c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human pancreatic cancer cells

Oncology Reports

Volumn 28, Issue 3, 2012, Pages 862-866

  Hayashi, Keitaro ^a   Jutabha, Promsuk ^a   Endou, Hitoshi ^b   Anzai, Naohiko ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b J Pharma Co   (Japan)

Author keywords

c Myc; Human pancreatic cancer cells; LAT1; Neutral amino acid transporter

Indexed keywords

AMINO ACID TRANSPORTER; COMPLEMENTARY DNA; L TYPE AMINO ACID TRANSPORTER 1; LEUCINE; MESSENGER RNA; MYC PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CANCER GROWTH; CELL METABOLISM; CELL PROLIFERATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; PANCREAS CANCER; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSLATION INITIATION; UPREGULATION;

BASE SEQUENCE; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; CONSENSUS SEQUENCE; DOWN-REGULATION; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GENES, REPORTER; HUMANS; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; LEUCINE; LUCIFERASES; PANCREATIC NEOPLASMS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-MYC; RNA, SMALL INTERFERING;

EID: 84865346124     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1878     Document Type: Article

References (26)

1. DeBerardinis RJ, Lum JJ, Hatzivassiliou G and Thompson CB: The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7: 11-20, 2008.
2. Warburg O: On the origin of cancer cells. Science 123: 309-314, 1956.
3. Airley RE and Mobasheri A: Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics. Chemotherapy 53: 233-256, 2007.
4. Macheda ML, Rogers S and Best JD: Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 202: 654-662, 2005.
5. Witte D, Ali N, Carlson N and Younes M: Overexpression of the neutral amino acid transporter ASCT2 in human colorectal adenocarcinoma. Anticancer Res 22: 2555-2557, 2002.
6. Li R, Younes M, Frolov A Wheeler TM, Scardino P, Ohori M and Ayala G: Expression of neutral amino acid transporter ASCT2 in human prostate. Anticancer Res 23: 3413-3418, 2003.
7. Levine AJ and Puzio-Kuter AM: The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 330: 1340-1344, 2010.
8. Ganapathy V, Thangaraju M and Prasad PD: Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol Ther 121: 29-40, 2009.
9. Kanai Y, Segawa H, Miyamoto K, Uchino H, Takeda E and Endou H: Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J Biol Chem 273: 23629-23632, 1998.
10. Yanagida O, Kanai Y, Chairoungdua A, et al: Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochim Biophys Acta 1514: 291-302, 2001.
11. Oda K, Hosoda N, Endo H, et al: L-type amino acid transporter 1 inhibitors inhibit tumor cell growth. Cancer Sci 101: 173-179, 2010.
12. Ichinoe M, Mikami T, Yoshida T, et al: High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: comparison with non-cancerous lesions. Pathol Int 61: 281-289, 2011.
13. +-independent neutral amino acid transporter LAT1 during T-cell activation. Biochem J 358: 693-604, 2001.
14. Blackwell TK, Kretzner L, Blackwood EM, Eisenman RN and Weintraub H: Sequence-specific DNA binding by the c-Myc protein. Science 250: 1149-1151, 1990.
15. Alex R, Sözeri O, Meyer S and Dildrop R: Determination of the DNA sequence recognized by the bHLH-zip domain of the N-Myc protein. Nucleic Acids Res 20: 2257-2263, 1992.
16. Sakata T, Ferdous G, Tsuruta T, et al: L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer. Pathol Int 59: 7-18, 2009.
17. Kaira K, Oriuchi N, Imai H, et al: Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung. Cancer Sci 100: 248-254, 2009.
18. Kaji M, Kabir-Salmani M, Anzai N, et al: Properties of L-type amino acid transporter 1 in epidermal ovarian cancer. Int J Gynecol Cancer 20: 329-336, 2010.
19. Bouchard C, Thieke K, Maier A, et al: Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27. EMBO J 18: 5321-5333, 1999.
20. Bouchard C, Dittrich O, Kiermaier A, Dohmann K, Menkel A, Eilers M and Lüscher B: Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter. Genes Dev 15: 2042-2047, 2001.
21. Menssen A and Hermeking H: Characterization of the c-Myc-regulated transcriptome by SAGE: identification and analysis of c-Myc target genes. Proc Natl Acad Sci USA 99: 6274-6279, 2002.
22. Kim JW, Zeller KI, Wang Y, Jegga AG, Aronow BJ, O'Donnell KA and Dang CV: Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. Mol Cell Biol 24: 5923-5936, 2004.
23. Osthus RC, Shim H, Kim S, et al: Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem 275: 21797-21800, 2000.
24. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV and Mendell JT: c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435: 839-843, 2005.
25. Frank SR, Schroeder M, Fernandez P, Taubert S and Amati B: Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev 15: 2069-2082, 2001.
26. Frank SR, Parisi T, Taubert S, et al: Myc recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Rep 4: 575-580, 2003.