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Volumn 21, Issue 3, 2016, Pages

Deoxyelephantopin from elephantopus scaber inhibits HCT116 human colorectal carcinoma cell growth through apoptosis and cell cycle arrest

Author keywords

Apoptosis; Cell cycle; Colorectal cancer; Deoxyelephantopin; Elephantopus scaber

Indexed keywords

ANTINEOPLASTIC AGENT; PLANT EXTRACT; TUMOR PROTEIN;

EID: 84964573773     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules21030385     Document Type: Article
Times cited : (33)

References (40)
  • 1
    • 84881021704 scopus 로고    scopus 로고
    • Antineoplastic effects of deoxyelephantopin, a sesquiterpene lactone from elephantopus scaber, on lung adenocarcinoma (A549) cells
    • [CrossRef] [PubMed]
    • Kabeer, F.A.; Sreedevi, G.B.; Nair, M.S.; Rajalekshmi, D.S.; Gopalakrishnan, L.P.; Kunjuraman, S.; Prathapan, R. Antineoplastic effects of deoxyelephantopin, a sesquiterpene lactone from elephantopus scaber, on lung adenocarcinoma (A549) cells. J. Integr. Med. 2013, 11, 269-277. [CrossRef] [PubMed]
    • (2013) J. Integr. Med. , vol.11 , pp. 269-277
    • Kabeer, F.A.1    Sreedevi, G.B.2    Nair, M.S.3    Rajalekshmi, D.S.4    Gopalakrishnan, L.P.5    Kunjuraman, S.6    Prathapan, R.7
  • 3
    • 80053348989 scopus 로고    scopus 로고
    • Apoptosis in cancer: From pathogenesis to treatment
    • [CrossRef] [PubMed]
    • Wong, R.S. Apoptosis in cancer: From pathogenesis to treatment. J. Exp. Clin. Cancer Res. 2011, 30, 87. [CrossRef] [PubMed]
    • (2011) J. Exp. Clin. Cancer Res. , vol.30 , pp. 87
    • Wong, R.S.1
  • 5
    • 84964292597 scopus 로고    scopus 로고
    • Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from cajanus cajan in breast cancer cells
    • [CrossRef] [PubMed]
    • Fu, Y.; Kadioglu, O.; Wiench, B.; Wei, Z.; Gao, C.; Luo, M.; Gu, C.; Zu, Y.; Efferth, T. Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from cajanus cajan in breast cancer cells. Phytomedicine 2015, 22, 462-468. [CrossRef] [PubMed]
    • (2015) Phytomedicine , vol.22 , pp. 462-468
    • Fu, Y.1    Kadioglu, O.2    Wiench, B.3    Wei, Z.4    Gao, C.5    Luo, M.6    Gu, C.7    Zu, Y.8    Efferth, T.9
  • 6
    • 0036301453 scopus 로고    scopus 로고
    • Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines
    • [PubMed]
    • Joe, A.K.; Liu, H.; Suzui, M.; Vural, M.E.; Xiao, D.; Weinstein, I.B. Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clin. Cancer Res. 2002, 8, 893-903. [PubMed]
    • (2002) Clin. Cancer Res. , vol.8 , pp. 893-903
    • Joe, A.K.1    Liu, H.2    Suzui, M.3    Vural, M.E.4    Xiao, D.5    Weinstein, I.B.6
  • 8
    • 0030657690 scopus 로고    scopus 로고
    • The restriction point and control of cell proliferation
    • [CrossRef]
    • Planas-Silva, M.D.; Weinberg, R.A. The restriction point and control of cell proliferation. Curr. Opin. Cell Biol. 1997, 9, 768-772. [CrossRef]
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 768-772
    • Planas-Silva, M.D.1    Weinberg, R.A.2
  • 9
    • 0342368778 scopus 로고    scopus 로고
    • Hierarchy of S-phase-promoting factors: Yeast Dbf4-Cdc7 kinase requires prior s-phase cyclin-dependent kinase activation
    • [CrossRef] [PubMed]
    • Nougarede, R.; Della Seta, F.; Zarzov, P.; Schwob, E. Hierarchy of S-phase-promoting factors: Yeast Dbf4-Cdc7 kinase requires prior s-phase cyclin-dependent kinase activation. Mol. Cell. Biol. 2000, 20, 3795-3806. [CrossRef] [PubMed]
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3795-3806
    • Nougarede, R.1    Della Seta, F.2    Zarzov, P.3    Schwob, E.4
  • 10
    • 0035235736 scopus 로고    scopus 로고
    • Mitotic kinases as regulators of cell division and its checkpoints
    • [CrossRef] [PubMed]
    • Nigg, E.A. Mitotic kinases as regulators of cell division and its checkpoints. Nat. Rev. Mol. Cell Biol. 2001, 2, 21-32. [CrossRef] [PubMed]
    • (2001) Nat. Rev. Mol. Cell Biol. , vol.2 , pp. 21-32
    • Nigg, E.A.1
  • 11
    • 67649424560 scopus 로고    scopus 로고
    • P21 in cancer: Intricate networks and multiple activities
    • [CrossRef] [PubMed]
    • Abbas, T.; Dutta, A. p21 in cancer: Intricate networks and multiple activities. Nat. Rev. Cancer 2009, 9, 400-414. [CrossRef] [PubMed]
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 400-414
    • Abbas, T.1    Dutta, A.2
  • 12
    • 0036594890 scopus 로고    scopus 로고
    • The role of the cyclin-dependent kinase inhibitor p21 in apoptosis
    • [PubMed]
    • Gartel, A.L.; Tyner, A.L. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol. Cancer Ther. 2002, 1, 639-649. [PubMed]
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 639-649
    • Gartel, A.L.1    Tyner, A.L.2
  • 13
    • 0027330142 scopus 로고
    • Tapping an amazonian plethora: Four medicinal plants of marajo island, para (Brazil)
    • [CrossRef]
    • Hammer, M.L.; Johns, E.A. Tapping an amazonian plethora: Four medicinal plants of marajo island, para (Brazil). J. Ethnopharmacol. 1993, 40, 53-75. [CrossRef]
    • (1993) J. Ethnopharmacol. , vol.40 , pp. 53-75
    • Hammer, M.L.1    Johns, E.A.2
  • 14
    • 0028878048 scopus 로고
    • The evaluation of hepatoprotective effects of Taiwan folk medicine "teng-Khia-U"
    • [CrossRef]
    • Lin, C.C.; Tsai, C.C.; Yen, M.H. The evaluation of hepatoprotective effects of Taiwan folk medicine "Teng-Khia-U". J. Ethnopharmacol. 1995, 45, 113-123. [CrossRef]
    • (1995) J. Ethnopharmacol. , vol.45 , pp. 113-123
    • Lin, C.C.1    Tsai, C.C.2    Yen, M.H.3
  • 15
    • 7044249880 scopus 로고    scopus 로고
    • Cancer - An ayurvedic perspective
    • [CrossRef] [PubMed]
    • Balachandran, P.; Govindarajan, R. Cancer - An ayurvedic perspective. Pharmacol. Res. 2005, 51, 19-30. [CrossRef] [PubMed]
    • (2005) Pharmacol. Res. , vol.51 , pp. 19-30
    • Balachandran, P.1    Govindarajan, R.2
  • 16
    • 73949153090 scopus 로고    scopus 로고
    • Antiproliferative activities of five Chinese medicinal herbs and active compounds in elephantopus scaber
    • [PubMed]
    • Su, M.; Wu, X.; Chung, H.Y.; Li, Y.; Ye, W. Antiproliferative activities of five chinese medicinal herbs and active compounds in elephantopus scaber. Nat. Prod. Commun. 2009, 4, 1025-1030. [PubMed]
    • (2009) Nat. Prod. Commun. , vol.4 , pp. 1025-1030
    • Su, M.1    Wu, X.2    Chung, H.Y.3    Li, Y.4    Ye, W.5
  • 17
    • 84942981510 scopus 로고    scopus 로고
    • Anti-metastatic effect of deoxyelephantopin from elephantopus scaber in A549 lung cancer cells in vitro
    • [CrossRef] [PubMed]
    • Farha, A.K.; Dhanya, S.R.; Mangalam, S.N.; Remani, P. Anti-metastatic effect of deoxyelephantopin from elephantopus scaber in A549 lung cancer cells in vitro. Nat. Prod. Res. 2015, 29, 2341-2345. [CrossRef] [PubMed]
    • (2015) Nat. Prod. Res. , vol.29 , pp. 2341-2345
    • Farha, A.K.1    Dhanya, S.R.2    Mangalam, S.N.3    Remani, P.4
  • 18
    • 77249177609 scopus 로고    scopus 로고
    • Deoxyelephantopin, a novel multifunctional agent, suppresses mammary tumour growth and lung metastasis and doubles survival time in mice
    • [CrossRef] [PubMed]
    • Huang, C.C.; Lo, C.P.; Chiu, C.Y.; Shyur, L.F. Deoxyelephantopin, a novel multifunctional agent, suppresses mammary tumour growth and lung metastasis and doubles survival time in mice. Br. J. Pharmacol. 2010, 159, 856-871. [CrossRef] [PubMed]
    • (2010) Br. J. Pharmacol. , vol.159 , pp. 856-871
    • Huang, C.C.1    Lo, C.P.2    Chiu, C.Y.3    Shyur, L.F.4
  • 19
    • 84912088450 scopus 로고    scopus 로고
    • Deoxyelephantopin impairs growth of cervical carcinoma siha cells and induces apoptosis by targeting multiple molecular signaling pathways
    • [CrossRef] [PubMed]
    • Farha, A.K.; Dhanya, S.R.; Mangalam, S.N.; Geetha, B.S.; Latha, P.G.; Remani, P. Deoxyelephantopin impairs growth of cervical carcinoma siha cells and induces apoptosis by targeting multiple molecular signaling pathways. Cell Biol. Toxicol. 2014, 30, 331-343. [CrossRef] [PubMed]
    • (2014) Cell Biol. Toxicol. , vol.30 , pp. 331-343
    • Farha, A.K.1    Dhanya, S.R.2    Mangalam, S.N.3    Geetha, B.S.4    Latha, P.G.5    Remani, P.6
  • 20
    • 84858146974 scopus 로고    scopus 로고
    • Sesquiterpene lactones isolated from elephantopus scaber l. Inhibits human lymphocyte proliferation and the growth of tumour cell lines and induces apoptosis in vitro
    • [CrossRef] [PubMed]
    • Geetha, B.S.; Nair, M.S.; Latha, P.G.; Remani, P. Sesquiterpene lactones isolated from elephantopus scaber l. Inhibits human lymphocyte proliferation and the growth of tumour cell lines and induces apoptosis in vitro. J. Biomed. Biotechnol. 2012, 2012, 721285. [CrossRef] [PubMed]
    • (2012) J. Biomed. Biotechnol. , vol.2012 , pp. 721285
    • Geetha, B.S.1    Nair, M.S.2    Latha, P.G.3    Remani, P.4
  • 21
    • 84899621882 scopus 로고    scopus 로고
    • Isodeoxyelephantopin from Elephantopus scaber (Didancao) induces cell cycle arrest and caspase-3-mediated apoptosis in breast carcinoma T47D cells and lung carcinoma A549 cells
    • [CrossRef] [PubMed]
    • Kabeer, F.A.; Sreedevi, G.B.; Nair, M.S.; Rajalekshmi, D.S.; Gopalakrishnan, L.P.; Prathapan, R. Isodeoxyelephantopin from Elephantopus scaber (Didancao) induces cell cycle arrest and caspase-3-mediated apoptosis in breast carcinoma T47D cells and lung carcinoma A549 cells. Chin. Med. 2014, 9, 14. [CrossRef] [PubMed]
    • (2014) Chin. Med. , vol.9 , pp. 14
    • Kabeer, F.A.1    Sreedevi, G.B.2    Nair, M.S.3    Rajalekshmi, D.S.4    Gopalakrishnan, L.P.5    Prathapan, R.6
  • 22
    • 33750291697 scopus 로고    scopus 로고
    • Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-κb (NF-κb) activation and NF-κb-regulated gene expression
    • [CrossRef] [PubMed]
    • Ichikawa, H.; Nair, M.S.; Takada, Y.; Sheeja, D.B.; Kumar, M.A.; Oommen, O.V.; Aggarwal, B.B. Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-κb (NF-κb) activation and NF-κb-regulated gene expression. Clin. Cancer Res. 2006, 12, 5910-5918. [CrossRef] [PubMed]
    • (2006) Clin. Cancer Res. , vol.12 , pp. 5910-5918
    • Ichikawa, H.1    Nair, M.S.2    Takada, Y.3    Sheeja, D.B.4    Kumar, M.A.5    Oommen, O.V.6    Aggarwal, B.B.7
  • 23
    • 84928475594 scopus 로고    scopus 로고
    • Elephantopus scaber induces apoptosis through ROS-dependent mitochondrial signaling pathway in HCT116 human colorectal carcinoma cells
    • [CrossRef] [PubMed]
    • Chan, C.K.; Supriady, H.; Goh, B.H.; Kadir, H.A. Elephantopus scaber induces apoptosis through ROS-dependent mitochondrial signaling pathway in HCT116 human colorectal carcinoma cells. J. Ethnopharmacol. 2015, 168, 291-304. [CrossRef] [PubMed]
    • (2015) J. Ethnopharmacol. , vol.168 , pp. 291-304
    • Chan, C.K.1    Supriady, H.2    Goh, B.H.3    Kadir, H.A.4
  • 26
    • 84880783793 scopus 로고    scopus 로고
    • Sesquiterpene lactones: Adverse health effects and toxicity mechanisms
    • [CrossRef] [PubMed]
    • Amorim, M.H.; Gil da Costa, R.M.; Lopes, C.; Bastos, M.M. Sesquiterpene lactones: Adverse health effects and toxicity mechanisms. Crit. Rev. Toxicol. 2013, 43, 559-579. [CrossRef] [PubMed]
    • (2013) Crit. Rev. Toxicol. , vol.43 , pp. 559-579
    • Amorim, M.H.1    Gil Da Costa, R.M.2    Lopes, C.3    Bastos, M.M.4
  • 27
    • 70349949009 scopus 로고    scopus 로고
    • Costunolide-induced apoptosis in human leukemia cells: Involvement of c-jun N-terminal kinase activation
    • [CrossRef] [PubMed]
    • Choi, J.H.; Lee, K.T. Costunolide-induced apoptosis in human leukemia cells: Involvement of c-jun N-terminal kinase activation. Biol. Pharm. Bull. 2009, 32, 1803-1808. [CrossRef] [PubMed]
    • (2009) Biol. Pharm. Bull. , vol.32 , pp. 1803-1808
    • Choi, J.H.1    Lee, K.T.2
  • 29
    • 0029043888 scopus 로고
    • A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin v
    • [CrossRef]
    • Vermes, I.; Haanen, C.; Steffens-Nakken, H.; Reutelingsperger, C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin v. J. Immunol. Methods 1995, 184, 39-51. [CrossRef]
    • (1995) J. Immunol. Methods , vol.184 , pp. 39-51
    • Vermes, I.1    Haanen, C.2    Steffens-Nakken, H.3    Reutelingsperger, C.4
  • 30
    • 0034712259 scopus 로고    scopus 로고
    • Cleavage of poly(adp-ribose) polymerase measured in situ in individual cells: Relationship to DNA fragmentation and cell cycle position during apoptosis
    • [CrossRef] [PubMed]
    • Li, X.; Darzynkiewicz, Z. Cleavage of poly(adp-ribose) polymerase measured in situ in individual cells: Relationship to DNA fragmentation and cell cycle position during apoptosis. Exp. Cell Res. 2000, 255, 125-132. [CrossRef] [PubMed]
    • (2000) Exp. Cell Res. , vol.255 , pp. 125-132
    • Li, X.1    Darzynkiewicz, Z.2
  • 31
    • 26444560960 scopus 로고    scopus 로고
    • Caspases: Pharmacological manipulation of cell death
    • [CrossRef] [PubMed]
    • Lavrik, I.N.; Golks, A.; Krammer, P.H. Caspases: Pharmacological manipulation of cell death. J. Clin. Investig. 2005, 115, 2665-2672. [CrossRef] [PubMed]
    • (2005) J. Clin. Investig. , vol.115 , pp. 2665-2672
    • Lavrik, I.N.1    Golks, A.2    Krammer, P.H.3
  • 33
    • 84886302360 scopus 로고    scopus 로고
    • Molecular imaging of p53 signal pathway in lung cancer cell cycle arrest induced by cisplatin
    • [CrossRef] [PubMed]
    • Wang, S.; Li, W.; Xue, Z.; Lu, Y.; Narsinh, K.; Fan, W.; Li, X.; Bu, Q.; Wang, F.; Liang, J.; et al. Molecular imaging of p53 signal pathway in lung cancer cell cycle arrest induced by cisplatin. Mol. Carcinog. 2013, 52, 900-907. [CrossRef] [PubMed]
    • (2013) Mol. Carcinog. , vol.52 , pp. 900-907
    • Wang, S.1    Li, W.2    Xue, Z.3    Lu, Y.4    Narsinh, K.5    Fan, W.6    Li, X.7    Bu, Q.8    Wang, F.9    Liang, J.10
  • 34
    • 79960847401 scopus 로고    scopus 로고
    • Deoxyelephantopin from elephantopus scaber l. Induces cell-cycle arrest and apoptosis in the human nasopharyngeal cancer cne cells
    • [CrossRef] [PubMed]
    • Su, M.; Chung, H.Y.; Li, Y. Deoxyelephantopin from elephantopus scaber l. Induces cell-cycle arrest and apoptosis in the human nasopharyngeal cancer cne cells. Biochem. Biophys. Res. Commun. 2011, 411, 342-347. [CrossRef] [PubMed]
    • (2011) Biochem. Biophys. Res. Commun. , vol.411 , pp. 342-347
    • Su, M.1    Chung, H.Y.2    Li, Y.3
  • 35
    • 84899622427 scopus 로고    scopus 로고
    • Unravelling mechanisms of p53-mediated tumour suppression
    • [CrossRef] [PubMed]
    • Bieging, K.T.; Mello, S.S.; Attardi, L.D. Unravelling mechanisms of p53-mediated tumour suppression. Nat. Rev. Cancer 2014, 14, 359-370. [CrossRef] [PubMed]
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 359-370
    • Bieging, K.T.1    Mello, S.S.2    Attardi, L.D.3
  • 36
    • 0038277105 scopus 로고    scopus 로고
    • Tumor cell senescence in cancer treatment
    • [PubMed]
    • Roninson, I.B. Tumor cell senescence in cancer treatment. Cancer Res. 2003, 63, 2705-2715. [PubMed]
    • (2003) Cancer Res. , vol.63 , pp. 2705-2715
    • Roninson, I.B.1
  • 37
    • 0034738420 scopus 로고    scopus 로고
    • P21(WAF1/Cip1): More than a break to the cell cycle? Biochim
    • [PubMed]
    • Dotto, G.P. p21(WAF1/Cip1): More than a break to the cell cycle? Biochim. Biophys. Acta 2000, 1471, M43-M56. [PubMed]
    • (2000) Biophys. Acta , vol.1471 , pp. M43-M56
    • Dotto, G.P.1
  • 38
    • 34347385839 scopus 로고    scopus 로고
    • P53-mediated cell cycle arrest and apoptosis through a caspase-3-independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells
    • [CrossRef] [PubMed]
    • Cui, Q.; Yu, J.H.;Wu, J.N.; Tashiro, S.; Onodera, S.; Minami, M.; Ikejima, T. p53-mediated cell cycle arrest and apoptosis through a caspase-3-independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells. Acta Pharmacol. Sin. 2007, 28, 1057-1066. [CrossRef] [PubMed]
    • (2007) Acta Pharmacol. Sin. , vol.28 , pp. 1057-1066
    • Cui, Q.1    Yu, J.H.2    Wu, J.N.3    Tashiro, S.4    Onodera, S.5    Minami, M.6    Ikejima, T.7
  • 39
    • 1242294418 scopus 로고    scopus 로고
    • Decreased p21 levels are required for efficient restart of DNA synthesis after s phase block
    • [CrossRef] [PubMed]
    • Gottifredi, V.; McKinney, K.; Poyurovsky, M.V.; Prives, C. Decreased p21 levels are required for efficient restart of DNA synthesis after s phase block. J. Biol. Chem. 2004, 279, 5802-5810. [CrossRef] [PubMed]
    • (2004) J. Biol. Chem. , vol.279 , pp. 5802-5810
    • Gottifredi, V.1    McKinney, K.2    Poyurovsky, M.V.3    Prives, C.4
  • 40
    • 84891405060 scopus 로고    scopus 로고
    • Hinokitiol inhibits cell growth through induction of S-phase arrest and apoptosis in human colon cancer cells and suppresses tumor growth in a mouse xenograft experiment
    • [CrossRef] [PubMed]
    • Lee, Y.S.; Choi, K.M.; Kim, W.; Jeon, Y.S.; Lee, Y.M.; Hong, J.T.; Yun, Y.P.; Yoo, H.S. Hinokitiol inhibits cell growth through induction of S-phase arrest and apoptosis in human colon cancer cells and suppresses tumor growth in a mouse xenograft experiment. J. Nat. Prod. 2013, 76, 2195-2202. [CrossRef] [PubMed]
    • (2013) J. Nat. Prod. , vol.76 , pp. 2195-2202
    • Lee, Y.S.1    Choi, K.M.2    Kim, W.3    Jeon, Y.S.4    Lee, Y.M.5    Hong, J.T.6    Yun, Y.P.7    Yoo, H.S.8


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