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Volumn 2, Issue , 2014, Pages 1-23

Membrane transporters for the special amino acid glutamine: Structure/function relationships and relevance to human health

Author keywords

Amino acids; Cancer; Glutamine; Homology models; Membrane; Nutrients; Transporters

Indexed keywords


EID: 84986915942     PISSN: None     EISSN: 22962646     Source Type: Journal    
DOI: 10.3389/fchem.2014.00061     Document Type: Article
Times cited : (204)

References (211)
  • 1
    • 33745756665 scopus 로고    scopus 로고
    • Crystal structure of yeast Sco1
    • Abajian, C., and Rosenzweig, A. C. (2006). Crystal structure of yeast Sco1. J. Biol. Inorg. Chem. 11, 459-466. doi: 10.1007/s00775-006-0096-7
    • (2006) J. Biol. Inorg. Chem. , vol.11 , pp. 459-466
    • Abajian, C.1    Rosenzweig, A.C.2
  • 3
    • 84857386481 scopus 로고    scopus 로고
    • Defining substrate and blocker activity of alanine-serine-cysteine transporter (ASCT2) ligands with novel serine analogs
    • Albers, T., Marsiglia, W., Thomas, T., Gameiro, A., and Grewer, C. (2012). Defining substrate and blocker activity of alanine-serine-cysteine transporter (ASCT2) ligands with novel serine analogs. Mol. Pharmacol. 81, 356-365. doi: 10.1124/mol.111.075648
    • (2012) Mol. Pharmacol. , vol.81 , pp. 356-365
    • Albers, T.1    Marsiglia, W.2    Thomas, T.3    Gameiro, A.4    Grewer, C.5
  • 4
    • 40649111632 scopus 로고    scopus 로고
    • Genomic regulation of intestinal amino acid transporters by aldosterone.Mol
    • Amaral, J. S., Pinho, M. J., and Soares-Da-Silva, P. (2008). Genomic regulation of intestinal amino acid transporters by aldosterone.Mol. Cell. Biochem. 313, 1-10. doi: 10.1007/s11010-008-9735-3
    • (2008) Cell. Biochem. , vol.313 , pp. 1-10
    • Amaral, J.S.1    Pinho, M.J.2    Soares-Da-Silva, P.3
  • 5
    • 78650197388 scopus 로고    scopus 로고
    • Human endogenous retroviruses and multiple sclerosis: innocent bystanders or disease determinants?
    • Antony, J. M., Deslauriers, A. M., Bhat, R. K., Ellestad, K. K., and Power, C. (2011). Human endogenous retroviruses and multiple sclerosis: innocent bystanders or disease determinants? Biochim. Biophys. Acta 1812, 162-176. doi: 10.1016/j.bbadis.2010.07.016
    • (2011) Biochim. Biophys. Acta , vol.1812 , pp. 162-176
    • Antony, J.M.1    Deslauriers, A.M.2    Bhat, R.K.3    Ellestad, K.K.4    Power, C.5
  • 6
    • 46449093702 scopus 로고    scopus 로고
    • In human entrocytes, GLN transport and ASCT2 surfaceexpressioninducedbyshort-termEGFareMAPK, PI3K, and Rho-dependent
    • Avissar, N. E., Sax, H. C., and Toia, L. (2008). In human entrocytes, GLN transportandASCT2surfaceexpressioninducedbyshort-termEGFareMAPK, PI3K, and Rho-dependent. Dig. Dis. Sci. 53, 2113-2125. doi: 10.1007/s10620-007-0120-y
    • (2008) Dig. Dis. Sci. , vol.53 , pp. 2113-2125
    • Avissar, N.E.1    Sax, H.C.2    Toia, L.3
  • 7
    • 33745893228 scopus 로고    scopus 로고
    • The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer
    • Bak, L. K., Schousboe, A., and Waagepetersen, H. S. (2006). The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer. J. Neurochem. 98, 641-653. doi: 10.1111/j.1471-4159.2006.03913.x
    • (2006) J. Neurochem. , vol.98 , pp. 641-653
    • Bak, L.K.1    Schousboe, A.2    Waagepetersen, H.S.3
  • 8
    • 84886555397 scopus 로고    scopus 로고
    • Increased expression of system large amino acid transporter (LAT)-1 mRNA is associated with invasive potential and unfavorable prognosis of human clear cell renal cell carcinoma.
    • Betsunoh, H., Fukuda, T., Anzai, N., Nishihara, D., Mizuno, T., Yuki, H., et al. (2013). Increased expression of system large amino acid transporter (LAT)-1 mRNA is associated with invasive potential and unfavorable prognosis of human clear cell renal cell carcinoma. BMC Cancer 13:509. doi: 10.1186/1471-2407-13-509
    • (2013) BMC Cancer , vol.13 , pp. 509
    • Betsunoh, H.1    Fukuda, T.2    Anzai, N.3    Nishihara, D.4    Mizuno, T.5    Yuki, H.6
  • 10
    • 24044468014 scopus 로고    scopus 로고
    • Site-directed mutagenesis of cysteine residues of large neutral amino acid transporter LAT1
    • Boado, R. J., Li, J. Y., Chu, C., Ogoshi, F., Wise, P., and Pardridge, W. M. (2005). Site-directed mutagenesis of cysteine residues of large neutral amino acid transporter LAT1. Biochim. Biophys. Acta 1715, 104-110. doi: 10.1016/j.bbamem.2005.07.007
    • (2005) Biochim. Biophys. Acta , vol.1715 , pp. 104-110
    • Boado, R.J.1    Li, J.Y.2    Chu, C.3    Ogoshi, F.4    Wise, P.5    Pardridge, W.M.6
  • 11
    • 0034843258 scopus 로고    scopus 로고
    • Recent molecular advances in mammalian glutamine transport
    • discussion: 2486S-2477S
    • Bode, B. P. (2001). Recent molecular advances in mammalian glutamine transport. J. Nutr. 131, 2475S-2485S. discussion: 2486S-2477S. doi: 10.1146/annurev.nutr. 13.1.137
    • (2001) J. Nutr. , vol.131 , pp. 2475S-2485S
    • Bode, B.P.1
  • 13
    • 84875142410 scopus 로고    scopus 로고
    • The small SLC43 family: facilitator systeml amino acid transporters and the orphan EEG1
    • Bodoy, S., Fotiadis, D., Stoeger, C., Kanai, Y., and Palacin, M. (2013). The small SLC43 family: facilitator systeml amino acid transporters and the orphan EEG1. Mol. Aspects Med. 34, 638-645. doi: 10.1016/j.mam.2012.12.006
    • (2013) Mol. Aspects Med. , vol.34 , pp. 638-645
    • Bodoy, S.1    Fotiadis, D.2    Stoeger, C.3    Kanai, Y.4    Palacin, M.5
  • 14
    • 84870749150 scopus 로고    scopus 로고
    • Up-regulation of amino acid transporter SLC6A19 activity and surface protein abundance by PKB/Akt and PIKfyve
    • Bogatikov, E., Munoz, C., Pakladok, T., Alesutan, I., Shojaiefard, M., Seebohm, G., et al. (2012). Up-regulation of amino acid transporter SLC6A19 activity and surface protein abundance by PKB/Akt and PIKfyve. Cell. Physiol. Biochem. 30, 1538-1546. doi: 10.1159/000343341
    • (2012) Cell. Physiol. Biochem. , vol.30 , pp. 1538-1546
    • Bogatikov, E.1    Munoz, C.2    Pakladok, T.3    Alesutan, I.4    Shojaiefard, M.5    Seebohm, G.6
  • 15
    • 23644437362 scopus 로고    scopus 로고
    • Characterization of mouse amino acid transporter B0AT1 (slc6a19)
    • Bohmer, C., Broer, A., Munzinger, M., Kowalczuk, S., Rasko, J. E., Lang, F., et al. (2005). Characterization of mouse amino acid transporter B0AT1 (slc6a19). Biochem. J. 389, 745-751. doi: 10.1042/BJ20050083
    • (2005) Biochem. J. , vol.389 , pp. 745-751
    • Bohmer, C.1    Broer, A.2    Munzinger, M.3    Kowalczuk, S.4    Rasko, J.E.5    Lang, F.6
  • 16
    • 77952990809 scopus 로고    scopus 로고
    • The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19
    • Bohmer, C., Sopjani, M., Klaus, F., Lindner, R., Laufer, J., Jeyaraj, S., et al. (2010). The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19. Cell.Physiol.Biochem. 25, 723-732. doi: 10.1159/000315092
    • (2010) Cell.Physiol.Biochem. , vol.25 , pp. 723-732
    • Bohmer, C.1    Sopjani, M.2    Klaus, F.3    Lindner, R.4    Laufer, J.5    Jeyaraj, S.6
  • 17
    • 33846505059 scopus 로고    scopus 로고
    • Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter
    • Boudker, O., Ryan, R. M., Yernool, D., Shimamoto, K., and Gouaux, E. (2007). Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature 445, 387-393. doi: 10.1038/nature05455
    • (2007) Nature , vol.445 , pp. 387-393
    • Boudker, O.1    Ryan, R.M.2    Yernool, D.3    Shimamoto, K.4    Gouaux, E.5
  • 18
    • 33745244792 scopus 로고    scopus 로고
    • Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase
    • Brizio, C., Galluccio, M., Wait, R., Torchetti, E. M., Bafunno, V., Accardi, R., et al. (2006). Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase. Biochem. Biophys. Res. Commun. 344, 1008-1016. doi: 10.1016/j.bbrc.2006.04.003
    • (2006) Biochem. Biophys. Res. Commun. , vol.344 , pp. 1008-1016
    • Brizio, C.1    Galluccio, M.2    Wait, R.3    Torchetti, E.M.4    Bafunno, V.5    Accardi, R.6
  • 19
    • 0038807482 scopus 로고    scopus 로고
    • The astroglial ASCT2 amino acid transporter as amediator of glutamine effiux
    • Broer, A., Brookes, N., Ganapathy, V., Dimmer, K. S., Wagner, C. A., Lang, F., et al. (1999). The astroglial ASCT2 amino acid transporter as amediator of glutamine effiux. J. Neurochem. 73, 2184-2194.
    • (1999) J. Neurochem. , vol.73 , pp. 2184-2194
    • Broer, A.1    Brookes, N.2    Ganapathy, V.3    Dimmer, K.S.4    Wagner, C.A.5    Lang, F.6
  • 20
    • 0035340403 scopus 로고    scopus 로고
    • Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains
    • Broer, A., Friedrich, B., Wagner, C. A., Fillon, S., Ganapathy, V., Lang, F., et al. (2001). Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains. Biochem. J. 355, 725-731.
    • (2001) Biochem. J. , vol.355 , pp. 725-731
    • Broer, A.1    Friedrich, B.2    Wagner, C.A.3    Fillon, S.4    Ganapathy, V.5    Lang, F.6
  • 21
    • 79960661606 scopus 로고    scopus 로고
    • Impaired nutrient signaling and body weight control in a Na+ neutral amino acid cotransporter (Slc6a19)-deficient mouse
    • Broer, A., Juelich, T., Vanslambrouck, J. M., Tietze, N., Solomon, P. S., Holst, J., et al. (2011). Impaired nutrient signaling and body weight control in a Na+ neutral amino acid cotransporter (Slc6a19)-deficient mouse. J. Biol. Chem. 286, 26638-26651. doi: 10.1074/jbc.M111.241323
    • (2011) J. Biol. Chem. , vol.286 , pp. 26638-26651
    • Broer, A.1    Juelich, T.2    Vanslambrouck, J.M.3    Tietze, N.4    Solomon, P.S.5    Holst, J.6
  • 22
    • 2642564455 scopus 로고    scopus 로고
    • Molecular cloning of mouse amino acid transport system B0, a neutral amino acid transporter related to Hartnup disorder
    • Broer, A., Klingel, K., Kowalczuk, S., Rasko, J. E., Cavanaugh, J., and Broer, S. (2004). Molecular cloning of mouse amino acid transport system B0, a neutral amino acid transporter related to Hartnup disorder. J. Biol. Chem. 279, 24467-24476. doi: 10.1074/jbc.M400904200
    • (2004) J. Biol. Chem. , vol.279 , pp. 24467-24476
    • Broer, A.1    Klingel, K.2    Kowalczuk, S.3    Rasko, J.E.4    Cavanaugh, J.5    Broer, S.6
  • 23
    • 0034254798 scopus 로고    scopus 로고
    • The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine effiux in exchange with glutamine
    • Broer, A., Wagner, C. A., Lang, F., and Broer, S. (2000). The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine effiux in exchange with glutamine. Biochem. J. 349(Pt 3), 787-795.
    • (2000) Biochem. J. , vol.349 , pp. 787-795
    • Broer, A.1    Wagner, C.A.2    Lang, F.3    Broer, S.4
  • 24
    • 33645901823 scopus 로고    scopus 로고
    • The SLC6 orphans are forming a family of amino acid transporters
    • Broer, S. (2006). The SLC6 orphans are forming a family of amino acid transporters. Neurochem. Int. 48, 559-567. doi: 10.1016/j.neuint.2005.11.021
    • (2006) Neurochem. Int. , vol.48 , pp. 559-567
    • Broer, S.1
  • 25
    • 42049122112 scopus 로고    scopus 로고
    • Apical transporters for neutral amino acids: physiology and patho-physiology
    • Broer, S. (2008). Apical transporters for neutral amino acids: physiology and patho-physiology. Physiology (Bethesda) 23, 95-103. doi: 10.1152/physiol.00045.2007
    • (2008) Physiology (Bethesda) , vol.23 , pp. 95-103
    • Broer, S.1
  • 26
    • 69449090536 scopus 로고    scopus 로고
    • The role of the neutral amino acid transporter B0AT1 (SLC6A19) in Hartnup disorder and protein nutrition
    • Broer, S. (2009). The role of the neutral amino acid transporter B0AT1 (SLC6A19) in Hartnup disorder and protein nutrition. IUBMB Life 61, 591-599. doi: 10.1002/iub.210
    • (2009) IUBMB Life , vol.61 , pp. 591-599
    • Broer, S.1
  • 27
    • 84891854907 scopus 로고    scopus 로고
    • The SLC38 family of sodium-amino acid co-transporters
    • Broer, S. (2014). The SLC38 family of sodium-amino acid co-transporters. Pfiugers Arch. 466, 155-172. doi: 10.1007/s00424-013-1393-y
    • (2014) Pfiugers Arch. , vol.466 , pp. 155-172
    • Broer, S.1
  • 28
    • 0038469628 scopus 로고    scopus 로고
    • Transfer of glutamine between astrocytes and neurons
    • Broer, S., and Brookes, N. (2001). Transfer of glutamine between astrocytes and neurons. J. Neurochem. 77, 705-719. doi: 10.1046/j.1471-4159.2001.00322.x
    • (2001) J. Neurochem. , vol.77 , pp. 705-719
    • Broer, S.1    Brookes, N.2
  • 29
    • 4344593427 scopus 로고    scopus 로고
    • Glutamine availability upregulates expression of the amino acid transporter protein ASCT2 in HepG2 cells and stimulates the ASCT2 promoter
    • Bungard, C. I., and McGivan, J. D. (2004). Glutamine availability upregulates expression of the amino acid transporter protein ASCT2 in HepG2 cells and stimulates the ASCT2 promoter. Biochem. J. 382, 27-32. doi: 10.1042/BJ20040487
    • (2004) Biochem. J. , vol.382 , pp. 27-32
    • Bungard, C.I.1    McGivan, J.D.2
  • 30
    • 27644540271 scopus 로고    scopus 로고
    • Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers
    • Bungard, C. I., and McGivan, J. D. (2005). Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers. Arch. Biochem. Biophys. 443, 53-59. doi: 10.1016/j.abb.2005.08.016
    • (2005) Arch. Biochem. Biophys. , vol.443 , pp. 53-59
    • Bungard, C.I.1    McGivan, J.D.2
  • 31
    • 67650938638 scopus 로고    scopus 로고
    • Calcineurin-inhibitor-free immunosuppression based on the JAK inhibitor CP-690,550: a pilot study in de novo kidney allograft recipients
    • Busque, S., Leventhal, J., Brennan, D. C., Steinberg, S., Klintmalm, G., Shah, T., et al. (2009). Calcineurin-inhibitor-free immunosuppression based on the JAK inhibitor CP-690,550: a pilot study in de novo kidney allograft recipients. Am. J. Transplant. 9, 1936-1945. doi: 10.1111/j.1600-6143.2009.02720.x
    • (2009) Am. J. Transplant. , vol.9 , pp. 1936-1945
    • Busque, S.1    Leventhal, J.2    Brennan, D.C.3    Steinberg, S.4    Klintmalm, G.5    Shah, T.6
  • 32
    • 68049095166 scopus 로고    scopus 로고
    • Potassiumrestriction, high protein intake, and metabolic acidosis increase expression of the glutamine transporter SNAT3 (Slc38a3) in mouse kidney
    • Busque, S.M., andWagner, C. A. (2009). Potassiumrestriction, high protein intake, and metabolic acidosis increase expression of the glutamine transporter SNAT3 (Slc38a3) in mouse kidney. Am. J. Physiol. Renal Physiol. 297, F440-F450. doi: 10.1152/ajprenal.90318.2008
    • (2009) Am. J. Physiol. Renal Physiol. , vol.297 , pp. F440-F450
    • Busque, S.M.1    Wagner, C.A.2
  • 33
    • 26844573413 scopus 로고    scopus 로고
    • Steady-state kinetic characterization of the mouse B(0)AT1 sodium-dependent neutral amino acid transporter
    • Camargo, S. M., Makrides, V., Virkki, L. V., Forster, I. C., and Verrey, F. (2005). Steady-state kinetic characterization of the mouse B(0)AT1 sodium-dependent neutral amino acid transporter. Pfiugers Arch. 451, 338-348. doi: 10.1007/s00424-005-1455-x
    • (2005) Pfiugers Arch. , vol.451 , pp. 338-348
    • Camargo, S.M.1    Makrides, V.2    Virkki, L.V.3    Forster, I.C.4    Verrey, F.5
  • 34
    • 84861206592 scopus 로고    scopus 로고
    • CD98 at the crossroads of adaptive immunity and cancer
    • Cantor, J. M., and Ginsberg, M. H. (2012). CD98 at the crossroads of adaptive immunity and cancer. J. Cell Sci. 125, 1373-1382. doi: 10.1242/jcs.096040
    • (2012) J. Cell Sci. , vol.125 , pp. 1373-1382
    • Cantor, J.M.1    Ginsberg, M.H.2
  • 35
    • 0037126633 scopus 로고    scopus 로고
    • Coupled and uncoupled proton movement by amino acid transport system N
    • Chaudhry, F. A., Krizaj, D., Larsson, P., Reimer, R. J., Wreden, C., Storm-Mathisen, J., et al. (2001). Coupled and uncoupled proton movement by amino acid transport system N. EMBO J. 20, 7041-7051. doi: 10.1093/emboj/20. 24.7041
    • (2001) EMBO J. , vol.20 , pp. 7041-7051
    • Chaudhry, F.A.1    Krizaj, D.2    Larsson, P.3    Reimer, R.J.4    Wreden, C.5    Storm-Mathisen, J.6
  • 36
    • 0033598956 scopus 로고    scopus 로고
    • Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission
    • Chaudhry, F. A., Reimer, R. J., Krizaj, D., Barber, D., Storm-Mathisen, J., Copenhagen, D. R., et al. (1999). Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. Cell 99, 769-780.
    • (1999) Cell , vol.99 , pp. 769-780
    • Chaudhry, F.A.1    Reimer, R.J.2    Krizaj, D.3    Barber, D.4    Storm-Mathisen, J.5    Copenhagen, D.R.6
  • 37
    • 0036139090 scopus 로고    scopus 로고
    • Glutamine uptake by neurons: interaction of protons with system atransporters
    • Chaudhry, F. A., Schmitz, D., Reimer, R. J., Larsson, P., Gray, A. T., Nicoll, R., et al. (2002). Glutamine uptake by neurons: interaction of protons with system atransporters. J. Neurosci. 22, 62-72.
    • (2002) J. Neurosci. , vol.22 , pp. 62-72
    • Chaudhry, F.A.1    Schmitz, D.2    Reimer, R.J.3    Larsson, P.4    Gray, A.T.5    Nicoll, R.6
  • 38
    • 84864040884 scopus 로고    scopus 로고
    • Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells
    • Chen, J. Q., and Russo, J. (2012). Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells. Biochim. Biophys. Acta 1826, 370-384. doi: 10.1016/j.bbcan.2012.06.004
    • (2012) Biochim. Biophys. Acta , vol.1826 , pp. 370-384
    • Chen, J.Q.1    Russo, J.2
  • 39
    • 0025095302 scopus 로고
    • Role of amino acid transport and countertransport in nutrition and metabolism
    • Christensen, H. N. (1990). Role of amino acid transport and countertransport in nutrition and metabolism. Physiol. Rev. 70, 43-77.
    • (1990) Physiol. Rev. , vol.70 , pp. 43-77
    • Christensen, H.N.1
  • 40
    • 0001594597 scopus 로고
    • The use of N-methylation to direct route of mediated transport of amino acids
    • Christensen, H. N., Oxender, D. L., Liang,M., and Vatz, K. A. (1965). The use of N-methylation to direct route of mediated transport of amino acids. J. Biol. Chem. 240, 3609-3616.
    • (1965) J. Biol. Chem. , vol.240 , pp. 3609-3616
    • Christensen, H.N.1    Oxender, D.L.2    Liang, M.3    Vatz, K.A.4
  • 41
    • 33645893484 scopus 로고    scopus 로고
    • The glutamine commute: lost in the tube?
    • Conti, F., and Melone, M. (2006). The glutamine commute: lost in the tube? Neurochem. Int. 48, 459-464. doi: 10.1016/j.neuint.2005.11.016
    • (2006) Neurochem. Int. , vol.48 , pp. 459-464
    • Conti, F.1    Melone, M.2
  • 42
    • 84868227315 scopus 로고    scopus 로고
    • Expression of human heteromeric amino acid transporters in the yeast Pichia pastoris
    • Costa, M., Rosell, A., Alvarez-Marimon, E., Zorzano, A., Fotiadis, D., and Palacin, M. (2013). Expression of human heteromeric amino acid transporters in the yeast Pichia pastoris. Protein Expr. Purif. 87, 35-40. doi: 10.1016/j.pep.2012.10.003
    • (2013) Protein Expr. Purif. , vol.87 , pp. 35-40
    • Costa, M.1    Rosell, A.2    Alvarez-Marimon, E.3    Zorzano, A.4    Fotiadis, D.5    Palacin, M.6
  • 44
    • 0036752957 scopus 로고    scopus 로고
    • Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance
    • Cynober, L. A. (2002). Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition 18, 761-766. doi: 10.1016/S0899-9007(02)00780-3
    • (2002) Nutrition , vol.18 , pp. 761-766
    • Cynober, L.A.1
  • 45
    • 77749326533 scopus 로고    scopus 로고
    • p32 (C1QBP) and cancer cellmetabolism: is theWarburg effect alotofhotair?
    • Dang, C. V. (2010). p32 (C1QBP) and cancer cellmetabolism: is theWarburg effect alotofhotair? Mol. Cell. Biol. 30, 1300-1302. doi: 10.1128/MCB.01661-09
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 1300-1302
    • Dang, C.V.1
  • 46
    • 33845864984 scopus 로고    scopus 로고
    • Essential role for collectrin in renal amino acid transport
    • Danilczyk, U., Sarao, R., Remy, C., Benabbas, C., Stange, G., Richter, A., et al. (2006). Essential role for collectrin in renal amino acid transport. Nature 444, 1088-1091. doi: 10.1038/nature05475
    • (2006) Nature , vol.444 , pp. 1088-1091
    • Danilczyk, U.1    Sarao, R.2    Remy, C.3    Benabbas, C.4    Stange, G.5    Richter, A.6
  • 47
    • 84861975431 scopus 로고    scopus 로고
    • Metabolic reprogramming in cancer: unraveling theroleofglutamineintumorigenesis
    • Daye, D., and Wellen, K. E. (2012).Metabolic reprogramming in cancer: unraveling theroleofglutamineintumorigenesis. Semin. Cell Dev. Biol. 23, 362-369. doi: 10.1016/j.semcdb.2012.02.002
    • (2012) Semin. Cell Dev. Biol , vol.23 , pp. 362-369
    • Daye, D.1    Wellen, K.E.2
  • 48
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer:metabolic reprogramming fuels cell growth and proliferation
    • Deberardinis, R. J., Lum, J. J., Hatzivassiliou, G., and Thompson, C. B. (2008). The biology of cancer:metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 7, 11-20. doi: 10.1016/j.cmet.2007.10.002
    • (2008) Cell Metab. , vol.7 , pp. 11-20
    • Deberardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 49
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • Deberardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., et al. (2007). Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl. Acad. Sci. U.S.A. 104, 19345-19350. doi: 10.1073/pnas.0709747104
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 19345-19350
    • Deberardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6
  • 50
    • 0141865766 scopus 로고    scopus 로고
    • Glutamine effiux from astrocytes is mediated bymultiple pathways
    • Deitmer, J. W., Broer, A., and Broer, S. (2003). Glutamine effiux from astrocytes is mediated bymultiple pathways. J. Neurochem. 87, 127-135. doi: 10.1046/j.1471-4159.2003.01981.x
    • (2003) J. Neurochem. , vol.87 , pp. 127-135
    • Deitmer, J.W.1    Broer, A.2    Broer, S.3
  • 51
    • 50449097993 scopus 로고    scopus 로고
    • Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2
    • Del Amo, E. M., Urtti, A., and Yliperttula, M. (2008). Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2. Eur. J. Pharm. Sci. 35, 161-174. doi: 10.1016/j.ejps.2008.06.015
    • (2008) Eur. J. Pharm. Sci. , vol.35 , pp. 161-174
    • Del Amo, E.M.1    Urtti, A.2    Yliperttula, M.3
  • 52
    • 84902002905 scopus 로고    scopus 로고
    • Crystal structure of the human glucose transporter GLUT1
    • Deng, D., Xu, C., Sun, P., Wu, J., Yan, C., Hu, M., et al. (2014). Crystal structure of the human glucose transporter GLUT1. Nature 510, 121-125. doi: 10.1038/ nature13306
    • (2014) Nature , vol.510 , pp. 121-125
    • Deng, D.1    Xu, C.2    Sun, P.3    Wu, J.4    Yan, C.5    Hu, M.6
  • 53
    • 17044450345 scopus 로고    scopus 로고
    • Glutamine transport in C6 glioma cells shows ASCT2 system characteristics
    • Dolinska, M., Dybel, A., Zablocka, B., and Albrecht, J. (2003). Glutamine transport in C6 glioma cells shows ASCT2 system characteristics. Neurochem. Int. 43, 501-507. doi: 10.1016/S0197-0186(03)00040-8
    • (2003) Neurochem. Int. , vol.43 , pp. 501-507
    • Dolinska, M.1    Dybel, A.2    Zablocka, B.3    Albrecht, J.4
  • 54
    • 77950839133 scopus 로고    scopus 로고
    • An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle
    • Drummond, M. J., Glynn, E. L., Fry, C. S., Timmerman, K. L., Volpi, E., and Rasmussen, B. B. (2010). An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 298, E1011-E1018. doi: 10.1152/ajpendo. 00690.2009
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.298 , pp. E1011-E1018
    • Drummond, M.J.1    Glynn, E.L.2    Fry, C.S.3    Timmerman, K.L.4    Volpi, E.5    Rasmussen, B.B.6
  • 55
    • 77954366369 scopus 로고    scopus 로고
    • Luminal leptin inhibits L-glutamine transport in rat small intestine: involvement of ASCT2 and B0AT1
    • Ducroc, R., Sakar, Y., Fanjul, C., Barber, A., Bado, A., and Lostao, M. P. (2010). Luminal leptin inhibits L-glutamine transport in rat small intestine: involvement of ASCT2 and B0AT1. Am. J. Physiol. Gastrointest. Liver Physiol. 299, G179-G185. doi: 10.1152/ajpgi.00048.2010
    • (2010) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.299 , pp. G179-G185
    • Ducroc, R.1    Sakar, Y.2    Fanjul, C.3    Barber, A.4    Bado, A.5    Lostao, M.P.6
  • 56
    • 78650244152 scopus 로고    scopus 로고
    • L-type amino-acid transporter 1 expression predicts the response to preoperative hyperthermo-chemoradiotherapy for advanced rectal cancer
    • Ebara, T., Kaira, K., Saito, J., Shioya, M., Asao, T., Takahashi, T., et al. (2010). L-type amino-acid transporter 1 expression predicts the response to preoperative hyperthermo-chemoradiotherapy for advanced rectal cancer. Anticancer Res. 30, 4223-4227.
    • (2010) Anticancer Res. , vol.30 , pp. 4223-4227
    • Ebara, T.1    Kaira, K.2    Saito, J.3    Shioya, M.4    Asao, T.5    Takahashi, T.6
  • 58
    • 84864742367 scopus 로고    scopus 로고
    • Intestinal pep-tidases form functional complexes with the neutral amino acid transporter B(0)AT1
    • Fairweather, S. J., Broer, A., O'mara, M. L., and Broer, S. (2012). Intestinal pep-tidases form functional complexes with the neutral amino acid transporter B(0)AT1. Biochem. J. 446, 135-148. doi: 10.1042/BJ20120307
    • (2012) Biochem. J. , vol.446 , pp. 135-148
    • Fairweather, S.J.1    Broer, A.2    O'mara, M.L.3    Broer, S.4
  • 59
    • 21444447994 scopus 로고    scopus 로고
    • Identification and functional characterization of a novel low affinity aromatic-preferring amino acid transporter (arpAT). One of the few proteins silenced during primate evolution.
    • Fernandez, E., Torrents, D., Zorzano, A., Palacin, M., and Chillaron, J. (2005). Identification and functional characterization of a novel low affinity aromatic-preferring amino acid transporter (arpAT). One of the few proteins silenced during primate evolution. J. Biol. Chem. 280, 19364-19372. doi: 10.1074/jbc.M412516200
    • (2005) J. Biol. Chem. , vol.280 , pp. 19364-19372
    • Fernandez, E.1    Torrents, D.2    Zorzano, A.3    Palacin, M.4    Chillaron, J.5
  • 60
    • 78650297251 scopus 로고    scopus 로고
    • The structural basis of secondary active transportmechanisms
    • Forrest, L. R., Kramer, R., and Ziegler, C. (2011). The structural basis of secondary active transportmechanisms. Biochim. Biophys. Acta 1807, 167-188. doi: 10.1016/j.bbabio.2010.10.014
    • (2011) Biochim. Biophys. Acta , vol.1807 , pp. 167-188
    • Forrest, L.R.1    Kramer, R.2    Ziegler, C.3
  • 61
    • 35748982140 scopus 로고    scopus 로고
    • The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane
    • Fort, J., De La Ballina, L. R., Burghardt, H. E., Ferrer-Costa, C., Turnay, J., Ferrer-Orta, C., et al. (2007). The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane. J. Biol. Chem. 282, 31444-31452. doi: 10.1074/jbc. M704524200
    • (2007) J. Biol. Chem. , vol.282 , pp. 31444-31452
    • Fort, J.1    De La Ballina, L.R.2    Burghardt, H.E.3    Ferrer-Costa, C.4    Turnay, J.5    Ferrer-Orta, C.6
  • 62
    • 84875190864 scopus 로고    scopus 로고
    • The SLC3 and SLC7 families of amino acid transporters
    • Fotiadis, D., Kanai, Y., and Palacin, M. (2013). The SLC3 and SLC7 families of amino acid transporters. Mol. Aspects Med. 34, 139-158. doi: 10.1016/j.mam.2012.10.007
    • (2013) Mol. Aspects Med. , vol.34 , pp. 139-158
    • Fotiadis, D.1    Kanai, Y.2    Palacin, M.3
  • 63
    • 28644433726 scopus 로고    scopus 로고
    • Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells
    • Fraga, S., Pinho, M. J., and Soares-Da-Silva, P. (2005). Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells. Amino Acids 29, 229-233. doi: 10.1007/s00726-005-0221-x
    • (2005) Amino Acids , vol.29 , pp. 229-233
    • Fraga, S.1    Pinho, M.J.2    Soares-Da-Silva, P.3
  • 64
    • 20544449944 scopus 로고    scopus 로고
    • Heterodimeric amino acid transporter glycoprotein domains determining functional subunit association
    • Franca, R., Veljkovic, E., Walter, S., Wagner, C. A., and Verrey, F. (2005). Heterodimeric amino acid transporter glycoprotein domains determining functional subunit association. Biochem. J. 388, 435-443. doi: 10.1042/BJ20050021
    • (2005) Biochem. J. , vol.388 , pp. 435-443
    • Franca, R.1    Veljkovic, E.2    Walter, S.3    Wagner, C.A.4    Verrey, F.5
  • 65
    • 23044474905 scopus 로고    scopus 로고
    • Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?
    • Fuchs, B. C., and Bode, B. P. (2005). Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime? Semin. Cancer Biol. 15, 254-266. doi: 10.1016/j.semcancer.2005.04.005
    • (2005) Semin. Cancer Biol. , vol.15 , pp. 254-266
    • Fuchs, B.C.1    Bode, B.P.2
  • 66
    • 34547135698 scopus 로고    scopus 로고
    • ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells
    • Fuchs, B. C., Finger, R. E., Onan, M. C., and Bode, B. P. (2007). ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells. Am.J.Physiol.CellPhysiol. 293, C55-C63. doi: 10.1152/ajpcell.00330.2006
    • (2007) Am.J.Physiol.CellPhysiol. , vol.293 , pp. C55-C63
    • Fuchs, B.C.1    Finger, R.E.2    Onan, M.C.3    Bode, B.P.4
  • 67
    • 1342322886 scopus 로고    scopus 로고
    • Inducible antisense RNA targeting amino acid transporter ATB0/ASCT2 elicits apoptosis in human hepatoma cells
    • Fuchs, B. C., Perez, J. C., Suetterlin, J. E., Chaudhry, S. B., and Bode, B. P. (2004). Inducible antisense RNA targeting amino acid transporter ATB0/ASCT2 elicits apoptosis in human hepatoma cells. Am. J. Physiol. Gastrointest. Liver Physiol. 286, G467-G478. doi: 10.1152/ajpgi.00344.2003
    • (2004) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.286 , pp. G467-G478
    • Fuchs, B.C.1    Perez, J.C.2    Suetterlin, J.E.3    Chaudhry, S.B.4    Bode, B.P.5
  • 68
    • 84856492407 scopus 로고    scopus 로고
    • Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis
    • Furuya, M., Horiguchi, J., Nakajima, H., Kanai, Y., and Oyama, T. (2012). Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis. Cancer Sci. 103, 382-389. doi: 10.1111/j.1349-7006.2011.02151.x
    • (2012) Cancer Sci. , vol.103 , pp. 382-389
    • Furuya, M.1    Horiguchi, J.2    Nakajima, H.3    Kanai, Y.4    Oyama, T.5
  • 69
    • 84884591979 scopus 로고    scopus 로고
    • Cloning, large scale over-expression in E. coli and purification of the components of the human LAT 1 (SLC7A5) amino acid transporter.
    • Galluccio,M., Pingitore, P., Scalise,M., and Indiveri, C. (2013). Cloning, large scale over-expression in E. coli and purification of the components of the human LAT 1 (SLC7A5) amino acid transporter. Protein J. 32, 442-448. doi: 10.1007/s10930-013-9503-4G7A
    • (2013) Protein J. , vol.32 , pp. 442-448
    • Galluccio, M.1    Pingitore, P.2    Scalise, M.3    Indiveri, C.4
  • 70
    • 28444473132 scopus 로고    scopus 로고
    • Amino Acid Transporter ATB0,+ as a delivery system for drugs and prodrugs
    • Ganapathy, M. E., and Ganapathy, V. (2005). Amino Acid Transporter ATB0,+ as a delivery system for drugs and prodrugs. Curr. Drug Targets Immune Endocr. Metabol. Disord. 5, 357-364. doi: 10.2174/156800805774912953
    • (2005) Curr. Drug Targets Immune Endocr. Metabol. Disord. , vol.5 , pp. 357-364
    • Ganapathy, M.E.1    Ganapathy, V.2
  • 71
    • 57749111596 scopus 로고    scopus 로고
    • Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond
    • Ganapathy, V., Thangaraju, M., and Prasad, P. D. (2009). Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol. Ther. 121, 29-40. doi: 10.1016/j.pharmthera.2008.09.005
    • (2009) Pharmacol. Ther. , vol.121 , pp. 29-40
    • Ganapathy, V.1    Thangaraju, M.2    Prasad, P.D.3
  • 72
    • 64749116346 scopus 로고    scopus 로고
    • c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
    • Gao, P., Tchernyshyov, I., Chang, T. C., Lee, Y. S., Kita, K., Ochi, T., et al. (2009). c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 458, 762-765. doi: 10.1038/ nature07823
    • (2009) Nature , vol.458 , pp. 762-765
    • Gao, P.1    Tchernyshyov, I.2    Chang, T.C.3    Lee, Y.S.4    Kita, K.5    Ochi, T.6
  • 73
    • 84875871890 scopus 로고    scopus 로고
    • Structure-based ligand discovery for the large-neutral amino acid transporter 1, LAT-1
    • Geier, E. G., Schlessinger, A., Fan, H., Gable, J. E., Irwin, J. J., Sali, A., et al. (2013). Structure-based ligand discovery for the large-neutral amino acid transporter 1, LAT-1. Proc. Natl. Acad. Sci. U.S.A. 110, 5480-5485. doi: 10.1073/pnas.1218165110
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 5480-5485
    • Geier, E.G.1    Schlessinger, A.2    Fan, H.3    Gable, J.E.4    Irwin, J.J.5    Sali, A.6
  • 75
    • 57549092055 scopus 로고    scopus 로고
    • Cellular distribution of the neutral amino acid transporter subtype ASCT2 in mouse brain
    • Gliddon, C. M., Shao, Z., Lemaistre, J. L., and Anderson, C. M. (2009). Cellular distribution of the neutral amino acid transporter subtype ASCT2 in mouse brain. J. Neurochem. 108, 372-383. doi: 10.1111/j.1471-4159.2008. 05767.x
    • (2009) J. Neurochem. , vol.108 , pp. 372-383
    • Gliddon, C.M.1    Shao, Z.2    Lemaistre, J.L.3    Anderson, C.M.4
  • 76
    • 3242689793 scopus 로고    scopus 로고
    • New inhibitors for the neutral amino acid transporter ASCT2 reveal its Na+-dependent anion leak
    • Grewer, C., and Grabsch, E. (2004). New inhibitors for the neutral amino acid transporter ASCT2 reveal its Na+-dependent anion leak. J. Physiol. 557, 747-759. doi: 10.1113/jphysiol.2004.062521
    • (2004) J. Physiol. , vol.557 , pp. 747-759
    • Grewer, C.1    Grabsch, E.2
  • 77
    • 20444459582 scopus 로고    scopus 로고
    • Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans
    • Gupta, N., Miyauchi, S., Martindale, R. G., Herdman, A. V., Podolsky, R., Miyake, K., et al. (2005). Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans. Biochim. Biophys. Acta 1741, 215-223. doi: 10.1016/j.bbadis.2005.04.002
    • (2005) Biochim. Biophys. Acta , vol.1741 , pp. 215-223
    • Gupta, N.1    Miyauchi, S.2    Martindale, R.G.3    Herdman, A.V.4    Podolsky, R.5    Miyake, K.6
  • 78
    • 29144507276 scopus 로고    scopus 로고
    • Up-regulation of the amino acid transporter ATB(0,+) (SLC6A14) in carcinoma of the cervix
    • Gupta, N., Prasad, P. D., Ghamande, S., Moore-Martin, P., Herdman, A. V., Martindale, R. G., et al. (2006). Up-regulation of the amino acid transporter ATB(0,+) (SLC6A14) in carcinoma of the cervix. Gynecol. Oncol. 100, 8-13. doi: 10.1016/j.ygyno.2005.08.016
    • (2006) Gynecol. Oncol. , vol.100 , pp. 8-13
    • Gupta, N.1    Prasad, P.D.2    Ghamande, S.3    Moore-Martin, P.4    Herdman, A.V.5    Martindale, R.G.6
  • 79
    • 79957984261 scopus 로고    scopus 로고
    • Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons
    • Hagglund, M. G., Sreedharan, S., Nilsson, V. C., Shaik, J. H., Almkvist, I. M., Backlin, S., et al. (2011). Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J. Biol. Chem. 286, 20500-20511. doi: 10.1074/jbc.M110.162404
    • (2011) J. Biol. Chem. , vol.286 , pp. 20500-20511
    • Hagglund, M.G.1    Sreedharan, S.2    Nilsson, V.C.3    Shaik, J.H.4    Almkvist, I.M.5    Backlin, S.6
  • 80
    • 84875183640 scopus 로고    scopus 로고
    • The SLC16 gene family-structure, role and regulation in health and disease
    • Halestrap, A. P. (2013). The SLC16 gene family-structure, role and regulation in health and disease. Mol. Aspects Med. 34, 337-349. doi: 10.1016/j.mam.2012.05.003
    • (2013) Mol. Aspects Med. , vol.34 , pp. 337-349
    • Halestrap, A.P.1
  • 81
    • 79960353171 scopus 로고    scopus 로고
    • Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism.
    • Hamdi,M.M., and Mutungi, G. (2011).Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism. J. Physiol. 589, 3623-3640. doi: 10.1113/jphys-iol.2011.207175
    • (2011) J. Physiol , vol.589 , pp. 3623-3640
    • Hamdi, M.M.1    Mutungi, G.2
  • 82
    • 79953189022 scopus 로고    scopus 로고
    • AaCAT1 of the yellow fever mosquito, Aedes aegypti: a novel histidine-specific amino acid transporter from the SLC7 family
    • Hansen, I. A., Boudko, D. Y., Shiao, S. H., Voronov, D. A., Meleshkevitch, E. A., Drake, L. L., et al. (2011). AaCAT1 of the yellow fever mosquito, Aedes aegypti: a novel histidine-specific amino acid transporter from the SLC7 family. J. Biol. Chem. 286, 10803-10813. doi: 10.1074/jbc.M110.179739
    • (2011) J. Biol. Chem. , vol.286 , pp. 10803-10813
    • Hansen, I.A.1    Boudko, D.Y.2    Shiao, S.H.3    Voronov, D.A.4    Meleshkevitch, E.A.5    Drake, L.L.6
  • 83
    • 84873363313 scopus 로고    scopus 로고
    • SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival
    • Hassanein, M., Hoeksema, M. D., Shiota, M., Qian, J., Harris, B. K., Chen, H., et al. (2013). SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival. Clin. Cancer Res. 19, 560-570. doi: 10.1158/1078-0432.CCR-12-2334
    • (2013) Clin. Cancer Res. , vol.19 , pp. 560-570
    • Hassanein, M.1    Hoeksema, M.D.2    Shiota, M.3    Qian, J.4    Harris, B.K.5    Chen, H.6
  • 84
    • 84865346124 scopus 로고    scopus 로고
    • c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human pancreatic cancer cells
    • Hayashi, K., Jutabha, P., Endou, H., and Anzai, N. (2012). c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human pancreatic cancer cells. Oncol. Rep. 28, 862-866. doi: 10.3892/or.2012.1878
    • (2012) Oncol. Rep. , vol.28 , pp. 862-866
    • Hayashi, K.1    Jutabha, P.2    Endou, H.3    Anzai, N.4
  • 85
    • 84863553135 scopus 로고    scopus 로고
    • Identification and functional expression of the mitochondrial pyruvate carrier
    • Herzig, S., Raemy, E., Montessuit, S., Veuthey, J. L., Zamboni, N., Westermann, B., et al. (2012). Identification and functional expression of the mitochondrial pyruvate carrier. Science 337, 93-96. doi: 10.1126/science.1218530
    • (2012) Science , vol.337 , pp. 93-96
    • Herzig, S.1    Raemy, E.2    Montessuit, S.3    Veuthey, J.L.4    Zamboni, N.5    Westermann, B.6
  • 86
    • 84883536378 scopus 로고    scopus 로고
    • Side effects of long-term glutamine supplementation
    • Holecek, M. (2013). Side effects of long-term glutamine supplementation. JPEN J. Parenter. Enteral Nutr. 37, 607-616. doi: 10.1177/0148607112460682
    • (2013) JPEN J. Parenter. Enteral Nutr. , vol.37 , pp. 607-616
    • Holecek, M.1
  • 87
    • 78751476207 scopus 로고    scopus 로고
    • Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer
    • Imai, H., Kaira, K., Oriuchi, N., Shimizu, K., Tominaga, H., Yanagitani, N., et al. (2010). Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer. Anticancer Res. 30, 4819-4828.
    • (2010) Anticancer Res. , vol.30 , pp. 4819-4828
    • Imai, H.1    Kaira, K.2    Oriuchi, N.3    Shimizu, K.4    Tominaga, H.5    Yanagitani, N.6
  • 88
    • 0032527979 scopus 로고    scopus 로고
    • Identification and purification of the reconstitutively active glutamine carrier from rat kidney mitochondria
    • Indiveri, C., Abruzzo, G., Stipani, I., and Palmieri, F. (1998). Identification and purification of the reconstitutively active glutamine carrier from rat kidney mitochondria. Biochem. J. 333(Pt 2), 285-290.
    • (1998) Biochem. J. , vol.333 , pp. 285-290
    • Indiveri, C.1    Abruzzo, G.2    Stipani, I.3    Palmieri, F.4
  • 89
    • 84882431644 scopus 로고    scopus 로고
    • Strategies of bacterial over expression of membrane transporters relevant in human health: the successful case of the three members of OCTN subfamily
    • Indiveri, C., Galluccio, M., Scalise, M., and Pochini, L. (2013). Strategies of bacterial over expression of membrane transporters relevant in human health: the successful case of the three members of OCTN subfamily. Mol. Biotechnol. 54, 724-736. doi: 10.1007/s12033-012-9586-8
    • (2013) Mol. Biotechnol. , vol.54 , pp. 724-736
    • Indiveri, C.1    Galluccio, M.2    Scalise, M.3    Pochini, L.4
  • 90
    • 0028567192 scopus 로고
    • Kinetic characterization of the reconstituted ornithine carrier from rat liver mitochondria
    • Indiveri, C., Palmieri, L., and Palmieri, F. (1994). Kinetic characterization of the reconstituted ornithine carrier from rat liver mitochondria. Biochim. Biophys. Acta 1188, 293-301. doi: 10.1016/0005-2728(94)90048-5
    • (1994) Biochim. Biophys. Acta , vol.1188 , pp. 293-301
    • Indiveri, C.1    Palmieri, L.2    Palmieri, F.3
  • 91
    • 84986885247 scopus 로고    scopus 로고
    • SLC1A5 (solute carrier family 1 (neutral amino acid transporter), member 5).
    • Indiveri, C., Pochini, L., Galluccio, M., and Scalise, M. (2014). SLC1A5 (solute carrier family 1 (neutral amino acid transporter), member 5). Atlas Genet. Cytogenet. Oncol. Haematol. Available online at: http://AtlasGeneticsOncology. org/Genes/SLC1A5ID42313ch19q13.html
    • (2014) Atlas Genet. Cytogenet. Oncol. Haematol
    • Indiveri, C.1    Pochini, L.2    Galluccio, M.3    Scalise, M.4
  • 92
    • 84892161340 scopus 로고    scopus 로고
    • The amino acid transporters of the glutamate/GABA-glutamine cycle and their impact on insulin and glucagon secretion.
    • Jenstad, M., and Chaudhry, F. A. (2013). The amino acid transporters of the glutamate/GABA-glutamine cycle and their impact on insulin and glucagon secretion. Front. Endocrinol. (Lausanne) 4:199. doi: 10.3389/fendo.2013.00199
    • (2013) Front. Endocrinol. (Lausanne) , vol.4 , pp. 199
    • Jenstad, M.1    Chaudhry, F.A.2
  • 93
  • 94
    • 17344392837 scopus 로고    scopus 로고
    • The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier
    • Kageyama, T., Nakamura, M., Matsuo, A., Yamasaki, Y., Takakura, Y., Hashida, M., et al. (2000). The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier. Brain Res. 879, 115-121. doi: 10.1016/S0006-8993(00) 02758-X
    • (2000) Brain Res. , vol.879 , pp. 115-121
    • Kageyama, T.1    Nakamura, M.2    Matsuo, A.3    Yamasaki, Y.4    Takakura, Y.5    Hashida, M.6
  • 95
    • 77955203324 scopus 로고    scopus 로고
    • Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in surgically resectable stage III non-small cell lung cancer
    • Kaira, K., Oriuchi, N., Imai, H., Shimizu, K., Yanagitani, N., Sunaga, N., et al. (2010). Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in surgically resectable stage III non-small cell lung cancer. Exp. Ther. Med. 1, 799-808. doi: 10.3892/etm.2010.117
    • (2010) Exp. Ther. Med. , vol.1 , pp. 799-808
    • Kaira, K.1    Oriuchi, N.2    Imai, H.3    Shimizu, K.4    Yanagitani, N.5    Sunaga, N.6
  • 96
    • 84855181114 scopus 로고    scopus 로고
    • L-type amino acid transporter 1 (LAT1) expression inmalignant pleural mesothelioma
    • Kaira, K., Oriuchi, N., Takahashi, T., Nakagawa, K., Ohde, Y., Okumura, T., et al. (2011). L-type amino acid transporter 1 (LAT1) expression inmalignant pleural mesothelioma. Anticancer Res. 31, 4075-4082.
    • (2011) Anticancer Res. , vol.31 , pp. 4075-4082
    • Kaira, K.1    Oriuchi, N.2    Takahashi, T.3    Nakagawa, K.4    Ohde, Y.5    Okumura, T.6
  • 97
    • 84885440579 scopus 로고    scopus 로고
    • Clinical significance of L-type amino acid transporter 1 expression as a prognosticmarker and potential of new targeting therapy in biliary tract cancer.
    • Kaira, K., Sunose, Y., Ohshima, Y., Ishioka, N. S., Arakawa, K., Ogawa, T., et al. (2013). Clinical significance of L-type amino acid transporter 1 expression as a prognosticmarker and potential of new targeting therapy in biliary tract cancer. BMC Cancer 13:482. doi: 10.1186/1471-2407-13-482
    • (2013) BMC Cancer , vol.13 , pp. 482
    • Kaira, K.1    Sunose, Y.2    Ohshima, Y.3    Ishioka, N.S.4    Arakawa, K.5    Ogawa, T.6
  • 98
    • 77952217376 scopus 로고    scopus 로고
    • Properties of L-type amino acid transporter 1 in epidermal ovarian cancer
    • Kaji, M., Kabir-Salmani, M., Anzai, N., Jin, C. J., Akimoto, Y., Horita, A., et al. (2010). Properties of L-type amino acid transporter 1 in epidermal ovarian cancer. Int. J. Gynecol. Cancer 20, 329-336. doi: 10.1111/IGC.0b013e3181d28e13
    • (2010) Int. J. Gynecol. Cancer , vol.20 , pp. 329-336
    • Kaji, M.1    Kabir-Salmani, M.2    Anzai, N.3    Jin, C.J.4    Akimoto, Y.5    Horita, A.6
  • 99
  • 100
    • 0032508585 scopus 로고    scopus 로고
    • Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)
    • Kanai, Y., Segawa, H.,Miyamoto, K., Uchino, H., Takeda, E., and Endou, H. (1998). Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J. Biol. Chem. 273, 23629-23632. doi: 10.1074/jbc.273.37.23629
    • (1998) J. Biol. Chem. , vol.273 , pp. 23629-23632
    • Kanai, Y.1    Segawa, H.2    Miyamoto, K.3    Uchino, H.4    Takeda, E.5    Endou, H.6
  • 101
    • 80052404126 scopus 로고    scopus 로고
    • SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer
    • Karunakaran, S., Ramachandran, S., Coothankandaswamy, V., Elangovan, S., Babu, E., Periyasamy-Thandavan, S., et al. (2011). SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer. J. Biol. Chem. 286, 31830-31838. doi: 10.1074/jbc.M111.229518
    • (2011) J. Biol. Chem. , vol.286 , pp. 31830-31838
    • Karunakaran, S.1    Ramachandran, S.2    Coothankandaswamy, V.3    Elangovan, S.4    Babu, E.5    Periyasamy-Thandavan, S.6
  • 102
    • 84899573241 scopus 로고    scopus 로고
    • Glutaminase regulation in cancer cells: a druggable chain of events
    • Katt, W. P., and Cerione, R. A. (2014). Glutaminase regulation in cancer cells: a druggable chain of events. Drug Discov. Today 19, 450-457. doi: 10.1016/j.drudis.2013.10.008
    • (2014) Drug Discov. Today , vol.19 , pp. 450-457
    • Katt, W.P.1    Cerione, R.A.2
  • 103
    • 0029744420 scopus 로고    scopus 로고
    • Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line
    • Kekuda, R., Prasad, P. D., Fei, Y. J., Torres-Zamorano, V., Sinha, S., Yang-Feng, T. L., et al. (1996). Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. J. Biol. Chem. 271, 18657-18661. doi: 10.1074/jbc.271.31.18657
    • (1996) J. Biol. Chem. , vol.271 , pp. 18657-18661
    • Kekuda, R.1    Prasad, P.D.2    Fei, Y.J.3    Torres-Zamorano, V.4    Sinha, S.5    Yang-Feng, T.L.6
  • 104
    • 0030761681 scopus 로고    scopus 로고
    • Molecular and functional characterization of intestinal Na(+)-dependent neutral amino acid transporter B0
    • Kekuda, R., Torres-Zamorano, V., Fei, Y. J., Prasad, P. D., Li, H. W., Mader, L. D., et al. (1997). Molecular and functional characterization of intestinal Na(+)-dependent neutral amino acid transporter B0. Am. J. Physiol. 272, G1463-G1472.
    • (1997) Am. J. Physiol. , vol.272 , pp. G1463-G1472
    • Kekuda, R.1    Torres-Zamorano, V.2    Fei, Y.J.3    Prasad, P.D.4    Li, H.W.5    Mader, L.D.6
  • 105
    • 0018971336 scopus 로고
    • The relation between membrane potential and the transport activity of system A and L in plasma membrane vesicles of the Ehrlich cell
    • Kilberg, M. S., and Christensen, H. N. (1980). The relation between membrane potential and the transport activity of system A and L in plasma membrane vesicles of the Ehrlich cell. Membr. Biochem. 3, 155-168. doi: 10.3109/09687688009063883
    • (1980) Membr. Biochem. , vol.3 , pp. 155-168
    • Kilberg, M.S.1    Christensen, H.N.2
  • 106
    • 84862287025 scopus 로고    scopus 로고
    • Quantification of nimesulide in human plasma by high-performance liquid chromatography with ultraviolet detector (HPLC-UV): application to pharmacokinetic studies in 28 healthy Korean subjects
    • Kim, M. S., Park, Y. S., Kim, S. H., Kim, S. Y., Lee, M. H., Kim, Y. H., et al. (2012). Quantification of nimesulide in human plasma by high-performance liquid chromatography with ultraviolet detector (HPLC-UV): application to pharmacokinetic studies in 28 healthy Korean subjects. J. Chromatogr. Sci. 50, 396-400. doi: 10.1093/chromsci/bms014
    • (2012) J. Chromatogr. Sci. , vol.50 , pp. 396-400
    • Kim, M.S.1    Park, Y.S.2    Kim, S.H.3    Kim, S.Y.4    Lee, M.H.5    Kim, Y.H.6
  • 107
    • 79961195158 scopus 로고    scopus 로고
    • Primary and secondary thyroid hormone transporters
    • Kinne, A., Schulein, R., and Krause, G. (2011). Primary and secondary thyroid hormone transporters. Thyroid Res. 4(Suppl. 1), S7. doi: 10.1186/1756-6614-4-S1-S7
    • (2011) Thyroid Res. , vol.4 , pp. S7
    • Kinne, A.1    Schulein, R.2    Krause, G.3
  • 108
    • 4444367483 scopus 로고    scopus 로고
    • Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder
    • Kleta, R., Romeo, E., Ristic, Z.,Ohura, T., Stuart, C., Arcos-Burgos,M., et al. (2004). Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder. Nat. Genet. 36, 999-1002. doi: 10.1038/ng1405
    • (2004) Nat. Genet. , vol.36 , pp. 999-1002
    • Kleta, R.1    Romeo, E.2    Ristic, Z.3    Ohura, T.4    Stuart, C.5    Arcos-Burgos, M.6
  • 109
    • 34548571952 scopus 로고    scopus 로고
    • Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues
    • Kondoh, N., Imazeki, N., Arai,M., Hada, A., Hatsuse, K.,Matsuo, H., et al. (2007). Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues. Int. J. Oncol. 31, 81-87. doi: 10.3892/ijo.31.1.81
    • (2007) Int. J. Oncol. , vol.31 , pp. 81-87
    • Kondoh, N.1    Imazeki, N.2    Arai, M.3    Hada, A.4    Hatsuse, K.5    Matsuo, H.6
  • 110
    • 84886946901 scopus 로고    scopus 로고
    • Sodium-coupled neutral amino acid transporter 4 functions as a regulator of protein synthesis during liver development
    • Kondou, H., Kawai, M., Tachikawa, K., Kimoto, A., Yamagata, M., Koinuma, T., et al. (2013). Sodium-coupled neutral amino acid transporter 4 functions as a regulator of protein synthesis during liver development. Hepatol. Res. 43, 1211-1223. doi: 10.1111/hepr.12069
    • (2013) Hepatol. Res. , vol.43 , pp. 1211-1223
    • Kondou, H.1    Kawai, M.2    Tachikawa, K.3    Kimoto, A.4    Yamagata, M.5    Koinuma, T.6
  • 111
    • 84856225222 scopus 로고    scopus 로고
    • X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
    • Krishnamurthy, H., and Gouaux, E. (2012). X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Nature 481, 469-474. doi: 10.1038/nature10737
    • (2012) Nature , vol.481 , pp. 469-474
    • Krishnamurthy, H.1    Gouaux, E.2
  • 112
    • 79959755211 scopus 로고    scopus 로고
    • Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis
    • Kurayama, R., Ito, N., Nishibori, Y., Fukuhara, D., Akimoto, Y., Higashihara, E., et al. (2011). Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis. Lab. Invest. 91, 992-1006. doi: 10.1038/labinvest.2011.43
    • (2011) Lab. Invest. , vol.91 , pp. 992-1006
    • Kurayama, R.1    Ito, N.2    Nishibori, Y.3    Fukuhara, D.4    Akimoto, Y.5    Higashihara, E.6
  • 113
    • 84885421993 scopus 로고    scopus 로고
    • The impact of L-type amino acid transporter 1 (LAT1) in human hepatocellular carcinoma
    • Li, J., Qiang, J., Chen, S. F., Wang, X., Fu, J., and Chen, Y. (2013). The impact of L-type amino acid transporter 1 (LAT1) in human hepatocellular carcinoma. Tumour Biol. 34, 2977-2981. doi: 10.1007/s13277-013-0861-5
    • (2013) Tumour Biol. , vol.34 , pp. 2977-2981
    • Li, J.1    Qiang, J.2    Chen, S.F.3    Wang, X.4    Fu, J.5    Chen, Y.6
  • 114
    • 84862819559 scopus 로고    scopus 로고
    • Structure and mechanism of a glutamate-GABA antiporter
    • Ma, D., Lu, P., Yan, C., Fan, C., Yin, P., Wang, J., et al. (2012). Structure and mechanism of a glutamate-GABA antiporter. Nature 483, 632-636. doi: 10.1038/nature10917
    • (2012) Nature , vol.483 , pp. 632-636
    • Ma, D.1    Lu, P.2    Yan, C.3    Fan, C.4    Yin, P.5    Wang, J.6
  • 115
    • 1242317638 scopus 로고    scopus 로고
    • Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family
    • Mackenzie, B., and Erickson, J. D. (2004). Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family. Pfiugers Arch. 447, 784-795. doi: 10.1007/s00424-003-1117-9
    • (2004) Pfiugers Arch. , vol.447 , pp. 784-795
    • Mackenzie, B.1    Erickson, J.D.2
  • 116
    • 0037930294 scopus 로고    scopus 로고
    • Functional properties and cellular distribution of the system a glutamine transporter SNAT1 support specialized roles in central neurons
    • Mackenzie,B.,Schafer,M.K.,Erickson,J.D.,Hediger,M.A.,Weihe,E.,and Varoqui,H. (2003). Functional properties and cellular distribution of the system a glutamine transporter SNAT1 support specialized roles in central neurons. J. Biol. Chem. 278, 23720-23730. doi: 10.1074/jbc.M212718200
    • (2003) J. Biol. Chem. , vol.278 , pp. 23720-23730
    • Mackenzie, B.1    Schafer, M.K.2    Erickson, J.D.3    Hediger, M.A.4    Weihe, E.5    Varoqui, H.6
  • 117
    • 0037370550 scopus 로고    scopus 로고
    • N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions
    • Marin, M., Lavillette, D., Kelly, S. M., and Kabat, D. (2003). N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions. J. Virol. 77, 2936-2945. doi: 10.1128/JVI.77.5.2936-2945.2003
    • (2003) J. Virol. , vol.77 , pp. 2936-2945
    • Marin, M.1    Lavillette, D.2    Kelly, S.M.3    Kabat, D.4
  • 118
    • 0032541636 scopus 로고    scopus 로고
    • Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family
    • Mastroberardino,L.,Spindler,B.,Pfeiffer,R.,Skelly,P.J.,Loffing,J.,Shoemaker, C. B., et al. (1998). Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. Nature 395, 288-291. doi: 10.1038/ 26246
    • (1998) Nature , vol.395 , pp. 288-291
    • Mastroberardino, L.1    Spindler, B.2    Pfeiffer, R.3    Skelly, P.J.4    Loffing, J.5    Shoemaker, C.B.6
  • 119
    • 84863194010 scopus 로고    scopus 로고
    • Up-regulation of L-type amino acid transporter 1 (LAT1) in cultured rat retinal capillary endothelial cells in response to glucose deprivation
    • Matsuyama, R., Tomi,M., Akanuma, S., Tabuchi, A., Kubo, Y., Tachikawa,M., et al. (2012). Up-regulation of L-type amino acid transporter 1 (LAT1) in cultured rat retinal capillary endothelial cells in response to glucose deprivation. Drug Metab. Pharmacokinet. 27, 317-324. doi: 10.2133/dmpk.DMPK-11-RG-122
    • (2012) Drug Metab. Pharmacokinet. , vol.27 , pp. 317-324
    • Matsuyama, R.1    Tomi, M.2    Akanuma, S.3    Tabuchi, A.4    Kubo, Y.5    Tachikawa, M.6
  • 120
    • 34249803325 scopus 로고    scopus 로고
    • The transport of glutamine into mammalian cells.
    • McGivan, J. D., and Bungard, C. I. (2007). The transport of glutamine into mammalian cells. Front. Biosci. 12:874-882. doi: 10.2741/2109
    • (2007) Front. Biosci , vol.12 , pp. 874-882
    • McGivan, J.D.1    Bungard, C.I.2
  • 121
    • 84870720407 scopus 로고    scopus 로고
    • Expanding the reach of cancer metabolomics
    • Metallo, C. M. (2012). Expanding the reach of cancer metabolomics. Cancer Prev. Res. (Phila.) 5, 1337-1340. doi: 10.1158/1940-6207.CAPR-12-0433
    • (2012) Cancer Prev. Res. (Phila.) , vol.5 , pp. 1337-1340
    • Metallo, C.M.1
  • 122
    • 0030593468 scopus 로고    scopus 로고
    • Over-production of proteins in Escherichia coli:mutant hosts that allow synthesis of somemembrane proteins and globular proteins at high levels
    • Miroux, B., and Walker, J. E. (1996). Over-production of proteins in Escherichia coli:mutant hosts that allow synthesis of somemembrane proteins and globular proteins at high levels. J. Mol. Biol. 260, 289-298. doi: 10.1006/jmbi.1996.0399
    • (1996) J. Mol. Biol. , vol.260 , pp. 289-298
    • Miroux, B.1    Walker, J.E.2
  • 123
    • 0035870096 scopus 로고    scopus 로고
    • Na+-and Cl-coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes
    • Nakanishi, T., Hatanaka, T., Huang, W., Prasad, P. D., Leibach, F. H., Ganapathy, M. E., et al. (2001). Na+-and Cl-coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes. J. Physiol. 532, 297-304. doi: 10.1111/j.1469-7793.2001.0297f.x
    • (2001) J. Physiol. , vol.532 , pp. 297-304
    • Nakanishi, T.1    Hatanaka, T.2    Huang, W.3    Prasad, P.D.4    Leibach, F.H.5    Ganapathy, M.E.6
  • 124
    • 0037372730 scopus 로고    scopus 로고
    • Glutamine and glutamate-their central role in cell metabolism and function
    • Newsholme, P., Procopio, J., Lima, M. M., Pithon-Curi, T. C., and Curi, R. (2003). Glutamine and glutamate-their central role in cell metabolism and function. Cell Biochem. Funct. 21, 1-9. doi: 10.1002/cbf.1003
    • (2003) Cell Biochem. Funct. , vol.21 , pp. 1-9
    • Newsholme, P.1    Procopio, J.2    Lima, M.M.3    Pithon-Curi, T.C.4    Curi, R.5
  • 125
    • 59049087460 scopus 로고    scopus 로고
    • Bidirectional transport of amino acids regulates mTOR and autophagy
    • Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., et al. (2009). Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 136, 521-534. doi: 10.1016/j.cell.2008.11.044
    • (2009) Cell , vol.136 , pp. 521-534
    • Nicklin, P.1    Bergman, P.2    Zhang, B.3    Triantafellow, E.4    Wang, H.5    Nyfeler, B.6
  • 126
    • 0035884416 scopus 로고    scopus 로고
    • Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during T-cell activation
    • Nii, T., Segawa, H., Taketani, Y., Tani, Y., Ohkido, M., Kishida, S., et al. (2001). Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during T-cell activation. Biochem. J. 358, 693-704. doi: 10.1042/0264-6021:3580693
    • (2001) Biochem. J. , vol.358 , pp. 693-704
    • Nii, T.1    Segawa, H.2    Taketani, Y.3    Tani, Y.4    Ohkido, M.5    Kishida, S.6
  • 127
    • 84885409208 scopus 로고    scopus 로고
    • Protein kinase C phosphorylates the system N glutamine transporter SN1 (Slc38a3) and regulates its membrane trafficking and degradation.
    • Nissen-Meyer, L. S., and Chaudhry, F. A. (2013). Protein kinase C phosphorylates the system N glutamine transporter SN1 (Slc38a3) and regulates its membrane trafficking and degradation. Front. Endocrinol. (Lausanne) 4:138. doi: 10.3389/fendo.2013.00138
    • (2013) Front. Endocrinol. (Lausanne) , vol.4 , pp. 138
    • Nissen-Meyer, L.S.1    Chaudhry, F.A.2
  • 128
    • 34347405954 scopus 로고    scopus 로고
    • Upregulation of the glutamine transporter through transactivation mediated by cAMP/protein kinase a signals toward exacerbation of vulnerability to oxidative stress in rat neocortical astrocytes
    • Ogura, M., Taniura, H., Nakamichi, N., and Yoneda, Y. (2007). Upregulation of the glutamine transporter through transactivation mediated by cAMP/protein kinase a signals toward exacerbation of vulnerability to oxidative stress in rat neocortical astrocytes. J. Cell. Physiol. 212, 375-385. doi: 10.1002/jcp.21031
    • (2007) J. Cell. Physiol. , vol.212 , pp. 375-385
    • Ogura, M.1    Taniura, H.2    Nakamichi, N.3    Yoneda, Y.4
  • 129
    • 84855560451 scopus 로고    scopus 로고
    • Tumor strengths and frailties: cancer SUMmOns Otto's metabolism
    • Ohh, M. (2012). Tumor strengths and frailties: cancer SUMmOns Otto's metabolism. Nat. Med. 18, 30-31. doi: 10.1038/nm.2631
    • (2012) Nat. Med. , vol.18 , pp. 30-31
    • Ohh, M.1
  • 130
    • 79955550737 scopus 로고    scopus 로고
    • 4F2hc stabilizes GLUT1 protein and increases glucose transport activity
    • Ohno, H., Nakatsu, Y., Sakoda, H., Kushiyama, A., Ono, H., Fujishiro, M., et al. (2011). 4F2hc stabilizes GLUT1 protein and increases glucose transport activity. Am.J.Physiol.CellPhysiol. 300, C1047-C1054. doi: 10.1152/ajpcell.004 16.2010
    • (2011) Am.J.Physiol.CellPhysiol. , vol.300 , pp. C1047-C1054
    • Ohno, H.1    Nakatsu, Y.2    Sakoda, H.3    Kushiyama, A.4    Ono, H.5    Fujishiro, M.6
  • 131
    • 79955775731 scopus 로고    scopus 로고
    • Putative transport mechanism and intracellular fate of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in human prostate cancer
    • Okudaira, H., Shikano, N., Nishii, R., Miyagi, T., Yoshimoto, M., Kobayashi, M., et al. (2011). Putative transport mechanism and intracellular fate of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in human prostate cancer. J. Nucl. Med. 52, 822-829. doi: 10.2967/jnumed.110.086074
    • (2011) J. Nucl. Med. , vol.52 , pp. 822-829
    • Okudaira, H.1    Shikano, N.2    Nishii, R.3    Miyagi, T.4    Yoshimoto, M.5    Kobayashi, M.6
  • 132
    • 34247273080 scopus 로고    scopus 로고
    • Mechanism and putative structure of B(0)-like neutral amino acid transporters
    • O'mara, M., Oakley, A., and Broer, S. (2006). Mechanism and putative structure of B(0)-like neutral amino acid transporters. J. Membr. Biol. 213, 111-118. doi: 10.1007/s00232-006-0879-3
    • (2006) J. Membr. Biol. , vol.213 , pp. 111-118
    • O'mara, M.1    Oakley, A.2    Broer, S.3
  • 133
    • 84867742110 scopus 로고    scopus 로고
    • Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity
    • Oppedisano, F., Catto, M., Koutentis, P. A., Nicolotti, O., Pochini, L., Koyioni, M., et al. (2012). Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity. Toxicol. Appl. Pharmacol. 265, 93-102. doi: 10.1016/j.taap.2012.09.011
    • (2012) Toxicol. Appl. Pharmacol. , vol.265 , pp. 93-102
    • Oppedisano, F.1    Catto, M.2    Koutentis, P.A.3    Nicolotti, O.4    Pochini, L.5    Koyioni, M.6
  • 134
    • 77956227928 scopus 로고    scopus 로고
    • Inactivation by Hg2+ and methylmercury of the glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: Prediction of the involvement of a CXXC motif by homology modelling
    • Oppedisano, F., Galluccio, M., and Indiveri, C. (2010). Inactivation by Hg2+ and methylmercury of the glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: Prediction of the involvement of a CXXC motif by homology modelling. Biochem. Pharmacol. 80, 1266-1273. doi: 10.1016/j.bcp.2010.06.032
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 1266-1273
    • Oppedisano, F.1    Galluccio, M.2    Indiveri, C.3
  • 135
    • 52049091019 scopus 로고    scopus 로고
    • Reconstitution into liposomes of the B degrees -like glutamine-neutral amino acid transporter from renal cell plasma membrane
    • Oppedisano, F., and Indiveri, C. (2008). Reconstitution into liposomes of the B degrees -like glutamine-neutral amino acid transporter from renal cell plasma membrane. Biochim. Biophys. Acta 1778, 2258-2265. doi: 10.1016/j.bbamem.2008.05.011
    • (2008) Biochim. Biophys. Acta , vol.1778 , pp. 2258-2265
    • Oppedisano, F.1    Indiveri, C.2
  • 136
    • 80051800568 scopus 로고    scopus 로고
    • The B degrees AT1 amino acid transporter fromrat kidney reconstituted in liposomes: kinetics and inactivation by methylmercury
    • Oppedisano, F., Pochini, L., Broer, S., and Indiveri, C. (2011). The B degrees AT1 amino acid transporter fromrat kidney reconstituted in liposomes: kinetics and inactivation by methylmercury. Biochim. Biophys. Acta 1808, 2551-2558. doi: 10.1016/j.bbamem.2011.05.011
    • (2011) Biochim. Biophys. Acta , vol.1808 , pp. 2551-2558
    • Oppedisano, F.1    Pochini, L.2    Broer, S.3    Indiveri, C.4
  • 137
    • 9644278151 scopus 로고    scopus 로고
    • Reconstitution into liposomes of the glutamine/amino acid transporter from renal cell plasma membrane: functional characterization, kinetics and activation by nucleotides
    • Oppedisano, F., Pochini, L., Galluccio, M., Cavarelli, M., and Indiveri, C. (2004). Reconstitution into liposomes of the glutamine/amino acid transporter from renal cell plasma membrane: functional characterization, kinetics and activation by nucleotides. Biochim. Biophys. Acta 1667, 122-131. doi: 10.1016/j.bbamem.2004.09.007
    • (2004) Biochim. Biophys. Acta , vol.1667 , pp. 122-131
    • Oppedisano, F.1    Pochini, L.2    Galluccio, M.3    Cavarelli, M.4    Indiveri, C.5
  • 138
    • 33846348275 scopus 로고    scopus 로고
    • The glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: transport mechanism, regulation by ATP and characterization of the glutamine/glutamate antiport
    • Oppedisano, F., Pochini, L., Galluccio, M., and Indiveri, C. (2007). The glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: transport mechanism, regulation by ATP and characterization of the glutamine/glutamate antiport. Biochim. Biophys. Acta 1768, 291-298. doi: 10.1016/j.bbamem.2006.09.002
    • (2007) Biochim. Biophys. Acta , vol.1768 , pp. 291-298
    • Oppedisano, F.1    Pochini, L.2    Galluccio, M.3    Indiveri, C.4
  • 140
    • 0000004395 scopus 로고
    • Evidence for two types ofmediation of neutral and amino-acid transport in Ehrlich cells
    • Oxender, D. L., and Christensen, H. N. (1963). Evidence for two types ofmediation of neutral and amino-acid transport in Ehrlich cells. Nature 197, 765-767. doi: 10.1038/197765a0
    • (1963) Nature , vol.197 , pp. 765-767
    • Oxender, D.L.1    Christensen, H.N.2
  • 141
    • 84874307156 scopus 로고    scopus 로고
    • Identification of a disulfide bridge important for transport function of SNAT4 neutral amino acid transporter.
    • Padmanabhan Iyer, R., Gu, S., Nicholson, B. J., and Jiang, J. X. (2013). Identification of a disulfide bridge important for transport function of SNAT4 neutral amino acid transporter. PLoS ONE 8:e56792. doi: 10.1371/journal.pone.0056792
    • (2013) PLoS ONE , vol.8
    • Padmanabhan Iyer, R.1    Gu, S.2    Nicholson, B.J.3    Jiang, J.X.4
  • 142
    • 1242295213 scopus 로고    scopus 로고
    • The ancillary proteins of HATs: SLC3 family of amino acid transporters
    • Palacin, M., and Kanai, Y. (2004). The ancillary proteins of HATs: SLC3 family of amino acid transporters. Pfiugers Arch. 447, 490-494. doi: 10.1007/s00424-003-1062-7
    • (2004) Pfiugers Arch. , vol.447 , pp. 490-494
    • Palacin, M.1    Kanai, Y.2
  • 143
    • 0942265548 scopus 로고    scopus 로고
    • Transcriptional control of the human sodium-coupled neutral amino acid transporter system a gene by amino acid availability is mediated by an intronic element
    • Palii, S. S., Chen, H., and Kilberg, M. S. (2004). Transcriptional control of the human sodium-coupled neutral amino acid transporter system a gene by amino acid availability is mediated by an intronic element. J. Biol. Chem. 279, 3463-3471. doi: 10.1074/jbc.M310483200
    • (2004) J. Biol. Chem. , vol.279 , pp. 3463-3471
    • Palii, S.S.1    Chen, H.2    Kilberg, M.S.3
  • 144
    • 17444400953 scopus 로고    scopus 로고
    • The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2
    • Palmada, M., Speil, A., Jeyaraj, S., Bohmer, C., and Lang, F. (2005). The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2. Biochem. Biophys. Res. Commun. 331, 272-277. doi: 10.1016/j.bbrc.2005.03.159
    • (2005) Biochem. Biophys. Res. Commun. , vol.331 , pp. 272-277
    • Palmada, M.1    Speil, A.2    Jeyaraj, S.3    Bohmer, C.4    Lang, F.5
  • 145
    • 46349088952 scopus 로고    scopus 로고
    • Diseases caused by defects of mitochondrial carriers: a review
    • Palmieri, F. (2008). Diseases caused by defects of mitochondrial carriers: a review. Biochim. Biophys. Acta 1777, 564-578. doi: 10.1016/j.bbabio.2008.03.008
    • (2008) Biochim. Biophys. Acta , vol.1777 , pp. 564-578
    • Palmieri, F.1
  • 146
    • 22844449962 scopus 로고    scopus 로고
    • Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule
    • Park, S. Y., Kim, J. K., Kim, I. J., Choi, B. K., Jung, K. Y., Lee, S., et al. (2005). Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule. Arch. Pharm. Res. 28, 421-432. doi: 10.1007/BF02977671
    • (2005) Arch. Pharm. Res. , vol.28 , pp. 421-432
    • Park, S.Y.1    Kim, J.K.2    Kim, I.J.3    Choi, B.K.4    Jung, K.Y.5    Lee, S.6
  • 147
    • 84873993390 scopus 로고    scopus 로고
    • Functional characterization and molecular expression of large neutral amino acid transporter (LAT1) in human prostate cancer cells
    • Patel, M., Dalvi, P., Gokulgandhi, M., Kesh, S., Kohli, T., Pal, D., et al. (2013). Functional characterization and molecular expression of large neutral amino acid transporter (LAT1) in human prostate cancer cells. Int. J. Pharm. 443, 245-253. doi: 10.1016/j.ijpharm.2012.12.029
    • (2013) Int. J. Pharm. , vol.443 , pp. 245-253
    • Patel, M.1    Dalvi, P.2    Gokulgandhi, M.3    Kesh, S.4    Kohli, T.5    Pal, D.6
  • 148
    • 84887404259 scopus 로고    scopus 로고
    • X-ray structure of dopamine transporter elucidates antidepressant mechanism
    • Penmatsa, A., Wang, K. H., and Gouaux, E. (2013). X-ray structure of dopamine transporter elucidates antidepressant mechanism. Nature 503, 85-90. doi: 10.1038/nature12533
    • (2013) Nature , vol.503 , pp. 85-90
    • Penmatsa, A.1    Wang, K.H.2    Gouaux, E.3
  • 149
    • 0033521614 scopus 로고    scopus 로고
    • Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family
    • Pfeiffer, R., Rossier, G., Spindler, B., Meier, C., Kuhn, L., and Verrey, F. (1999). Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family. EMBO J. 18, 49-57. doi: 10.1093/emboj/18.1.49
    • (1999) EMBO J. , vol.18 , pp. 49-57
    • Pfeiffer, R.1    Rossier, G.2    Spindler, B.3    Meier, C.4    Kuhn, L.5    Verrey, F.6
  • 150
    • 0032514944 scopus 로고    scopus 로고
    • Functional heterodimeric amino acid transporters lacking cysteine residues involved in disulfide bond
    • Pfeiffer, R., Spindler, B., Loffing, J., Skelly, P. J., Shoemaker, C. B., and Verrey, F. (1998). Functional heterodimeric amino acid transporters lacking cysteine residues involved in disulfide bond. FEBS Lett. 439, 157-162. doi: 10.1016/S0014-5793(98)01359-3
    • (1998) FEBS Lett. , vol.439 , pp. 157-162
    • Pfeiffer, R.1    Spindler, B.2    Loffing, J.3    Skelly, P.J.4    Shoemaker, C.B.5    Verrey, F.6
  • 151
    • 0040610689 scopus 로고    scopus 로고
    • Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids
    • Pineda, M., Fernandez, E., Torrents, D., Estevez, R., Lopez, C., Camps, M., et al. (1999). Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J. Biol. Chem. 274, 19738-19744. doi: 10.1074/jbc.274.28.19738
    • (1999) J. Biol. Chem. , vol.274 , pp. 19738-19744
    • Pineda, M.1    Fernandez, E.2    Torrents, D.3    Estevez, R.4    Lopez, C.5    Camps, M.6
  • 152
    • 84879473795 scopus 로고    scopus 로고
    • Large scale production of the active human ASCT2 (SLC1A5) transporter in Pichia pastoris-functional and kinetic asymmetry revealed in proteoliposomes
    • Pingitore, P., Pochini, L., Scalise, M., Galluccio, M., Hedfalk, K., and Indiveri, C. (2013). Large scale production of the active human ASCT2 (SLC1A5) transporter in Pichia pastoris-functional and kinetic asymmetry revealed in proteoliposomes. Biochim. Biophys. Acta 1828, 2238-2246. doi: 10.1016/j.bbamem.2013.05.034
    • (2013) Biochim. Biophys. Acta , vol.1828 , pp. 2238-2246
    • Pingitore, P.1    Pochini, L.2    Scalise, M.3    Galluccio, M.4    Hedfalk, K.5    Indiveri, C.6
  • 153
    • 84882294308 scopus 로고    scopus 로고
    • OCTN cation transporters in health and disease: role as drug targets and assay development
    • Pochini, L., Scalise, M., Galluccio, M., and Indiveri, C. (2013). OCTN cation transporters in health and disease: role as drug targets and assay development. J. Biomol. Screen. 18, 851-867. doi: 10.1177/1087057113493006
    • (2013) J. Biomol. Screen. , vol.18 , pp. 851-867
    • Pochini, L.1    Scalise, M.2    Galluccio, M.3    Indiveri, C.4
  • 154
    • 84899950891 scopus 로고    scopus 로고
    • Nimesulide binding site in the B0AT1 (SLC6A19) amino acid transporter.mechanism of inhibition revealed by proteoliposome transport assay and molecular modelling
    • Pochini, L., Seidita, A., Sensi, C., Scalise, M., Eberini, I., and Indiveri, C. (2014). Nimesulide binding site in the B0AT1 (SLC6A19) amino acid transporter.mechanism of inhibition revealed by proteoliposome transport assay and molecular modelling. Biochem. Pharmacol. 89, 422-430. doi: 10.1016/j.bcp.2014.03.014
    • (2014) Biochem. Pharmacol. , vol.89 , pp. 422-430
    • Pochini, L.1    Seidita, A.2    Sensi, C.3    Scalise, M.4    Eberini, I.5    Indiveri, C.6
  • 155
    • 84896303323 scopus 로고    scopus 로고
    • The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle.
    • Poncet, N., Mitchell, F. E., Ibrahim, A. F., McGuire, V. A., English, G., Arthur, J. S., et al. (2014). The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle. PLoS ONE 9:e89547. doi: 10.1371/journal.pone.0089547
    • (2014) PLoS ONE , vol.9
    • Poncet, N.1    Mitchell, F.E.2    Ibrahim, A.F.3    McGuire, V.A.4    English, G.5    Arthur, J.S.6
  • 156
    • 84875126075 scopus 로고    scopus 로고
    • SLC6 transporters: structure, function, regulation, disease association and therapeutics
    • Pramod, A. B., Foster, J., Carvelli, L., and Henry, L. K. (2013). SLC6 transporters: structure, function, regulation, disease association and therapeutics. Mol. Aspects Med. 34, 197-219. doi: 10.1016/j.mam.2012.07.002
    • (2013) Mol. Aspects Med. , vol.34 , pp. 197-219
    • Pramod, A.B.1    Foster, J.2    Carvelli, L.3    Henry, L.K.4
  • 157
    • 0033573892 scopus 로고    scopus 로고
    • Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function
    • Prasad, P. D., Wang, H., Huang, W., Kekuda, R., Rajan, D. P., Leibach, F. H., et al. (1999). Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function. Biochem. Biophys. Res. Commun. 255, 283-288. doi: 10.1006/bbrc.1999.0206
    • (1999) Biochem. Biophys. Res. Commun. , vol.255 , pp. 283-288
    • Prasad, P.D.1    Wang, H.2    Huang, W.3    Kekuda, R.4    Rajan, D.P.5    Leibach, F.H.6
  • 158
    • 84875137695 scopus 로고    scopus 로고
    • Solute carriers as drug targets: current use, clinical trials and prospective
    • Rask-Andersen,M.,Masuram, S., Fredriksson, R., and Schioth, H. B. (2013). Solute carriers as drug targets: current use, clinical trials and prospective. Mol. Aspects Med. 34, 702-710. doi: 10.1016/j.mam.2012.07.015
    • (2013) Mol. Aspects Med. , vol.34 , pp. 702-710
    • Rask-Andersen, M.1    Masuram, S.2    Fredriksson, R.3    Schioth, H.B.4
  • 160
    • 72449164409 scopus 로고    scopus 로고
    • Transport mechanism of a bacterial homologue of glutamate transporters
    • Reyes, N., Ginter, C., and Boudker, O. (2009). Transport mechanism of a bacterial homologue of glutamate transporters. Nature 462, 880-885. doi: 10.1038/nature08616
    • (2009) Nature , vol.462 , pp. 880-885
    • Reyes, N.1    Ginter, C.2    Boudker, O.3
  • 161
    • 84895071580 scopus 로고    scopus 로고
    • Control of glutamine metabolism by the tumor suppressor Rb
    • Reynolds, M. R., Lane, A. N., Robertson, B., Kemp, S., Liu, Y., Hill, B. G., et al. (2014). Control of glutamine metabolism by the tumor suppressor Rb. Oncogene 33, 556-566. doi: 10.1038/onc.2012.635
    • (2014) Oncogene , vol.33 , pp. 556-566
    • Reynolds, M.R.1    Lane, A.N.2    Robertson, B.3    Kemp, S.4    Liu, Y.5    Hill, B.G.6
  • 162
    • 34247327455 scopus 로고    scopus 로고
    • The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury
    • Rooney, J. P. (2007). The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury. Toxi colog y 234, 145-156. doi: 10.1016/j.tox.2007.02.016
    • (2007) Toxi colog y , vol.234 , pp. 145-156
    • Rooney, J.P.1
  • 163
    • 84896804967 scopus 로고    scopus 로고
    • Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc
    • Rosell, A.,Meury,M., Alvarez-Marimon, E., Costa,M., Perez-Cano, L., Zorzano, A., et al. (2014). Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc. Proc. Natl. Acad. Sci. U.S.A. 111, 2966-2971. doi: 10.1073/pnas.1323779111
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 2966-2971
    • Rosell, A.1    Meury, M.2    Alvarez-Marimon, E.3    Costa, M.4    Perez-Cano, L.5    Zorzano, A.6
  • 164
    • 84855718118 scopus 로고    scopus 로고
    • Na-glutamine co-transporters B(0)AT1 in villus and SN2 in crypts are differentially altered in chronically infiamed rabbit intestine
    • Saha, P., Arthur, S., Kekuda, R., and Sundaram, U. (2012). Na-glutamine co-transporters B(0)AT1 in villus and SN2 in crypts are differentially altered in chronically infiamed rabbit intestine. Biochim. Biophys. Acta 1818, 434-442. doi: 10.1016/j.bbamem.2011.11.005
    • (2012) Biochim. Biophys. Acta , vol.1818 , pp. 434-442
    • Saha, P.1    Arthur, S.2    Kekuda, R.3    Sundaram, U.4
  • 165
    • 0027136282 scopus 로고
    • Comparative protein modelling by satisfaction of spatial restraints
    • Sali, A., and Blundell, T. L. (1993). Comparative protein modelling by satisfaction of spatial restraints. J. Mol. Biol. 234, 779-815. doi: 10.1006/jmbi.1993.1626
    • (1993) J. Mol. Biol. , vol.234 , pp. 779-815
    • Sali, A.1    Blundell, T.L.2
  • 166
    • 0024828485 scopus 로고
    • Glutamine transport in submitochondrial particles
    • Sastrasinh, S., and Sastrasinh, M. (1989). Glutamine transport in submitochondrial particles. Am.J.Physiol. 257, F1050-F1058.
    • (1989) Am.J.Physiol , vol.257 , pp. F1050-F1058
    • Sastrasinh, S.1    Sastrasinh, M.2
  • 167
    • 33645242182 scopus 로고    scopus 로고
    • Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations
    • Savas, S., Schmidt, S., Jarjanazi, H., and Ozcelik, H. (2006). Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations. Hum. Genomics 2, 287-296. doi: 10.1186/1479-7364-2-5-287
    • (2006) Hum. Genomics , vol.2 , pp. 287-296
    • Savas, S.1    Schmidt, S.2    Jarjanazi, H.3    Ozcelik, H.4
  • 168
    • 84884741685 scopus 로고    scopus 로고
    • Proteoliposomes as tool for assaying membrane transporter functions and interactions with xenobiotics
    • Scalise, M., Pochini, L., Giangregorio, N., Tonazzi, A., and Indiveri, C. (2013). Proteoliposomes as tool for assaying membrane transporter functions and interactions with xenobiotics. Pharmaceutics 5, 472-497. doi: 10.3390/pharma-ceutics5030472
    • (2013) Pharmaceutics , vol.5 , pp. 472-497
    • Scalise, M.1    Pochini, L.2    Giangregorio, N.3    Tonazzi, A.4    Indiveri, C.5
  • 169
    • 84875161720 scopus 로고    scopus 로고
    • Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects
    • Schioth, H. B., Roshanbin, S., Hagglund, M. G., and Fredriksson, R. (2013). Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol. Aspects Med. 34, 571-585. doi: 10.1016/j.mam.2012.07.012
    • (2013) Mol. Aspects Med. , vol.34 , pp. 571-585
    • Schioth, H.B.1    Roshanbin, S.2    Hagglund, M.G.3    Fredriksson, R.4
  • 170
    • 33947520707 scopus 로고    scopus 로고
    • Heterologous expression of the glutamine transporter SNAT3 in Xenopus oocytes is associated with four modes of uncoupled transport
    • Schneider, H. P., Broer, S., Broer, A., and Deitmer, J. W. (2007). Heterologous expression of the glutamine transporter SNAT3 in Xenopus oocytes is associated with four modes of uncoupled transport. J. Biol. Chem. 282, 3788-3798. doi: 10.1074/jbc.M609452200
    • (2007) J. Biol. Chem. , vol.282 , pp. 3788-3798
    • Schneider, H.P.1    Broer, S.2    Broer, A.3    Deitmer, J.W.4
  • 171
    • 84918829013 scopus 로고    scopus 로고
    • L-type amino acid transporter 1 expression is highly correlated with Gleason score in prostate cancer
    • Segawa, A., Nagamori, S., Kanai, Y., Masawa, N., and Oyama, T. (2013). L-type amino acid transporter 1 expression is highly correlated with Gleason score in prostate cancer. Mol. Clin. Oncol. 1, 274-280. doi: 10.3892/mco. 2012.54
    • (2013) Mol. Clin. Oncol. , vol.1 , pp. 274-280
    • Segawa, A.1    Nagamori, S.2    Kanai, Y.3    Masawa, N.4    Oyama, T.5
  • 172
    • 0033538560 scopus 로고    scopus 로고
    • Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity
    • Segawa, H., Fukasawa, Y., Miyamoto, K., Takeda, E., Endou, H., and Kanai, Y. (1999). Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity. J. Biol. Chem. 274, 19745-19751. doi: 10.1074/jbc.274.28.19745
    • (1999) J. Biol. Chem. , vol.274 , pp. 19745-19751
    • Segawa, H.1    Fukasawa, Y.2    Miyamoto, K.3    Takeda, E.4    Endou, H.5    Kanai, Y.6
  • 173
    • 4444377675 scopus 로고    scopus 로고
    • Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19
    • Seow, H. F., Broer, S., Broer, A., Bailey, C. G., Potter, S. J., Cavanaugh, J. A., et al. (2004). Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19. Nat. Genet. 36, 1003-1007. doi: 10.1038/ng1406
    • (2004) Nat. Genet. , vol.36 , pp. 1003-1007
    • Seow, H.F.1    Broer, S.2    Broer, A.3    Bailey, C.G.4    Potter, S.J.5    Cavanaugh, J.A.6
  • 174
    • 69249116947 scopus 로고    scopus 로고
    • Structure and mechanism of a Na+-independent amino acid transporter
    • Shaffer, P. L., Goehring, A., Shankaranarayanan, A., and Gouaux, E. (2009). Structure and mechanism of a Na+-independent amino acid transporter. Science 325, 1010-1014. doi: 10.1126/science.1176088
    • (2009) Science , vol.325 , pp. 1010-1014
    • Shaffer, P.L.1    Goehring, A.2    Shankaranarayanan, A.3    Gouaux, E.4
  • 175
    • 79955764625 scopus 로고    scopus 로고
    • Glutamine: pleiotropic roles in tumor growth and stress resistance
    • Shanware, N. P., Mullen, A. R., Deberardinis, R. J., and Abraham, R. T. (2011). Glutamine: pleiotropic roles in tumor growth and stress resistance. J. Mol.Med. (Berl) 89, 229-236. doi: 10.1007/s00109-011-0731-9
    • (2011) J. Mol.Med. (Berl) , vol.89 , pp. 229-236
    • Shanware, N.P.1    Mullen, A.R.2    Deberardinis, R.J.3    Abraham, R.T.4
  • 176
    • 84878337374 scopus 로고    scopus 로고
    • Downregulation of L-type amino acid transporter 1 expression inhibits the growth, migration and invasion of gastric cancer cells
    • Shi, L., Luo, W., Huang, W., Huang, S., and Huang, G. (2013). Downregulation of L-type amino acid transporter 1 expression inhibits the growth, migration and invasion of gastric cancer cells. Oncol. Lett. 6, 106-112. doi: 10.3892/ol.2013.1342
    • (2013) Oncol. Lett. , vol.6 , pp. 106-112
    • Shi, L.1    Luo, W.2    Huang, W.3    Huang, S.4    Huang, G.5
  • 177
    • 80055081131 scopus 로고    scopus 로고
    • Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein
    • Shi, Q., Padmanabhan, R., Villegas, C. J., Gu, S., and Jiang, J. X. (2011). Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein. J. Biol. Chem. 286, 38086-38094. doi: 10.1074/jbc.M111.220277
    • (2011) J. Biol. Chem. , vol.286 , pp. 38086-38094
    • Shi, Q.1    Padmanabhan, R.2    Villegas, C.J.3    Gu, S.4    Jiang, J.X.5
  • 178
    • 84901823650 scopus 로고    scopus 로고
    • ASC amino-acid transporter 2 (ASCT2) as a novel prognostic marker in non-small cell lung cancer
    • Shimizu, K., Kaira, K., Tomizawa, Y., Sunaga, N., Kawashima, O., Oriuchi, N., et al. (2014). ASC amino-acid transporter 2 (ASCT2) as a novel prognostic marker in non-small cell lung cancer. Br. J. Cancer 110, 2030-2039. doi: 10.1038/bjc.2014.88
    • (2014) Br. J. Cancer , vol.110 , pp. 2030-2039
    • Shimizu, K.1    Kaira, K.2    Tomizawa, Y.3    Sunaga, N.4    Kawashima, O.5    Oriuchi, N.6
  • 179
    • 1842451798 scopus 로고    scopus 로고
    • Increased expression of a glutamine transporter SNAT3 is a marker ofmalignant gliomas
    • Sidoryk, M., Matyja, E., Dybel, A., Zielinska, M., Bogucki, J., Jaskolski, D. J., et al. (2004). Increased expression of a glutamine transporter SNAT3 is a marker ofmalignant gliomas. Neuroreport 15, 575-578. doi: 10.1097/00001756-200403220-00001
    • (2004) Neuroreport , vol.15 , pp. 575-578
    • Sidoryk, M.1    Matyja, E.2    Dybel, A.3    Zielinska, M.4    Bogucki, J.5    Jaskolski, D.J.6
  • 180
    • 0037216281 scopus 로고    scopus 로고
    • Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal
    • Sloan, J. L., Grubb, B. R., and Mager, S. (2003). Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal. Am. J. Physiol. Lung Cell. Mol. Physiol. 284, L39-L49. doi: 10.1152/ajplung.001 64.2002
    • (2003) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.284 , pp. L39-L49
    • Sloan, J.L.1    Grubb, B.R.2    Mager, S.3
  • 181
    • 0033588179 scopus 로고    scopus 로고
    • Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+)
    • Sloan, J. L., and Mager, S. (1999). Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+). J. Biol. Chem. 274, 23740-23745. doi: 10.1074/jbc.274.34.23740
    • (1999) J. Biol. Chem. , vol.274 , pp. 23740-23745
    • Sloan, J.L.1    Mager, S.2
  • 182
    • 84857084876 scopus 로고    scopus 로고
    • SAT1, A Glutamine transporter, is preferentially expressed in GABAergic neurons.
    • Solbu, T. T., Bjorkmo, M., Berghuis, P., Harkany, T., and Chaudhry, F. A. (2010). SAT1, A Glutamine transporter, is preferentially expressed in GABAergic neurons. Front. Neuroanat. 4:1. doi: 10.3389/neuro.05.001.2010
    • (2010) Front. Neuroanat , vol.4 , pp. 1
    • Solbu, T.T.1    Bjorkmo, M.2    Berghuis, P.3    Harkany, T.4    Chaudhry, F.A.5
  • 183
    • 84875894714 scopus 로고    scopus 로고
    • Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
    • Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., et al. (2013). Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature 496, 101-105. doi: 10.1038/nature12040
    • (2013) Nature , vol.496 , pp. 101-105
    • Son, J.1    Lyssiotis, C.A.2    Ying, H.3    Wang, X.4    Hua, S.5    Ligorio, M.6
  • 184
    • 0026480222 scopus 로고
    • Kinetics of the sodium-dependent glutamine transporter in human intestinal cell confiuent monolayers
    • Souba, W. W., Pan, M., and Stevens, B. R. (1992). Kinetics of the sodium-dependent glutamine transporter in human intestinal cell confiuent monolayers. Biochem. Biophys. Res. Commun. 188, 746-753. doi: 10.1016/0006-291X(92) 91119-B
    • (1992) Biochem. Biophys. Res. Commun. , vol.188 , pp. 746-753
    • Souba, W.W.1    Pan, M.2    Stevens, B.R.3
  • 185
    • 0032988976 scopus 로고    scopus 로고
    • Role of glutamine in human carbohydrate metabolism in kidney and other tissues
    • Stumvoll, M., Perriello, G., Meyer, C., and Gerich, J. (1999). Role of glutamine in human carbohydrate metabolism in kidney and other tissues. Kidney Int. 55, 778-792. doi: 10.1046/j.1523-1755.1999.055003778.x
    • (1999) Kidney Int. , vol.55 , pp. 778-792
    • Stumvoll, M.1    Perriello, G.2    Meyer, C.3    Gerich, J.4
  • 186
    • 49849090426 scopus 로고    scopus 로고
    • The evolutionary history and tissue mapping of amino acid transporters belonging to solute carrier families SLC32, SLC36, and SLC38
    • Sundberg, B. E.,Waag, E., Jacobsson, J. A., Stephansson, O., Rumaks, J., Svirskis, S., et al. (2008). The evolutionary history and tissue mapping of amino acid transporters belonging to solute carrier families SLC32, SLC36, and SLC38. J. Mol. Neurosci. 35, 179-193. doi: 10.1007/s12031-008-9046-x
    • (2008) J. Mol. Neurosci. , vol.35 , pp. 179-193
    • Sundberg, B.E.1    Waag, E.2    Jacobsson, J.A.3    Stephansson, O.4    Rumaks, J.5    Svirskis, S.6
  • 187
    • 0037376971 scopus 로고    scopus 로고
    • Chemical modification of the mitochondrial ornithine/citrulline carrier by SH reagents: effects on the transport activity and transition from carrier to pore-like function
    • Tonazzi, A., and Indiveri, C. (2003). Chemical modification of the mitochondrial ornithine/citrulline carrier by SH reagents: effects on the transport activity and transition from carrier to pore-like function. Biochim. Biophys. Acta 1611, 123-130. doi: 10.1016/S0005-2736(03)00033-6
    • (2003) Biochim. Biophys. Acta , vol.1611 , pp. 123-130
    • Tonazzi, A.1    Indiveri, C.2
  • 188
    • 83555174345 scopus 로고    scopus 로고
    • Effects of heavy metal cations on the mitochondrial ornithine/citrulline transporter reconstituted in liposomes
    • Tonazzi, A., and Indiveri, C. (2011). Effects of heavy metal cations on the mitochondrial ornithine/citrulline transporter reconstituted in liposomes. Biometals 24, 1205-1215. doi: 10.1007/s10534-011-9479-5
    • (2011) Biometals , vol.24 , pp. 1205-1215
    • Tonazzi, A.1    Indiveri, C.2
  • 189
    • 80255129380 scopus 로고    scopus 로고
    • Human FAD synthase (isoform 2): a component of the machinery that delivers FAD to apo-flavoproteins
    • Torchetti, E. M., Bonomi, F., Galluccio, M., Gianazza, E., Giancaspero, T. A., Iametti, S., et al. (2011). Human FAD synthase (isoform 2): a component of the machinery that delivers FAD to apo-flavoproteins. FEBS J. 278, 4434-4449. doi: 10.1111/j.1742-4658.2011.08368.x
    • (2011) FEBS J. , vol.278 , pp. 4434-4449
    • Torchetti, E.M.1    Bonomi, F.2    Galluccio, M.3    Gianazza, E.4    Giancaspero, T.A.5    Iametti, S.6
  • 190
    • 0032576974 scopus 로고    scopus 로고
    • Sodium-dependent homo-and hetero-exchange of neutral amino acids mediated by the amino acid transporter ATB degree
    • Torres-Zamorano, V., Leibach, F. H., and Ganapathy, V. (1998). Sodium-dependent homo-and hetero-exchange of neutral amino acids mediated by the amino acid transporter ATB degree. Biochem. Biophys. Res. Commun. 245, 824-829. doi: 10.1006/bbrc.1998.8434
    • (1998) Biochem. Biophys. Res. Commun. , vol.245 , pp. 824-829
    • Torres-Zamorano, V.1    Leibach, F.H.2    Ganapathy, V.3
  • 191
    • 0029888341 scopus 로고    scopus 로고
    • Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter
    • Utsunomiya-Tate, N., Endou, H., and Kanai, Y. (1996). Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter. J. Biol. Chem. 271, 14883-14890. doi: 10.1074/jbc.271.25.14883
    • (1996) J. Biol. Chem. , vol.271 , pp. 14883-14890
    • Utsunomiya-Tate, N.1    Endou, H.2    Kanai, Y.3
  • 192
    • 80052242132 scopus 로고    scopus 로고
    • Targeting cancer metabolism: a therapeutic window opens
    • Vander Heiden, M. G. (2011). Targeting cancer metabolism: a therapeutic window opens. Nat. Rev. Drug Discov. 10, 671-684. doi: 10.1038/nrd3504
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 671-684
    • Vander Heiden, M.G.1
  • 193
    • 66249108601 scopus 로고    scopus 로고
    • Understanding theWarburg effect: themetabolic requirements of cell proliferation
    • Vander Heiden,M. G., Cantley, L. C., and Thompson, C. B. (2009). Understanding theWarburg effect: themetabolic requirements of cell proliferation. Science 324, 1029-1033. doi: 10.1126/science.1160809
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 194
    • 0037291723 scopus 로고    scopus 로고
    • System L: heteromeric exchangers of large, neutral amino acids involved in directional transport
    • Verrey, F. (2003). System L: heteromeric exchangers of large, neutral amino acids involved in directional transport. Pfiugers Arch. 445, 529-533. doi: 10.1007/s00424-002-0973-z
    • (2003) Pfiugers Arch. , vol.445 , pp. 529-533
    • Verrey, F.1
  • 195
    • 1342281232 scopus 로고    scopus 로고
    • CATs and HATs: the SLC7 family of aminoacid transporters
    • Verrey, F., Closs, E. I., Wagner, C. A., Palacin, M., Endou, H., and Kanai, Y. (2004). CATs and HATs: the SLC7 family of aminoacid transporters. Pfiugers Arch. 447, 532-542. doi: 10.1007/s00424-003-1086-z
    • (2004) Pfiugers Arch. , vol.447 , pp. 532-542
    • Verrey, F.1    Closs, E.I.2    Wagner, C.A.3    Palacin, M.4    Endou, H.5    Kanai, Y.6
  • 198
    • 0034796442 scopus 로고    scopus 로고
    • Function and structure of heterodimeric amino acid transporters
    • Wagner, C. A., Lang, F., and Broer, S. (2001). Function and structure of heterodimeric amino acid transporters. Am.J.Physiol.CellPhysiol. 281, C1077-C1093.
    • (2001) Am.J.Physiol.CellPhysiol. , vol.281 , pp. C1077-C1093
    • Wagner, C.A.1    Lang, F.2    Broer, S.3
  • 199
    • 85009144960 scopus 로고    scopus 로고
    • Insulin increases mRNA abundance of the amino acid transporter SLC7A5/LAT1 via an mTORC1-dependent mechanism in skeletal muscle cells
    • Walker, D. K., Drummond, M. J., Dickinson, J. M., Borack, M. S., Jennings, K., Volpi, E., et al. (2014). Insulin increases mRNA abundance of the amino acid transporter SLC7A5/LAT1 via an mTORC1-dependent mechanism in skeletal muscle cells. Physiol. Rep. 2, e00238. doi: 10.1002/phy2.238
    • (2014) Physiol. Rep. , vol.2
    • Walker, D.K.1    Drummond, M.J.2    Dickinson, J.M.3    Borack, M.S.4    Jennings, K.5    Volpi, E.6
  • 200
    • 84880017125 scopus 로고    scopus 로고
    • Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression.
    • Wang, K., Cao, F., Fang, W., Hu, Y., Chen, Y., Ding, H., et al. (2013). Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpres-sion. BMC Cancer 13:343. doi: 10.1186/1471-2407-13-343
    • (2013) BMC Cancer , vol.13 , pp. 343
    • Wang, K.1    Cao, F.2    Fang, W.3    Hu, Y.4    Chen, Y.5    Ding, H.6
  • 201
    • 0036080341 scopus 로고    scopus 로고
    • Characterization of L-glutamine transport by a human neuroblastoma cell line
    • Wasa, M., Wang, H. S., and Okada, A. (2002). Characterization of L-glutamine transport by a human neuroblastoma cell line. Am.J.Physiol.CellPhysiol. 282, C1246-C1253. doi: 10.1152/ajpcell.00324.2001
    • (2002) Am.J.Physiol.CellPhysiol , vol.282 , pp. C1246-C1253
    • Wasa, M.1    Wang, H.S.2    Okada, A.3
  • 202
    • 84900436147 scopus 로고    scopus 로고
    • L-type amino acid transporter 1 expression increases in well-differentiated but decreases in poorly differentiated endometrial endometrioid adenocarcinoma and shows an inverse correlation with p53 expression
    • Watanabe, J., Yokoyama, Y., Futagami, M., Mizunuma, H., Yoshioka, H., Washiya, K., et al. (2014). L-type amino acid transporter 1 expression increases in well-differentiated but decreases in poorly differentiated endometrial endometrioid adenocarcinoma and shows an inverse correlation with p53 expression. Int. J. Gynecol. Cancer 24, 659-663. doi: 10.1097/IGC.0000000000000123
    • (2014) Int. J. Gynecol. Cancer , vol.24 , pp. 659-663
    • Watanabe, J.1    Yokoyama, Y.2    Futagami, M.3    Mizunuma, H.4    Yoshioka, H.5    Washiya, K.6
  • 203
    • 0036765406 scopus 로고    scopus 로고
    • Overexpression of the neutral amino acid transporter ASCT2 in human colorectal adenocarcinoma
    • Witte, D., Ali, N., Carlson, N., and Younes, M. (2002). Overexpression of the neutral amino acid transporter ASCT2 in human colorectal adenocarcinoma. Anticancer Res. 22, 2555-2557.
    • (2002) Anticancer Res. , vol.22 , pp. 2555-2557
    • Witte, D.1    Ali, N.2    Carlson, N.3    Younes, M.4
  • 204
    • 24044511771 scopus 로고    scopus 로고
    • Metabolic activation-related CD147-CD98 complex.
    • Xu, D., and Hemler,M. E. (2005).Metabolic activation-related CD147-CD98 complex. Mol. Cell. Proteomics 4, 1061-1071. doi: 10.1074/mcp.M400207-MCP200
    • (2005) Mol. Cell. Proteomics , vol.4 , pp. 1061-1071
    • Xu, D.1    Hemler, M.E.2
  • 205
    • 24644470065 scopus 로고    scopus 로고
    • Crystal structure of a bacterial homologue of Na+/Cl-dependent neurotransmitter transporters
    • Yamashita, A., Singh, S. K., Kawate, T., Jin, Y., and Gouaux, E. (2005). Crystal structure of a bacterial homologue of Na+/Cl-dependent neurotransmitter transporters. Nature 437, 215-223. doi: 10.1038/nature03978
    • (2005) Nature , vol.437 , pp. 215-223
    • Yamashita, A.1    Singh, S.K.2    Kawate, T.3    Jin, Y.4    Gouaux, E.5
  • 206
    • 84867904232 scopus 로고    scopus 로고
    • High expression of L-type amino acid transporter 1 (LAT1) predicts poor prognosis in pancreatic ductal adenocarcinomas
    • Yanagisawa, N., Ichinoe, M., Mikami, T., Nakada, N., Hana, K., Koizumi, W., et al. (2012). High expression of L-type amino acid transporter 1 (LAT1) predicts poor prognosis in pancreatic ductal adenocarcinomas. J. Clin. Pathol. 65, 1019-1023. doi: 10.1136/jclinpath-2012-200826
    • (2012) J. Clin. Pathol. , vol.65 , pp. 1019-1023
    • Yanagisawa, N.1    Ichinoe, M.2    Mikami, T.3    Nakada, N.4    Hana, K.5    Koizumi, W.6
  • 207
    • 7244254186 scopus 로고    scopus 로고
    • Structure of a glutamate transporter homologue from Pyrococcus horikoshii
    • Yernool, D., Boudker, O., Jin, Y., and Gouaux, E. (2004). Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature 431, 811-818. doi: 10.1038/nature03018
    • (2004) Nature , vol.431 , pp. 811-818
    • Yernool, D.1    Boudker, O.2    Jin, Y.3    Gouaux, E.4
  • 208
    • 18044375547 scopus 로고    scopus 로고
    • Amino acid transport system L is differently expressed in human normal oral keratinocytes and human oral cancer cells
    • Yoon, J. H., Kim, I. J., Kim, H., Kim, H. J., Jeong, M. J., Ahn, S. G., et al. (2005). Amino acid transport system L is differently expressed in human normal oral keratinocytes and human oral cancer cells. Cancer Lett. 222, 237-245. doi: 10.1016/j.canlet.2004.09.040
    • (2005) Cancer Lett. , vol.222 , pp. 237-245
    • Yoon, J.H.1    Kim, I.J.2    Kim, H.3    Kim, H.J.4    Jeong, M.J.5    Ahn, S.G.6
  • 209
    • 84878576023 scopus 로고    scopus 로고
    • Voltage-dependent processes in the electroneutral amino acid exchanger ASCT2
    • Zander, C. B., Albers, T., and Grewer, C. (2013). Voltage-dependent processes in the electroneutral amino acid exchanger ASCT2. J. Gen. Physiol. 141, 659-672. doi: 10.1085/jgp.201210948
    • (2013) J. Gen. Physiol. , vol.141 , pp. 659-672
    • Zander, C.B.1    Albers, T.2    Grewer, C.3
  • 210
    • 69949166501 scopus 로고    scopus 로고
    • A conserved Na(+) binding site of the sodium-coupled neutral amino acid transporter 2 (SNAT2)
    • Zhang, Z., Albers, T., Fiumera, H. L., Gameiro, A., and Grewer, C. (2009). A conserved Na(+) binding site of the sodium-coupled neutral amino acid transporter 2 (SNAT2). J. Biol. Chem. 284, 25314-25323. doi: 10.1074/jbc.M109. 038422
    • (2009) J. Biol. Chem. , vol.284 , pp. 25314-25323
    • Zhang, Z.1    Albers, T.2    Fiumera, H.L.3    Gameiro, A.4    Grewer, C.5


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