Costunolide, an active sesquiterpene lactone, induced apoptosis via ROS-mediated ER stress and JNK pathway in human U2OS cells

Biomedicine and Pharmacotherapy

Volumn 80, Issue , 2016, Pages 253-259

  Zhang, Chao ^a   Lu, Tan ^a   Wang, Guo Dong ^a   Ma, Chao ^a   Zhou, Ying Feng ^a  

^a XINXIANG MEDICAL UNIVERSITY   (China)

Author keywords

Costunolide; JNK; ROS; U2OS

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 8; CASPASE 9; COSTUNOLIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; LACTONE; SESQUITERPENE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ELECTRIC POTENTIAL; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; INTRACELLULAR SIGNALING; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM; MITOCHONDRION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LACTONES; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; SESQUITERPENES;

EID: 84961918599     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.03.031     Document Type: Article

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