Overexpression of the neutral amino acid transporter ASCT2 in human colorectal adenocarcinoma

Anticancer Research

Volumn 22, Issue 5, 2002, Pages 2555-2557

  Witte, Deborah ^a   Ali, Najeeba ^a   Carlson, Nicole ^a   Younes, Mamoun ^a,b  

^a HOUSTON METHODIST HOSPITAL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cancer; Glutamine; Immunohistochemistry; Prognosis; Survival

Indexed keywords

AMINO ACID TRANSPORTER; GLUTAMINE;

ADENOCARCINOMA; ADULT; AMINO ACID TRANSPORT; ARTICLE; CANCER CELL; COLORECTAL CARCINOMA; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL RATE; WESTERN BLOTTING;

ADENOCARCINOMA; ADULT; AMINO ACID TRANSPORT SYSTEM ASC; BLOTTING, WESTERN; COLORECTAL NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PROGNOSIS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 0036765406     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Johnstone RM and Scholefield PG: Amino acid transport in tumor cells. Adv Cancer Res 9: 143-226, 1965.
2. Isselbacher KJ: Sugar and amino acid transport by cells in culture-differences between normal and malignant cells. N Engl J Med 286: 929-33, 1972.
3. Isselbacher KJ: Increased uptake of amino acids and 2-deoxy-D-glucose by virus-transformed cells in culture. Proc Natl Acad Sci USA 69: 585-9, 1972.
4. Christensen HN and Liang M: An amino acid transport system of unassigned function in the Ehrlich ascitis tumor cell. J Biol Chem 240: 3601-8, 1965.
5. Weber MJ, Evans PK, Johnson MA, McNair TF, Nakamura KD and Salter DW: Transport of potassium, amino acids, and glucose in cells transformed by Rous sarcoma virus. Fed Proc 43: 107-12, 1984.
6. Piedimonte G, Baginski I, Silvotti L, Petronini PG and Borghetti AF: Density-dependent regulation of amino acid transport in a Burkitt lymphoma cell line. Cancer Lett 47: 121-5, 1989.
7. Goenner S, Boutron A, Soni T, Lemonnier A and Moatti N: Amino acid transport systems in the human hepatoma cell line Hep G2. Biochem Biophys Res Commun 189: 472-9, 1992.
8. Bode BP, Kaminski DL, Souba WW and Li AP: Glutamine transport in isolated human hepatocytes and transformed liver cells. Hepatology 21: 511-20, 1995.
9. Miyagawa T, Oku T, Uehara H, Desai R, Beattie B, Tjuvajev J et al: "Facilitated" amino acid transport is up-regulated in brain tumors. J Cereb Blood Flow Metab 18: 500-9, 1998.
10. Holm E, Hagmuller E, Staedt U, Schlickeiser G, Gunther HJ, Leweling H et al: Substrate balances across colonic carcinomas in humans. Cancer Res 55: 1373-8, 1995.
11. Hagmuller E, Kollmar HB, Gunther HJ, Holm E and Trede M: Protein metabolism in human colon carcinomas: in vivo investigations using a modified tracer technique with L-[1-13C]leucine. Cancer Res 55: 1160-7, 1995.
12. Utsunomiya-Tate N, Endou H and Kanai Y: Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter. J Biol Chem 271: 14883-90, 1996.
13. Broer A, Brookes N, Ganapathy V, Dimmer KS, Wagner CA, Lang F et al: The astroglial ASCT2 amino acid transporter as a mediator of glutamine efflux. J Neurochem 73: 2184-94, 1999.
14. Tailor CS, Marin M, Nouri A, Kavanaugh MP and Kabat D: Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons. J Biol Chem 276: 27221-30, 2001.
15. Kovacevic Z and Morris HP: The role of glutamine in the oxidative metabolism of malignant cells. Cancer Res 32: 326-33, 1972.
16. Wasa M, Bode BP, Abcouwer SF, Collins CL, Tanabe KK and Souba WW: Glutamine as a regulator of DNA and protein biosynthesis in human solid tumor cell lines. Ann Surg 224: 189-97, 1996.
17. Souba WW: Glutamine and cancer. Ann Surg 278: 715-28, 1993.