Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 14, 2013, Pages 5480-5485

  Geier, Ethan G ^a   Schlessinger, Avner ^a,b,c   Fan, Hao ^a,b   Gable, Jonathan E ^a   Irwin, John J ^a,b   Sali, Andrej ^a,b   Giacomini, Kathleen M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Glioblastoma multiforme; Membrane transporter; Polypharmacology; Solute carrier (SLC) transporter

Indexed keywords

ACIVICIN; AMINO ACID TRANSPORTER; BENZIMIDAZOLE DERIVATIVE; CYSTINE; DIIODOTYROSINE; FENCLONINE; GABAPENTIN; IODOTYROSINE; LIGAND; MEBENDAZOLE; NOCADEZOLE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CANCER CELL CULTURE; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG METABOLISM; DRUG PENETRATION; DRUG SCREENING; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN TRANSPORT;

AMINES; ANALYSIS OF VARIANCE; BLOOD-BRAIN BARRIER; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANECARBOXYLIC ACIDS; DRUG DELIVERY SYSTEMS; FLOW CYTOMETRY; GAMMA-AMINOBUTYRIC ACID; GLIOBLASTOMA; HEK293 CELLS; HUMANS; ISOXAZOLES; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; LEUCINE; LIGANDS; MODELS, MOLECULAR; TRITIUM;

EID: 84875871890     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1218165110     Document Type: Article

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