메뉴 건너뛰기




Volumn 140, Issue 2, 2016, Pages 345-351

Wnt signalling in gynaecological cancers: A future target for personalised medicine?

Author keywords

Cervical cancer; Ovarian cancer; ROR1; ROR2; Uterine cancer; Wnt

Indexed keywords

BETA CATENIN; PROTEIN TYROSINE KINASE; WNT PROTEIN; TUMOR MARKER;

EID: 84945963753     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2015.09.085     Document Type: Review
Times cited : (34)

References (70)
  • 1
    • 84875804295 scopus 로고    scopus 로고
    • Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012
    • J. Ferlay, and et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012 Eur. J. Cancer 49 6 2013 1374 1403
    • (2013) Eur. J. Cancer , vol.49 , Issue.6 , pp. 1374-1403
    • Ferlay, J.1
  • 2
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • T.C.G. Atlas Integrated genomic analyses of ovarian carcinoma Nature 474 7353 2011 609 615
    • (2011) Nature , vol.474 , Issue.7353 , pp. 609-615
    • Atlas, T.C.G.1
  • 3
    • 84877254190 scopus 로고    scopus 로고
    • Integrated genomic characterization of endometrial carcinoma
    • Genome Atlas Research Netwrok C.et al.
    • Cancer Genome Atlas Research Netwrok, and et al. Integrated genomic characterization of endometrial carcinoma Nature 497 7447 2013 67 73
    • (2013) Nature , vol.497 , Issue.7447 , pp. 67-73
  • 4
    • 84873862912 scopus 로고    scopus 로고
    • Prognostically relevant gene signatures of high-grade serous ovarian carcinoma
    • R.G. Verhaak, and et al. Prognostically relevant gene signatures of high-grade serous ovarian carcinoma J. Clin. Invest. 123 1 2013 517 525
    • (2013) J. Clin. Invest. , vol.123 , Issue.1 , pp. 517-525
    • Verhaak, R.G.1
  • 5
    • 84861860715 scopus 로고    scopus 로고
    • The changing view of high-grade serous ovarian cancer
    • E.M. Berns, and D.D. Bowtell The changing view of high-grade serous ovarian cancer Cancer Res. 72 11 2012 2701 2704
    • (2012) Cancer Res. , vol.72 , Issue.11 , pp. 2701-2704
    • Berns, E.M.1    Bowtell, D.D.2
  • 6
    • 52649085237 scopus 로고    scopus 로고
    • Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome
    • R.W. Tothill, and et al. Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome Clin. Cancer Res. 14 16 2008 5198 5208
    • (2008) Clin. Cancer Res. , vol.14 , Issue.16 , pp. 5198-5208
    • Tothill, R.W.1
  • 7
    • 84930638395 scopus 로고    scopus 로고
    • Whole-genome characterization of chemoresistant ovarian cancer
    • A.M. Patch, and et al. Whole-genome characterization of chemoresistant ovarian cancer Nature 521 7553 2015 489 494
    • (2015) Nature , vol.521 , Issue.7553 , pp. 489-494
    • Patch, A.M.1
  • 8
    • 84942508634 scopus 로고    scopus 로고
    • Targeting Wnts at the source - New mechanisms, new Biomarkers
    • B. Madan, and D.M. Virshup Targeting Wnts at the source - new mechanisms, new Biomarkers New Drugs Mol. Cancer. Ther. 14 5 2015 1087 1094
    • (2015) New Drugs Mol. Cancer. Ther. , vol.14 , Issue.5 , pp. 1087-1094
    • Madan, B.1    Virshup, D.M.2
  • 9
    • 55749102279 scopus 로고    scopus 로고
    • Alternative wnt signaling is initiated by distinct receptors
    • R. van Amerongen, A. Mikels, and R. Nusse Alternative wnt signaling is initiated by distinct receptors Sci Signal 1 35 2008 re9
    • (2008) Sci Signal , vol.1 , Issue.35 , pp. re9
    • Van Amerongen, R.1    Mikels, A.2    Nusse, R.3
  • 10
    • 78349276165 scopus 로고    scopus 로고
    • Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors
    • L. Grumolato, and et al. Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors Genes Dev. 24 22 2010 2517 2530
    • (2010) Genes Dev. , vol.24 , Issue.22 , pp. 2517-2530
    • Grumolato, L.1
  • 11
    • 84871846692 scopus 로고    scopus 로고
    • WNT signalling pathways as therapeutic targets in cancer
    • J. Anastas, and R. Moon WNT signalling pathways as therapeutic targets in cancer Nat. Rev. Cancer 13 2013 11 26
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 11-26
    • Anastas, J.1    Moon, R.2
  • 12
    • 77958484951 scopus 로고    scopus 로고
    • The genesis and evolution of high-grade serous ovarian cancer
    • D.D. Bowtell The genesis and evolution of high-grade serous ovarian cancer Nat. Rev. Cancer 10 11 2010 803 808
    • (2010) Nat. Rev. Cancer , vol.10 , Issue.11 , pp. 803-808
    • Bowtell, D.D.1
  • 13
    • 84940462511 scopus 로고    scopus 로고
    • New insights in the pathophysiology of ovarian cancer and implications for screening and prevention
    • F.R. Nezhat, and et al. New insights in the pathophysiology of ovarian cancer and implications for screening and prevention Am. J. Obstet. Gynecol. 2015
    • (2015) Am. J. Obstet. Gynecol.
    • Nezhat, F.R.1
  • 14
    • 84858605181 scopus 로고    scopus 로고
    • WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/beta-catenin pathway
    • S. Yoshioka, and et al. WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/beta-catenin pathway Molecular Cancer Research: MCR 10 3 2012 469 482
    • (2012) Molecular Cancer Research: MCR , vol.10 , Issue.3 , pp. 469-482
    • Yoshioka, S.1
  • 15
    • 84933037846 scopus 로고    scopus 로고
    • WNT7A/[beta]-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer
    • M.L. King, and et al. WNT7A/[beta]-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer Oncogene 34 26 2015 3452 3462
    • (2015) Oncogene , vol.34 , Issue.26 , pp. 3452-3462
    • King, M.L.1
  • 16
    • 84857402982 scopus 로고    scopus 로고
    • Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients
    • Jacob, F.; et al.; Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients. PLoS One, 2012. 7(2): p. e31885.
    • (2012) PLoS One , vol.7 , Issue.2 , pp. e31885
    • Jacob, F.1
  • 17
    • 84872221731 scopus 로고    scopus 로고
    • The Wnt gatekeeper SFRP4 modulates EMT, cell migration and downstream Wnt signalling in serous ovarian cancer cells
    • C.E. Ford, and et al. The Wnt gatekeeper SFRP4 modulates EMT, cell migration and downstream Wnt signalling in serous ovarian cancer cells PLoS One 2013 8(1)
    • (2013) PLoS One , pp. 81
    • Ford, C.E.1
  • 18
    • 77954108899 scopus 로고    scopus 로고
    • Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway
    • H.Y. Su, and et al. Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway Int. J. Cancer 2009
    • (2009) Int. J. Cancer
    • Su, H.Y.1
  • 19
    • 79954431274 scopus 로고    scopus 로고
    • Expression of the Wnt antagonist DKK3 is frequently suppressed in sporadic epithelial ovarian cancer
    • A. You, and et al. Expression of the Wnt antagonist DKK3 is frequently suppressed in sporadic epithelial ovarian cancer J. Cancer Res. Clin. Oncol. 137 4 2011 621 627
    • (2011) J. Cancer Res. Clin. Oncol. , vol.137 , Issue.4 , pp. 621-627
    • You, A.1
  • 20
    • 84870327013 scopus 로고    scopus 로고
    • Epigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinoma
    • J. Zhu, and et al. Epigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinoma Carcinogenesis 33 12 2012 2334 2343
    • (2012) Carcinogenesis , vol.33 , Issue.12 , pp. 2334-2343
    • Zhu, J.1
  • 21
    • 79960898036 scopus 로고    scopus 로고
    • Dickkopf-1 is frequently overexpressed in ovarian serous carcinoma and involved in tumor invasion
    • S. Wang, and S. Zhang Dickkopf-1 is frequently overexpressed in ovarian serous carcinoma and involved in tumor invasion Clin. Exp. Metastasis 28 6 2011 581 591
    • (2011) Clin. Exp. Metastasis , vol.28 , Issue.6 , pp. 581-591
    • Wang, S.1    Zhang, S.2
  • 22
    • 42449158088 scopus 로고    scopus 로고
    • R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling
    • K. Tomizuka, and et al. R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling Hum. Mol. Genet. 17 9 2008 1278 1291
    • (2008) Hum. Mol. Genet. , vol.17 , Issue.9 , pp. 1278-1291
    • Tomizuka, K.1
  • 23
    • 84861532137 scopus 로고    scopus 로고
    • Interaction between sex hormones and WNT/beta-catenin signal transduction in endometrial physiology and disease
    • P.H. van der Horst, and et al. Interaction between sex hormones and WNT/beta-catenin signal transduction in endometrial physiology and disease Mol. Cell. Endocrinol. 358 2 2012 176 184
    • (2012) Mol. Cell. Endocrinol. , vol.358 , Issue.2 , pp. 176-184
    • Van Der Horst, P.H.1
  • 24
    • 84894492492 scopus 로고    scopus 로고
    • Wnt/beta-catenin pathway as a potential prognostic and predictive marker in patients with advanced ovarian cancer
    • L. Bodnar, and et al. Wnt/beta-catenin pathway as a potential prognostic and predictive marker in patients with advanced ovarian cancer J. Ovarian Res. 7 2014 16
    • (2014) J. Ovarian Res. , vol.7 , pp. 16
    • Bodnar, L.1
  • 25
    • 0242361176 scopus 로고    scopus 로고
    • Wnt-signalling pathway in ovarian epithelial tumours: Increased expression of beta-catenin and GSK3beta
    • K. Rask, and et al. Wnt-signalling pathway in ovarian epithelial tumours: increased expression of beta-catenin and GSK3beta Br. J. Cancer 89 7 2003 1298 1304
    • (2003) Br. J. Cancer , vol.89 , Issue.7 , pp. 1298-1304
    • Rask, K.1
  • 26
    • 84922328143 scopus 로고    scopus 로고
    • CD44v6 promotes beta-catenin and TGF-beta expression, inducing aggression in ovarian cancer cells
    • J. Wang, and et al. CD44v6 promotes beta-catenin and TGF-beta expression, inducing aggression in ovarian cancer cells Mol. Med. Rep. 11 5 2015 3505 3510
    • (2015) Mol. Med. Rep. , vol.11 , Issue.5 , pp. 3505-3510
    • Wang, J.1
  • 27
    • 84920387526 scopus 로고    scopus 로고
    • Interference with the expression of beta-catenin reverses cisplatin resistance in A2780/DDP cells and inhibits the progression of ovarian cancer in mouse model
    • H. Zhao, and et al. Interference with the expression of beta-catenin reverses cisplatin resistance in A2780/DDP cells and inhibits the progression of ovarian cancer in mouse model DNA Cell Biol. 34 1 2015 55 62
    • (2015) DNA Cell Biol. , vol.34 , Issue.1 , pp. 55-62
    • Zhao, H.1
  • 28
    • 19444384545 scopus 로고    scopus 로고
    • Beta-catenin expression, DNA ploidy and clinicopathological features in ovarian cancer: A study in 253 patients
    • W. Kildal, and et al. Beta-catenin expression, DNA ploidy and clinicopathological features in ovarian cancer: a study in 253 patients Eur. J. Cancer 41 8 2005 1127 1134
    • (2005) Eur. J. Cancer , vol.41 , Issue.8 , pp. 1127-1134
    • Kildal, W.1
  • 29
    • 0032813907 scopus 로고    scopus 로고
    • Beta-catenin expression pattern in stage i and II ovarian carcinomas: Relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome
    • C. Gamallo, and et al. Beta-catenin expression pattern in stage I and II ovarian carcinomas: relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome Am. J. Pathol. 155 2 1999 527 536
    • (1999) Am. J. Pathol. , vol.155 , Issue.2 , pp. 527-536
    • Gamallo, C.1
  • 30
    • 73949156925 scopus 로고    scopus 로고
    • Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases
    • Minami, Y.; et al.; Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases. Dev. Dyn.; 2010. 239(1): p. 1-15.
    • (2010) Dev. Dyn. , vol.239 , Issue.1 , pp. 1-15
    • Minami, Y.1
  • 31
    • 62849100998 scopus 로고    scopus 로고
    • Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer
    • L. Badiglian Filho, and et al. Canonical and noncanonical Wnt pathway: a comparison among normal ovary, benign ovarian tumor and ovarian cancer Oncol. Rep. 21 2 2009 313 320
    • (2009) Oncol. Rep. , vol.21 , Issue.2 , pp. 313-320
    • Badiglian Filho, L.1
  • 32
    • 84905561583 scopus 로고    scopus 로고
    • The non-canonical Wnt ligand, Wnt5a, is upregulated and associated with epithelial to mesenchymal transition in epithelial ovarian cancer
    • C.E. Ford, and et al. The non-canonical Wnt ligand, Wnt5a, is upregulated and associated with epithelial to mesenchymal transition in epithelial ovarian cancer Gynecol. Oncol. 134 2 2014 338 345
    • (2014) Gynecol. Oncol. , vol.134 , Issue.2 , pp. 338-345
    • Ford, C.E.1
  • 33
    • 79956116022 scopus 로고    scopus 로고
    • Wnt5a as a predictor in poor clinical outcome of patients and a mediator in chemoresistance of ovarian cancer
    • C. Peng, and et al. Wnt5a as a predictor in poor clinical outcome of patients and a mediator in chemoresistance of ovarian cancer Int. J. Gynecol. Cancer 21 2 2011 280 288
    • (2011) Int. J. Gynecol. Cancer , vol.21 , Issue.2 , pp. 280-288
    • Peng, C.1
  • 34
    • 84890409203 scopus 로고    scopus 로고
    • The involvement of RhoA and Wnt-5a in the tumorigenesis and progression of ovarian epithelial carcinoma
    • S. Chen, and et al. The involvement of RhoA and Wnt-5a in the tumorigenesis and progression of ovarian epithelial carcinoma Int. J. Mol. Sci. 14 12 2013 24187 24199
    • (2013) Int. J. Mol. Sci. , vol.14 , Issue.12 , pp. 24187-24199
    • Chen, S.1
  • 35
    • 84903146004 scopus 로고    scopus 로고
    • Wnt5a promotes vasculogenic mimicry and epithelial-mesenchymal transition via protein kinase Calpha in epithelial ovarian cancer
    • H. Qi, and et al. Wnt5a promotes vasculogenic mimicry and epithelial-mesenchymal transition via protein kinase Calpha in epithelial ovarian cancer Oncol. Rep. 32 2 2014 771 779
    • (2014) Oncol. Rep. , vol.32 , Issue.2 , pp. 771-779
    • Qi, H.1
  • 36
    • 80053361798 scopus 로고    scopus 로고
    • Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence
    • B.G. Bitler, and et al. Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence Cancer Res. 71 19 2011 6184 6194
    • (2011) Cancer Res. , vol.71 , Issue.19 , pp. 6184-6194
    • Bitler, B.G.1
  • 37
    • 84887981252 scopus 로고    scopus 로고
    • Mechanisms governing metastatic dormancy and reactivation
    • F.G. Giancotti Mechanisms governing metastatic dormancy and reactivation Cell 155 4 2013 750 764
    • (2013) Cell , vol.155 , Issue.4 , pp. 750-764
    • Giancotti, F.G.1
  • 38
    • 84896810295 scopus 로고    scopus 로고
    • Differential Wnt11 expression related to Wnt5a in high- and low-grade serous ovarian cancer: Implications for migration, adhesion and survival
    • F. Jannesari-Ladani, G. Hossein, and N. Izadi-Mood Differential Wnt11 expression related to Wnt5a in high- and low-grade serous ovarian cancer: implications for migration, adhesion and survival Asian Pac. J. Cancer Prev. 15 3 2014 1489 1495
    • (2014) Asian Pac. J. Cancer Prev. , vol.15 , Issue.3 , pp. 1489-1495
    • Jannesari-Ladani, F.1    Hossein, G.2    Izadi-Mood, N.3
  • 39
    • 84914140232 scopus 로고    scopus 로고
    • Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy
    • S. Zhang, and et al. Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy Proc. Natl. Acad. Sci. U. S. A. 111 48 2014 17266 17271
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , Issue.48 , pp. 17266-17271
    • Zhang, S.1
  • 40
    • 84904795696 scopus 로고    scopus 로고
    • ROR1 expression correlated with poor clinical outcome in human ovarian cancer
    • H. Zhang, and et al. ROR1 expression correlated with poor clinical outcome in human ovarian cancer Sci. Rep. 4 2014 5811
    • (2014) Sci. Rep. , vol.4 , pp. 5811
    • Zhang, H.1
  • 41
    • 84876244484 scopus 로고    scopus 로고
    • Overexpression of Wnt7a is associated with tumor progression and unfavorable prognosis in endometrial cancer
    • Y. Liu, and et al. Overexpression of Wnt7a is associated with tumor progression and unfavorable prognosis in endometrial cancer Int. J. Gynecol. Cancer 23 2 2013 304 311
    • (2013) Int. J. Gynecol. Cancer , vol.23 , Issue.2 , pp. 304-311
    • Liu, Y.1
  • 42
    • 50349095325 scopus 로고    scopus 로고
    • Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells
    • K.S. Carmon, and D.S. Loose Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells Mol. Cancer Res. 6 6 2008 1017 1028
    • (2008) Mol. Cancer Res. , vol.6 , Issue.6 , pp. 1017-1028
    • Carmon, K.S.1    Loose, D.S.2
  • 43
    • 80755171394 scopus 로고    scopus 로고
    • Canonical and noncanonical Wnt pathways: A comparison between endometrial cancer type i and atrophic endometrium in Brazil
    • P. Menezes Mde, and et al. Canonical and noncanonical Wnt pathways: a comparison between endometrial cancer type I and atrophic endometrium in Brazil Sao Paulo Med. J. 129 5 2011 320 324
    • (2011) Sao Paulo Med. J. , vol.129 , Issue.5 , pp. 320-324
    • Menezes Mde, P.1
  • 44
    • 84898670339 scopus 로고    scopus 로고
    • Expression and prognostic significance of wnt7a in human endometrial carcinoma
    • C. Peng, and et al. Expression and prognostic significance of wnt7a in human endometrial carcinoma Obstet. Gynecol. Int. 2012 2012 134962
    • (2012) Obstet. Gynecol. Int. , vol.2012 , pp. 134962
    • Peng, C.1
  • 45
    • 85059108124 scopus 로고    scopus 로고
    • Dkk3 Wnt inhibitor expression in endometrial cancer predicts pelvic lymph node status, and correlates with clinicopathologic factors
    • T. Dellinger, and et al. Dkk3 Wnt inhibitor expression in endometrial cancer predicts pelvic lymph node status, and correlates with clinicopathologic factors Gynecol. Oncol. 127 1 Suppl 2012 S20
    • (2012) Gynecol. Oncol. , vol.127 , Issue.1 , pp. S20
    • Dellinger, T.1
  • 46
    • 84862866541 scopus 로고    scopus 로고
    • Expression of the Wnt antagonist Dickkopf-3 is associated with prognostic clinicopathologic characteristics and impairs proliferation and invasion in endometrial cancer
    • T.H. Dellinger, and et al. Expression of the Wnt antagonist Dickkopf-3 is associated with prognostic clinicopathologic characteristics and impairs proliferation and invasion in endometrial cancer Gynecol. Oncol. 126 2 2012 259 267
    • (2012) Gynecol. Oncol. , vol.126 , Issue.2 , pp. 259-267
    • Dellinger, T.H.1
  • 47
    • 84961900166 scopus 로고    scopus 로고
    • Expression patterns of the Wnt pathway inhibitor dickKOPF-3 (Dkk3) and secreted frizzled-related proteins (sFRP) 1 and 4 in endometrial endometrioid adenocarcinoma: A gynecologic oncology group study
    • R. Eskander, and et al. Expression patterns of the Wnt pathway inhibitor dickKOPF-3 (Dkk3) and secreted frizzled-related proteins (sFRP) 1 and 4 in endometrial endometrioid adenocarcinoma: a gynecologic oncology group study Gynecol. Oncol. 127 1 Suppl 2012 S5
    • (2012) Gynecol. Oncol. , vol.127 , Issue.1 , pp. S5
    • Eskander, R.1
  • 48
    • 84880435782 scopus 로고    scopus 로고
    • RNA interference-mediated targeting of DKK1 gene expression in Ishikawa endometrial carcinoma cells causes increased tumor cell invasion and migration
    • Yi, N.; et al.; RNA interference-mediated targeting of DKK1 gene expression in Ishikawa endometrial carcinoma cells causes increased tumor cell invasion and migration. Oncol. Lett.; 2013. 6(3): p. 756-762.
    • (2013) Oncol. Lett. , vol.6 , Issue.3 , pp. 756-762
    • Yi, N.1
  • 49
    • 84872821599 scopus 로고    scopus 로고
    • Expression and the clinical significance of Wnt10a and Wnt10b in endometrial cancer are associated with the Wnt/beta-catenin pathway
    • H. Chen, Y. Wang, and F. Xue Expression and the clinical significance of Wnt10a and Wnt10b in endometrial cancer are associated with the Wnt/beta-catenin pathway Oncol. Rep. 29 2 2013 507 514
    • (2013) Oncol. Rep. , vol.29 , Issue.2 , pp. 507-514
    • Chen, H.1    Wang, Y.2    Xue, F.3
  • 50
    • 84909619822 scopus 로고    scopus 로고
    • Clinical significance of CTNNB1 mutation and Wnt pathway activation in endometrioid endometrial carcinoma
    • Y. Liu, and et al. Clinical significance of CTNNB1 mutation and Wnt pathway activation in endometrioid endometrial carcinoma J. Natl. Cancer Inst. 2014 106(9)
    • (2014) J. Natl. Cancer Inst. , pp. 1069
    • Liu, Y.1
  • 51
    • 84891747639 scopus 로고    scopus 로고
    • Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles
    • M.K. McConechy, and et al. Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles Mod. Pathol. 27 1 2014 128 134
    • (2014) Mod. Pathol. , vol.27 , Issue.1 , pp. 128-134
    • McConechy, M.K.1
  • 52
    • 0036792576 scopus 로고    scopus 로고
    • Beta-catenin and E-cadherin expression patterns in high-grade endometrial carcinoma are associated with histological subtype
    • P.W. Schlosshauer, L.H. Ellenson, and R.A. Soslow Beta-catenin and E-cadherin expression patterns in high-grade endometrial carcinoma are associated with histological subtype Mod. Pathol. 15 10 2002 1032 1037
    • (2002) Mod. Pathol. , vol.15 , Issue.10 , pp. 1032-1037
    • Schlosshauer, P.W.1    Ellenson, L.H.2    Soslow, R.A.3
  • 53
    • 0242475205 scopus 로고    scopus 로고
    • Nuclear beta-catenin is a molecular feature of type i endometrial carcinoma
    • A.N. Scholten, and et al. Nuclear beta-catenin is a molecular feature of type I endometrial carcinoma J. Pathol. 201 3 2003 460 465
    • (2003) J. Pathol. , vol.201 , Issue.3 , pp. 460-465
    • Scholten, A.N.1
  • 54
    • 4544281344 scopus 로고    scopus 로고
    • APC, beta-catenin, and E-cadherin and the development of recurrent endometrial carcinoma
    • J.M. Pijnenborg, and et al. APC, beta-catenin, and E-cadherin and the development of recurrent endometrial carcinoma Int. J. Gynecol. Cancer 14 5 2004 947 956
    • (2004) Int. J. Gynecol. Cancer , vol.14 , Issue.5 , pp. 947-956
    • Pijnenborg, J.M.1
  • 56
    • 60749096511 scopus 로고    scopus 로고
    • SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway
    • M.T. Chung, and et al. SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway Gynecol. Oncol. 112 3 2009 646 653
    • (2009) Gynecol. Oncol. , vol.112 , Issue.3 , pp. 646-653
    • Chung, M.T.1
  • 57
    • 70349766097 scopus 로고    scopus 로고
    • Methylation analysis of SFRP genes family in cervical adenocarcinoma
    • Y.-W. Lin, and et al. Methylation analysis of SFRP genes family in cervical adenocarcinoma J. Cancer Res. Clin. Oncol. 135 12 2009 1665 1674
    • (2009) J. Cancer Res. Clin. Oncol. , vol.135 , Issue.12 , pp. 1665-1674
    • Lin, Y.-W.1
  • 58
    • 42749094483 scopus 로고    scopus 로고
    • Epigenetic silencing of the WNT antagonist DICKKOPF-1 in cervical cancer cell lines
    • J. Lee, Y.S. Yoon, and J.H. Chung Epigenetic silencing of the WNT antagonist DICKKOPF-1 in cervical cancer cell lines Gynecol. Oncol. 109 2 2008 270 274
    • (2008) Gynecol. Oncol. , vol.109 , Issue.2 , pp. 270-274
    • Lee, J.1    Yoon, Y.S.2    Chung, J.H.3
  • 59
    • 80455129710 scopus 로고    scopus 로고
    • Beta-catenin accelerates human papilloma virus type-16 mediated cervical carcinogenesis in transgenic mice
    • G. Bulut, and et al. Beta-catenin accelerates human papilloma virus type-16 mediated cervical carcinogenesis in transgenic mice PLoS One 6 11 2011 e27243
    • (2011) PLoS One , vol.6 , Issue.11
    • Bulut, G.1
  • 60
    • 84885187265 scopus 로고    scopus 로고
    • Resveratrol induces cell death in cervical cancer cells through apoptosis and autophagy
    • S.P. García-Zepeda, and et al. Resveratrol induces cell death in cervical cancer cells through apoptosis and autophagy Eur. J. Cancer Prev. 22 6 2013 577 584
    • (2013) Eur. J. Cancer Prev. , vol.22 , Issue.6 , pp. 577-584
    • García-Zepeda, S.P.1
  • 61
    • 84866599883 scopus 로고    scopus 로고
    • The beta-catenin/TCF complex as a novel target of resveratrol in the Wnt/beta-catenin signaling pathway
    • H.J. Chen, and et al. The beta-catenin/TCF complex as a novel target of resveratrol in the Wnt/beta-catenin signaling pathway Biochem. Pharmacol. 84 9 2012 1143 1153
    • (2012) Biochem. Pharmacol. , vol.84 , Issue.9 , pp. 1143-1153
    • Chen, H.J.1
  • 62
    • 84957432047 scopus 로고    scopus 로고
    • Clinical significance of Wnt-11 and squamous cell carcinoma antigen expression in cervical cancer
    • H. Wei, and et al. Clinical significance of Wnt-11 and squamous cell carcinoma antigen expression in cervical cancer Med. Oncol. 31 5 2014 933
    • (2014) Med. Oncol. , vol.31 , Issue.5 , pp. 933
    • Wei, H.1
  • 63
    • 84923078268 scopus 로고    scopus 로고
    • Up-regulation of ROR2 is associated with unfavorable prognosis and tumor progression in cervical cancer
    • B. Sun, and et al. Up-regulation of ROR2 is associated with unfavorable prognosis and tumor progression in cervical cancer Int. J. Clin. Exp. Pathol. 8 1 2015 856 861
    • (2015) Int. J. Clin. Exp. Pathol. , vol.8 , Issue.1 , pp. 856-861
    • Sun, B.1
  • 64
    • 84903767326 scopus 로고    scopus 로고
    • Can we safely target the WNT pathway?
    • M. Kahn Can we safely target the WNT pathway? Nat. Rev. Drug Discov. 13 7 2014 513 532
    • (2014) Nat. Rev. Drug Discov. , vol.13 , Issue.7 , pp. 513-532
    • Kahn, M.1
  • 65
    • 84903120790 scopus 로고    scopus 로고
    • Inhibition of Wnt/β-catenin pathway by niclosamide: A therapeutic target for ovarian cancer
    • R.C. Arend, and et al. Inhibition of Wnt/β-catenin pathway by niclosamide: a therapeutic target for ovarian cancer Gynecol. Oncol. 134 1 2014 112 120
    • (2014) Gynecol. Oncol. , vol.134 , Issue.1 , pp. 112-120
    • Arend, R.C.1
  • 66
    • 83455182133 scopus 로고    scopus 로고
    • Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway
    • W. Lu, and et al. Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway PLoS One 6 12 2011 e29290
    • (2011) PLoS One , vol.6 , Issue.12
    • Lu, W.1
  • 67
    • 79958812414 scopus 로고    scopus 로고
    • Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations
    • T. Osada, and et al. Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations Cancer Res. 71 12 2011 4172 4182
    • (2011) Cancer Res. , vol.71 , Issue.12 , pp. 4172-4182
    • Osada, T.1
  • 68
    • 70350489312 scopus 로고    scopus 로고
    • The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling
    • M. Chen, and et al. The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling Biochemistry 48 43 2009 10267 10274
    • (2009) Biochemistry , vol.48 , Issue.43 , pp. 10267-10274
    • Chen, M.1
  • 69
    • 84927578271 scopus 로고    scopus 로고
    • The receptor tyrosine kinase ROR1 - An oncofetal antigen for targeted cancer therapy
    • Hojjat-Farsangi, M.; et al.; The receptor tyrosine kinase ROR1 - an oncofetal antigen for targeted cancer therapy. Semin. Cancer Biol.; 2014. 29(0): p. 21-31.
    • (2014) Semin. Cancer Biol. , vol.29 , pp. 21-31
    • Hojjat-Farsangi, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.