How sesquiterpenes modulate signaling cascades in cancers

Cellular and Molecular Biology

Volumn 62, Issue 7, 2016, Pages 110-117

  Jabeen, S ^a   Qureshi, M Z ^b   Attar, R ^c   Aslam, A ^d   Kanwal, S ^e   Khalid, S ^e   Qureshi, J M ^f   Aras Perk, A ^g   Farooqi, Ammad Ahmad ^h   Ismail, M ⁱ  

^a PMAS ARID AGRICULTURE UNIVERSITY   (Pakistan)

^b GCU   (Pakistan)

^c YEDITEPE UNIVERSITY   (Turkey)

^d QUAID I AZAM UNIVERSITY   (Pakistan)

^e INTERNATIONAL ISLAMIC UNIVERSITY   (Pakistan)

^f Pearl Continental   (Pakistan)

^g ISTANBUL UNIVERSITY   (Turkey)

^h RASHID LATIF MEDICAL COLLEGE   (Pakistan)

ⁱ INSTITUTE OF BIOMEDICAL AND GENETIC ENGINEERING IBGE   (Pakistan)

Author keywords

Apoptosis; Cancer; Notch; Sesquiterpene; SHH; Signaling; TRAIL; Wnt

Indexed keywords

NOTCH RECEPTOR; SESQUITERPENE DERIVATIVE; SONIC HEDGEHOG PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; WNT PROTEIN; SESQUITERPENE; TUMOR PROTEIN;

APOPTOSIS; CANCER CELL LINE; CANCER RESISTANCE; CANCER THERAPY; DRUG TARGETING; IN VIVO STUDY; INTRACELLULAR SIGNALING; NONHUMAN; REVIEW; ANIMAL; DRUG EFFECTS; DRUG RESISTANCE; HUMAN; METABOLISM; NEOPLASMS; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; DRUG RESISTANCE, NEOPLASM; HUMANS; NEOPLASM PROTEINS; NEOPLASMS; SESQUITERPENES; SIGNAL TRANSDUCTION;

EID: 84994798407     PISSN: 01455680     EISSN: 1165158X     Source Type: Journal    
DOI: 10.14715/cmb/2016.62.7.19     Document Type: Review

References (86)

1. Jones, C., Baker, S.J. Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma. Nat Rev Cancer, 2014, 14(10): 651-661.
2. Brown, R, Curry, E, Magnani, L, Wilhelm-Benartzi, CS, Borley, J. Poised epigenetic states and acquired drug resistance in cancer. Nat Rev Cancer, 2014, 14(11):747-53.
3. Mertens, F., Johansson, B., Fioretos, T., Mitelman, F. The emerging complexity of gene fusions in cancer. Nat Rev Cancer, 2015, 15(6):371-81.
4. Buchheit, C.L., Weigel, K.J., Schafer, Z.T. Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression. Nat Rev Cancer, 2014, 14(9):632-41. Knowles, M.A., Hurst, C.D. Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity. Nat Rev Cancer, 2015, 15(1):25-41.
5. Knowles M.A., Hurst, C.D. Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity. Nat Rev Cancer, 2015, 15(1):25-41
6. Roberts, S.A., Gordenin, D.A. Hypermutation in human cancer genomes: footprints and mechanisms. Nat Rev Cancer, 2014, 14(12):786-800.
7. Igney, F.H., Krammer, P.H. Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer, 2002, 2(4):277-88.
8. Cotter, T.G. Apoptosis and cancer: the genesis of a research field. Nat Rev Cancer, 2009, 9(7):501-7.
9. Brown, J.M., Attardi, L.D. The role of apoptosis in cancer development and treatment response. Nat Rev Cancer, 2005, 5(3):231-7.
10. Wiley, S.R., Schooley, K., Smolak, P., Din, W.S., Huang, C.P., Nicholl, J.K., Sutherland, G. R., Smith, T.D., Rauch, C., Smith, C.A., Goodwin, R.G. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity, 1995, 3(6): 673-682.
11. Sprick, M. R., Walczak, H. The interplay between the Bcl-2 family and death receptor-mediated apoptosis. Biochim Biophys Acta, 2004, 1644(2): 125-132.
12. Ashkenazi, A., Dixit, V.M. Death receptors: signaling and modulation. Science, 1998, 281(5381): 1305-1308.
13. LeBlanc, H.N., Ashkenazi, A. Apo2L/TRAIL and its death and decoy receptors. Cell Death Differ, 2003, 10(1): 66-75.
14. Wang, S., El-Deiry W. S. TRAIL and apoptosis induction by TNF-family death receptors. Oncogene, 2003, 22(53): 8628-8633
15. Yu, H.J., Jung, J.Y., Jeong, J.H., Cho, S.D., Lee, J.S. Induction of apoptosis by parthenolide in human oral cancer cell lines and tumor xenografts. Oral Oncol, 2015, 51(6):602-9.
16. Kim, S.L., Liu, Y.C., Park, Y.R., Seo, S.Y., Kim, S.H., Kim, I.H., Lee, S.O., Lee, S.T., Kim, D.G., Kim, S.W. Parthenolide enhances sensitivity of colorectal cancer cells to TRAIL by inducing death receptor 5 and promotes TRAIL-induced apoptosis. Int J Oncol, 2015 46(3):1121-30.
17. Liu, J., Ma, L., Wu, N., Liu, G., Zheng, L., Lin, X. Aplysin sensitizes cancer cells to TRAIL by suppressing P38 MAPK/survivin pathway. Mar Drugs, 2014, 12(9):5072-88.
18. Do, M.T., Na, M., Kim, H.G., Khanal, T., Choi, J.H., Jin, S.W., Oh, S.H., Hwang, I.H., Chung, Y.C., Kim, H.S., Jeong, T.C., Jeong, H.G. Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways. Food Chem Toxicol, 2014 71:51-9.
19. Moon, D.O., Asami, Y., Long, H., Jang, J.H., Bae, E.Y., Kim, B.Y., Choi, Y.H., Kang, C.H., Ahn, J.S., Kim, G.Y. Verrucarin A sensitizes TRAIL-induced apoptosis via the upregulation of DR5 in an eIF2a/CHOP-dependent manner. Toxicol In Vitro, 2013, 27(1):257-63.
20. Minakawa, T., Toume, K., Arai, M.A., Sadhu, S.K., Ahmed, F., Ishibashi, M. Eudesmane-type sesquiterpenoid and guaianolides from Kandelia candel in a screening program for compounds to overcome TRAIL resistance. J Nat Prod, 2012, 75(8):1431-5.
21. Zhong, Z.F., Tan, W., Qiang, W.W., Scofield, V.L., Tian, K., Wang, C.M., Qiang, W.A., Wang, Y.T. Furanodiene alters mitochondrial function in doxorubicin-resistant MCF-7 human breast cancer cells in an AMPK-dependent manner. Mol Biosyst, 2016, 12(5):1626-37.
22. Kong, R., Jia, G., Cheng, Z.X., Wang, Y.W., Mu, M., Wang, S.J., Pan, S.H., Gao, Y., Jiang, H.C., Dong, D.L., Sun, B. Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5. PLoS One, 2012, 7(5):e37222.
23. Lee, J., Hwangbo, C., Lee, J.J., Seo, J., Lee, J.H. The sesquiterpene lactone eupatolide sensitizes breast cancer cells to TRAIL through down-regulation of c-FLIP expression. Oncol Rep, 2010, 23(1):229-37.
24. Ford, C.E., Henry, C., Llamosas, E., Djordjevic, A., Hacker, N. Wnt signalling in gynaecological cancers: A future target for personalised medicine? Gynecol Oncol, 2016, 140(2):345-51.
25. Anastas, J.N., Moon, R.T. WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer, 2013, 13(1):11-26.
26. Klaus, A., Birchmeier, W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer, 2008, 8(5):387-98.
27. Tang, L., Zhu, H., Yang, X., Xie, F., Peng, J., Jiang, D., Xie, J., Qi, M., Yu, L. Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway. PLoS One, 2016, 11(3):e0152012.
28. Hui, H.Y., Wu, N., Wu, M., Liu, Y., Xiao, S.X., Zhang, M.F. Dihydroartemisinin suppresses growth of squamous cell carcinoma A431 cells by targeting the Wnt/β-catenin pathway. Anticancer Drugs, 2016, 27(2):99-105.
29. Liu, Y., Wang, W., Xu, J., Li, L., Dong, Q., Shi, Q., Zuo, G., Zhou, L., Weng, Y., Tang, M., He, T., Luo, J. Dihydroartemisinin inhibits tumor growth of human osteosarcoma cells by suppressing Wnt/β-catenin signaling. Oncol Rep, 2013, 30(4):1723-30.
30. Dong, G.Z., Shim, A.R., Hyeon, J.S., Lee, H.J., Ryu, J.H. Inhibition of Wnt/β-Catenin Pathway by Dehydrocostus Lactone and Costunolide in Colon Cancer Cells. Phytother Res, 2015, 29(5):680-6.
31. Gong, Y., Gallis, B.M., Goodlett, D.R., Yang, Y., Lu, H., Lacoste, E., Lai, H., Sasaki, T. Effects of transferrin conjugates of artemisinin and artemisinin dimer on breast cancer cell lines. Anticancer Res, 2013, 33(1):123-32.
32. Park, S., Yun, E., Hwang, I.H., Yoon, S., Kim, D.E., Kim, J.S., Na, M., Song, G.Y., Oh, S. Ilimaquinone and ethylsmenoquinone, marine sponge metabolites, suppress the proliferation of multiple myeloma cells by down-regulating the level of β-catenin. Mar Drugs, 2014, 12(6):3231-44.
33. Das, A., Miller, R., Lee, P., Holden, C.A., Lindhorst, S.M., Jaboin, J., Vandergrift, W.A.3rd., Banik, N.L., Giglio, P., Varma, A.K., Raizer, J.J., Patel, S.J. A novel component from citrus, ginger, and mushroom family exhibits antitumor activity on human meningioma cells through suppressing the Wnt/β-catenin signaling pathway. Tumour Biol, 2015, 36(9):7027-34.
34. Lu, D., Choi, M.Y., Yu, J., Castro, J.E., Kipps, T.J., Carson, D.A. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A, 2011, 108(32):13253-7.
35. Radtke, F., Raj, K. The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer, 2003, 3(10):756-67.
36. Ranganathan, P., Weaver, K.L., Capobianco, A.J. Notch signalling in solid tumours: a little bit of everything but not all the time. Nat Rev Cancer, 2011, 11(5):338-51.
37. Rizzo, P., Osipo, C., Foreman, K., Golde, T., Osborne, B., Miele, L. Rational targeting of Notch signaling in cancer. Oncogene, 2008, 27(38):5124-31.
38. Lan, L., Appelman, C., Smith, A.R., Yu, J., Larsen, S., Marquez, R.T., Liu, H., Wu, X., Gao, P., Roy, A., Anbanandam, A., Gowthaman, R., Karanicolas,.J., Guzman, R.N., Rogers, S., Aubé, J., Ji, M., Cohen, R.S., Neufeld, K.L., Xu, L. Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1. Mol Oncol, 2015, 9(7):1406-20.
39. Sehrawat, A., Sakao, K., Singh, S.V. Notch2 activation is protective against anticancer effects of zerumbone in human breast cancer cells. Breast Cancer Res Trea, 2014, 146(3):543-55.
40. Ma, L., Mao, R., Shen, K., Zheng, Y., Li, Y., Liu, J., Ni, L. Atractylenolide I-mediated Notch pathway inhibition attenuates gastric cancer stem cell traits. Biochem Biophys Res Commun, 2014, 450(1):353-9.
41. Crompton, T., Outram, S.V., Hager-Theodorides, A.L. Sonic hedgehog signalling in T-cell development and activation. Nat Rev Immunol, 2007, 7(9):726-35.
42. Sharpe, H.J., Wang, W., Hannoush, R.N., de Sauvage, F.J. Regulation of the oncoprotein Smoothened by small molecules. Nat Chem Biol, 2015, 11(4):246-55.
43. Alman, B.A. The role of hedgehog signalling in skeletal health and disease. Nat Rev Rheumatol, 2015, 11(9):552-60.
44. Chiang, M.F., Chen, H.H., Chi, C.W., Sze, C.I., Hsu, M.L., Shieh, H.R., Lin, C.P., Tsai, J.T., Chen, Y.J. Modulation of Sonic hedgehog signaling and WW domain containing oxidoreductase WOX1 expression enhances radiosensitivity of human glioblastoma cells. Exp Biol Med, 2015, 240(3):392-9.
45. Sun, Y., Sheng, Q., Cheng, Y., Xu, Y., Han, Y., Wang, J., Shi, L., Zhao, H., Du, C. Zerumbone induces apoptosis in human renal cell carcinoma via Gli-1/Bcl-2 pathway. Pharmazie, 2013, 68(2):141-5.
46. Shao, F.Y., Wang, S., Li, H.Y., Chen, W.B., Wang, G.C., Ma, D.L., Wong, N.S., Xiao, H., Liu, Q.Y., Zhou, G.X., Li, Y.L., Li, M.M., Wang, Y.F., Liu, Z. EM23, a natural sesquiterpene lactone, targets thioredoxin reductase to activate JNK and cell death pathways in human cervical cancer cells. Oncotarget, 2016, 7(6):6790-808.
47. Jia, Y., Zhou, L., Tian, C., Shi, Y., Wang, C., Tong, Z. Dynaminrelated protein 1 is involved in micheliolide-induced breast cancer cell death. Onco Targets Ther, 2015, 8:3371-81.
48. Zhang, C., Lu, T., Wang, G.D., Ma, C., Zhou, Y.F. Costunolide, an active sesquiterpene lactone, induced apoptosis via ROS-mediated ER stress and JNK pathway in human U2OS cells. Biomed Pharmacother, 2016, 80:253-9.
49. Liu, H., Zhang, G., Huang, J., Ma, S., Mi, K., Cheng, J., Zhu, Y., Zha, X., Huang, W. Atractylenolide I modulates ovarian cancer cell-mediated immunosuppression by blocking MD-2/TLR4 complex-mediated MyD88/NF-κB signaling in vitro. J Transl Med, 2016, 14(1):104.
50. Feng, J.H., Nakagawa-Goto, K., Lee, K.H., Shyur, L.F. A Novel Plant Sesquiterpene Lactone Derivative, DETD-35, Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice. Mol Cancer Ther, 2016, 15(6):1163-76.
51. Costantino, V.V., Lobos-Gonzalez, L., Ibañez, J., Fernandez, D., Cuello-Carrión, F.D., Valenzuela, M.A., Barbieri, M.A., Semino, S.N., Jahn, G.A., Quest, A.F., Lopez, L.A. Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis. Cancer Lett, 2016, 372(1):10-23.
52. Xi, S., Peng, Y., Minuk, G.Y., Shi, M., Fu, B., Yang, J., Li, Q., Gong, Y., Yue,. L., Li, L., Guo, J., Peng, Y., Wang, Y. The combination effects of Shen-Ling-Bai-Zhu on promoting apoptosis of transplanted H22 hepatocellular carcinoma in mice receiving chemotherapy. J Ethnopharmacol, 2016, 22;190;1-2.
53. Yu, R., Yu, B.X., Chen, J.F., Lv, X.Y., Yan, Z.J., Cheng, Y., Ma, Q. Anti-tumor effects of Atractylenolide I on bladder cancer cells. J Exp Clin Cancer Res, 2016, 35:40.
54. Rahman, H.S., Rasedee, A., How, C.W., Zeenathul, N.A., Chartrand, M.S., Yeap, S.K., Abdul, A.B. Antileukemic effect of zerumbone-loaded nanostructured lipid carrier in WEHI-3B cell-induced murine leukemia model. Int J Nanomedicine, 2015, 10:1649-66.
55. Li, K., Liu, H., Gao, W., Chen, M., Zeng, Y., Liu, J., Xu, L., Wu, D. Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy. Biomaterials, 2015, 39:131-44.
56. Chen, J., Zhang, W., Zhang, M., Guo, Z., Wang, H., He, M., Xu, P., Zhou, J., Liu, Z., Chen, Q. Mn(II) mediated degradation of artemisinin based on Fe3O4@MnSiO3-FA nanospheres for cancer therapy in vivo. Nanoscale, 2015, 7(29):12542-51.
57. Emoto, M., Yoshihisa, H., Yano, K., Choijamts, B., Tsugu, H., Tachibana, K., Aizawa, M. Advanced Chemoembolization by Antiangiogenic Calcium-Phosphate Ceramic Microspheres Targeting the Vascular Heterogeneity of Cancer Xenografts. Anticancer Res, 2015, 35(9):4757-64.
58. Jung, J., Kim, E.J., Kwon, G.T., Jung, Y.J., Park, T., Kim, Y., Yu, R., Choi, M.S., Chun, H.S., Kwon, S.H., Her, S., Lee, K.W., Park, J.H. β-Caryophyllene potently inhibits solid tumor growth and lymph node metastasis of B16F10 melanoma cells in high-fat dietinduced obese C57BL/6N mice. Carcinogenesis, 2015, 36(9):1028-39.
59. Liu, L., Wei, Y., Zhai, S., Chen, Q., Xing, D. Dihydroartemisinin and transferrin dual-dressed nano-graphene oxide for a pH-triggered chemotherapy. Biomaterials, 2015, 62:35-46.
60. Kreuger, M.R., Grootjans, S., Biavatti, M.W., Vandenabeele, P., D'Herde, K. Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide. Anticancer Drugs, 2012, 23(9):883-96.
61. Wei, N., Zhou, Z., Wei, Q., Wang, Y., Jiang, J., Zhang, J., Wu, L., Dai, S., Li, Y. A novel diarylheptanoid-bearing sesquiterpene moiety from the rhizomes of Alpinia officinarum. Nat Prod Res, 2016, 25:1-6.
62. Fan, D., Zhu, G.Y., Chen, M., Xie, L.M., Jiang, Z.H., Xu, L., Bai, L.P. Dihydro-β-agarofuran sesquiterpene polyesters isolated from the stems of Tripterygium regelii. Fitoterapia, 2016, 112:1-8.
63. Fratoni, E., Claudino, V.D., Yunes, R.A., Franchi, G.C. Jr., Nowill, A.E., Filho, V.C., Monache, F.D., Malheiros, A. Further drimane sesquiterpenes from Drimys brasiliensis stem barks with cytotoxic potential. Naunyn Schmiedebergs Arch Pharmacol, 2016, 19:1-7.
64. Ding, Y., Wang, H., Niu, J., Luo, M., Gou, Y., Miao, L., Zou, Z., Cheng, Y. Induction of ROS Overload by Alantolactone Prompts Oxidative DNA Damage and Apoptosis in Colorectal Cancer Cells. Int J Mol Sci, 2016, 17(4), pii: E558.
65. Hua, P., Sun, M., Zhang, G., Zhang, Y., Song, G., Liu, Z., Li, X., Zhang, X., Li, B. Costunolide Induces Apoptosis through Generation of ROS and Activation of P53 in Human Esophageal Cancer Eca-109 Cells. J Biochem Mol Toxicol, 2016, 1.
66. Jegannathan, S.D., Arul, S., Dayalan, H. Zerumbone, a Sesquiterpene, Controls Proliferation and Induces Cell Cycle Arrest in Human Laryngeal Carcinoma Cell Line Hep-2. Nutr Cancer, 2016, 4:1-8.
67. Li, C.S., Ding, Y., Yang, B.J., Hoffman, N., Yin, H.Q., Mahmud, T., Turkson, J., Cao, S. Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087. Phytochemistry, 2016, 126:41-6.
68. Chan, C.K., Chan, G., Awang, K., Abdul, K. H. Deoxyelephantopin from Elephantopus scaber Inhibits HCT116 Human Colorectal Carcinoma Cell Growth through Apoptosis and Cell Cycle Arrest. Molecules, 2016, 21(3), pii: E385.
69. Li, Z., Wang, Y., Jiang, B., Li, W., Zheng, L., Yang, X., Bao, Y., Sun, L., Huang, Y., Li, Y. Structure, cytotoxic activity and mechanism of protoilludane sesquiterpene aryl esters from the mycelium of Armillaria mellea. J Ethnopharmacol, 2016, 184:119-27.
70. Fallahian, F., Aghaei, M., Abdolmohammadi, M.H., Hamzeloo-Moghadam, M. Molecular mechanism of apoptosis induction by Gaillardin, a sesquiterpene lactone, in breast cancer cell lines: Gaillardin-induced apoptosis in breast cancer cell lines. Cell Biol Toxicol, 2015, 31(6):295-305.
71. Uno, M., Kokuryo, T., Yokoyama, Y., Senga, T., Nagino, M. a-Bisabolol Inhibits Invasiveness and Motility in Pancreatic Cancer Through KISS1R Activation. Anticancer Res, 2016, 36(2):583-9.
72. Yeo, S.K., Ali, A.Y., Hayward, O.A., Turnham, D., Jackson, T., Bowen, I.D., Clarkson, R. β-Bisabolene, a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines. Phytother Res, 2016, 30(3):418-25.
73. Chiu, K.Y., Wu, C.C., Chia, C.H., Hsu, S.L., Tzeng, Y.M. Inhibition of growth, migration and invasion of human bladder cancer cells by antrocin, a sesquiterpene lactone isolated from Antrodia cinnamomea, and its molecular mechanisms. Cancer Lett, 2016, 373(2):174-84.
74. Saeed, M., Jacob, S., Sandjo, L.P., Sugimoto, Y., Khalid, H.E., Opatz, T., Thines, E., Efferth, T. Cytotoxicity of the Sesquiterpene Lactones Neoambrosin and Damsin from Ambrosia maritima Against Multidrug-Resistant Cancer Cells. Front Pharmacol, 2015, 6:267.
75. Bosio, C., Tomasoni, G., Martínez, R., Olea, A.F., Carrasco, H., Villena, J. Cytotoxic and apoptotic effects of leptocarpin, a plant-derived sesquiterpene lactone, on human cancer cell lines. Chem Biol Interact, 2015, 242:415-21.
76. Iranshahy, M., Tayarani-Najaran, Z., Kasaian, J., Ghandadi, M., Emami, S.A., Asili, J., Chandran, J.N., Schneider, B., Iranshahi, M. Highly Oxygenated Sesquiterpene Lactones from Cousinia aitchisonii and their Cytotoxic Properties: Rhaserolide Induces Apoptosis in Human T Lymphocyte (Jurkat) Cells via the Activation of c-Jun nterminal Kinase Phosphorylation. Phytother Res, 2016, 30(2):222-6.
77. Karmakar, U.K., Ishikawa, N., Toume, K., Arai, M.A., Sadhu, S.K., Ahmed, F., Ishibashi, M. Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium. Bioorg Med Chem, 2015, 23(15):4746-54.
78. Kisim, A., Atmaca, H., Cakar, B., Karabulut, B., Sezgin, C., Uzunoglu, S., Uslu, R., Karaca, B. Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels. J Cancer Res Clin Oncol, 2012, 138(7):1155-63.
79. Thanaketpaisarn, O., Waiwut, P., Sakurai, H., Saiki, I. Artesunate enhances TRAIL-induced apoptosis in human cervical carcinoma cells through inhibition of the NF-κB and PI3K/Akt signaling pathways. Int J Oncol, 2011, 39(1):279-85.
80. Carlisi, D., D'Anneo, A., Angileri, L., Lauricella, M., Emanuele, S., Santulli, A., Vento, R., Tesoriere, G. Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation. J Cell Physiol, 2011, 226(6):1632-41.
81. Taleb, R.I., Najm, P., Shebaby, W., Boulos, J.C., Demirdjian, S., Hariri, E., El-Sibai, M. Daher, C., Mroueh, M. β-2-Himachalen-6-ol: A Novel Anticancer Sesquiterepene Unique to the Lebanese Wild Carrot. J Ethnopharmacol, 2016, 22(190):59-67. pii: S0378-8741(16)30333-6.
82. Rigo, A., Vinante, F. The antineoplastic agent α-bisabolol promotes cell death by inducing pores in mitochondria and lysosomes. Apoptosis, 2016, 6: 1-11.
83. Ambrož, M., Boušová, I., Skarka, A., Hanušová, V., Králová, V., Matoušková, P., Szotáková, B., Skálová, L. The Influence of Sesquiterpenes from Myrica rubra on the Antiproliferative and Pro-Oxidative Effects of Doxorubicin and Its Accumulation in Cancer Cells. Molecules, 2015, 20(8):15343-58.
84. Chan, M.L., Liang, J.W., Hsu, L.C., Chang, W.L., Lee, S.S., Guh, J.H. Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult. Naunyn Schmiedebergs Arch Pharmacol, 2015, 388(11):1223-36.
85. Unger, C., Kiss, I., Vasas, A., Lajter, I., Kramer, N., Atanasov, A.G., Nguyen, C.H., Chatuphonprasert, W. The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R. Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-κB-driven tumour intravasation. Phytomedicine, 2015, 22(9):862-74.
86. Jin, S., Yun, H.J., Jeong, H.Y., Oh, Y.N., Park, H.J., Yun, S.G., Kim, B.W., Kwon, H.J. Widdrol, a sesquiterpene isolated from Juniperus chinensis, inhibits angiogenesis by targeting vascular endothelial growth factor receptor 2 signaling. Oncol Rep, 2015, 34(3):1178-84.