Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1

Molecular Oncology

Volumn 9, Issue 7, 2015, Pages 1406-1420

  Lan, Lan ^a   Appelman, Carl ^a   Smith, Amber R ^a   Yu, Jia ^a,c   Larsen, Sarah ^a   Marquez, Rebecca T ^a   Liu, Hao ^a,f   Wu, Xiaoqing ^a   Gao, Philip ^a   Roy, Anuradha ^a   Anbanandam, Asokan ^a   Gowthaman, Ragul ^a   Karanicolas, John ^a   De Guzman, Roberto N ^a   Rogers, Steven ^a   Aubé, Jeffrey ^a,b   Ji, Min ^c   Cohen, Robert S ^d   Neufeld, Kristi L ^a   Xu, Liang ^a,e  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c SOUTHEAST UNIVERSITY   (China)

^d CLEMSON UNIVERSITY   (United States)

^e UNIVERSITY OF KANSAS CANCER CENTER   (United States)

^f XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Colon cancer; Musashi 1; Notch; RNA binding protein; Wnt

Indexed keywords

APC PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; GOSSYPOL; MESSENGER RNA; NATURAL PRODUCT; NOTCH RECEPTOR; PROTEIN MUSASHI 1; PROTEIN NUMB; PROTEIN P21; RNA BINDING PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; MSI1 PROTEIN, HUMAN; NERVE PROTEIN; PROTEIN BINDING;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BINDING SITE; CANCER GROWTH; CANCER MODEL; COLON CANCER; CONTROLLED STUDY; COTTON; DOWN REGULATION; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; FEMALE; FLUORESCENCE POLARIZATION; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NITROGEN NUCLEAR MAGNETIC RESONANCE; NONHUMAN; NUMB GENE; PRIORITY JOURNAL; PROTEIN RNA BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; SURVIVIN GENE; TUMOR XENOGRAFT; ANIMAL; CELL LINE; CELL PROLIFERATION; COLON TUMOR; DRUG EFFECTS; DRUG SCREENING; METABOLISM; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

MICROPUS;

ANIMALS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; FEMALE; GOSSYPOL; HUMANS; MICE; MICE, NUDE; NERVE TISSUE PROTEINS; PROTEIN BINDING; RNA-BINDING PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84938203353     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2015.03.014     Document Type: Article

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