Genomic regulation of intestinal amino acid transporters by aldosterone

Molecular and Cellular Biochemistry

Volumn 313, Issue 1-2, 2008, Pages 1-10

  Amaral, João S ^a   Pinho, Maria João ^a   Soares da Silva, Patrício ^a  

^a Institute of Pharmacology and Therapeutics   (Portugal)

Author keywords

4F2hc; Aldosterone; ASCT2; LAT1; LAT2

Indexed keywords

4F2HC TYPE AMINO ACID TRANSPORTER; ALDOSTERONE; AMINO ACID TRANSPORTER; AMINO ACID TRANSPORTER 2; CARRIER PROTEIN; L TYPE AMINO ACID TRANSPORTER 1; L TYPE AMINO ACID TRANSPORTER 2; MESSENGER RNA; PLACEBO; SODIUM ION; SPIRONOLACTONE;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC REGULATION; INTESTINE EPITHELIUM; LONG TERM CARE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMA OSMOLALITY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALT INTAKE; SODIUM BLOOD LEVEL; SODIUM TRANSPORT; WISTAR RAT;

ALDOSTERONE; AMINO ACID TRANSPORT SYSTEMS; ANIMALS; BODY WEIGHT; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GENOME; INTESTINES; JEJUNUM; KIDNEY; MALE; OSMOLAR CONCENTRATION; RATS; RATS, WISTAR; RNA, MESSENGER; SODIUM; SODIUM CHLORIDE, DIETARY; SPIRONOLACTONE;

RATTUS; RATTUS NORVEGICUS;

EID: 40649111632     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-008-9735-3     Document Type: Article

References (45)

1. Pinho MJ, Serrao MP, Gomes P, Hopfer U, Jose PA, Soares-da-Silva P (2004) Over-expression of renal LAT1 and LAT2 and enhanced l-DOPA uptake in SHR immortalized renal proximal tubular cells. Kidney Int 66:216-226
2. Pinho MJ, Gomes P, Serrao MP, Bonifacio MJ, Soares-da-Silva P (2003) Organ-specific overexpression of renal LAT2 and enhanced tubular l-DOPA uptake precede the onset of hypertension. Hypertension 42:613-618
3. 0,+, exchange l-DOPA with neutral and basic amino acids in two clonal renal cell lines. J Membr Biol 186:63-80
4. Soares-da-Silva P, Fernandes MH, Pinto-do-Ó PC (1994) Cell inward transport of l-DOPA and 3-O-methyl-l-DOPA in rat renal tubules. Br J Pharmacol 112:611-615
5. Soares-da-Silva P, Pestana M, Fernandes MH (1993) Involvement of tubular sodium in the formation of dopamine in the human renal cortex. J Am Soc Nephrol 3:1591-1599
6. Soares-da-Silva P, Serrao MP (2004) High- and low-affinity transport of l-leucine and l-DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK1 renal cells. Am J Physiol Ren Physiol 287:F252-F261
7. 1 cells. Amino Acids 29:213-219
8. Soares-da-Silva P, Serrao MP, Pinho MJ, Bonifacio MJ (2004) Cloning and gene silencing of LAT2, the l-3,4-dihydroxyphenylalanine (l-DOPA) transporter, in pig renal LLC-PK1 epithelial cells. FASEB J 18:1489-1498
9. Soares-da-Silva P, Serrao MP, Vieira-Coelho MA (1998) Apical and basolateral uptake and intracellular fate of dopamine precursor l-dopa in LLC-PK1 cells. Am J Physiol 274:F243-F251
10. Soares-da-Silva P, Serrao P, Fraga S, Pinho MJ (2005) Expression and function of LAT1, a neutral amino acid exchanger, in renal porcine epithelial cell line LLC-PK. Acta Physiol Scand 185:71-78
11. Pinho MJ, Serrao MP, Soares-da-Silva P (2007) High salt intake and the renal expression of amino acid transporters in spontaneously hypertensive rats. Am J Physiol Ren Physiol 292:F1452-F1463
12. Pinho MJ, Soares-da-Silva P (2005) Influence of aldosterone on the expression of renal LAT2 tranporter. FASEB J 19:A746
13. Pinho MJ, Soares-da-Silva P (2005) Aldosterone effects on the expression of renal l-type amino acid transporter 2. J Hypertens 23:S232
14. Alvelos M, Ferreira A, Bettencourt P, Serrao P, Pestana M, Cerqueira-Gomes M, Soares-Da-Silva P (2004) The effect of dietary sodium restriction on neurohumoral activity and renal dopaminergic response in patients with heart failure. Eur J Heart Fail 6:593-599
15. Ferreira A, Bettencourt P, Dias P, Pestana M, Serrao P, Soares-da-Silva P, Cerqueira-Gomes M (2001) Neurohormonal activation, the renal dopaminergic system and sodium handling in patients with severe heart failure under vasodilator therapy. Clin Sci (Lond) 100:557-566
16. Ferreira A, Bettencourt P, Pimenta J, Frioes F, Pestana M, Soares-da-Silva P, Cerqueira-Gomes M (2002) The renal dopaminergic system, neurohumoral activation, and sodium handling in heart failure. Am Heart J 143:391-397
17. Vieira-Coelho MA, Gomes P, Serrao MP, Soares-da-Silva P (1997) Renal and intestinal autocrine monoaminergic systems: Dopamine versus 5-hydroxytryptamine. Clin Exp Hypertens 19:43-58
18. Sampaio-Maia B, Serrao P, Moura M, Pestana M (2006) Jejunal dopamine and Na,K-ATPase activity in early chronic renal insufficiency. Nephrology (Carlton) 11:63-67
19. +-ATPase in the rat remnant kidney. Am J Physiol Ren Physiol 279:F1033-F1044
20. Laverty G, Elbrond VS, Arnason SS, Skadhauge E (2006) Endocrine regulation of ion transport in the avian lower intestine. Gen Comp Endocrinol 147:70-77
21. Mate A, Barfull A, Hermosa AM, Gomez-Amores L, Vazquez CM, Planas JM (2006) Regulation of sodium-glucose cotransporter SGLT1 in the intestine of hypertensive rats. Am J Physiol Regul Integr Comp Physiol 291:R760-R767
22. Moreto M, Cristia E, Perez-Bosque A, Afzal-Ahmed I, Amat C, Naftalin RJ (2005) Aldosterone reduces crypt colon permeability during low-sodium adaptation. J Membr Biol 206:43-51
23. Fraga S, Serrao MP, Soares-da-Silva P (2002) The l-3,4-dihydroxyphenylalanine transporter in human and rat epithelial intestinal cells is a type 2 hetero amino acid exchanger. Eur J Pharmacol 441:127-135
24. Fraga S, Serrao MP, Soares-da-Silva P (2002) l-Type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acids. J Nutr 132:733-738
25. Fraga S, Pinho MJ, Soares-da-Silva P (2005) Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells. Amino Acids 29:229-233
26. Boldyreff B, Wehling M (2003) Rapid aldosterone actions: From the membrane to signaling cascades to gene transcription and physiological effects. J Steroid Biochem Mol Biol 85:375-381
27. Boldyreff B, Wehling M (2004) Aldosterone: Refreshing a slow hormone by swift action. News Physiol Sci 19:97-100
28. Lerner J (1985) Effectors of amino acid transport processes in animal cell membranes. Comp Biochem Physiol A 81:713-739
29. Schwertfeger M, Roskos M, Fleck C (2000) Identification of the site of glucocorticoid action on neutral amino acid transport in superficial nephrons of rat kidney. Amino Acids 18:279-288
30. Spindler B, Mastroberardino L, Custer M, Verrey F (1997) Characterization of early aldosterone-induced RNAs identified in A6 kidney epithelia. Pflugers Arch 434:323-331
31. Wagner CA, Broer A, Albers A, Gamper N, Lang F, Broer S (2000) The heterodimeric amino acid transporter 4F2hc/LAT1 is associated in Xenopus oocytes with a non-selective cation channel that is regulated by the serine/threonine kinase sgk-1. J Physiol 526:35-46
32. Atwill WH, Boyarsky S, Glenn JF (1965) Effect of spironolactone on experimental renovascular hypertension. Surg Forum 16:494-495
33. Rocha R, Chander PN, Khanna K, Zuckerman A, Stier CT Jr (1998) Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats. Hypertension 31:451-458
34. Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M (1999) Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an l-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J Biol Chem 274:19738-19744
35. Rossier G, Meier C, Bauch C, Summa V, Sordat B, Verrey F, Kuhn LC (1999) LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. J Biol Chem 274:34948-34954
36. Segawa H, Fukasawa Y, Miyamoto K, Takeda E, Endou H, Kanai Y (1999) Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity. J Biol Chem 274:19745-19751
37. Nakamura E, Sato M, Yang H, Miyagawa F, Harasaki M, Tomita K, Matsuoka S, Noma A, Iwai K, Minato N (1999) 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer. J Biol Chem 274:3009-3016
38. Kanai Y, Endou H (2001) Heterodimeric amino acid transporters: Molecular biology and pathological and pharmacological relevance. Curr Drug Metab 2:339-354
39. Verrey F (1999) Early aldosterone action: Toward filling the gap between transcription and transport. Am J Physiol 277:F319-F327
40. Broer S, Broer A, Hamprecht B (1997) Expression of the surface antigen 4F2hc affects system-l-like neutral-amino-acid-transport activity in mammalian cells. Biochem J 324(Pt 2):535-541
41. Campbell WA, Sah DE, Medina MM, Albina JE, Coleman WB, Thompson NL (2000) TA1/LAT-1/CD98 light chain and system l activity, but not 4F2/ CD98 heavy chain, respond to arginine availability in rat hepatic cells. Loss Of response in tumor cells. J Biol Chem 275:5347-5354
42. Kudo Y, Boyd CA (2000) Heterodimeric amino acid transporters: Expression of heavy but not light chains of CD98 correlates with induction of amino acid transport systems in human placental trophoblast. J Physiol 523(Pt 1):13-18
43. Uchiyama T, Matsuda Y, Wada M, Takahashi S, Fujita T (2005) Functional regulation of Na+-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells. FEBS Lett 579:2499-2506
44. Avissar NE, Ziegler TR, Wang HT, Gu LH, Miller JH, Iannoli P, Leibach FH, Ganapathy V, Sax HC (2001) Growth factors regulation of rabbit sodium-dependent neutral amino acid transporter ATB0 and oligopeptide transporter 1 mRNAs expression after enteretomy. J Parenter Enteral Nutr 25:65-72
45. Bungard CI, McGivan JD (2005) Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers. Arch Biochem Biophys 443:53-59