Induction of ROS overload by alantolactone prompts oxidative DNA damage and apoptosis in colorectal cancer cells

International Journal of Molecular Sciences

Volumn 17, Issue 4, 2016, Pages

  Ding, Yushuang ^a   Wang, Hongge ^b   Niu, Jiajing ^b   Luo, Manyu ^a   Gou, Yangmei ^b   Miao, Lining ^a   Zou, Zhihua ^b   Cheng, Ying ^a,c  

^a THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

^c JILIN PROVINCIAL CANCER HOSPITAL   (China)

Author keywords

8 oxoG; Alantolactone; Apoptosis; Cell cycle arrest; Colorectal cancer; DNA damage

Indexed keywords

8 HYDROXYGUANINE; ALANTOLACTONE; REACTIVE OXYGEN METABOLITE; 7,8-DIHYDRO-8-OXOGUANINE; ANTINEOPLASTIC AGENT; GUANINE; LACTONE; SESQUITERPENE;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL VIABILITY; COLONY FORMATION; COLORECTAL CANCER CELL LINE; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; EXCISION REPAIR; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; TUNEL ASSAY; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CELL CYCLE CHECKPOINT; CHEMISTRY; COLON; COLORECTAL NEOPLASMS; DRUG EFFECTS; INULA; METABOLISM; PATHOLOGY; RECTUM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; COLON; COLORECTAL NEOPLASMS; DNA DAMAGE; GUANINE; HUMANS; INULA; LACTONES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RECTUM; SESQUITERPENES, EUDESMANE;

EID: 84963717023     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17040558     Document Type: Article

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