Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 27, 2006, Pages 10289-10293

  Truksa, Jaroslav ^a   Peng, Hongfan ^a   Lee, Pauline ^a   Beutler, Ernest ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

HepG2; Inflammation; Iron

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 9; CYTOKINE; CYTOKINE RECEPTOR; HEMOJUVELIN; HEPCIDIN; HEPCIDIN 1; HFE PROTEIN; INTERLEUKIN 6; IRON; PEPTIDE; SMAD4 PROTEIN; TRANSFERRIN RECEPTOR 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA TRANSCRIPTION; DOSE RESPONSE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IRON BALANCE; KNOCKOUT MOUSE; LIVER CELL; MOUSE; MOUSE MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BONE MORPHOGENETIC PROTEINS; CELLS, CULTURED; HEPATOCYTES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; RECEPTORS, TRANSFERRIN; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

MURINAE;

EID: 33745898241     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0603124103     Document Type: Article

References (25)

1. Varga, A. C. & Wrana, J. L. (2005) Oncogene 24, 5713-5721.
2. Gambaro, K., Aberdam, E., Virolle, T., Aberdam, D. & Rouleau, M. (2006) Cell Death Differ. 13, 1075-1087.
3. Ten, D. P., Korchynskyi, O., Valdimarsdottir, G. & Goumans, M. J. (2003) Mol. Cell. Endocrinol. 211, 105-113.
4. Ten, D. P. & Hill, C. S. (2004) Trends Biochem. Sci. 29, 265-273.
5. Liu, F. (2003) Front. Biosci. 8, s1280-s1303.
6. Massague, J., Seoane, J. & Wotton, D. (2005) Genes Dev. 19, 2783-2810.
7. Babitt, J. L., Zhang, Y., Samad, T. A., Xia, Y., Tang, J., Campagna, J. A., Schneyer, A. L., Woolf, C. J. & Lin, H. Y. (2005) J. Biol. Chem. 280, 29820-29827.
8. Babitt, J. L., Huang, F. W., Wrighting, D. M., Xia, Y., Sidis, Y., Samad, T. A., Campagna, J. A., Chung, R. T., Schneyer, A. L., Woolf, C. J., et al. (2006) Nat. Genet. 38, 531-539.
9. Wang, R. H., Li, C. L., Xu, X. L., Zheng, Y., Xiao, C. Y., Zerfas, P., Cooperman, S., Eckhaus, M., Rouault, T., Mishra, L., et al. (2005) Cell Metab. 2, 399-409.
10. Lee, P., Peng, H., Gelbart, T., Wang, L. & Beutler, E. (2005) Proc. Natl. Acad. Sci. USA 102, 1906-1910.
11. Lee, P., Peng, H., Gelbart, T. & Beutler, E. (2006) Proc. Natl. Acad. Sci. USA 101, 9263-9265.
12. Ganz, T. (2004) Curr. Opin. Hematol. 11, 251-254.
13. Means, R. T. (2004) Blood Rev. 18, 219-225.
14. Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A. & Vaulont, S. (2002) J. Clin. Invest. 110, 1037-1044.
15. Dallalio, G., Law, E. & Means, R. T. (2006) Blood 107, 2702-2704.
16. Ahmad, K. A., Ahmann, J. R., Migas, M. C., Waheed, A., Britton, R. S., Bacon, B. R., Sly, W. S. & Fleming, R. E. (2002) Blood Cells Mol. Dis. 29, 361-366.
17. Biasiotto, G., Belloli, S., Ruggeri, G., Zanella, I., Gerardi, G., Corrado, M., Gobbi, E., Albertini, A. & Arosio, P. (2003) Clin. Chem. 49, 1981-1988.
18. Kawabata, H., Fleming, R. E., Gui, D., Moon, S. Y., Saitoh, T., O'Kelly, J., Umehara, Y., Wano, Y., Said, J. W. & Koeffler, H. P. (2005) Blood 105, 376-381.
19. Nemeth, E., Roetto, A., Garozzo, G., Ganz, T. & Camaschella, C. (2005) Blood 105, 1803-1806.
20. Niederkofler, V., Salie, R. & Arber, S. (2005) J. Clin. Invest. 115, 2180-2186.
21. Lee, P. L., Beutler, E., Rao, S. V. & Barton, J. C. (2004) Blood 103, 4669-4671.
22. Miller, A. F., Harvey, S. A., Thies, R. S. & Olson, M. S. (2000) J. Biol. Chem. 275, 17937-17945.
23. Frazer, D. M., Wilkins, S. J., Millard, K. N., McKie, A. T., Vulpe, C. D. & Anderson, G. J. (2004) Br. J. Haematol. 126, 434-436.
24. Lee, P. L., Peng, H., Gelbart, T. & Beutler, E. (2004) Proc. Natl. Acad. Sci. USA 101, 9263-9265.
25. Nakamura, K., Shirai, T., Morishita, S., Uchida, S., Saeki-Miura, K. & Makishima, F. (1999) Exp. Cell Res. 250, 351-363.