메뉴 건너뛰기




Volumn 9, Issue 7, 2009, Pages 501-507

Apoptosis and cancer: The genesis of a research field

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ABT 263; ANTINEOPLASTIC AGENT; COMPLEMENTARY RNA; CYTOCHROME C; DEATH RECEPTOR 4; DEATH RECEPTOR 5; DNA; FAS ANTIGEN; MYC PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

EID: 67649595826     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc2663     Document Type: Review
Times cited : (658)

References (106)
  • 1
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J. F, WyIlie, A. H. & Currie, A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancers, 239-257 (1972).
    • (1972) Br. J. Cancers , vol.239-257
    • Kerr, J.F.1    WyIlie, A.H.2    Currie, A.R.3
  • 2
    • 0004146789 scopus 로고
    • Untersuchungen über die Entwicklungsgeschichte der Geburtshelferkröte
    • Vogt, C. Untersuchungen über die Entwicklungsgeschichte der Geburtshelferkröte. [Alytes obstetricians) 130 (Jent und Gassman, 1842).
    • (1842) Alytes obstetricians) 130 (Jent und Gassman
    • Vogt, C.1
  • 3
    • 84915943405 scopus 로고
    • Cell death in normal vertebrate ontogeny
    • Glucksmann, A. Cell death in normal vertebrate ontogeny. Biol. Rev. 26, 59-86 (1951).
    • (1951) Biol. Rev , vol.26 , pp. 59-86
    • Glucksmann, A.1
  • 4
    • 0014006159 scopus 로고
    • Death in embryonic systems
    • Saunders, J. W. Jr. Death in embryonic systems. Science 154, 604-612 (1966).
    • (1966) Science , vol.154 , pp. 604-612
    • Saunders Jr., J.W.1
  • 5
    • 0001139444 scopus 로고
    • Programmed cell death - 1. Cytology of degeneration in the intersegmental muscles of the pernyi silkmoth
    • Lockshin, R. A. & Williams, C. M. Programmed cell death - 1. Cytology of degeneration in the intersegmental muscles of the pernyi silkmoth. J. Insect Physiol. 11, 123-133 (1965).
    • (1965) J. Insect Physiol , vol.11 , pp. 123-133
    • Lockshin, R.A.1    Williams, C.M.2
  • 6
    • 0013803932 scopus 로고
    • A histochemical study of hypertrophy and ishaemic injury or rat liver with special reference to changes in lysosomes
    • Kerr, J. F A histochemical study of hypertrophy and ishaemic injury or rat liver with special reference to changes in lysosomes. J. Pathol. Bacteriol. 90, 419-435 (1965).
    • (1965) J. Pathol. Bacteriol , vol.90 , pp. 419-435
    • Kerr, J.F.1
  • 7
    • 0018830636 scopus 로고
    • Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
    • Wyllie, A. H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284, 555-560 (1980).
    • (1980) Nature , vol.284 , pp. 555-560
    • Wyllie, A.H.1
  • 8
    • 0019225636 scopus 로고
    • Cell death: The significance of apoptosis
    • Wyllie, A. H., Kerr, J. F. & Currie, A. R. Cell death: the significance of apoptosis. Int. Rev. Cytol. 68, 251-306 (1980).
    • (1980) Int. Rev. Cytol , vol.68 , pp. 251-306
    • Wyllie, A.H.1    Kerr, J.F.2    Currie, A.R.3
  • 9
    • 0031888955 scopus 로고    scopus 로고
    • A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
    • 1 998
    • Enari, M. et al. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391, 43-50 (1 998).
    • Nature , vol.391 , pp. 43-50
    • Enari, M.1
  • 10
    • 2342443000 scopus 로고    scopus 로고
    • Nobel lecture. Worms, life and death
    • Horvitz, H. R. Nobel lecture. Worms, life and death. Biosci. Rep. 5, 239-303 (2003).
    • (2003) Biosci. Rep , vol.5 , pp. 239-303
    • Horvitz, H.R.1
  • 11
    • 0028329172 scopus 로고    scopus 로고
    • Kerr, J. F, Winterford, C. M. & Harmon, B. V. Apoptosis. Its significance in cancer and cancer therapy. Cancer 73, 2013-2026(1994).
    • Kerr, J. F, Winterford, C. M. & Harmon, B. V. Apoptosis. Its significance in cancer and cancer therapy. Cancer 73, 2013-2026(1994).
  • 12
    • 0027451668 scopus 로고
    • P53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe, S. W. et al. P53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74, 957-967 (1993).
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1
  • 13
    • 0027979832 scopus 로고
    • BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death
    • McGahon, A. etal. BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death. Blood 83, 1179-1187(1994).
    • (1994) Blood , vol.83 , pp. 1179-1187
    • McGahon, A.1
  • 14
    • 0031681296 scopus 로고    scopus 로고
    • CD95(APO-1/Fas)-mediated apoptosis in normal and malignant liver, colon, and hematopoietic cells
    • Krammer, P. H. etal. CD95(APO-1/Fas)-mediated apoptosis in normal and malignant liver, colon, and hematopoietic cells. Adv. Cancer Res. 75, 251-273 (1998).
    • (1998) Adv. Cancer Res , vol.75 , pp. 251-273
    • Krammer, P.H.1
  • 15
    • 0021679848 scopus 로고    scopus 로고
    • Tsujimoto, Y etal. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;1 8) chromosome translocation. Science 226, 1097-1099 (1984).
    • Tsujimoto, Y etal. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;1 8) chromosome translocation. Science 226, 1097-1099 (1984).
  • 16
    • 0022546957 scopus 로고
    • Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma
    • Tsujimoto, Y & Croce, C. M. Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc. Natl Acad. Sci. USA83, 5214-5218(1986).
    • (1986) Proc. Natl Acad. Sci , vol.USA83 , pp. 5214-5218
    • Tsujimoto, Y.1    Croce, C.M.2
  • 17
    • 0022971142 scopus 로고    scopus 로고
    • Cleary, M. L, Smith, S. D. & Sklar, J. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid ¿>c/-2/immunoglobulin transcript resulting from the t(14; 1 8) translocation. Cell 47, 19-28 ( 1986).
    • Cleary, M. L, Smith, S. D. & Sklar, J. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid ¿>c/-2/immunoglobulin transcript resulting from the t(14; 1 8) translocation. Cell 47, 19-28 ( 1986).
  • 18
    • 4344641255 scopus 로고    scopus 로고
    • Early work on the function of Bcl-2, an interview with David Vaux
    • Vaux, D. L. Early work on the function of Bcl-2, an interview with David Vaux. Cell Death Differ. 11, S28-S32 (2004).
    • (2004) Cell Death Differ , vol.11
    • Vaux, D.L.1
  • 19
    • 0015694748 scopus 로고
    • A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and giemsa staining
    • Rowley, J. D. A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and giemsa staining. Nature 243, 290-293 (1973).
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 20
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
    • Vaux, D. L, Cory, S. & Adams, J. M. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335, 440-442(1988).
    • (1988) Nature , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 21
    • 0024454762 scopus 로고
    • Stress-resista nee conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell
    • Tsujimoto, Y. Stress-resista nee conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell. Oncogene 11, 1331-1336(1989).
    • (1989) Oncogene , vol.11 , pp. 1331-1336
    • Tsujimoto, Y.1
  • 22
    • 0025091773 scopus 로고
    • Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis
    • Williams, G. T et al. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature 343, 76-79 (1990).
    • (1990) Nature , vol.343 , pp. 76-79
    • Williams, G.T.1
  • 23
    • 0025163927 scopus 로고
    • Regulation of apoptosis in interleukin-3-dependent hemopoietic cells by interleukin-3 and calcium ionophores
    • Rodriguez-Tarduchy, G., Collins, M. & López-Rivas, A. Regulation of apoptosis in interleukin-3-dependent hemopoietic cells by interleukin-3 and calcium ionophores. EMBOJ. 9, 2997-3002 (1990).
    • (1990) EMBOJ , vol.9 , pp. 2997-3002
    • Rodriguez-Tarduchy, G.1    Collins, M.2    López-Rivas, A.3
  • 24
    • 0025963456 scopus 로고
    • IL3-dependent cells die by apoptosis on removal of their growth factor
    • Crompton, T IL3-dependent cells die by apoptosis on removal of their growth factor. Growth Factors 4, 109-116(1991).
    • (1991) Growth Factors , vol.4 , pp. 109-116
    • Crompton, T.1
  • 25
    • 0023812417 scopus 로고
    • Oncogenic potential of bcl-2 demonstrated by gene transfer
    • Reed, J. C. et al. Oncogenic potential of bcl-2 demonstrated by gene transfer. Nature 336, 259-261 (1988).
    • (1988) Nature , vol.336 , pp. 259-261
    • Reed, J.C.1
  • 26
    • 0024521441 scopus 로고    scopus 로고
    • McDonnell, T J. et al. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation.Cell 57, 79-88 (1989).
    • McDonnell, T J. et al. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation.Cell 57, 79-88 (1989).
  • 27
    • 0025011006 scopus 로고
    • Antisense-mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: Comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides
    • Reed, J. C. et al. Antisense-mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides. Cancer Res. 50, 6565-6570 (1990).
    • (1990) Cancer Res , vol.50 , pp. 6565-6570
    • Reed, J.C.1
  • 28
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenbery, D. et al. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348, 334-336 (1990).
    • (1990) Nature , vol.348 , pp. 334-336
    • Hockenbery, D.1
  • 29
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
    • Liu, X. et al. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86, 147-157(1996).
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, X.1
  • 30
    • 0031036872 scopus 로고    scopus 로고
    • Prevention of apoptosis by Bcl-2: Release of cytochrome cfrom mitochondria blocked
    • Yang, J. et al. Prevention of apoptosis by Bcl-2: release of cytochrome cfrom mitochondria blocked. Science 275, 1129-1132 (1997).
    • (1997) Science , vol.275 , pp. 1129-1132
    • Yang, J.1
  • 31
    • 0037833742 scopus 로고    scopus 로고
    • Caspaseactivation pathways in apoptosis and immunity
    • Creagh, E. M., Conroy, H. & Martin, S. J. Caspaseactivation pathways in apoptosis and immunity. Immunol. Rev. 193, 10-21 (2003).
    • (2003) Immunol. Rev , vol.193 , pp. 10-21
    • Creagh, E.M.1    Conroy, H.2    Martin, S.J.3
  • 32
    • 33845977959 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization in cell death
    • Kroemer, G., Galluzzi, L. & Brenner, C. Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 87, 99-163(2007).
    • (2007) Physiol. Rev , vol.87 , pp. 99-163
    • Kroemer, G.1    Galluzzi, L.2    Brenner, C.3
  • 33
    • 0027282044 scopus 로고
    • bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
    • Boise, L. H. et al. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74, 597-608 (1993).
    • (1993) Cell , vol.74 , pp. 597-608
    • Boise, L.H.1
  • 34
    • 9544250358 scopus 로고    scopus 로고
    • bcl-w, a novel member of the bcl-2 family, promotes cell survival
    • Gibson, L. et al. bcl-w, a novel member of the bcl-2 family, promotes cell survival. Oncogene 13, 665-675 (1996).
    • (1996) Oncogene , vol.13 , pp. 665-675
    • Gibson, L.1
  • 35
    • 0027480450 scopus 로고
    • MCL 1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2
    • Kozopas, K. M. et al. MCL 1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc. Natl Acad. Sci. USA 90, 3516-3520(1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 3516-3520
    • Kozopas, K.M.1
  • 36
    • 0034616945 scopus 로고    scopus 로고
    • Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
    • Du, C, Fang, M., Li, Y, Li, L & Wang, X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102, 33-42 (2000).
    • (2000) Cell , vol.102 , pp. 33-42
    • Du, C.1    Fang, M.2    Li, Y.3    Li, L.4    Wang, X.5
  • 37
    • 0034616942 scopus 로고    scopus 로고
    • Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
    • Verhagen, A. M. et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102, 43-53(2000).
    • (2000) Cell , vol.102 , pp. 43-53
    • Verhagen, A.M.1
  • 38
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai, Z. N., Milliman, C. L & Korsmeyer, S. J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74, 609-619(1993).
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 39
    • 0028986876 scopus 로고
    • Induction of apoptosis by the Bcl-2 homologue Bak
    • Chittenden, T. et al. Induction of apoptosis by the Bcl-2 homologue Bak. Nature 374, 733-736 (1995).
    • (1995) Nature , vol.374 , pp. 733-736
    • Chittenden, T.1
  • 40
    • 0032518787 scopus 로고    scopus 로고
    • O'Connor, L. et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBOJ. 1 7, 384-395 (1998).
    • O'Connor, L. et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBOJ. 1 7, 384-395 (1998).
  • 41
    • 0029807585 scopus 로고    scopus 로고
    • BID: A novel BH3 domain-only death agonist
    • Wang, K. et al. BID: a novel BH3 domain-only death agonist. Genes Dev. 10, 2859-2869 (1996).
    • (1996) Genes Dev , vol.10 , pp. 2859-2869
    • Wang, K.1
  • 42
    • 0028809209 scopus 로고
    • Bad, a heterodimeric partner for BcI-XL and Bcl-2, displaces Bax and promotes cell death
    • Yang, E. et al. Bad, a heterodimeric partner for BcI-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80,285-291 (1995).
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1
  • 43
    • 54949132875 scopus 로고    scopus 로고
    • Bcl-2 family proteins and cancer
    • Yip, K. W. & Reed, J. C. Bcl-2 family proteins and cancer. Oncogene 27, 6398-6406 (2008).
    • (2008) Oncogene , vol.27 , pp. 6398-6406
    • Yip, K.W.1    Reed, J.C.2
  • 44
    • 0030740592 scopus 로고    scopus 로고
    • BCL2 over-ex press ¡on associated with chromosomal amplification in diffuse large B-cell lymphoma
    • Monni, O. et al. BCL2 over-ex press ¡on associated with chromosomal amplification in diffuse large B-cell lymphoma. Blood 90, 11 68-11 74 (1997).
    • (1997) Blood , vol.90
    • Monni, O.1
  • 45
    • 0028081924 scopus 로고
    • Expression of bcl-2 in small cell lung carcinoma cells
    • Ikegaki, N. et al. Expression of bcl-2 in small cell lung carcinoma cells. Cancer Res. 54, 6-8 (1994).
    • (1994) Cancer Res , vol.54 , pp. 6-8
    • Ikegaki, N.1
  • 46
    • 0027239823 scopus 로고
    • bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia
    • Hanada, M. et al. bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood 82, 1820-1828 (1993).
    • (1993) Blood , vol.82 , pp. 1820-1828
    • Hanada, M.1
  • 47
    • 25444520537 scopus 로고    scopus 로고
    • miR-15 and miR-16 induce apoptosis by targeting BCL2
    • Cimmino, A. et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc. Natl Acad. Sci. USA 102, 13944-13949(2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 13944-13949
    • Cimmino, A.1
  • 48
    • 0028335717 scopus 로고
    • Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
    • Miyashita, T. et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 6, 1799-1805 (1994).
    • (1994) Oncogene , vol.6 , pp. 1799-1805
    • Miyashita, T.1
  • 49
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita, T & Reed, J. C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293-299(1995).
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 50
    • 0034640281 scopus 로고    scopus 로고
    • Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
    • Oda, E. et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288, 1053-1058 (2000).
    • (2000) Science , vol.288 , pp. 1053-1058
    • Oda, E.1
  • 51
    • 85006263913 scopus 로고    scopus 로고
    • BID regulation by p53 contributes to chemosensitivity
    • Sax, J. K. et al. BID regulation by p53 contributes to chemosensitivity. Nature Cell Biol. 11, 842-849 (2002).
    • (2002) Nature Cell Biol , vol.11 , pp. 842-849
    • Sax, J.K.1
  • 52
  • 53
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • Nakano, K. & Vousden, K. H. PUMA, a novel proapoptotic gene, is induced by p53. Moi. Cell 7, 683-694(2001).
    • (2001) Moi. Cell , vol.7 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 54
    • 0042424706 scopus 로고    scopus 로고
    • Bad-deficient mice develop diffuse large B cell lymphoma
    • Ranger, A. M. et al. Bad-deficient mice develop diffuse large B cell lymphoma. Proc. Nati Acad. Sci. USA 100, 9324-9329 (2003).
    • (2003) Proc. Nati Acad. Sci. USA , vol.100 , pp. 9324-9329
    • Ranger, A.M.1
  • 55
    • 23944445368 scopus 로고    scopus 로고
    • A role for proapoptotic BID in the DNA-damage response
    • Zinkel, S. S. et al. A role for proapoptotic BID in the DNA-damage response. Cell 122, 579-591 (2005).
    • (2005) Cell , vol.122 , pp. 579-591
    • Zinkel, S.S.1
  • 56
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    • Bouillet, P. et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286, 1735-1738(1999).
    • (1999) Science , vol.286 , pp. 1735-1738
    • Bouillet, P.1
  • 57
    • 0030985194 scopus 로고    scopus 로고
    • Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma
    • Gascoyne, R. D. et al. Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma. Blood 90,244-251 (1997).
    • (1997) Blood , vol.90 , pp. 244-251
    • Gascoyne, R.D.1
  • 58
    • 0036251711 scopus 로고    scopus 로고
    • Apoptosis and expression of Bcl-2, BcI-XL, and Bax in renal cell carcinomas
    • Gobe, G. E. et al. Apoptosis and expression of Bcl-2, BcI-XL, and Bax in renal cell carcinomas. Cancer Invest. 20, 324-332 (2002).
    • (2002) Cancer Invest , vol.20 , pp. 324-332
    • Gobe, G.E.1
  • 59
    • 0028357022 scopus 로고
    • Loss of heterozygosity at the bcl-2 gene locus and expression of bcl-2 in human gastric and colorectal carcinomas
    • Ayhan, A. et al. Loss of heterozygosity at the bcl-2 gene locus and expression of bcl-2 in human gastric and colorectal carcinomas. Jpn J. Cancer Res. 85, 584-591 (1994).
    • (1994) Jpn J. Cancer Res , vol.85 , pp. 584-591
    • Ayhan, A.1
  • 60
    • 0027757091 scopus 로고
    • Expression of the apoptosissuppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification
    • Castle, V P. et al. Expression of the apoptosissuppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification. Am. J. Pathol. 143, 1543-1550(1993).
    • (1993) Am. J. Pathol , vol.143 , pp. 1543-1550
    • Castle, V.P.1
  • 61
    • 0036898492 scopus 로고    scopus 로고
    • Predictive value of P53, BCL-2, and BAX in advanced head and neck carcinoma
    • Casado, S. et al. Predictive value of P53, BCL-2, and BAX in advanced head and neck carcinoma. Am. J. Clin. Oncol. 25, 588-590 (2002).
    • (2002) Am. J. Clin. Oncol , vol.25 , pp. 588-590
    • Casado, S.1
  • 62
    • 0037440238 scopus 로고    scopus 로고
    • Survivin, bcl-2, bax, and bcl-X gene expression in sentinel lymph nodes from melanoma patients
    • Gradilone, A. et al. Survivin, bcl-2, bax, and bcl-X gene expression in sentinel lymph nodes from melanoma patients. J. Clin. Oncol. 21, 306-31 2 (2003).
    • (2003) J. Clin. Oncol , vol.21 , Issue.306-331 , pp. 2
    • Gradilone, A.1
  • 63
    • 0036875813 scopus 로고    scopus 로고
    • Prognostic significance of p53, bcl-2 and Ki-67 in high risk superficial bladder cancer
    • Stavropoulos, N. E. et al. Prognostic significance of p53, bcl-2 and Ki-67 in high risk superficial bladder cancer. Anticancer Res. 22, 3759-3764 (2002).
    • (2002) Anticancer Res , vol.22 , pp. 3759-3764
    • Stavropoulos, N.E.1
  • 64
    • 0037301972 scopus 로고    scopus 로고
    • Survival of patients with metastatic breast carcinoma: Importance of prognostic markers of the primary tumor
    • Chang, J. et al. Survival of patients with metastatic breast carcinoma: importance of prognostic markers of the primary tumor. Cancer 97, 545-553 (2003).
    • (2003) Cancer , vol.97 , pp. 545-553
    • Chang, J.1
  • 65
    • 0028944271 scopus 로고
    • Expression of the bcl-2 gene family in normal and malignant breast tissue: Low bax-alpha expression in tumor cells correlates with resistance towards apoptosis
    • Bargou, R. C. et al. Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis. Int. J. Cancer. 60, 854-859 (1995).
    • (1995) Int. J. Cancer , vol.60 , pp. 854-859
    • Bargou, R.C.1
  • 66
    • 0029045784 scopus 로고
    • Reduced expression of proapoptotic gene SAV is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma
    • Krajewski, S. et al. Reduced expression of proapoptotic gene SAV is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. CancerRes. 55,4471-4478(1995).
    • (1995) CancerRes , vol.55 , pp. 4471-4478
    • Krajewski, S.1
  • 67
    • 0031714496 scopus 로고    scopus 로고
    • A multivariate analysis of tumour biological factors predicting response to cytotoxic treatment in advanced breast cancer
    • Sjöström, J. et al. A multivariate analysis of tumour biological factors predicting response to cytotoxic treatment in advanced breast cancer. Br. J. Cancer 78, 812-815(1998).
    • (1998) Br. J. Cancer , vol.78 , pp. 812-815
    • Sjöström, J.1
  • 68
    • 0032943691 scopus 로고    scopus 로고
    • Prognostic significance of apoptosis regulators in breast cancer
    • Krajewski, S. et al. Prognostic significance of apoptosis regulators in breast cancer. Endocr. Relat. Cancer 6, 29-40 (1999).
    • (1999) Endocr. Relat. Cancer , vol.6 , pp. 29-40
    • Krajewski, S.1
  • 69
    • 0034901006 scopus 로고    scopus 로고
    • Can expression of apoptosis genes, bcl-2 and bax, predict survival and responsiveness to chemotherapy in node-negative breast cancer patients?
    • Kymionis, G. D. et al. Can expression of apoptosis genes, bcl-2 and bax, predict survival and responsiveness to chemotherapy in node-negative breast cancer patients? J. Surg. Res. 99, 161 -168 (2001).
    • (2001) J. Surg. Res , vol.99 , pp. 161-168
    • Kymionis, G.D.1
  • 70
    • 38549145044 scopus 로고    scopus 로고
    • Diagnosing and exploiting cancer's addiction to blocks in apoptosis
    • Letai, A. G. Diagnosing and exploiting cancer's addiction to blocks in apoptosis. Nature Rev. Cancer 8, 121-132 (2008).
    • (2008) Nature Rev. Cancer , vol.8 , pp. 121-132
    • Letai, A.G.1
  • 71
    • 0025751550 scopus 로고
    • bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
    • Sentman, C. L. et al. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67, 879-888(1991).
    • (1991) Cell , vol.67 , pp. 879-888
    • Sentman, C.L.1
  • 72
    • 0030888664 scopus 로고    scopus 로고
    • BCL-2 antisense therapy in patients with non-Hodgkin lymphoma
    • Webb, A. et al. BCL-2 antisense therapy in patients with non-Hodgkin lymphoma. Lancets 349, 1137-1141 (1997).
    • (1997) Lancets , vol.349 , pp. 1137-1141
    • Webb, A.1
  • 74
    • 67649593773 scopus 로고
    • Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis
    • Askew, D. S., Ashmun, R. A., Simmons, B. C. & Cleveland, J. L Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 19, 15-22 (1991).
    • (1991) Oncogene , vol.19 , pp. 15-22
    • Askew, D.S.1    Ashmun, R.A.2    Simmons, B.C.3    Cleveland, J.L.4
  • 75
    • 0026667219 scopus 로고
    • Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas
    • Shi, Y. et al. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 257,212-214(1992).
    • (1992) Science , vol.257 , pp. 212-214
    • Shi, Y.1
  • 76
    • 0026642195 scopus 로고
    • Induction of apoptosis in fibroblasts by c-myc protein
    • Evan, G. I. et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69, 119-128(1992).
    • (1992) Cell , vol.69 , pp. 119-128
    • Evan, G.I.1
  • 77
    • 0025251664 scopus 로고
    • Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
    • Strasser, A., Harris, A. W, Bath, M. L & Cory, S. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 348,331-333 (1990).
    • (1990) Nature , vol.348 , pp. 331-333
    • Strasser, A.1    Harris, A.W.2    Bath, M.L.3    Cory, S.4
  • 78
    • 0034948677 scopus 로고    scopus 로고
    • Myc potentiates apoptosis by stimulating Bax activity at the mitochondria
    • Soucie, E. L et al. Myc potentiates apoptosis by stimulating Bax activity at the mitochondria. Mol. Cell. Biol. 21, 4725-4736 (2001).
    • (2001) Mol. Cell. Biol , vol.21 , pp. 4725-4736
    • Soucie, E.L.1
  • 79
    • 1642555717 scopus 로고    scopus 로고
    • c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death
    • de Alborãn, I. M. Baena, E. & Martinez-A. C. c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death. Cell Death Differ. 11, 61-68(2004).
    • (2004) Cell Death Differ , vol.11 , pp. 61-68
    • de Alborãn, I.M.1    Baena, E.2    Martinez-A, C.3
  • 80
    • 0035950521 scopus 로고    scopus 로고
    • Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1
    • Eischen, C. M. et al. Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1. Oncogene 20, 6983-6993(2001).
    • (2001) Oncogene , vol.20 , pp. 6983-6993
    • Eischen, C.M.1
  • 81
    • 0141864362 scopus 로고    scopus 로고
    • c-Myc augments gamma irradiation-induced apoptosis by suppressing BcI-XL
    • Maclean, K. H. et al. c-Myc augments gamma irradiation-induced apoptosis by suppressing BcI-XL Mol. Cell. Biol. 23, 7256-7270 (2003).
    • (2003) Mol. Cell. Biol , vol.23 , pp. 7256-7270
    • Maclean, K.H.1
  • 82
    • 33646348235 scopus 로고    scopus 로고
    • Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo
    • Dansen, T B. et al. Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo. J. Biol. Chem.281, 10890-10895 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 10890-10895
    • Dansen, T.B.1
  • 83
    • 0033180211 scopus 로고    scopus 로고
    • Reversible tumorigenesis by MYC in hematopoietic lineages
    • Felsher, D. W. & Bishop, J. M. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol. Cell4, 199-207 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 199-207
    • Felsher, D.W.1    Bishop, J.M.2
  • 84
    • 0033001621 scopus 로고    scopus 로고
    • Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion
    • Pelengaris, S. et al. Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol. Cell 3, 565-577 (1999).
    • (1999) Mol. Cell , vol.3 , pp. 565-577
    • Pelengaris, S.1
  • 85
    • 0025784539 scopus 로고
    • Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited byinterleukin-6
    • Yonish-Rouach, E. et al. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited byinterleukin-6. Nature352, 345-347 (1991).
    • (1991) Nature , vol.352 , pp. 345-347
    • Yonish-Rouach, E.1
  • 86
    • 0027944228 scopus 로고    scopus 로고
    • Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis
    • 1 994
    • Zhan, Q. et al. Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene 9, 3743-3751 (1 994).
    • Oncogene , vol.9 , pp. 3743-3751
    • Zhan, Q.1
  • 87
    • 33646807491 scopus 로고    scopus 로고
    • Transcriptional regulation by p53: One protein, many possibilities
    • Lapenko, O. & Prives, C. Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ. 13,951-961 (2006).
    • (2006) Cell Death Differ , vol.13 , pp. 951-961
    • Lapenko, O.1    Prives, C.2
  • 88
    • 0024347970 scopus 로고
    • Monoclonal antibody-mediated tumor regression by induction of apoptosis
    • Trauth, B. C. et al. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245, 301-305 (1989).
    • (1989) Science , vol.245 , pp. 301-305
    • Trauth, B.C.1
  • 89
    • 0024596722 scopus 로고
    • A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-down regulated with the receptor of tumor necrosis factor
    • Yonehara, S., Ishii, A. SiYonehara, M. A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-down regulated with the receptor of tumor necrosis factor. J. Exp. Med. 169, 1747-1756 (1989).
    • (1989) J. Exp. Med , vol.169 , pp. 1747-1756
    • Yonehara, S.1    Ishii, A.2    SiYonehara, M.3
  • 90
    • 0025916387 scopus 로고
    • The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
    • Itoh, N. et al. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66, 233-243 (1991).
    • (1991) Cell , vol.66 , pp. 233-243
    • Itoh, N.1
  • 91
    • 0027145632 scopus 로고
    • Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family
    • Suda, T, Takahashi, T, Golstein, P. & Nagata, S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75, 1169-1178(1993).
    • (1993) Cell , vol.75 , pp. 1169-1178
    • Suda, T.1    Takahashi, T.2    Golstein, P.3    Nagata, S.4
  • 92
    • 0027291205 scopus 로고
    • Lethal effect of the anti-Fas antibody in mice
    • Ogasawara, J. et al. Lethal effect of the anti-Fas antibody in mice. Nature 364, 806-809 (1993).
    • (1993) Nature , vol.364 , pp. 806-809
    • Ogasawara, J.1
  • 93
    • 52649109068 scopus 로고    scopus 로고
    • The TRAIL apoptotic pathway in cancer onset, progression and therapy
    • Johnstone, R. W., Frew, A. J. & Smyth, M. J. The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nature Rev. Cancer 8, 782-798 (2008).
    • (2008) Nature Rev. Cancer , vol.8 , pp. 782-798
    • Johnstone, R.W.1    Frew, A.J.2    Smyth, M.J.3
  • 94
    • 17544367410 scopus 로고    scopus 로고
    • Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
    • Pitti, R. M. et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271, 12687-12690 (1996).
    • (1996) J. Biol. Chem , vol.271 , pp. 12687-12690
    • Pitti, R.M.1
  • 95
    • 13344285339 scopus 로고
    • Identification and characterization of a new member of the TNF family that induces apoptosis
    • Wiley, S. R. et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3, 673-682 (1995).
    • (1995) Immunity , vol.3 , pp. 673-682
    • Wiley, S.R.1
  • 96
    • 0029935682 scopus 로고    scopus 로고
    • Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells
    • Friesen, C., Herr, I., Krammer, P. H. či Debatin, K. M. Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nature Med. 2, 574-577 (1996).
    • (1996) Nature Med , vol.2 , pp. 574-577
    • Friesen, C.1    Herr, I.2    Krammer, P.H.3    či Debatin, K.M.4
  • 97
    • 0032189535 scopus 로고    scopus 로고
    • Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells
    • Fulda, S., Susin, S. A., Kroemer, G. & Debatin, K. M. Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells. Cancer Res. 58, 4453-4460 (1998).
    • (1998) Cancer Res , vol.58 , pp. 4453-4460
    • Fulda, S.1    Susin, S.A.2    Kroemer, G.3    Debatin, K.M.4
  • 98
    • 0040419494 scopus 로고    scopus 로고
    • Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ ligand system and involves activation of wild-type p53
    • 1 997
    • Müller, M. et al. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ ligand system and involves activation of wild-type p53. J. Clin. Invest. 99, 403-41 3 (1 997).
    • J. Clin. Invest , vol.99 , Issue.403-441 , pp. 3
    • Müller, M.1
  • 99
    • 0031743648 scopus 로고    scopus 로고
    • p53 activates the CD95 (APO-I/Fas) gene in response to DNA damage by anticancer drugs
    • Müller, M. et al. p53 activates the CD95 (APO-I/Fas) gene in response to DNA damage by anticancer drugs. J. Exp. Med. 188, 2033-2045 (1998).
    • (1998) J. Exp. Med , vol.188 , pp. 2033-2045
    • Müller, M.1
  • 100
    • 0028864778 scopus 로고
    • A role for CD95 ligand in preventing graft rejection
    • Bellgrau, D. et al. A role for CD95 ligand in preventing graft rejection. Nature 377, 630-632 (1995).
    • (1995) Nature , vol.377 , pp. 630-632
    • Bellgrau, D.1
  • 101
    • 0028879109 scopus 로고
    • Fas ligand-induced apoptosis as a mechanism of immune privilege
    • Griffith, T. S. et al. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270, 1189-1192 (1995).
    • (1995) Science , vol.270 , pp. 1189-1192
    • Griffith, T.S.1
  • 102
    • 16144363507 scopus 로고    scopus 로고
    • Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells -a mechanism of immune evasion?
    • Strand, S. et al. Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells -a mechanism of immune evasion? Nature Med. 2, 1361-1366(1996).
    • (1996) Nature Med , vol.2 , pp. 1361-1366
    • Strand, S.1
  • 103
    • 10544232277 scopus 로고    scopus 로고
    • Melanoma cell expression of Fas (Apo-1/CD95) ligand: Implications for tumor immune escape
    • Hahne, M. et al. Melanoma cell expression of Fas (Apo-1/CD95) ligand: implications for tumor immune escape. Science 274, 1363-1366 (1996).
    • (1996) Science , vol.274 , pp. 1363-1366
    • Hahne, M.1
  • 104
    • 0030972396 scopus 로고    scopus 로고
    • Allison, J., Georgiou, H. M., Strasser, A. &Vaux, D. L Transgenic expression of CD95 ligand on islet ß cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. Proc. Natl Acad. Sci. USA 94, 3943-3947 (1997).
    • Allison, J., Georgiou, H. M., Strasser, A. &Vaux, D. L Transgenic expression of CD95 ligand on islet ß cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. Proc. Natl Acad. Sci. USA 94, 3943-3947 (1997).
  • 105
    • 20444486559 scopus 로고    scopus 로고
    • An inhibitor of the Bcl-2 family proteins induces regression of solid tumours
    • Oltersdorf, T. et al. An inhibitor of the Bcl-2 family proteins induces regression of solid tumours. Nature 435, 677-681 (2005).
    • (2005) Nature , vol.435 , pp. 677-681
    • Oltersdorf, T.1
  • 106
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • Qu, X. et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.J. Clin. Invest. 112, 1809-1820 (2003).
    • (2003) J. Clin. Invest , vol.112 , pp. 1809-1820
    • Qu, X.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.