The sesquiterpene lactone eupatolide sensitizes breast cancer cells to TRAIL through down-regulation of c-FLIP expression

Oncology Reports

Volumn 23, Issue 1, 2010, Pages 229-237

  Lee, Jongkyu ^a   Hwangbo, Cheol ^a   Lee, Jung Joon ^b   Seo, Juhee ^a   Lee, Jeong Hyung ^a  

^a Kangwon National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

AKT; Apoptosis; Cellular FLICE inhibitory protein; Eupatolide; Tumor necrosis factor related apoptosis inducing ligand

Indexed keywords

CASPASE 8; EUPATOLID; FLICE INHIBITORY PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BID; PROTEIN KINASE B; SESQUITERPENE LACTONE DERIVATIVE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN MCF 7; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL LINE, TUMOR; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SESQUITERPENES; TIME FACTORS; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 76049125661     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00000628     Document Type: Article

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