Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 388, Issue 11, 2015, Pages 1223-1236

  Chan, Mei Ling ^a   Liang, Jui Wei ^a   Hsu, Lih Ching ^a   Chang, Wei Ling ^b   Lee, Shoei Sheng ^a   Guh, Jih Hwa ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Autophagy; ER stress; Hormone refractory prostate cancers; Mitochondria; Tubulin

Indexed keywords

CALPAIN 1; CASPASE 3; CASPASE 7; CASPASE 9; CYCLIN A; CYCLIN B1; FODRIN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HISTONE H3; PACLITAXEL; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; THYMIDINE; TUBULIN; ZERUMBONE; APOPTOSIS REGULATORY PROTEIN; CALCIUM; CELL CYCLE PROTEIN; SESQUITERPENE;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CASTRATION RESISTANT PROSTATE CANCER; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMATIN STRUCTURE; CHROMOSOME CONDENSATION; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; G2 PHASE CELL CYCLE CHECKPOINT; HISTONE ACETYLATION; HISTONE PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MALE; MICROTUBULE ASSEMBLY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOSIS INHIBITION; PROTEIN BINDING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION; DRUG EFFECTS; GINGER; METABOLISM; TUMOR CELL LINE;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CALCIUM; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; GINGER; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; SESQUITERPENES; TUBULIN;

EID: 84945474085     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-015-1152-z     Document Type: Article

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