Functional characterization and molecular expression of large neutral amino acid transporter (LAT1) in human prostate cancer cells

International Journal of Pharmaceutics

Volumn 443, Issue 1-2, 2013, Pages 245-253

  Patel, Mitesh ^a   Dalvi, Pranjali ^b   Gokulgandhi, Mitan ^a   Kesh, Susamita ^c   Kohli, Tanvi ^c   Pal, Dhananjay ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cellular uptake mechanism; Drug delivery; LAT1; Prodrugs; Prostate cancer; Tyrosine

Indexed keywords

AMINO ACID TRANSPORTER; ARGININE; ASPARTIC ACID; CYSTEINE; GLUTAMIC ACID; ISOLEUCINE; LEUCINE; LYSINE; PHENYLALANINE; SERINE; SODIUM ION; TRYPTOPHAN; TYROSINE;

ARTICLE; CANCER CELL; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; ENERGY; HUMAN; HUMAN CELL; PH; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN ANALYSIS; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEMPERATURE; TEMPERATURE DEPENDENCE;

BIOLOGICAL TRANSPORT; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN-ION CONCENTRATION; ISOLEUCINE; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; MALE; PRODRUGS; PROSTATIC NEOPLASMS; QUINIDINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUBSTRATE SPECIFICITY; TANDEM MASS SPECTROMETRY; TEMPERATURE; TIME FACTORS; TYROSINE;

EID: 84873993390     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.12.029     Document Type: Article

References (50)

1. B.S. Anand, S. Katragadda, Y.E. Nashed, and A.K. Mitra Amino acid prodrugs of acyclovir as possible antiviral agents against ocular HSV-1 infections: interactions with the neutral and cationic amino acid transporter on the corneal epithelium Curr. Eye Res. 29 2004 153 166
2. H. Atluri, R.S. Talluri, and A.K. Mitra Functional activity of a large neutral amino acid transporter (LAT) in rabbit retina: a study involving the in vivo retinal uptake and vitreal pharmacokinetics of l-phenyl alanine Int. J. Pharm. 347 2008 23 30
3. E. Babu, Y. Kanai, A. Chairoungdua, D.K. Kim, Y. Iribe, S. Tangtrongsup, P. Jutabha, Y. Li, N. Ahmed, S. Sakamoto, N. Anzai, S. Nagamori, and H. Endou Identification of a novel system l amino acid transporter structurally distinct from heterodimeric amino acid transporters J. Biol. Chem. 278 2003 43838 43845
4. A. Balakrishnan, B. Jain-Vakkalagadda, C. Yang, D. Pal, and A.K. Mitra Carrier mediated uptake of l-tyrosine and its competitive inhibition by model tyrosine linked compounds in a rabbit corneal cell line (SIRC)-strategy for the design of transporter/receptor targeted prodrugs Int. J. Pharm. 247 2002 115 125
5. M. Bauwens, T. Lahoutte, K. Kersemans, C. Gallez, A. Bossuyt, and J. Mertens Comparison of the uptake of [123/125I]-2-iodo-d-tyrosine and [123/125I]-2-iodo-l-tyrosine in R1M rhabdomyosarcoma cells in vitro and in R1M tumor-bearing Wag/Rij rats in vivo Nucl. Med. Biol. 33 2006 735 741
6. V. Berger, Y. Larondelle, A. Trouet, and Y.J. Schneider Transport mechanisms of the large neutral amino acid l-phenylalanine in the human intestinal epithelial caco-2 cell line J. Nutr. 130 2000 2780 2788
7. R.J. Boado, J.Y. Li, M. Nagaya, C. Zhang, and W.M. Pardridge Selective expression of the large neutral amino acid transporter at the blood-brain barrier Proc. Natl. Acad. Sci. U.SA. 96 1999 12079 12084
8. S. Bodoy, L. Martin, A. Zorzano, M. Palacin, R. Estevez, and J. Bertran Identification of LAT4, a novel amino acid transporter with system L activity J. Biol. Chem. 280 2005 12002 12011
9. G. Buchanan, P.S. Craft, M. Yang, A. Cheong, J. Prescott, L. Jia, G.A. Coetzee, and W.D. Tilley PC-3 cells with enhanced androgen receptor signaling: a model for clonal selection in prostate cancer Prostate 60 2004 352 366
10. H.N. Christensen Role of amino acid transport and countertransport in nutrition and metabolism Physiol. Rev. 70 1990 43 77
11. B.M. Eaton, and S.R. Sooranna Transport of large neutral amino acids into BeWo cells Placenta 21 2000 558 564
12. P. Effert, A.J. Beniers, Y. Tamimi, S. Handt, and G. Jakse Expression of glucose transporter 1 (Glut-1) in cell lines and clinical specimens from human prostate adenocarcinoma Anticancer Res. 24 2004 3057 3063
13. R.B. Franklin, J. Zou, Z. Yu, and L.C. Costello EAAC1 is expressed in rat and human prostate epithelial cells; functions as a high-affinity l-aspartate transporter; and is regulated by prolactin and testosterone BMC Biochem. 7 2006 10
14. V. Ganapathy, M. Thangaraju, and P.D. Prasad Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond Pharmacol. Ther. 121 2009 29 40
15. M.D. Gandhi, D. Pal, and A.K. Mitra Identification and functional characterization of a Na(+)-independent large neutral amino acid transporter (LAT2) on ARPE-19 cells Int. J. Pharm. 275 2004 189 200
16. B. Gaucher, M. Rouquayrol, D. Roche, J. Greiner, A.M. Aubertin, and P. Vierling Prodrugs of HIV protease inhibitors-saquinavir, indinavir and nelfinavir-derived from diglycerides or amino acids: synthesis, stability and anti-HIV activity Org. Biomol. Chem. 2 2004 345 357
17. T. Hara, A. Bansal, and T.R. DeGrado Choline transporter as a novel target for molecular imaging of cancer Mol. Imaging. 5 2006 498 509
18. K.M. Hargreaves, and W.M. Pardridge Neutral amino acid transport at the human blood-brain barrier J. Biol. Chem. 263 1988 19392 19397
19. I.J. Hidalgo, and R.T. Borchardt Transport of a large neutral amino acid (phenylalanine) in a human intestinal epithelial cell line: caco-2 Biochim. Biophys. Acta 1028 1990 25 30
20. D.W. Horne, and K.A. Reed Transport of methotrexate into PC-3 human prostate cancer cells Arch. Biochem. Biophys. 394 2001 39 44
21. M. Hu, and R.T. Borchardt Transport of a large neutral amino acid in a human intestinal epithelial cell line (Caco-2): uptake and efflux of phenylalanine Biochim. Biophys. Acta 1135 1992 233 244
22. +-independent large neutral amino acid transporter, LAT1, in human and rabbit cornea Invest. Ophthalmol. Vis. Sci. 44 2003 2919 2927
23. R. Jain, S. Majumdar, Y. Nashed, D. Pal, and A.K. Mitra Circumventing P-glycoprotein-mediated cellular efflux of quinidine by prodrug derivatization Mol Pharm 1 2004 290 299
24. Y. Kanai, H. Segawa, K. Miyamoto, H. Uchino, E. Takeda, and H. Endou Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98) J. Biol. Chem. 273 1998 23629 23632
25. D.M. Killian, and P.J. Chikhale Predominant functional activity of the large, neutral amino acid transporter (LAT1) isoform at the cerebrovasculature Neurosci. Lett. 306 2001 1 4
26. D.K. Kim, Y. Kanai, H.W. Choi, S. Tangtrongsup, A. Chairoungdua, E. Babu, K. Tachampa, N. Anzai, Y. Iribe, and H. Endou Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells Biochim. Biophys. Acta 1565 2002 112 121
27. H. Kobayashi, Y. Ishii, and T. Takayama Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinoma J. Surg. Oncol. 90 2005 233 238
28. Y. Kudo, and C.A. Boyd Characterisation of l-tryptophan transporters in human placenta: a comparison of brush border and basal membrane vesicles J. Physiol. 531 2001 405 416
29. S. Majumdar, T. Hingorani, R. Srirangam, R.S. Gadepalli, J.M. Rimoldi, and M.A. Repka Transcorneal permeation of l- and d-aspartate ester prodrugs of acyclovir: delineation of passive diffusion versus transporter involvement Pharm. Res. 26 2009 1261 1269
30. L. Mastroberardino, B. Spindler, R. Pfeiffer, P.J. Skelly, J. Loffing, C.B. Shoemaker, and F. Verrey Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family Nature 395 1998 288 291
31. C. Meier, Z. Ristic, S. Klauser, and F. Verrey Activation of system L heterodimeric amino acid exchangers by intracellular substrates EMBO J. 21 2002 580 589
32. E. Morimoto, Y. Kanai, K. Kim do, A. Chairoungdua, H.W. Choi, M.F. Wempe, N. Anzai, and H. Endou Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters J. Pharmacol. Sci. 108 2008 505 516
33. M. Palacin, R. Estevez, J. Bertran, and A. Zorzano Molecular biology of mammalian plasma membrane amino acid transporters Physiol. Rev. 78 1998 969 1054
34. W.M. Pardridge Blood-brain barrier carrier-mediated transport and brain metabolism of amino acids Neurochem. Res. 23 1998 635 644
35. M. Patel, R.K. Vadlapatla, S. Shah, and A.K. Mitra Molecular expression and functional activity of sodium dependent multivitamin transporter in human prostate cancer cells Int. J. Pharm. 436 2012 324 331
36. M. Pineda, E. Fernandez, D. Torrents, R. Estevez, C. Lopez, M. Camps, J. Lloberas, A. Zorzano, and M. Palacin Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids J. Biol. Chem. 274 1999 19738 19744
37. N. Pissimissis, E. Papageorgiou, P. Lembessis, A. Armakolas, and M. Koutsilieris The glutamatergic system expression in human PC-3 and LNCaP prostate cancer cells Anticancer Res. 29 2009 371 377
38. P.D. Prasad, H. Wang, W. Huang, R. Kekuda, D.P. Rajan, F.H. Leibach, and V. Ganapathy Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function Biochem. Biophys. Res. Commun. 255 1999 283 288
39. D.P. Rajan, R. Kekuda, W. Huang, L.D. Devoe, F.H. Leibach, P.D. Prasad, and V. Ganapathy Cloning and functional characterization of a Na(+)-independent, broad-specific neutral amino acid transporter from mammalian intestine Biochim. Biophys. Acta 1463 2000 6 14
40. M.S. Rathore, and V.B. Gupta Functional characterization of amino acid transport system for transport of phenylalanine on mammalian cornea for better ocular drug delivery J. Pharm. Sci. Res. 2 2010 329 337
41. A. Reichel, N.J. Abbott, and D.J. Begley Evaluation of the RBE4 cell line to explore carrier-mediated drug delivery to the CNS via the L-system amino acid transporter at the blood-brain barrier J. Drug Target. 10 2002 277 283
42. G. Rossier, C. Meier, C. Bauch, V. Summa, B. Sordat, F. Verrey, and L.C. Kuhn LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine J. Biol. Chem. 274 1999 34948 34954
43. M. Rouquayrol, B. Gaucher, D. Roche, J. Greiner, and P. Vierling Transepithelial transport of prodrugs of the HIV protease inhibitors saquinavir, indinavir, and nelfinavir across Caco-2 cell monolayers Pharm. Res. 19 2002 1704 1712
44. +-independent neutral amino acid transporter with broad substrate selectivity J. Biol. Chem. 274 1999 19745 19751
45. M.A. Shotwell, M.S. Kilberg, and D.L. Oxender The regulation of neutral amino acid transport in mammalian cells Biochim. Biophys. Acta 737 1983 267 284
46. P. Soares-da-Silva, P. Serrao, S. Fraga, and M.J. Pinho Expression and function of LAT1, a neutral amino acid exchanger, in renal porcine epithelial cell line LLC-PK Acta Physiol. Scand. 185 2005 71 78
47. H. Uchino, Y. Kanai, D.K. Kim, M.F. Wempe, A. Chairoungdua, E. Morimoto, M.W. Anders, and H. Endou Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition Mol. Pharmacol. 61 2002 729 737
48. C.A. Wagner, F. Lang, and S. Broer Function and structure of heterodimeric amino acid transporters Am. J. Physiol. Cell Physiol. 281 2001 C1077 C1093
49. A. Yamamoto, S. Akanuma, M. Tachikawa, and K. Hosoya Involvement of LAT1 and LAT2 in the high- and low-affinity transport of l-leucine in human retinal pigment epithelial cells (ARPE-19 cells) J. Pharm. Sci. 99 2010 2475 2482
50. O. Yanagida, Y. Kanai, A. Chairoungdua, D.K. Kim, H. Segawa, T. Nii, S.H. Cha, H. Matsuo, J. Fukushima, Y. Fukasawa, Y. Tani, Y. Taketani, H. Uchino, J.Y. Kim, J. Inatomi, I. Okayasu, K. Miyamoto, E. Takeda, T. Goya, and H. Endou Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines Biochim. Biophys. Acta 1514 2001 291 302