Regulation of the oncoprotein Smoothened by small molecules

Nature Chemical Biology

Volumn 11, Issue 4, 2015, Pages 246-255

  Sharpe, Hayley J ^a   Wang, Weiru ^a   Hannoush, Rami N ^a   De Sauvage, Frederic J ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; BUDESONIDE; CICLESONIDE; CYCLOPAMINE; EBI2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; ITRACONAZOLE; LIVER X RECEPTOR; ONCOPROTEIN; OXYSTEROL; OXYSTEROL BINDING PROTEIN; PATIDEGIB; PROTEIN PATCHED; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; SONIDEGIB; TALADEGIB; UNCLASSIFIED DRUG; VISMODEGIB; CELL SURFACE RECEPTOR; LIGAND; PATCHED RECEPTORS; PROTEIN BINDING; SMO PROTEIN, HUMAN; STEROL; VERATRUM ALKALOID;

ALLOSTERISM; AMELOBLASTOMA; BASAL CELL CARCINOMA; BINDING SITE; BIRTH DEFECT; CRYSTAL STRUCTURE; GENETIC TRANSCRIPTION; HUMAN; LIGAND BINDING; MEDULLOBLASTOMA; MENINGIOMA; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CELL MEMBRANE; CHEMISTRY; CONFORMATION; DROSOPHILA; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; NEOPLASM; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY;

ANIMALIA; ERINACEIDAE;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; DROSOPHILA; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIGANDS; MICE; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE HOMOLOGY, AMINO ACID; STEROLS; VERATRUM ALKALOIDS;

EID: 84925852119     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1776     Document Type: Review

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