EM23, a natural sesquiterpene lactone, targets thioredoxin reductase to activate JNK and cell death pathways in human cervical cancer cells

Oncotarget

Volumn 7, Issue 6, 2016, Pages 6790-6808

  Shao, Fang Yuan ^a,b   Wang, Sheng ^a   Li, Hong Yu ^a   Chen, Wen Bo ^a   Wang, Guo Cai ^a   Ma, Dong Lei ^a   Wong, Nai Sum ^c   Xiao, Hao ^d   Liu, Qiu Ying ^a   Zhou, Guang Xiong ^a   Li, Yao Lan ^a   Li, Man Mei ^a   Wang, Yi Fei ^a   Liu, Zhong ^a  

^a JINAN UNIVERSITY   (China)

^b University of Macau   (Macao)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Apoptosis; ROS; Sesquiterpene lactone; Thioredoxin; Thioredoxin reductase

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; EM 23; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SESQUITERPENE LACTONE; STRESS ACTIVATED PROTEIN KINASE; THIOREDOXIN; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG; EM23 SESQUITERPENE; LACTONE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; SESQUITERPENE;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BINDING SITE; BIOACCUMULATION; CANCER INHIBITION; CARBOXY TERMINAL SEQUENCE; CELL CYCLE ARREST; CELL DEATH; CERVICAL CANCER CELL LINE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENETIC TRANSFECTION; HL-60 CELL LINE; K-562 CELL LINE; MCF-7 CELL LINE; METABOLISM; PATHOLOGY; TUMOR CELL LINE; UTERINE CERVICAL NEOPLASMS;

APOPTOSIS; CELL DEATH; CELL LINE, TUMOR; ENZYME ACTIVATION; FEMALE; HL-60 CELLS; HUMANS; K562 CELLS; LACTONES; MAP KINASE KINASE 4; MCF-7 CELLS; REACTIVE OXYGEN SPECIES; SESQUITERPENES; THIOREDOXIN-DISULFIDE REDUCTASE; TRANSFECTION; UTERINE CERVICAL NEOPLASMS;

EID: 84981218630     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6828     Document Type: Article

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