Upregulation of the glutamine transporter through transactivation mediated by cAMP/protein kinase A signals toward exacerbation of vulnerability to oxidative stress in rat neocortical astrocytes

Journal of Cellular Physiology

Volumn 212, Issue 2, 2007, Pages 375-385

  Ogura, Masato ^a   Taniura, Hideo ^a   Nakamichi, Noritaka ^a   Yoneda, Yukio ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FORSKOLIN; GLUTAMINE; HYDROGEN PEROXIDE; MESSENGER RNA; SERINE; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; GLIOMA CELL; NEOCORTEX; NEUROTRANSMITTER RELEASE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RAT; TRANSACTIVATION; UPREGULATION;

ADENYLATE CYCLASE; AMINO ACID TRANSPORT SYSTEM A; ANIMALS; ASTROCYTES; CARRIER PROTEINS; CELL SURVIVAL; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; FORSKOLIN; GLUTAMIC ACID; HYDROGEN PEROXIDE; ISOQUINOLINES; MUTATION; NEOCORTEX; NEURONS; OXIDATIVE STRESS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, WISTAR; RNA, MESSENGER; SIGNAL TRANSDUCTION; SULFONAMIDES; TIME FACTORS; TRANSCRIPTION FACTOR AP-1; TRANSFECTION; UP-REGULATION;

RATTUS;

EID: 34347405954     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21031     Document Type: Article

References (42)

1. + transport by the neural glutamine transporter TA1. Pflugers Arch 443:92-101.
2. Albrecht J, Norenberg MD. 2006. Glutamine: A Trojan horse in ammonia neurotoxicity. Hepatology 44:788-794.
3. Balcar VJ, Johnston GAR. 1975. High affinity uptake of L-glutamine in rat brain slices. J Neurochem 24:875-879.
4. Broer S. 2002. Adaptation of plasma membrane amino acid transport mechanisms to physiological demands. Pflugers Arch 444:457-466.
5. Broer A, Brookes N, Ganapathy V, Dimmer KS, Wagner CA, Lang F, Broer S. 1999. The astroglial ASCT2 amino acid transporter as a mediator of glutamine efflux. J Neurochem 73:2184-2194.
6. Broer A, Albers A, Setiawan I, Edwards RH, Chaudhry FA, Lang F, Wagner CA, Broer S. 2002. Regulation of the glutamine transporter SN1 by extracellular pH and intracellular sodium ions. J Physiol 539:3-14.
7. Broer A, Deitmer JW, Broer S. 2004. Astroglial glutamine transport by system N is upregulated by glutamate. Glia 48:298-310.
8. Chaudhry FA, Reimer RJ, Krizaj D, Barber D, Storm-Mathisen J, Copenhagen DR, Edwards RH. 1999. Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. Cell 99:769-780.
9. Chaudhry FA, Schmitz D, Reimer RJ, Larsson P, Gray AT, Nicoll R, Kavanaugh M, Edwards RH. 2002. Glutamine uptake by neurons: Interaction of protons with system a transporters. J Neurosci 22:62-72.
10. Chillaron J, Roca R, Valencia A, Zorzano A, Palacn M. 2001. Heteromeric amino acid transporters: Biochemistry, genetics, and physiology. Am J Physiol Renal Physiol 281:995-1018.
11. D'Aniello A, Fisher G, Migliaccio N, Cammisa G, D'Aniello E, Spinelli P. 2005. Amino acids and transaminases activity in ventricular CSF and in brain of normal and Alzheimer patients. Neurosci Lett 388:49-53.
12. Deitmer JW, Broer A, Broer S. 2003. Glutamine efflux from astrocytes is mediated by multiple pathways. J Neurochem 87:127-135.
13. di Porzio U, Daguet MC, Glowinski J, Prochiantz A. 1980. Effect of striatal cells on in vitro maturation of mesencephalic dopaminergic neurones grown in serum-free conditions. Nature 288:370-373.
14. Dolinska M, Zablocka B, Sonnewald U, Albrecht J. 2004. Glutamine uptake and expression of mRNA's of glutamine transporting proteins in mouse cerebellar and cerebral cortical astrocytes and neurons. Neurochem Int 44:75-81.
15. B receptors expressed in cultured calvarial osteoblasts. Biochem Biophys Res Commun 293:1445-1452.
16. 2+ signals in astrocytes and 3T3 fibroblasts. Exp Cell Res 194:210-217.
17. Gubits RM, Yu H, Casey G, Munell F, Vitek MP. 1992. Altered genetic response to beta-adrenergic receptor activation in late passage C6 glioma cells. J Neurosci Res 33:297-305.
18. Guerin PJ, Furtak T, Eng K, Gauthier ER. 2006. Oxidative stress is not required for the induction of apoptosis upon glutamine starvation of Sp2/0-Ag14 hybridoma cells. Eur J Cell Biol 85:355-365.
19. Hatanaka T, Huang W, Martindale RG, Ganapathy V. 2001. Differential influence of cAMP on the expression of the three subtypes (ATA1, ATA2, and ATA3) of the amino acid transport system A. FEBS Lett 505:317-320.
20. Heckel T, Broer A, Wiesinger H, Lang F, Broer S. 2003. Asymmetry of glutamine transporters in cultured neural cells. Neurochem Int 43:289-298.
21. Herdegen T, Leah JD. 1998. Inducible and constitutive transcription factors in the mammalian nervous system: Control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Brain Res Brain Res Rev 28:370-490.
22. Hinoi E, Fujimori S, Nakamura Y, Yoneda Y. 2001. Group III metabotropic glutamate receptors in rat cultured calvarial osteoblasts. Biochem Biophys Res Commun 281:341-346.
23. Hinoi E, Ueshima T, Hojo H, Iemata M, Takarada T, Yoneda Y. 2006. Up-regulation of per mRNA expression by parathyroid hormone through a protein kinase A-CREB-dependent mechanism in chondrocytes. J Biol Chem 281:23632-23642.
24. Melone M, Quagliano F, Barbaresi P, Varoqui H, Erickson JD, Conti F. 2004. Localization of the glutamine transporter SNAT1 in rat cerebral cortex and neighboring structures, with a note on its localization in human cortex. Cereb Cortex 14:562-574.
25. Mocchetti I, De Bernardi MA, Szekely AM, Alho H, Brooker G, Costa E. 1989. Regulation of nerve growth factor biosynthesis by beta-adrenergic receptor activation in astrocytoma cells: A potential role of c-Fos protein. Proc Natl Acad Sci USA 86:3891-3895.
26. Murakami K, Nakamura Y, Yoneda Y. 2003. Potentiation by ATP of lipopolysaccharide-stimulated nitric oxide production in cultured astrocytes. Neuroscience 117:37-42.
27. Nagaraja TN, Brookes N. 1996. Glutamine transport in mouse cerebral astrocytes. J Neurochem 66:1665-1674.
28. 2+ influx through N-methyl-D-aspartate receptor channels in immature cultured rat cortical neurons. J Neurochem 83:1-11.
29. Ogura M, Nakamichi N, Takano K, Oikawa H, Kambe Y, Ohno Y, Taniura H, Yoneda Y. 2006. Functional expression of a glutamine transporter responsive to downregulation by lipopolysaccharide through reduced promoter activity in cultured rat neocortical astrocytes. J Neurosci Res 83:1447-1460.
30. Rama Rao KV, Jayakumar AR, Norenberg MD. 2005. Differential response of glutamine in cultured neurons and astrocytes. J Neurosci Res 79:193-199.
31. Reimer RJ, Chaudhry FA, Gray AT, Edwards RH. 2000. Amino acid transport system A resembles system N in sequence but differs in mechanism. Proc Natl Acad Sci USA 97:7715-7720.
32. Schinelli S, Zanassi P, Paolillo M, Wang H, Feliciello A, Gallo V. 2001. Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways. J Neurosci 21:8842-8853.
33. Schousboe A, Hertz L, Svenneby G, Kvamme E. 1979. Phosphate activated glutaminase activity and glutamine uptake in primary cultures of astrocytes. J Neurochem 32:943-950.
34. Shin JY, Suh D, Kim JM, Choi HG, Kim JA, Ko JJ, Lee YB, Kim JS, Oh YK. 2005. Low molecular weight polyethylenimine for efficient transaction of human hematopoietic and umbilical cord blood-derived CD34+ cells. Biochim Biophys Acta 1725:377-384.
35. Sng JC, Taniura H, Yoneda Y. 2006. Histone modifications in kainate-induced status epilepticus. Eur J Neurosci 23:1269-1282.
36. Sugawara M, Nakanishi T, Fei YJ, Huang W, Ganapathy ME, Leibach FH, Ganapathy V. 2000. Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A. J Biol Chem 275:16473-16477.
37. Sun X, Erb H, Murphy TH. 2005. Coordinate regulation of glutathione metabolism in astrocytes by Nrf2. Biochem Biophys Res Commun 326:371-377.
38. 3H]glutamate in cultured rat calvarial osteoblasts. Biochem Pharmacol 68:177-184.
39. Thiel G, Al Sarraj J, Vinson C, Stefano L, Bach K. 2005. Role of basic region leucine zipper transcription factors cyclic AMP response element binding protein (CREB), CREB2, activating transcription factor 2 and CAAT/enhancer binding protein alpha in cyclic AMP response element-mediated transcription. J Neurochem 92:321-336.
40. +-dependent neutral amino acid transporter. J Biol Chem 271:14883-14890.
41. Varoqui H, Zhu H, Yao D, Ming H, Erickson JD. 2000. Cloning and functional identification of a neuronal glutamine transporter. J Biol Chem 275:4049-4054.
42. Wagner CA, Lang F, Broer S. 2001. Function and structure of heteromeric amino acid transporters. Am J Physiol Cell Physiol 281:1077-1093.