The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-κB-driven tumour intravasation

Phytomedicine

Volumn 22, Issue 9, 2015, Pages 862-874

  Unger, Christine ^a   Kiss, Izabella ^a   Vasas, Andrea ^b   Lajter, Ildikó ^b   Kramer, Nina ^a   Atanasov, Atanas Georgiev ^c   Nguyen, Chi Huu ^a   Chatuphonprasert, Waranya ^a,d   Brenner, Stefan ^a   Krieger, Sigurd ^a   McKinnon, Ruxandra ^c   Peschel, Andrea ^a   Kain, Renate ^a   Saiko, Philipp ^a   Szekeres, Thomas ^a   Kenner, Lukas ^a   Hassler, Melanie R ^a   Diaz, Rene ^e   Frisch, Richard ^e   Dirsch, Verena M ^c   Jäger, Walter ^a   De Martin, Rainer ^a   Bochkov, Valery N ^f   Passreiter, Claus M ^g   Peter Vörösmarty, Barbara ^a   Mader, Robert M ^a   Grusch, Michael ^a   Dolznig, Helmut ^a   Kopp, Brigitte ^c   Zupko, Istvan ^b   Hohmann, Judit ^b   Krupitza, Georg ^a   more..

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF SZEGED   (Hungary)

^c UNIVERSITY OF VIENNA   (Austria)

^d MAHASARAKHAM UNIVERSITY   (Thailand)

^e Institute for Ethnobiology   (Guatemala)

^f UNIVERSITY OF GRAZ   (Austria)

^g HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

3D compound testing; ALCL; Intravasation; Neurolenins; NPM ALK; Toxicity

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; CASPASE 3; CYTOCHROME P450; CYTOCHROME P450 1A1; GERMACRANOLIDE DERIVATIVE; HISTONE H3; HYBRID PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEUROLAENA LOBATA EXTRACT; NEUROLENIN B; NUCLEOPHOSMIN; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; SESQUITERPENE LACTONE; TRANSCRIPTION FACTOR JUNB; UNCLASSIFIED DRUG; GERMACRANOLIDE; LACTONE; P80(NPM-ALK) PROTEIN; PROTEIN TYROSINE KINASE; SESQUITERPENE;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CELL ACTIVITY; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL EXPANSION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; LARGE CELL LYMPHOMA; LEUKEMIA; MITOCHONDRION; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR SPHEROID; ASTERACEAE; CELL CYCLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; MEDICINAL PLANT; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

NEUROLAENA LOBATA;

APOPTOSIS; ASTERACEAE; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; LACTONES; LEUKOCYTES, MONONUCLEAR; LYMPHOMA, LARGE-CELL, ANAPLASTIC; MOLECULAR STRUCTURE; NF-KAPPA B; PLANTS, MEDICINAL; PROTEIN-TYROSINE KINASES; SESQUITERPENES; SESQUITERPENES, GERMACRANE; SIGNAL TRANSDUCTION;

EID: 84937560391     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2015.06.003     Document Type: Article

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