMID: 15514116
2. Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dube MP, et al. (2004) Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nature genetics 36: 77-82. PMID: 14647275
3. Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, et al. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nature genetics 38: 531-539. PMID: 16604073
4. Xia Y, Yu PB, Sidis Y, Beppu H, Bloch KD, Schneyer AL, et al. (2007) Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. The Journal of biological chemistry 282: 18129-18140. PMID: 17472960
5. Steinbicker AU, Bartnikas TB, Lohmeyer LK, Leyton P, Mayeur C, Kao SM, et al. (2011) Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice. Blood 118: 4224-4230. doi: 10.1182/blood-2011-03-339952 PMID: 21841161
6. Nohe A, Keating E, Knaus P, Petersen NO (2004) Signal transduction of bone morphogenetic protein receptors. Cellular signalling 16: 291-299. PMID: 14687659
7. Wang RH, Li C, Xu X, Zheng Y, Xiao C, Zerfas P, et al. (2005) A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell metabolism 2: 399-409. PMID: 16330325
8. Niederkofler V, Salie R, Arber S (2005) Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. The Journal of clinical investigation 115: 2180-2186. PMID: 16075058
9. Huang FW, Pinkus JL, Pinkus GS, Fleming MD, Andrews NC (2005) A mouse model of juvenile hemochromatosis. The Journal of clinical investigation 115: 2187-2191. PMID: 16075059
10. Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, et al. (2001) Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proceedings of the National Academy of Sciences of the United States of America 98: 8780-8785. PMID: 11447267
11. Bragdon B, Moseychuk O, Saldanha S, King D, Julian J, Nohe A (2011) Bone morphogenetic proteins: a critical review. Cellular signalling 23: 609-620. doi: 10.1016/j.cellsig.2010.10.003 PMID: 20959140
12. Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY (2008) Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111: 5195-5204. doi: 10.1182/blood-2007-09-111567 PMID: 18326817
13. Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, Wang RH, et al. (2008) Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 112: 1503-1509. doi: 10.1182/blood-2008-03-143354 PMID: 18539898
14. Kautz L, Besson-Fournier C, Meynard D, Latour C, Roth MP, Coppin H (2011) Iron overload induces BMP6 expression in the liver but not in the duodenum. Haematologica 96: 199-203. doi: 10.3324/haematol.2010.031963 PMID: 20952515
15. Yin C, Evason KJ, Asahina K, Stainier DY (2013) Hepatic stellate cells in liver development, regeneration, and cancer. The Journal of clinical investigation 123: 1902-1910. doi: 10.1172/JCI66369 PMID: 23635788
16. Knittel T, Fellmer P, Muller L, Ramadori G (1997) Bone morphogenetic protein-6 is expressed in nonparenchymal liver cells and upregulated by transforming growth factor-beta 1. Experimental cell research 232: 263-269. PMID: 9168801
17. Zhang AS, Anderson SA, Wang J, Yang F, DeMaster K, Ahmed R, et al. (2011) Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein. Blood 117: 1687-1699. doi: 10.1182/blood-2010-06-287292 PMID: 21115976
18. Folgueras AR, de Lara FM, Pendas AM, Garabaya C, Rodriguez F, Astudillo A, et al. (2008) Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis. Blood 112: 2539-2545. doi: 10.1182/blood-2008-04-149773 PMID: 18523150
19. Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, Ginzburg Y, et al. (2011) Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology 53: 1333-1341. doi: 10.1002/hep.24178 PMID: 21480335
20. Pagani A, Nai A, Corna G, Bosurgi L, Rovere-Querini P, Camaschella C, et al. (2011) Low hepcidin accounts for the proinflammatory status associated with iron deficiency. Blood 118: 736-746. doi: 10.1182/blood-2011-02-337212 PMID: 21628413
21. Liu W, Hou Y, Chen H, Wei H, Lin W, Li J, et al. (2011) Sample preparation method for isolation of single-cell types from mouse liver for proteomic studies. Proteomics 11: 3556-3564. doi: 10.1002/pmic.201100157 PMID: 21751380
22. Campanella A, Levi S, Cairo G, Biasiotto G, Arosio P (2004) Blotting analysis of native IRP1: a novel approach to distinguish the different forms of IRP1 in cells and tissues. Biochemistry 43: 195-204. PMID: 14705945
23. Rouault TA (2006) The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nature chemical biology 2: 406-414. PMID: 16850017
24. Riba M, Rausa M, Sorosina M, Cittaro D, Garcia Manteiga JM, Nai A, et al. (2013) A strong anti-inflammatory signature revealed by liver transcription profiling of Tmprss6-/- mice. PloS one 8: e69694. doi: 10.1371/journal.pone.0069694 PMID: 23922777
25. Meynard D, Vaja V, Sun CC, Corradini E, Chen S, Lopez-Otin C, et al. (2011) Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood 118: 747-756. doi: 10.1182/blood-2011-04-348698 PMID: 21622652
26. Hentze MW, Muckenthaler MU, Galy B, Camaschella C (2010) Two to tango: regulation of Mammalian iron metabolism. Cell 142: 24-38. doi: 10.1016/j.cell.2010.06.028 PMID: 20603012
27. Enns CA, Ahmed R, Wang J, Ueno A, Worthen C, Tsukamoto H, et al. (2013) Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway. PloS one 8: e60534. doi: 10.1371/journal.pone.0060534 PMID: 23565256
28. Feng Q, Migas MC, Waheed A, Britton RS, Fleming RE (2012) Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice. American journal of physiology Gastrointestinal and liver physiology 302: G1397-1404. doi: 10.1152/ajpgi.00020.2012 PMID: 22517766
29. Zhang Z, Guo X, Herrera C, Tao Y, Wu Q, Wu A, et al. (2014) Bmp6 expression can be regulated independently of liver iron in mice. PloS one 9: e84906. doi: 10.1371/journal.pone.0084906 PMID: 24454764