Ilimaquinone and ethylsmenoquinone, marine sponge metabolites, suppress the proliferation of multiple myeloma cells by down-regulating the level of β-catenin

Marine Drugs

Volumn 12, Issue 6, 2014, Pages 3231-3244

  Park, Seoyoung ^a   Yun, Eunju ^b   Hwang, In Hyun ^c   Yoon, Soojin ^d   Kim, Dong Eun ^d   Kim, Ji Seon ^a   Na, MinKyun ^b   Song, Gyu Yong ^b   Oh, Sangtaek ^a  

^a Kookmin University   (South Korea)

^b Chungnam National University   (South Korea)

^c E11 SSH   (United States)

^d Konkuk University   (South Korea)

Author keywords

Ethylsmenoquinone; Ilimaquinone; Multiple myeloma; Wnt catenin signaling

Indexed keywords

AXIN; AXIN 2; BETA CATENIN; CYCLIN D1; ETHYLSMENOQUINONE; GLYCOGEN SYNTHASE KINASE 3BETA; ILIMAQUINONE; MYC PROTEIN; QUINONE DERIVATIVE; SESQUITERPENE; UNCLASSIFIED DRUG; WNT3A PROTEIN; ANTINEOPLASTIC AGENT; BENZOQUINONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL VIABILITY ASSAY; DOWN REGULATION; DRUG EFFICACY; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; GENE TARGETING; MULTIPLE MYELOMA; PHARMACOLOGICAL BLOCKING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TARGETING; ANIMAL; CELL CYCLE CHECKPOINT; DRUG EFFECTS; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; PATHOLOGY; SPONGE (PORIFERA); TUMOR CELL LINE; WNT SIGNALING PATHWAY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOQUINONES; BETA CATENIN; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; G0 PHASE; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MULTIPLE MYELOMA; PORIFERA; QUINONES; SESQUITERPENES; WNT SIGNALING PATHWAY;

EID: 84903553606     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md12063231     Document Type: Article

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