Inhibition of Wnt/β-catenin pathway by dehydrocostus lactone and costunolide in colon cancer cells

Phytotherapy Research

Volumn 29, Issue 5, 2015, Pages 680-686

  Dong, Guang Zhi ^a   Shim, Ah Ram ^a   Hyeon, Jin Seong ^a   Lee, Hwa Jin ^b   Ryu, Jae Ha ^a  

^a Sookmyung Women's University   (South Korea)

^b Semyung University   (South Korea)

Author keywords

colon cancer cell; costunolide; dehydrocostus lactone; catenin

Indexed keywords

BETA CATENIN; COSTUNOLIDE; CYCLIN D1; DEHYDROCOSTUS LACTONE; GALECTIN 3; SURVIVIN; WNT PROTEIN; BIRC5 PROTEIN, HUMAN; CCND1 PROTEIN, HUMAN; CTNNB1 PROTEIN, HUMAN; GALECTIN-3, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; LACTONE; SESQUITERPENE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL LINE; CELL CYCLE ARREST; CELL DEATH; CELL NUCLEUS; CELL SURVIVAL; COLON CANCER; CONTROLLED STUDY; DRUG ISOLATION; HUMAN; HUMAN CELL; PLANT ROOT; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; SAUSSUREA; SAUSSUREA LAPPA; SIGNAL TRANSDUCTION; SW 480 CELL LINE; CELL CYCLE CHECKPOINT; CHEMISTRY; COLORECTAL TUMOR; DRUG EFFECTS; METABOLISM; PATHOLOGY; TUMOR CELL LINE; WNT SIGNALING PATHWAY;

SAUSSUREA LAPPA;

BETA CATENIN; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; CYCLIN D1; GALECTIN 3; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; LACTONES; PLANT ROOTS; SAUSSUREA; SESQUITERPENES; WNT SIGNALING PATHWAY;

EID: 84929463661     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5299     Document Type: Article

References (33)

1. Barker N, Clevers H,. 2000. Catenins, Wnt signaling and cancer. Bioessays 22 (11): 961-965.
2. Chen HC, Chou CK, Lee SD, Wang JC, Yeh SF,. 1995. Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells. Antiviral Res 27 (1-2): 99-109.
3. Clark MC, Pang M, Hsu DK, et al., 2012. Galectin-3 binds to CD45 on diffuse large B-cell lymphoma cells to regulate susceptibility to cell death. Blood 120 (23): 4635-4644.
4. Duan JA, Hou P, Tang Y, Liu P, Su S, Liu H,. 2010. A new sesquiterpene and other constituents from Saussurea lappa root. Nat Prod Commun 5 (10): 1531-1534.
5. Gokhale AB, Damre AS, Kulkami KR, Saraf MN,. 2002. Preliminary evaluation of anti-inflammatory and anti-arthritic activity of S. lappa, A. speciosa and A. aspera. Phytomedicine 9 (5): 433-437.
6. He TC, Sparks AB, Rago C, et al., 1998. Identification of c-MYC as a target of the APC pathway. Science 281 (5382): 1509-1512.
7. Huelsken J, Behrens J,. 2002. The Wnt signalling pathway. J Cell Sci 115 (Pt 21): 3977-3978.
8. Huh J,. 1613. Donguibogam.
9. Inohara H, Raz A,. 1994. Effects of natural complex carbohydrate (citrus pectin) on murine melanoma cell properties related to galectin-3 functions. Glycoconj J 11 (6): 527-532.
10. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D,. 2011. Global cancer statistics. CA Cancer J Clin 61 (2): 69-90.
11. Jin M, Lee HJ, Ryu JH, Chung KS,. 2000. Inhibition of LPS-induced NO production and NF-kappaB activation by a sesquiterpene from Saussurea lappa. Arch Pharm Res 23 (1): 54-58.
12. Kahn M,. 2014. Can we safely target the WNT pathway? Nat Rev Drug Discov 13 (7): 513-532.
13. Karim R, Tse G, Putti T, Scolyer R, Lee S,. 2004. The significance of the Wnt pathway in the pathology of human cancers. Pathology 36 (2): 120-128.
14. Klaus A, Birchmeier W,. 2008. Wnt signalling and its impact on development and cancer. Nat Rev Cancer 8 (5): 387-398.
15. Kobayashi M, Honma T, Matsuda Y, Suzuki Y, Narisawa R, Ajioka Y, Asakura H,. 2000. Nuclear translocation of beta-catenin in colorectal cancer. Br J Cancer 82 (10): 1689-1693.
16. Kumar A, Kumar S, Kumar D, Agnihotri VK,. 2014. UPLC/MS/MS method for quantification and cytotoxic activity of sesquiterpene lactones isolated from Saussurea lappa. J Ethnopharmacol 155 (2): 1393-1397.
17. Lee HJ, Kim NY, Jang MK, et al., 1999. A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages. Planta Med 65 (2): 104-108.
18. Liu FT, Rabinovich GA,. 2005. Galectins as modulators of tumour progression. Nat Rev Cancer 5 (1): 29-41.
19. Madhuri K, Elango K, Ponnusankar S,. 2012. Saussurea lappa (Kuth root): review of its traditional uses, phytochemistry and pharmacology. Orient Pharm Exp Med 12 (1): 1-9.
20. Matsuda HKT, Inoue Y, Morikawa T, Yoshikawa M,. 2000. Absolute stereo structures and syntheses of Saussureamines A, B, C, D and E, amino acid-sesquiterpene conjugates with gastroprotective effect from the roots of Saussurea lappa. Tetrahedron 56: 7763-7777.
21. Miyaki M, Konishi M, Kikuchi-Yanoshita R, et al., 1994. Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res 54 (11): 3011 -0 3020.
22. Morgan RG, Ridsdale J, Tonks A, Darley RL,. 2014. Factors affecting the nuclear localization of beta-catenin in normal and malignant tissue. J Cell Biochem 115 (8): 1351-1361.
23. Park S, Gwak J, Cho M, et al., 2006. Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation. Mol Pharmacol 70 (3): 960-966.
24. Pienta KJ, Naik H, Akhtar A, et al., 1995. Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin. J Natl Cancer Inst 87 (5): 348-353.
25. Shimura T, Takenaka Y, Tsutsumi S, Hogan V, Kikuchi A, Raz A,. 2004. Galectin-3, a novel binding partner of beta-catenin. Cancer Res 64 (18): 6363-6367.
26. Song L, Tang JW, Owusu L, Sun MZ, Wu J, Zhang J,. 2014. Galectin-3 in cancer. Clin Chim Acta 431: 185-191.
27. Song S, Mazurek N, Liu C, et al., 2009. Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity. Cancer Res 69 (4): 1343-1349.
28. Sun CM, Syu WJ, Don MJ, Lu JJ, Lee GH,. 2003. Cytotoxic sesquiterpene lactones from the root of Saussurea lappa. J Nat Prod 66 (9): 1175-1180.
29. Takahashi M, Tsunoda T, Seiki M, Nakamura Y, Furukawa Y,. 2002. Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers. Oncogene 21 (38): 5861-5867.
30. Tetsu O, McCormick F,. 1999. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398 (6726): 422-426.
31. Wodarz A, Nusse R,. 1998. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 14: 59-88.
32. Yaeesh SJQ, Shah AJ, Gilani AH,. 2010. Antihepatotoxic activity of Saussurea lappa extract on D-galactosamine and lipopolysaccharide-induced hepatitis in mice. Phytother Res 24: 229-232.
33. Zhang T, Otevrel T, Gao Z, et al., 2001. Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. Cancer Res 61 (24): 8664-8667.