메뉴 건너뛰기




Volumn 8, Issue 4, 2013, Pages

Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; HEPCIDIN; IRON; MESSENGER RNA;

EID: 84875649042     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060534     Document Type: Article
Times cited : (55)

References (42)
  • 1
    • 79551583056 scopus 로고    scopus 로고
    • Hepcidin and disorders of iron metabolism
    • Ganz T, Nemeth E, (2011) Hepcidin and disorders of iron metabolism. Annu Rev Med 62: 347-360.
    • (2011) Annu Rev Med , vol.62 , pp. 347-360
    • Ganz, T.1    Nemeth, E.2
  • 2
    • 37549059612 scopus 로고    scopus 로고
    • Regulation of iron acquisition and storage: consequences for iron-linked disorders
    • De Domenico I, McVey Ward D, Kaplan J, (2008) Regulation of iron acquisition and storage: consequences for iron-linked disorders. Nat Rev Mol Cell Biol 9: 72-81.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 72-81
    • De Domenico, I.1    McVey Ward, D.2    Kaplan, J.3
  • 3
    • 0037111732 scopus 로고    scopus 로고
    • Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease
    • Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, et al. (2002) Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 100: 3776-3781.
    • (2002) Blood , vol.100 , pp. 3776-3781
    • Weinstein, D.A.1    Roy, C.N.2    Fleming, M.D.3    Loda, M.F.4    Wolfsdorf, J.I.5
  • 4
    • 20244388240 scopus 로고    scopus 로고
    • Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
    • Roetto A, Papanikolaou G, Politou M, Alberti F, Girelli D, et al. (2003) Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 33: 21-22.
    • (2003) Nat Genet , vol.33 , pp. 21-22
    • Roetto, A.1    Papanikolaou, G.2    Politou, M.3    Alberti, F.4    Girelli, D.5
  • 7
  • 8
    • 63449122819 scopus 로고    scopus 로고
    • Lack of the bone morphogenetic protein BMP6 induces massive iron overload
    • Meynard D, Kautz L, Darnaud V, Canonne-Hergaux F, Coppin H, et al. (2009) Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet 41: 478-481.
    • (2009) Nat Genet , vol.41 , pp. 478-481
    • Meynard, D.1    Kautz, L.2    Darnaud, V.3    Canonne-Hergaux, F.4    Coppin, H.5
  • 9
    • 63449103712 scopus 로고    scopus 로고
    • BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
    • Andriopoulos B Jr, Corradini E, Xia Y, Faasse SA, Chen S, et al. (2009) BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet 41: 482-487.
    • (2009) Nat Genet , vol.41 , pp. 482-487
    • Andriopoulos Jr, B.1    Corradini, E.2    Xia, Y.3    Faasse, S.A.4    Chen, S.5
  • 10
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, Ganz T, (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276: 7806-7810.
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 11
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, et al. (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276: 7811-7819.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5
  • 12
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in tgf-beta signaling through Smads
    • Feng XH, Derynck R, (2005) Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol 21: 659-693.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 659-693
    • Feng, X.H.1    Derynck, R.2
  • 13
    • 51649096725 scopus 로고    scopus 로고
    • Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
    • Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, et al. (2008) Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 112: 1503-1509.
    • (2008) Blood , vol.112 , pp. 1503-1509
    • Kautz, L.1    Meynard, D.2    Monnier, A.3    Darnaud, V.4    Bouvet, R.5
  • 14
    • 79959562083 scopus 로고    scopus 로고
    • Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice
    • Corradini E, Meynard D, Wu Q, Chen S, Ventura P, et al. (2011) Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice. Hepatology 54: 273-284.
    • (2011) Hepatology , vol.54 , pp. 273-284
    • Corradini, E.1    Meynard, D.2    Wu, Q.3    Chen, S.4    Ventura, P.5
  • 15
    • 79953757053 scopus 로고    scopus 로고
    • Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice
    • Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, et al. (2011) Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology 53: 1333-1341.
    • (2011) Hepatology , vol.53 , pp. 1333-1341
    • Ramos, E.1    Kautz, L.2    Rodriguez, R.3    Hansen, M.4    Gabayan, V.5
  • 16
    • 79551629285 scopus 로고    scopus 로고
    • Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matripatase-2 protein
    • Zhang AS, Anderson SA, Wang J, Yang F, Demaster K, et al. (2011) Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matripatase-2 protein. Blood 117: 1687-1699.
    • (2011) Blood , vol.117 , pp. 1687-1699
    • Zhang, A.S.1    Anderson, S.A.2    Wang, J.3    Yang, F.4    Demaster, K.5
  • 17
    • 60649103774 scopus 로고    scopus 로고
    • Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression
    • Gao J, Chen J, Kramer M, Tsukamoto H, Zhang AS, et al. (2009) Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab 9: 217-227.
    • (2009) Cell Metab , vol.9 , pp. 217-227
    • Gao, J.1    Chen, J.2    Kramer, M.3    Tsukamoto, H.4    Zhang, A.S.5
  • 19
    • 84858988409 scopus 로고    scopus 로고
    • Hepatic Stellate Cell-derived Delta-like Homolog 1 (DLK1) Protein in Liver Regeneration
    • Zhu NL, Asahina K, Wang J, Ueno A, Lazaro R, et al. (2012) Hepatic Stellate Cell-derived Delta-like Homolog 1 (DLK1) Protein in Liver Regeneration. J Biol Chem 287: 10355-10367.
    • (2012) J Biol Chem , vol.287 , pp. 10355-10367
    • Zhu, N.L.1    Asahina, K.2    Wang, J.3    Ueno, A.4    Lazaro, R.5
  • 21
    • 0014267781 scopus 로고
    • A simple technique for measuring storage iron concentrations in formalinised liver samples
    • Torrance JD, Bothwell TH, (1968) A simple technique for measuring storage iron concentrations in formalinised liver samples. S Afr J Med Sci 33: 9-11.
    • (1968) S Afr J Med Sci , vol.33 , pp. 9-11
    • Torrance, J.D.1    Bothwell, T.H.2
  • 22
    • 0842263988 scopus 로고    scopus 로고
    • Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes
    • Zhang AS, Xiong S, Tsukamoto H, Enns CA, (2004) Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes. Blood 103: 1509-1514.
    • (2004) Blood , vol.103 , pp. 1509-1514
    • Zhang, A.S.1    Xiong, S.2    Tsukamoto, H.3    Enns, C.A.4
  • 23
    • 77952747961 scopus 로고    scopus 로고
    • The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo
    • Zhang AS, Gao J, Koeberl DD, Enns CA, (2010) The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo. J Biol Chem 285: 16416-16423.
    • (2010) J Biol Chem , vol.285 , pp. 16416-16423
    • Zhang, A.S.1    Gao, J.2    Koeberl, D.D.3    Enns, C.A.4
  • 25
    • 79551552424 scopus 로고    scopus 로고
    • Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors
    • Schledzewski K, Geraud C, Arnold B, Wang S, Grone HJ, et al. (2011) Deficiency of liver sinusoidal scavenger receptors stabilin-1 and-2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest 121: 703-714.
    • (2011) J Clin Invest , vol.121 , pp. 703-714
    • Schledzewski, K.1    Geraud, C.2    Arnold, B.3    Wang, S.4    Grone, H.J.5
  • 26
    • 1942474781 scopus 로고    scopus 로고
    • Role of Hepatic Stellate Cells in the Early Phase of Liver Regeneration in Rat: Formation of Tight Adhesion to Parenchymal Cells
    • Mabuchi A, Mullaney I, Sheard P, Hessian P, Zimmermann A, et al. (2004) Role of Hepatic Stellate Cells in the Early Phase of Liver Regeneration in Rat: Formation of Tight Adhesion to Parenchymal Cells. Comp Hepatol 3Suppl 1: S29.
    • (2004) Comp Hepatol , vol.3
    • Mabuchi, A.1    Mullaney, I.2    Sheard, P.3    Hessian, P.4    Zimmermann, A.5
  • 27
    • 84859429257 scopus 로고    scopus 로고
    • BMPs are mediators in tissue crosstalk of the regenerating musculoskeletal system
    • Ruschke K, Hiepen C, Becker J, Knaus P, (2012) BMPs are mediators in tissue crosstalk of the regenerating musculoskeletal system. Cell Tissue Res 347: 521-544.
    • (2012) Cell Tissue Res , vol.347 , pp. 521-544
    • Ruschke, K.1    Hiepen, C.2    Becker, J.3    Knaus, P.4
  • 28
    • 76049083237 scopus 로고    scopus 로고
    • Multiple endocrine regulation by bone morphogenetic protein system
    • Otsuka F, (2010) Multiple endocrine regulation by bone morphogenetic protein system. Endocr J 57: 3-14.
    • (2010) Endocr J , vol.57 , pp. 3-14
    • Otsuka, F.1
  • 29
    • 0036920086 scopus 로고    scopus 로고
    • The role of non-parenchymal cells in liver growth
    • Malik R, Selden C, Hodgson H, (2002) The role of non-parenchymal cells in liver growth. Semin Cell Dev Biol 13: 425-431.
    • (2002) Semin Cell Dev Biol , vol.13 , pp. 425-431
    • Malik, R.1    Selden, C.2    Hodgson, H.3
  • 30
    • 77952573858 scopus 로고    scopus 로고
    • Downregulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis
    • Finberg KE, Whittlesey RL, Fleming MD, Andrews NC, (2010) Downregulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. Blood 115: 3817-3826.
    • (2010) Blood , vol.115 , pp. 3817-3826
    • Finberg, K.E.1    Whittlesey, R.L.2    Fleming, M.D.3    Andrews, N.C.4
  • 31
    • 84861355868 scopus 로고    scopus 로고
    • Hepcidin and iron homeostasis
    • Ganz T, Nemeth E, (2012) Hepcidin and iron homeostasis. Biochim Biophys Acta 1823: 1434-1443.
    • (2012) Biochim Biophys Acta , vol.1823 , pp. 1434-1443
    • Ganz, T.1    Nemeth, E.2
  • 32
    • 80052655782 scopus 로고    scopus 로고
    • The molecular pathogenesis of hereditary hemochromatosis
    • Babitt JL, Lin HY, (2012) The molecular pathogenesis of hereditary hemochromatosis. Semin Liver Dis 31: 280-292.
    • (2012) Semin Liver Dis , vol.31 , pp. 280-292
    • Babitt, J.L.1    Lin, H.Y.2
  • 33
    • 69249118614 scopus 로고    scopus 로고
    • Hemojuvelin-Neogenin Interaction Is Required for Bone Morphogenic Protein-4-induced Hepcidin Expression
    • Zhang AS, Yang F, Wang J, Tsukamoto H, Enns CA, (2009) Hemojuvelin-Neogenin Interaction Is Required for Bone Morphogenic Protein-4-induced Hepcidin Expression. J Biol Chem 284: 22580-22589.
    • (2009) J Biol Chem , vol.284 , pp. 22580-22589
    • Zhang, A.S.1    Yang, F.2    Wang, J.3    Tsukamoto, H.4    Enns, C.A.5
  • 34
    • 46749158788 scopus 로고    scopus 로고
    • Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
    • Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY, (2008) Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111: 5195-5204.
    • (2008) Blood , vol.111 , pp. 5195-5204
    • Xia, Y.1    Babitt, J.L.2    Sidis, Y.3    Chung, R.T.4    Lin, H.Y.5
  • 35
    • 0031149802 scopus 로고    scopus 로고
    • Bone morphogenetic protein-6 is expressed in nonparenchymal liver cells and upregulated by transforming growth factor-beta 1
    • Knittel T, Fellmer P, Muller L, Ramadori G, (1997) Bone morphogenetic protein-6 is expressed in nonparenchymal liver cells and upregulated by transforming growth factor-beta 1. Exp Cell Res 232: 263-269.
    • (1997) Exp Cell Res , vol.232 , pp. 263-269
    • Knittel, T.1    Fellmer, P.2    Muller, L.3    Ramadori, G.4
  • 36
    • 78751558997 scopus 로고    scopus 로고
    • Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice
    • Bartnikas TB, Andrews NC, Fleming MD, (2011) Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. Blood 117: 630-637.
    • (2011) Blood , vol.117 , pp. 630-637
    • Bartnikas, T.B.1    Andrews, N.C.2    Fleming, M.D.3
  • 37
    • 84860842095 scopus 로고    scopus 로고
    • Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression
    • Frazer DM, Wilkins SJ, Darshan D, Badrick AC, McLaren GD, et al. (2012) Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression. Br J Haematol 157: 615-626.
    • (2012) Br J Haematol , vol.157 , pp. 615-626
    • Frazer, D.M.1    Wilkins, S.J.2    Darshan, D.3    Badrick, A.C.4    McLaren, G.D.5
  • 38
    • 34447137331 scopus 로고    scopus 로고
    • Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
    • Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, et al. (2007) Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest 117: 1933-1939.
    • (2007) J Clin Invest , vol.117 , pp. 1933-1939
    • Babitt, J.L.1    Huang, F.W.2    Xia, Y.3    Sidis, Y.4    Andrews, N.C.5
  • 39
    • 33745898241 scopus 로고    scopus 로고
    • Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6
    • Truksa J, Peng H, Lee P, Beutler E, (2006) Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci U S A 103: 10289-10293.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10289-10293
    • Truksa, J.1    Peng, H.2    Lee, P.3    Beutler, E.4
  • 40
    • 80054101329 scopus 로고    scopus 로고
    • Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice
    • Steinbicker AU, Bartnikas TB, Lohmeyer LK, Leyton P, Mayeur C, et al. (2011) Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice. Blood 118: 4224-4230.
    • (2011) Blood , vol.118 , pp. 4224-4230
    • Steinbicker, A.U.1    Bartnikas, T.B.2    Lohmeyer, L.K.3    Leyton, P.4    Mayeur, C.5
  • 42
    • 77956605615 scopus 로고    scopus 로고
    • Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway
    • Cohen LA, Gutierrez L, Weiss A, Leichtmann-Bardoogo Y, Zhang DL, et al. (2010) Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Blood 116: 1574-1584.
    • (2010) Blood , vol.116 , pp. 1574-1584
    • Cohen, L.A.1    Gutierrez, L.2    Weiss, A.3    Leichtmann-Bardoogo, Y.4    Zhang, D.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.