The SLC3 and SLC7 families of amino acid transporters

Molecular Aspects of Medicine

Volumn 34, Issue 2-3, 2013, Pages 139-158

  Fotiadis, Dimitrios ^a   Kanai, Yoshikatsu ^b   Palacín, Manuel ^c  

^a UNIVERSITY OF BERN   (Switzerland)

^b OSAKA UNIVERSITY   (Japan)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Aminoacidurias; Cancer; Cationic amino acid transporter; Heteromeric amino acid transporter; L Type amino acid transporter; SLC3; SLC7

Indexed keywords

AMINO ACID TRANSPORTER; PROTEIN SLC3; PROTEIN SLC7; UNCLASSIFIED DRUG;

AMINOACIDURIA; BINDING AFFINITY; CANCER CELL; CELL SURVIVAL; CELL VIABILITY; GENE MUTATION; GENETIC DISORDER; HUMAN; MACROPHAGE ACTIVATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PHENOTYPE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; REVIEW; TUMOR GROWTH; UPREGULATION;

AMINO ACID TRANSPORT SYSTEMS, BASIC; AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; BIOLOGICAL TRANSPORT; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MULTIGENE FAMILY; NEOPLASMS; PHYLOGENY; PROTEIN CONFORMATION;

EID: 84875190864     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2012.10.007     Document Type: Review

References (189)

1. D.A. Baker, K. McFarland, R.W. Lake, H. Shen, X.C. Tang, S. Toda, and P.W. Kalivas Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse Nat. Neurosci. 6 7 2003 743 749
2. A. Barilli, B.M. Rotoli, R. Visigalli, O. Bussolati, G.C. Gazzola, Z. Kadija, G. Rodi, F. Mariani, M.L. Ruzza, M. Luisetti, and V. Dall'Asta In lysinuric protein intolerance system y+L activity is defective in monocytes and in GM-CSF-differentiated macrophages Orphanet J. Rare Dis. 5 2010 32
3. P. Bartoccioni, C. Del Rio, M. Ratera, L. Kowalczyk, J.M. Baldwin, A. Zorzano, M. Quick, S.A. Baldwin, J.L. Vazquez-Ibar, and M. Palacin Role of transmembrane domain 8 in substrate selectivity and translocation of SteT, a member of the l-amino acid transporter (LAT) family J. Biol. Chem. 285 37 2010 28764 28776
4. P. Bartoccioni, M. Rius, A. Zorzano, M. Palacin, and J. Chillaron Distinct classes of trafficking rBAT mutants cause the type I cystinuria phenotype Hum. Mol. Genet. 17 12 2008 1845 1854
5. - Pflugers Arch. 442 2 2001 286 296
6. C. Bauch, N. Forster, D. Loffing-Cueni, V. Summa, and F. Verrey Functional cooperation of epithelial heteromeric amino acid transporters expressed in Madin-Darby canine kidney cells J. Biol. Chem. 278 2 2003 1316 1322
7. C. Bauch, and F. Verrey Apical heterodimeric cystine and cationic amino acid transporter expressed in MDCK cells Am. J. Physiol. Renal Physiol. 283 1 2002 F181 F189
8. E. Beitz T(E)Xtopo: shaded membrane protein topology plots in LAT(E)X2epsilon Bioinformatics 16 11 2000 1050 1051
9. J. Bertran, A. Werner, M.L. Moore, G. Stange, D. Markovich, J. Biber, X. Testar, A. Zorzano, M. Palacin, and H. Murer Expression cloning of a cDNA from rabbit kidney cortex that induces a single transport system for cystine and dibasic and neutral amino acids Proc. Natl. Acad. Sci. USA 89 12 1992 5601 5605
10. S.N. Bhattacharyya, R. Habermacher, U. Martine, E.I. Closs, and W. Filipowicz Relief of microRNA-mediated translational repression in human cells subjected to stress Cell 125 6 2006 1111 1124
11. S.N. Bhattacharyya, R. Habermacher, U. Martine, E.I. Closs, and W. Filipowicz Stress-induced reversal of microRNA repression and mRNA P-body localization in human cells Cold Spring Harb. Symp. Quant. Biol. 71 2006 513 521
12. G. Borsani, M.T. Bassi, M.P. Sperandeo, A. De Grandi, A. Buoninconti, M. Riboni, M. Manzoni, B. Incerti, A. Pepe, G. Andria, A. Ballabio, and G. Sebastio SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance Nat. Genet. 21 3 1999 297 301
13. D. Braun, E.K. Wirth, F. Wohlgemuth, N. Reix, M.O. Klein, A. Gruters, J. Kohrle, and U. Schweizer Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8 Biochem. J. 439 2 2011 249 255
14. C.C. Bridges, R. Kekuda, H. Wang, P.D. Prasad, P. Mehta, W. Huang, S.B. Smith, and V. Ganapathy Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells Invest. Ophthalmol. Vis. Sci. 42 1 2001 47 54
15. - cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS Br. J. Pharmacol. 165 1 2012 20 34
16. A. Broer, N. Brookes, V. Ganapathy, K.S. Dimmer, C.A. Wagner, F. Lang, and S. Broer The astroglial ASCT2 amino acid transporter as a mediator of glutamine efflux J. Neurochem. 73 5 1999 2184 2194
17. A. Broer, C.A. Wagner, F. Lang, and S. Broer The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine Biochem. J. 349 3 2000 787 795
18. S. Broer, and M. Palacin The role of amino acid transporters in inherited and acquired diseases Biochem. J. 436 2 2011 193 211
19. A.E. Busch, T. Herzer, S. Waldegger, F. Schmidt, M. Palacin, J. Biber, D. Markovich, H. Murer, and F. Lang Opposite directed currents induced by the transport of dibasic and neutral amino acids in Xenopus oocytes expressing the protein rBAT J. Biol. Chem. 269 41 1994 25581 25586
20. M.J. Calonge, P. Gasparini, J. Chillaron, M. Chillon, M. Gallucci, F. Rousaud, L. Zelante, X. Testar, B. Dallapiccola, F. Di Silverio, P. Barceló, X. Estivill, A. Zorzano, V. Nunes, and M. Palacín Cystinuria caused by mutations in rBAT, a gene involved in the transport of cystine Nat. Genet. 6 4 1994 420 425
21. J. Cantor, C.D. Browne, R. Ruppert, C.C. Feral, R. Fassler, R.C. Rickert, and M.H. Ginsberg CD98hc facilitates B cell proliferation and adaptive humoral immunity Nat. Immunol. 10 4 2009 412 419
22. F. Casals, A. Ferrer-Admetlla, J. Chillaron, D. Torrents, M. Palacin, and J. Bertranpetit Is there selection for the pace of successive inactivation of the arpAT gene in primates? J. Mol. Evol. 67 1 2008 23 28
23. A. Chairoungdua, Y. Kanai, H. Matsuo, J. Inatomi, D.K. Kim, and H. Endou Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain J. Biol. Chem. 276 52 2001 49390 49399
24. X. Chen, J. Lin, T. Kanekura, J. Su, W. Lin, H. Xie, Y. Wu, J. Li, M. Chen, and J. Chang A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma Cancer Res. 66 23 2006 11323 11330
25. J. Chillaron, R. Estevez, C. Mora, C.A. Wagner, H. Suessbrich, F. Lang, J.L. Gelpi, X. Testar, A.E. Busch, A. Zorzano, and M. Palacin Obligatory amino acid exchange via systems bo,+-like and y+L-like. A tertiary active transport mechanism for renal reabsorption of cystine and dibasic amino acids J. Biol. Chem. 271 30 1996 17761 17770
26. J. Chillaron, M. Font-Llitjos, J. Fort, A. Zorzano, D.S. Goldfarb, V. Nunes, and M. Palacin Pathophysiology and treatment of cystinuria Nat. Rev. Nephrol. 6 7 2010 424 434
27. J. Chillaron, R. Roca, A. Valencia, A. Zorzano, and M. Palacin Heteromeric amino acid transporters: biochemistry, genetics, and physiology Am. J. Physiol. Renal Physiol. 281 6 2001 F995 F1018
28. E.I. Closs Expression, regulation and function of carrier proteins for cationic amino acids Curr. Opin. Nephrol. Hypertens. 11 1 2002 99 107
29. E.I. Closs, J.P. Boissel, A. Habermeier, and A. Rotmann Structure and function of cationic amino acid transporters (CATs) J. Membr. Biol. 213 2 2006 67 77
30. M. Conrad, and H. Sato The oxidative stress-inducible cystine/glutamate antiporter, system x (c) (-): cystine supplier and beyond Amino Acids 42 1 2012 231 246
31. V. Dall'Asta, O. Bussolati, R. Sala, B.M. Rotoli, G. Sebastio, M.P. Sperandeo, G. Andria, and G.C. Gazzola Arginine transport through system y(+)l in cultured human fibroblasts: normal phenotype of cells from LPI subjects Am. J. Physiol. Cell Physiol. 279 6 2000 C1829 C1837
32. N.C. Danbolt Glutamate uptake Prog. Neurobiol. 65 1 2001 1 105
33. D. De Bundel, A. Schallier, E. Loyens, R. Fernando, H. Miyashita, J. Van Liefferinge, K. Vermoesen, S. Bannai, H. Sato, Y. Michotte, I. Smolders, and A. Massie Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility J. Neurosci. 31 15 2011 5792 5803
34. D. Denoyer, L. Kirby, K. Waldeck, P. Roselt, O.C. Neels, T. Bourdier, R. Shepherd, A. Katsifis, and R.J. Hicks Preclinical characterization of 18F-D-FPHCys, a new amino acid-based PET tracer Eur. J. Nucl. Med. Mol. Imaging 39 15 2012 703 712
35. R. Deves, and C.A. Boyd Transporters for cationic amino acids in animal cells: discovery, structure, and function Physiol. Rev. 78 2 1998 487 545
36. T. Eggermann, M. Elbracht, F. Haverkamp, C. Schmidt, and K. Zerres Isolated cystinuria (OMIM 238200) is not a separate entity but is caused by a mutation in the cystinuria gene SLC7A9 Clin. Genet. 71 6 2007 597 598
37. X. Fan, D.D. Ross, H. Arakawa, V. Ganapathy, I. Tamai, and T. Nakanishi Impact of system l-amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with anti-proliferative aminopeptidase inhibitors Biochem. Pharmacol. 80 6 2010 811 818
38. Y. Fang, H. Jayaram, T. Shane, L. Kolmakova-Partensky, F. Wu, C. Williams, Y. Xiong, and C. Miller Structure of a prokaryotic virtual proton pump at 3.2 Å resolution Nature 460 7258 2009 1040 1043
39. L. Feliubadalo, M.L. Arbones, S. Manas, J. Chillaron, J. Visa, M. Rodes, F. Rousaud, A. Zorzano, M. Palacin, and V. Nunes Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis Hum. Mol. Genet. 12 17 2003 2097 2108
40. o,+AT) of rBAT Nat. Genet. 23 1 1999 52 57
41. C.A. Fenczik, R. Zent, M. Dellos, D.A. Calderwood, J. Satriano, C. Kelly, and M.H. Ginsberg Distinct domains of CD98hc regulate integrins and amino acid transport J. Biol. Chem. 276 12 2001 8746 8752
42. C.C. Feral, N. Nishiya, C.A. Fenczik, H. Stuhlmann, M. Slepak, and M.H. Ginsberg CD98hc (SLC3A2) mediates integrin signaling Proc. Natl. Acad. Sci. USA 102 2 2005 355 360
43. E. Fernandez, M. Jimenez-Vidal, M. Calvo, A. Zorzano, F. Tebar, M. Palacin, and J. Chillaron The structural and functional units of heteromeric amino acid transporters. The heavy subunit rBAT dictates oligomerization of the heteromeric amino acid transporters J. Biol. Chem. 281 36 2006 26552 26561
44. E. Fernandez, D. Torrents, J. Chillaron, R. Martin Del Rio, A. Zorzano, and M. Palacin Basolateral LAT-2 has a major role in the transepithelial flux of l-cystine in the renal proximal tubule cell line OK J. Am. Soc. Nephrol. 14 4 2003 837 847
45. E. Fernandez, D. Torrents, A. Zorzano, M. Palacin, and J. Chillaron Identification and functional characterization of a novel low affinity aromatic-preferring amino acid transporter (arpAT). One of the few proteins silenced during primate evolution J. Biol. Chem. 280 19 2005 19364 19372
46. P. Fogelstrand, C.C. Feral, R. Zargham, and M.H. Ginsberg Dependence of proliferative vascular smooth muscle cells on CD98hc (4F2hc, SLC3A2) J. Exp. Med. 206 11 2009 2397 2406
47. M.A. Font, L. Feliubadalo, X. Estivill, V. Nunes, E. Golomb, Y. Kreiss, E. Pras, L. Bisceglia, A.P. d'Adamo, L. Zelante, P. Gasparini, M.T. Bassi, A.L. George Jr.; M. Manzoni, M. Riboni, A. Ballabio, G. Borsani, N. Reig, E. Fernandez, A. Zorzano, J. Bertran, and M. Palacin Functional analysis of mutations in SLC7A9, and genotype-phenotype correlation in non-Type I cystinuria Hum. Mol. Genet. 10 4 2001 305 316
48. M. Font-Llitjos, M. Jimenez-Vidal, L. Bisceglia, M. Di Perna, L. de Sanctis, F. Rousaud, L. Zelante, M. Palacin, and V. Nunes New insights into cystinuria: 40 new mutations, genotype-phenotype correlation, and digenic inheritance causing partial phenotype J. Med. Genet. 42 1 2005 58 68
49. J. Fort, L.R. de la Ballina, H.E. Burghardt, C. Ferrer-Costa, J. Turnay, C. Ferrer-Orta, I. Uson, A. Zorzano, J. Fernandez-Recio, M. Orozco, M.A. Lizarbe, I. Fita, and M. Palacin The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane J. Biol. Chem. 282 43 2007 31444 31452
50. E.C. Friesema, R. Docter, E.P. Moerings, F. Verrey, E.P. Krenning, G. Hennemann, and T.J. Visser Thyroid hormone transport by the heterodimeric human system l-amino acid transporter Endocrinology 142 10 2001 4339 4348
51. B.C. Fuchs, and B.P. Bode Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime? Semin. Cancer Biol. 15 4 2005 254 266
52. B.C. Fuchs, R.E. Finger, M.C. Onan, and B.P. Bode ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells Am. J. Physiol. Cell Physiol. 293 1 2007 C55 C63
53. Y. Fukasawa, H. Segawa, J.Y. Kim, A. Chairoungdua, D.K. Kim, H. Matsuo, S.H. Cha, H. Endou, and Y. Kanai Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral d- and l-amino acids J. Biol. Chem. 275 13 2000 9690 9698
54. M. Furuya, J. Horiguchi, H. Nakajima, Y. Kanai, and T. Oyama Correlation of l-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis Cancer Sci. 103 2 2012 382 389
55. M. Gabrisko, and S. Janecek Looking for the ancestry of the heavy-chain subunits of heteromeric amino acid transporters rBAT and 4F2hc within the GH13 alpha-amylase family FEBS J. 276 24 2009 7265 7278
56. X. Gao, F. Lu, L. Zhou, S. Dang, L. Sun, X. Li, J. Wang, and Y. Shi Structure and mechanism of an amino acid antiporter Science 324 5934 2009 1565 1568
57. X. Gao, L. Zhou, X. Jiao, F. Lu, C. Yan, X. Zeng, J. Wang, and Y. Shi Mechanism of substrate recognition and transport by an amino acid antiporter Nature 463 7282 2010 828 832
58. - light subunit reveals a re-entrant loop with substrate-restricted accessibility J. Biol. Chem. 279 30 2004 31228 31236
59. C.E. Gleason, D. Lu, L.A. Witters, C.B. Newgard, and M.J. Birnbaum The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells J. Biol. Chem. 282 14 2007 10341 10351
60. W. Guo, Y. Zhao, Z. Zhang, N. Tan, F. Zhao, C. Ge, L. Liang, D. Jia, T. Chen, M. Yao, J. Li, and X. He Disruption of xCT inhibits cell growth via the ROS/autophagy pathway in hepatocellular carcinoma Cancer Lett. 312 1 2011 55 61
61. D.M. Gwinn, D.B. Shackelford, D.F. Egan, M.M. Mihaylova, A. Mery, D.S. Vasquez, B.E. Turk, and R.J. Shaw AMPK phosphorylation of raptor mediates a metabolic checkpoint Mol. Cell 30 2 2008 214 226
62. A. Habermeier, S. Wolf, U. Martine, P. Graf, and E.I. Closs Two amino acid residues determine the low substrate affinity of human cationic amino acid transporter-2A J. Biol. Chem. 278 21 2003 19492 19499
63. A.P. Halestrap, and D. Meredith The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond Pflugers Arch. 447 5 2004 619 628
64. I.A. Hansen, D.Y. Boudko, S.H. Shiao, D.A. Voronov, E.A. Meleshkevitch, L.L. Drake, S.E. Aguirre, J.M. Fox, G.M. Attardo, and A.S. Raikhel AaCAT1 of the yellow fever mosquito, Aedes aegypti: a novel histidine-specific amino acid transporter from the SLC7 family J. Biol. Chem. 286 12 2011 10803 10813
65. A. Hashimoto, and T. Oka Free d-aspartate and d-serine in the mammalian brain and periphery Prog. Neurobiol. 52 4 1997 325 353
66. M. Hatzoglou, J. Fernandez, I. Yaman, and E. Closs Regulation of cationic amino acid transport: the story of the CAT-1 transporter Annu. Rev. Nutr. 24 2004 377 399
67. M.A. Hediger, M.F. Romero, J.B. Peng, A. Rolfs, H. Takanaga, and E.A. Bruford The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins Pflugers Arch. 447 5 2004 465 468
68. L. Helboe, J. Egebjerg, M. Moller, and C. Thomsen Distribution and pharmacology of alanine-serine-cysteine transporter 1 (asc-1) in rodent brain Eur. J. Neurosci. 18 8 2003 2227 2238
69. N.C. Henderson, E.A. Collis, A.C. Mackinnon, K.J. Simpson, C. Haslett, R. Zent, M. Ginsberg, and T. Sethi CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation J. Biol. Chem. 279 52 2004 54731 54741
70. M. Ichinoe, T. Mikami, T. Yoshida, I. Igawa, T. Tsuruta, N. Nakada, N. Anzai, Y. Suzuki, H. Endou, and I. Okayasu High expression of l-type amino-acid transporter 1 (LAT1) in gastric carcinomas: comparison with non-cancerous lesions Pathol. Int. 61 5 2011 281 289
71. H. Imai, K. Kaira, N. Oriuchi, K. Shimizu, H. Tominaga, N. Yanagitani, N. Sunaga, T. Ishizuka, S. Nagamori, K. Promchan, T. Nakajima, N. Yamamoto, M. Mori, and Y. Kanai Inhibition of l-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer Anticancer Res. 30 12 2010 4819 4828
72. T. Ishii, K. Itoh, S. Takahashi, H. Sato, T. Yanagawa, Y. Katoh, S. Bannai, and M. Yamamoto Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages J. Biol. Chem. 275 21 2000 16023 16029
73. K. Ito, and M. Groudine A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain J. Biol. Chem. 272 42 1997 26780 26786
74. Y. Iuchi, N. Kibe, S. Tsunoda, F. Okada, S. Bannai, H. Sato, and J. Fujii Deficiency of the cystine-transporter gene, xCT, does not exacerbate the deleterious phenotypic consequences of SOD1 knockout in mice Mol. Cell. Biochem. 319 1-2 2008 125 132
75. K. Jäger, U. Bonisch, M. Risch, D. Worlitzsch, and F. Paulsen Detection and regulation of cationic amino acid transporters in healthy and diseased ocular surface Invest. Ophthalmol. Vis. Sci. 50 3 2009 1112 1121
76. Jeschke, G.; 2012. A comparative study of structures and structural transitions of secondary transporters with the LeuT fold. Eur. Biophys. J. [Epub ahead of print].
77. M. Jimenez-Vidal, E. Gasol, A. Zorzano, V. Nunes, M. Palacin, and J. Chillaron Thiol modification of cysteine 327 in the eighth transmembrane domain of the light subunit xCT of the heteromeric cystine/glutamate antiporter suggests close proximity to the substrate binding site/permeation pathway J. Biol. Chem. 279 12 2004 11214 11221
78. T. Kageyama, M. Nakamura, A. Matsuo, Y. Yamasaki, Y. Takakura, M. Hashida, Y. Kanai, M. Naito, T. Tsuruo, N. Minato, and S. Shimohama The 4F2hc/LAT1 complex transports l-DOPA across the blood-brain barrier Brain Res. 879 1-2 2000 115 121
79. K. Kaira, N. Oriuchi, H. Imai, K. Shimizu, N. Yanagitani, N. Sunaga, T. Hisada, T. Ishizuka, Y. Kanai, H. Endou, T. Nakajima, and M. Mori l-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas J. Surg. Oncol. 99 7 2009 433 438
80. K. Kaira, N. Oriuchi, H. Imai, K. Shimizu, N. Yanagitani, N. Sunaga, T. Hisada, O. Kawashima, Y. Kamide, T. Ishizuka, Y. Kanai, T. Nakajima, and M. Mori CD98 expression is associated with poor prognosis in resected non-small-cell lung cancer with lymph node metastases Ann. Surg. Oncol. 16 12 2009 3473 3481
81. K. Kaira, N. Oriuchi, H. Imai, K. Shimizu, N. Yanagitani, N. Sunaga, T. Hisada, S. Tanaka, T. Ishizuka, Y. Kanai, H. Endou, T. Nakajima, and M. Mori l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms Cancer Sci. 99 12 2008 2380 2386
82. K. Kaira, N. Oriuchi, Y. Otani, K. Shimizu, S. Tanaka, H. Imai, N. Yanagitani, N. Sunaga, T. Hisada, T. Ishizuka, K. Dobashi, Y. Kanai, H. Endou, T. Nakajima, K. Endo, and M. Mori Fluorine-18-alpha-methyltyrosine positron emission tomography for diagnosis and staging of lung cancer: a clinicopathologic study Clin. Cancer Res. 13 21 2007 6369 6378
83. K. Kaira, N. Oriuchi, K. Shimizu, H. Imai, H. Tominaga, N. Yanagitani, N. Sunaga, T. Hisada, T. Ishizuka, Y. Kanai, T. Oyama, M. Mori, and K. Endo Comparison of L-type amino acid transporter 1 expression and l-[3-18F]-alpha-methyl tyrosine uptake in outcome of non-small cell lung cancer Nucl. Med. Biol. 37 8 2010 911 916
84. K. Kaira, N. Oriuchi, K. Shimizu, T. Ishikita, T. Higuchi, H. Imai, N. Yanagitani, N. Sunaga, T. Hisada, T. Ishizuka, Y. Kanai, H. Endou, T. Nakajima, K. Endo, and M. Mori Correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in non-small cell lung cancer Cancer Sci. 100 4 2009 753 758
85. K. Kaira, N. Oriuchi, T. Takahashi, K. Nakagawa, Y. Ohde, T. Okumura, H. Murakami, T. Shukuya, H. Kenmotsu, T. Naito, Y. Kanai, M. Endo, H. Kondo, T. Nakajima, and N. Yamamoto l-type amino acid transporter 1 (LAT1) expression in malignant pleural mesothelioma Anticancer Res. 31 12 2011 4075 4082
86. J.A. Kaleeba, and E.A. Berger Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT Science 311 5769 2006 1921 1924
87. Y. Kanai, Y. Fukasawa, S.H. Cha, H. Segawa, A. Chairoungdua, D.K. Kim, H. Matsuo, J.Y. Kim, K. Miyamoto, E. Takeda, and H. Endou Transport properties of a system y+L neutral and basic amino acid transporter. Insights into the mechanisms of substrate recognition J. Biol. Chem. 275 27 2000 20787 20793
88. Y. Kanai, H. Segawa, K. Miyamoto, H. Uchino, E. Takeda, and H. Endou Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98) J. Biol. Chem. 273 37 1998 23629 23632
89. T. Kaper, L.L. Looger, H. Takanaga, M. Platten, L. Steinman, and W.B. Frommer Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle PLoS Biol. 5 10 2007 e257
90. K.S. Kau, A. Madayag, J.R. Mantsch, M.D. Grier, O. Abdulhameed, and D.A. Baker Blunted cystine-glutamate antiporter function in the nucleus accumbens promotes cocaine-induced drug seeking Neuroscience 155 2 2008 530 537
91. M.P. Kavanaugh Voltage dependence of facilitated arginine flux mediated by the system y+ basic amino acid transporter Biochemistry 32 22 1993 5781 5785
92. C.H. Kim, K.J. Park, J.R. Park, Y. Kanai, H. Endou, J.C. Park, and K. Kim do The RNA interference of amino acid transporter LAT1 inhibits the growth of KB human oral cancer cells Anticancer Res. 26 4B 2006 2943 2948
93. J.W. Kim, E.I. Closs, L.M. Albritton, and J.M. Cunningham Transport of cationic amino acids by the mouse ecotropic retrovirus receptor Nature 352 6337 1991 725 728
94. J.Y. Kim, Y. Kanai, A. Chairoungdua, S.H. Cha, H. Matsuo, D.K. Kim, J. Inatomi, H. Sawa, Y. Ida, and H. Endou Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells Biochim. Biophys. Acta 1512 2 2001 335 344
95. A. Kinne, R. Schulein, and G. Krause Primary and secondary thyroid hormone transporters Thyroid Res. 4 Suppl. 1 2011 S7
96. K. Kobayashi, A. Ohnishi, J. Promsuk, S. Shimizu, Y. Kanai, Y. Shiokawa, and M. Nagane Enhanced tumor growth elicited by l-type amino acid transporter 1 in human malignant glioma cells Neurosurgery 62 2 2008 493 503
97. T.V. Kolesnikova, B.A. Mannion, F. Berditchevski, and M.E. Hemler Beta1 integrins show specific association with CD98 protein in low density membranes BMC Biochem. 2 2001 10
98. L. Kowalczyk, M. Ratera, A. Paladino, P. Bartoccioni, E. Errasti-Murugarren, E. Valencia, G. Portella, S. Bial, A. Zorzano, I. Fita, M. Orozco, X. Carpena, J.L. Vazquez-Ibar, and M. Palacin Molecular basis of substrate-induced permeation by an amino acid antiporter Proc. Natl. Acad. Sci. USA 108 10 2011 3935 3940
99. S.D. Kramer, L. Mu, A. Muller, C. Keller, O.F. Kuznetsova, C. Schweinsberg, D. Franck, C. Muller, T.L. Ross, R. Schibli, and S.M. Ametamey 5-(2-18F-fluoroethoxy)-l-tryptophan as a substrate of system L transport for tumor imaging by PET J. Nucl. Med. 53 3 2012 434 442
100. H. Krishnamurthy, C.L. Piscitelli, and E. Gouaux Unlocking the molecular secrets of sodium-coupled transporters Nature 459 7245 2009 347 355
101. R. Kurayama, N. Ito, Y. Nishibori, D. Fukuhara, Y. Akimoto, E. Higashihara, Y. Ishigaki, Y. Sai, K. Miyamoto, H. Endou, Y. Kanai, and K. Yan Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis Lab. Invest. 91 7 2011 992 1006
102. M.A. Larkin, G. Blackshields, N.P. Brown, R. Chenna, P.A. McGettigan, H. McWilliam, F. Valentin, I.M. Wallace, A. Wilm, R. Lopez, J.D. Thompson, T.J. Gibson, and D.G. Higgins Clustal W and Clustal X version 2.0 Bioinformatics 23 21 2007 2947 2948
103. J. Lewerenz, and P. Maher Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression J. Biol. Chem. 284 2 2009 1106 1115
104. J. Lewerenz, H. Sato, P. Albrecht, N. Henke, R. Noack, A. Methner, and P. Maher Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression Cell Death Differ. 19 5 2012 847 858
105. S.A. Lyons, W.J. Chung, A.K. Weaver, T. Ogunrinu, and H. Sontheimer Autocrine glutamate signaling promotes glioma cell invasion Cancer Res. 67 19 2007 9463 9471
106. D. Ma, P. Lu, C. Yan, C. Fan, P. Yin, J. Wang, and Y. Shi Structure and mechanism of a glutamate-GABA antiporter Nature 483 7391 2012 632 636
107. M. Majumder, I. Yaman, F. Gaccioli, V.V. Zeenko, C. Wang, M.G. Caprara, R.C. Venema, A.A. Komar, M.D. Snider, and M. Hatzoglou The hnRNA-binding proteins hnRNP L and PTB are required for efficient translation of the Cat-1 arginine/lysine transporter mRNA during amino acid starvation Mol. Cell. Biol. 29 10 2009 2899 2912
108. P.K. Mandal, A. Seiler, T. Perisic, P. Kolle, A. Banjac Canak, H. Forster, N. Weiss, E. Kremmer, M.W. Lieberman, S. Bannai, P. Kuhlencordt, H. Sato, G.W. Bornkamm, and M. Conrad System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency J. Biol. Chem. 285 29 2010 22244 22253
109. L. Mastroberardino, B. Spindler, R. Pfeiffer, P.J. Skelly, J. Loffing, C.B. Shoemaker, and F. Verrey Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family Nature 395 6699 1998 288 291
110. H. Matsuo, Y. Kanai, J.Y. Kim, A. Chairoungdua, D.K. Kim, J. Inatomi, Y. Shigeta, H. Ishimine, S. Chaekuntode, K. Tachampa, H.W. Choi, E. Babu, J. Fukuda, and H. Endou Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains J. Biol. Chem. 277 23 2002 21017 21026
111. C. Meier, Z. Ristic, S. Klauser, and F. Verrey Activation of system l heterodimeric amino acid exchangers by intracellular substrates EMBO J. 21 4 2002 580 589
112. R.I. Melendez, J. Vuthiganon, and P.W. Kalivas Regulation of extracellular glutamate in the prefrontal cortex: focus on the cystine glutamate exchanger and group I metabotropic glutamate receptors J. Pharmacol. Exp. Ther. 314 1 2005 139 147
113. K. Moussawi, A. Pacchioni, M. Moran, M.F. Olive, J.T. Gass, A. Lavin, and P.W. Kalivas N-Acetylcysteine reverses cocaine-induced metaplasticity Nat. Neurosci. 12 2 2009 182 189
114. B.G. Munck Lysine transport across the small intestine. Stimulating and inhibitory effects of neutral amino acids J. Membr. Biol. 53 1 1980 45 53
115. B.G. Munck Transport of neutral and cationic amino acids across the brush-border membrane of the rabbit ileum J. Membr. Biol. 83 1-2 1985 1 13
116. J. Mykkanen, D. Torrents, M. Pineda, M. Camps, M.E. Yoldi, N. Horelli-Kuitunen, K. Huoponen, M. Heinonen, J. Oksanen, O. Simell, M.L. Savontaus, A. Zorzano, M. Palacin, and P. Aula Functional analysis of novel mutations in y(+)LAT-1 amino acid transporter gene causing lysinuric protein intolerance (LPI) Hum. Mol. Genet. 9 3 2000 431 438
117. A. Nabeyama, A. Kurita, K. Asano, Y. Miyake, T. Yasuda, I. Miura, G. Nishitai, S. Arakawa, S. Shimizu, S. Wakana, H. Yoshida, and M. Tanaka XCT deficiency accelerates chemically induced tumorigenesis Proc. Natl. Acad. Sci. USA 107 14 2010 6436 6441
118. J. Nakauchi, H. Matsuo, D.K. Kim, A. Goto, A. Chairoungdua, S.H. Cha, J. Inatomi, Y. Shiokawa, K. Yamaguchi, I. Saito, H. Endou, and Y. Kanai Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports d-serine with high affinity Neurosci. Lett. 287 3 2000 231 235
119. A.M. Nassl, I. Rubio-Aliaga, H. Fenselau, M.K. Marth, G. Kottra, and H. Daniel Amino acid absorption and homeostasis in mice lacking the intestinal peptide transporter PEPT1 Am. J. Physiol. Gastrointest. Liver Physiol. 301 1 2011 G128 G137
120. B. Nicholson, C.K. Manner, J. Kleeman, and C.L. MacLeod Sustained nitric oxide production in macrophages requires the arginine transporter CAT2 J. Biol. Chem. 276 19 2001 15881 15885
121. B. Nicholson, T. Sawamura, T. Masaki, and C.L. MacLeod Increased Cat3-mediated cationic amino acid transport functionally compensates in Cat1 knockout cell lines J. Biol. Chem. 273 24 1998 14663 14666
122. P. Nicklin, P. Bergman, B. Zhang, E. Triantafellow, H. Wang, B. Nyfeler, H. Yang, M. Hild, C. Kung, C. Wilson, V.E. Myer, J.P. MacKeigan, J.A. Porter, Y.K. Wang, L.C. Cantley, P.M. Finan, and L.O. Murphy Bidirectional transport of amino acids regulates mTOR and autophagy Cell 136 3 2009 521 534
123. K.A. Niese, M.G. Chiaramonte, L.G. Ellies, M.E. Rothenberg, and N. Zimmermann The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis Respir. Res. 11 2010 87
124. K. Oda, N. Hosoda, H. Endo, K. Saito, K. Tsujihara, M. Yamamura, T. Sakata, N. Anzai, M.F. Wempe, Y. Kanai, and H. Endou l-type amino acid transporter 1 inhibitors inhibit tumor cell growth Cancer Sci. 101 1 2010 173 179
125. S. Ohgimoto, N. Tabata, S. Suga, M. Nishio, H. Ohta, M. Tsurudome, H. Komada, M. Kawano, N. Watanabe, and Y. Ito Molecular characterization of fusion regulatory protein-1 (FRP-1) that induces multinucleated giant cell formation of monocytes and HIV gp160-mediated cell fusion. FRP-1 and 4F2/CD98 are identical molecules J. Immunol. 155 7 1995 3585 3592
126. M. Ohkawa, Y. Ohno, K. Masuko, A. Takeuchi, K. Suda, A. Kubo, R. Kawahara, S. Okazaki, T. Tanaka, H. Saya, M. Seki, T. Enomoto, H. Yagi, Y. Hashimoto, and T. Masuko Oncogenicity of l-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells: LAT1 is a promising molecular target for human cancer therapy Biochem. Biophys. Res. Commun. 406 4 2011 649 655
127. M. Palacin, G. Borsani, and G. Sebastio The molecular bases of cystinuria and lysinuric protein intolerance Curr. Opin. Genet. Dev. 11 3 2001 328 335
128. M. Palacin, and Y. Kanai The ancillary proteins of HATs: SLC3 family of amino acid transporters Pflugers Arch. 447 5 2004 490 494
129. S.Y. Park, J.K. Kim, I.J. Kim, B.K. Choi, K.Y. Jung, S. Lee, K.J. Park, A. Chairoungdua, Y. Kanai, H. Endou, and D.K. Kim Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule Arch. Pharma. Res. 28 4 2005 421 432
130. -: an obligate exchanger of l-glutamate and l-cystine Neuropharmacology 46 2 2004 273 284
131. C.P. Perkins, V. Mar, J.R. Shutter, J. del Castillo, D.M. Danilenko, E.S. Medlock, I.L. Ponting, M. Graham, K.L. Stark, Y. Zuo, J.M. Cunningham, and R.A. Bosselman Anemia and perinatal death result from loss of the murine ecotropic retrovirus receptor mCAT-1 Genes Dev. 11 7 1997 914 925
132. T. Peters, C. Thaete, S. Wolf, A. Popp, R. Sedlmeier, J. Grosse, M.C. Nehls, A. Russ, and V. Schlueter A mouse model for cystinuria type I Hum. Mol. Genet. 12 17 2003 2109 2120
133. R. Pfeiffer, G. Rossier, B. Spindler, C. Meier, L. Kuhn, and F. Verrey Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family EMBO J. 18 1 1999 49 57
134. M. Pineda, E. Fernandez, D. Torrents, R. Estevez, C. Lopez, M. Camps, J. Lloberas, A. Zorzano, and M. Palacin Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an l-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids J. Biol. Chem. 274 28 1999 19738 19744
135. M. Pineda, M. Font, M.T. Bassi, M. Manzoni, G. Borsani, V. Marigo, E. Fernandez, R.M. Rio, J. Purroy, A. Zorzano, V. Nunes, and M. Palacin The amino acid transporter asc-1 is not involved in cystinuria Kidney Int. 66 4 2004 1453 1464
136. K.V. Prasanth, S.G. Prasanth, Z. Xuan, S. Hearn, S.M. Freier, C.F. Bennett, M.Q. Zhang, and D.L. Spector Regulating gene expression through RNA nuclear retention Cell 123 2 2005 249 263
137. Z. Qin, E. Freitas, R. Sullivan, S. Mohan, R. Bacelieri, D. Branch, M. Romano, P. Kearney, J. Oates, K. Plaisance, R. Renne, J. Kaleeba, and C. Parsons Upregulation of xCT by KSHV-encoded microRNAs facilitates KSHV dissemination and persistence in an environment of oxidative stress PLoS Pathog. 6 1 2010 e1000742
138. N. Reig, J. Chillaron, P. Bartoccioni, E. Fernandez, A. Bendahan, A. Zorzano, B. Kanner, M. Palacin, and J. Bertran The light subunit of system b(o,+) is fully functional in the absence of the heavy subunit EMBO J. 21 18 2002 4906 4914
139. N. Reig, C. del Rio, F. Casagrande, M. Ratera, J.L. Gelpi, D. Torrents, P.J. Henderson, H. Xie, S.A. Baldwin, A. Zorzano, D. Fotiadis, and M. Palacin Functional and structural characterization of the first prokaryotic member of the l-amino acid transporter (LAT) family: a model for APC transporters J. Biol. Chem. 282 18 2007 13270 13281
140. R.C. Rintoul, R.C. Buttery, A.C. Mackinnon, W.S. Wong, D. Mosher, C. Haslett, and T. Sethi Cross-linking CD98 promotes integrin-like signaling and anchorage-independent growth Mol. Biol. Cell 13 8 2002 2841 2852
141. J.W. Ritchie, and P.M. Taylor Role of the system L permease LAT1 in amino acid and iodothyronine transport in placenta Biochem. J. 356 Pt 3 2001 719 725
142. M. Rius, and J. Chillaron The carrier subunit of a plasma membrane transporter is required for the oxidative folding of its helper subunit J. Biol. Chem. 287 22 2012 18190 18200
143. G. Rossier, C. Meier, C. Bauch, V. Summa, B. Sordat, F. Verrey, and L.C. Kuhn LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine J. Biol. Chem. 274 49 1999 34948 34954
144. M.E. Rothenberg, M.P. Doepker, I.P. Lewkowich, M.G. Chiaramonte, K.F. Stringer, F.D. Finkelman, C.L. MacLeod, L.G. Ellies, and N. Zimmermann Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung Proc. Natl. Acad. Sci. USA 103 40 2006 14895 14900
145. M.H. Saier Jr.; C.V. Tran, and R.D. Barabote TCDB: the transporter classification database for membrane transport protein analyses and information Nucleic Acids Res. 34 2006 D181 D186 (Database issue)
146. M.H. Saier Jr.; M.R. Yen, K. Noto, D.G. Tamang, and C. Elkan The transporter classification database: recent advances Nucleic Acids Res. 37 2009 D274 D278 (Database issue)
147. S. Sakamoto, A. Chairoungdua, S. Nagamori, P. Wiriyasermkul, K. Promchan, H. Tanaka, T. Kimura, T. Ueda, M. Fujimura, Y. Shigeta, Y. Naya, K. Akakura, H. Ito, H. Endou, T. Ichikawa, and Y. Kanai A novel role of the C-terminus of b(0,+)AT in the ER-Golgi trafficking of the rBAT-b(0,+)AT heterodimeric amino acid transporter Biochem. J. 417 2 2009 441 448
148. T. Sakata, G. Ferdous, T. Tsuruta, T. Satoh, S. Baba, T. Muto, A. Ueno, Y. Kanai, H. Endou, and I. Okayasu l-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer Pathol. Int. 59 1 2009 7 18
149. H. Sasaki, H. Sato, K. Kuriyama-Matsumura, K. Sato, K. Maebara, H. Wang, M. Tamba, K. Itoh, M. Yamamoto, and S. Bannai Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression J. Biol. Chem. 277 47 2002 44765 44771
150. H. Sato, A. Shiiya, M. Kimata, K. Maebara, M. Tamba, Y. Sakakura, N. Makino, F. Sugiyama, K. Yagami, T. Moriguchi, S. Takahashi, and S. Bannai Redox imbalance in cystine/glutamate transporter-deficient mice J. Biol. Chem. 280 45 2005 37423 37429
151. H. Sato, M. Tamba, T. Ishii, and S. Bannai Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins J. Biol. Chem. 274 17 1999 11455 11458
152. H. Sato, M. Tamba, S. Okuno, K. Sato, K. Keino-Masu, M. Masu, and S. Bannai Distribution of cystine/glutamate exchange transporter, system x(c)-, in the mouse brain J. Neurosci. 22 18 2002 8028 8033
153. N.E. Savaskan, A. Heckel, E. Hahnen, T. Engelhorn, A. Doerfler, O. Ganslandt, C. Nimsky, M. Buchfelder, and I.Y. Eyupoglu Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema Nat. Med. 14 6 2008 629 632
154. W. Schneiderhan, M. Scheler, K.H. Holzmann, M. Marx, J.E. Gschwend, M. Bucholz, T.M. Gress, T. Seufferlein, G. Adler, and F. Oswald CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models Gut 58 10 2009 1391 1398
155. T.M. Seib, S.A. Patel, and R.J. Bridges Regulation of the system x(C)- cystine/glutamate exchanger by intracellular glutathione levels in rat astrocyte primary cultures Glia 59 10 2011 1387 1401
156. P.L. Shaffer, A. Goehring, A. Shankaranarayanan, and E. Gouaux Structure and mechanism of a Na+-independent amino acid transporter Science 325 5943 2009 1010 1014
157. Y. Shigeta, Y. Kanai, A. Chairoungdua, N. Ahmed, S. Sakamoto, H. Matsuo, D.K. Kim, M. Fujimura, N. Anzai, K. Mizoguchi, T. Ueda, K. Akakura, T. Ichikawa, H. Ito, and H. Endou A novel missense mutation of SLC7A9 frequent in Japanese cystinuria cases affecting the C-terminus of the transporter Kidney Int. 69 7 2006 1198 1206
158. O. Simell Lysinuric protein intolerance and other cationic aminoacidurias C.R. Scriver, A.L. Beaudet, S.W. Sly, D. Valle, Metabolic and Molecular Basis of Inherited Diseases 2001 McGraw-Hill New York 4933 4956
159. M.P. Sperandeo, G. Andria, and G. Sebastio Lysinuric protein intolerance: update and extended mutation analysis of the SLC7A7 gene Hum. Mutat. 29 1 2008 14 21
160. M.P. Sperandeo, P. Annunziata, V. Ammendola, V. Fiorito, A. Pepe, M.V. Soldovieri, M. Taglialatela, G. Andria, and G. Sebastio Lysinuric protein intolerance: identification and functional analysis of mutations of the SLC7A7 gene Hum. Mutat. 25 4 2005 410
161. M.P. Sperandeo, P. Annunziata, A. Bozzato, P. Piccolo, L. Maiuri, M. D'Armiento, A. Ballabio, G. Corso, G. Andria, G. Borsani, and G. Sebastio Slc7a7 disruption causes fetal growth retardation by downregulating Igf1 in the mouse model of lysinuric protein intolerance Am. J. Physiol. Cell Physiol. 293 1 2007 C191 C198
162. M.P. Sperandeo, G. Borsani, B. Incerti, M. Zollo, E. Rossi, O. Zuffardi, P. Castaldo, M. Taglialatela, G. Andria, and G. Sebastio The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome Genomics 49 2 1998 230 236
163. M.P. Sperandeo, S. Paladino, L. Maiuri, G.D. Maroupulos, C. Zurzolo, M. Taglialatela, G. Andria, and G. Sebastio A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance Eur. J. Hum. Genet. 13 5 2005 628 634
164. S. Sreedharan, O. Stephansson, H.B. Schioth, and R. Fredriksson Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters Gene 478 1-2 2011 11 18
165. A. Takesono, J. Moger, S. Farooq, E. Cartwright, I.B. Dawid, S.W. Wilson, and T. Kudoh Solute carrier family 3 member 2 (Slc3a2) controls yolk syncytial layer (YSL) formation by regulating microtubule networks in the zebrafish embryo Proc. Natl. Acad. Sci. USA 109 9 2012 3371 3376
166. M. Tomi, M. Mori, M. Tachikawa, K. Katayama, T. Terasaki, and K. Hosoya l-type amino acid transporter 1-mediated l-leucine transport at the inner blood-retinal barrier Invest. Ophthalmol. Vis. Sci. 46 7 2005 2522 2530
167. D. Torrents, R. Estevez, M. Pineda, E. Fernandez, J. Lloberas, Y.B. Shi, A. Zorzano, and M. Palacin Identification and characterization of a membrane protein (y+l amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+l. A candidate gene for lysinuric protein intolerance J. Biol. Chem. 273 49 1998 32437 32445
168. +LAT-1, as the lysinuric protein intolerance gene Nat. Genet. 21 3 1999 293 296
169. H. Tsumura, N. Suzuki, H. Saito, M. Kawano, S. Otake, Y. Kozuka, H. Komada, M. Tsurudome, and Y. Ito The targeted disruption of the CD98 gene results in embryonic lethality Biochem. Biophys. Res. Commun. 308 4 2003 847 851
170. G.E. Tusnady, and I. Simon The HMMTOP transmembrane topology prediction server Bioinformatics 17 9 2001 849 850
171. M.V. Veettil, S. Sadagopan, N. Sharma-Walia, F.Z. Wang, H. Raghu, L. Varga, and B. Chandran Kaposi's sarcoma-associated herpesvirus forms a multimolecular complex of integrins (alphaVbeta5, alphaVbeta3, and alpha3beta1) and CD98-xCT during infection of human dermal microvascular endothelial cells, and CD98-xCT is essential for the postentry stage of infection J. Virol. 82 24 2008 12126 12144
172. N. Vékony, S. Wolf, J.P. Boissel, K. Gnauert, and E.I. Closs Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues Biochemistry 40 41 2001 12387 12394
173. F. Verrey, E.I. Closs, C.A. Wagner, M. Palacin, H. Endou, and Y. Kanai CATs and HATs: the SLC7 family of amino acid transporters Pflugers Arch. 447 5 2004 532 542
174. A. Vina-Vilaseca, J. Bender-Sigel, T. Sorkina, E.I. Closs, and A. Sorkin Protein kinase C-dependent ubiquitination and clathrin-mediated endocytosis of the cationic amino acid transporter CAT-1 J. Biol. Chem. 286 10 2011 8697 8706
175. R. Vumma, F.A. Wiesel, L. Flyckt, L. Bjerkenstedt, and N. Venizelos Functional characterization of tyrosine transport in fibroblast cells from healthy controls Neurosci. Lett. 434 1 2008 56 60
176. H. Wang, M.P. Kavanaugh, and D. Kabat A critical site in the cell surface receptor for ecotropic murine retroviruses required for amino acid transport but not for viral reception Virology 202 2 1994 1058 1060
177. L. Wang, B.P. Lieberman, K. Plossl, W. Qu, and H.F. Kung Synthesis and comparative biological evaluation of l- and d-isomers of 18F-labeled fluoroalkyl phenylalanine derivatives as tumor imaging agents Nucl. Med. Biol. 38 3 2011 301 312
178. U.H. Weidle, W. Scheuer, D. Eggle, S. Klostermann, and H. Stockinger Cancer-related issues of CD147 Cancer Genomics Proteomics 7 3 2010 157 169
179. M.F. White, and H.N. Christensen Cationic amino acid transport into cultured animal cells. II. Transport system barely perceptible in ordinary hepatocytes, but active in hepatoma cell lines J. Biol. Chem. 257 8 1982 4450 4457
180. P. Wiriyasermkul, S. Nagamori, H. Tominaga, N. Oriuchi, K. Kaira, H. Nakao, T. Kitashoji, R. Ohgaki, H. Tanaka, H. Endou, K. Endo, H. Sakurai, and Y. Kanai Transport of 3-fluoro-l-α-methyl tyrosine by tumor-upregulated amino acid transporter LAT1: a cause of the tumor uptake in PET J. Nucl. Med. 53 8 2012 1253 1261
181. Z.X. Xi, D.A. Baker, H. Shen, D.S. Carson, and P.W. Kalivas Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens J. Pharmacol. Exp. Ther. 300 1 2002 162 171
182. Z.X. Xi, S. Ramamoorthy, D.A. Baker, H. Shen, D.J. Samuvel, and P.W. Kalivas Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine J. Pharmacol. Exp. Ther. 303 2 2002 608 615
183. X. Xie, T. Dumas, L. Tang, T. Brennan, T. Reeder, W. Thomas, R.D. Klein, J. Flores, B.F. O'Hara, H.C. Heller, and P. Franken Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice Brain Res. 1052 2 2005 212 221
184. D. Xu, and M.E. Hemler Metabolic activation-related CD147-CD98 complex Mol. Cell. Proteomics 4 8 2005 1061 1071
185. -dependent neurotransmitter transporters Nature 437 7056 2005 215 223
186. K. Yamauchi, H. Sakurai, T. Kimura, P. Wiriyasermkul, S. Nagamori, Y. Kanai, and N. Kohno System l amino acid transporter inhibitor enhances anti-tumor activity of cisplatin in a head and neck squamous cell carcinoma cell line Cancer Lett. 276 1 2009 95 101
187. O. Yanagida, Y. Kanai, A. Chairoungdua, D.K. Kim, H. Segawa, T. Nii, S.H. Cha, H. Matsuo, J. Fukushima, Y. Fukasawa, Y. Tani, Y. Taketani, H. Uchino, J.Y. Kim, J. Inatomi, I. Okayasu, K. Miyamoto, E. Takeda, T. Goya, and H. Endou Human l-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines Biochim. Biophys. Acta 1514 2 2001 291 302
188. A. Yeramian, L. Martin, N. Serrat, L. Arpa, C. Soler, J. Bertran, C. McLeod, M. Palacin, M. Modolell, J. Lloberas, and A. Celada Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages J. Immunol. 176 10 2006 5918 5924
189. J.H. Yoon, I.J. Kim, H. Kim, H.J. Kim, M.J. Jeong, S.G. Ahn, S.A. Kim, C.H. Lee, B.K. Choi, J.K. Kim, K.Y. Jung, S. Lee, Y. Kanai, H. Endou, and D.K. Kim Amino acid transport system L is differently expressed in human normal oral keratinocytes and human oral cancer cells Cancer Lett. 222 2 2005 237 245