Highly Oxygenated Sesquiterpene Lactones from Cousinia aitchisonii and their Cytotoxic Properties: Rhaserolide Induces Apoptosis in Human T Lymphocyte (Jurkat) Cells via the Activation of c-Jun n -terminal Kinase Phosphorylation

Phytotherapy Research

Volumn 30, Issue 2, 2016, Pages 222-226

  Iranshahy, Milad ^a   Tayarani Najaran, Zahra ^a   Kasaian, Jamal ^a   Ghandadi, Morteza ^a   Emami, Seyed Ahmad ^a   Asili, Javad ^a   Chandran, Jima N ^b   Schneider, Bernd ^b   Iranshahi, Mehrdad ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MAX PLANCK INSTITUTE FOR CHEMICAL ECOLOGY   (Germany)

Author keywords

Asteraceae; c Jun N terminal kinase; Cousinia; cytotoxic; Jurkat cells; sesquiterpene lactone

Indexed keywords

AITCHISONOLIDE; ARCTIGENIN; ARCTIIN; DESOXYJANERIN; DOXORUBICIN; RHASEROLIDE; SESQUITERPENE LACTONE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; LACTONE; PLANT EXTRACT; SESQUITERPENE;

APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL LINE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; COUSINIA AITCHISONII; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HL 60 CELL LINE; HUMAN; HUMAN CELL; HUMAN EMBRYONIC KIDNEY CELL LINE; IC50; JURKAT CELL LINE; KIDNEY CELL; MASS SPECTROMETRY; MCF 7 CELL LINE; MCF 7 MX CELL LINE; MEDICINAL PLANT; NONHUMAN; PC3 CELL LINE; PROTON NUCLEAR MAGNETIC RESONANCE; WESTERN BLOTTING; ASTERACEAE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

APOPTOSIS; ASTERACEAE; CELL LINE, TUMOR; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; JURKAT CELLS; LACTONES; MOLECULAR STRUCTURE; PHOSPHORYLATION; PLANT EXTRACTS; SESQUITERPENES;

EID: 84956725039     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5519     Document Type: Article

References (20)

1. Attar F, Ghahreman A, Mahdigholi K, Sheidai M,. 2007. A synopsis of Cousinia sect. Serratuloides (Asteraceae) in Iran. Novon 17: 1-7.
2. Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME,. 1999. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286: 1358-1362.
3. Elmore S,. 2007. Apoptosis: a review of programmed cell death. Toxicol Pathol 35: 495-516.
4. Emami SA, Aghazari F,. 2011. Les Phanerogames Endemiques de la flore d'Iran. de I'Université d'Iran des Sciences Médicales: Téhéran.
5. Ghantous A, Gali-Muhtasib H, Vuorela H, Saliba NA, Darwiche N,. 2010. What made sesquiterpene lactones reach cancer clinical trials? Drug Discov Today 15 (15): 668-678.
6. van Haaften C, Duke CC, et al., 2011. Potent cytotoxic effects of Calomeria amaranthoides on ovarian cancers. J Exp Clin Cancer Res 30: 29-1-29-6.
7. Iranshahi M, Emami A, Mahmoud-Soltani M,. 2007. Detection of sesquiterpene lactones in ten Artemisia species population of Khorasan provinces. Iran J Basic Med Sci 10 (3): 183-188.
8. Kreuger MRO, Grootjans S, Biavatti MW, Vandenabeele P, D'Herde K,. 2012. Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide. Anticancer Drugs 23: 883-896.
9. Liu J, Lin A,. 2005. Role of JNK activation in apoptosis: a double-edged sword. Cell Res 15: 36-42.
10. Marco JA, Sanz JF, Albiach R, Rustaiyan A, Habibi Z,. 1993. Bisabolene derivatives and sesquiterpene lactones from Cousinia species. Phytochemistry 32: 395-400.
11. McCubrey JA, Steelman LS, Chappell WH, et al., 2007. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta 1773: 1263-1284.
12. Mehregan I, Kadereit JW,. 2009. The role of hybridization in the evolution of Cousinia s. str.(Asteraceae, Cardueae). Willdenowia 35-47.
13. Merfort I,. 2011. Perspectives on sesquiterpene lactones in inflammation and cancer. Curr Drug Targets 12: 1560-1573.
14. Orofino Kreuger MR, Grootjans S, Biavatti MW, Vandenabeele P, D'Herde K,. 2012. Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide. Anticancer Drugs 23: 883-896.
15. Rustaiyan A, Sharif Z, Sadjadi AS,. 1987. Two farnesol derivatives from Cousinia adenostica. Phytochemistry 26: 2635-2636.
16. Suzuki H, Lee K-H, Haruna M, Iida T, Ito K, Huang H-C,. 1982. (+)-Arctigenin, a lignan from Wikstroemia indica. Phytochemistry 21: 1824-1825.
17. Taylor RC, Cullen SP, Martin SJ,. 2008. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 9: 231-241.
18. Zdero C, Bohlmann F,. 1989. Sesquiterpene lactones from Oldenburgia arbuscula and Pleiotaxis rugosa. Phytochemistry 28: 3345-3346.
19. Zhan YH, Liu J, Qu XJ, et al., 2012. beta-Elemene induces apoptosis in human renal-cell carcinoma 786-0 cells through inhibition of MAPK/ERK and PI3K/Akt/ mTOR signalling pathways. Asian Pac J Cancer Prev 13: 2739-2744.
20. Zhang S, Won YK, Ong CN, Shen HM,. 2005. Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms. Curr Med Chem Anticancer Agents 5: 239-249.