메뉴 건너뛰기




Volumn 349, Issue 3, 2000, Pages 787-795

The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine

Author keywords

Antiporter; Arginine transport; Astrocyte; Brain metabolism; Glutamine transport

Indexed keywords

ARGININE; GLUTAMIC ACID; GLUTAMINE; GLYCOPROTEIN; HISTIDINE; LEUCINE; LYSINE; MEMBRANE PROTEIN; METHIONINE;

EID: 0034254798     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3490787     Document Type: Article
Times cited : (172)

References (34)
  • 2
    • 0032142757 scopus 로고    scopus 로고
    • Discrimination of two amino acid transport activities in 4F2 heavy chain expressing Xenopus laevis oocytes
    • 2 Bröer, A., Hamprecht, B. and Bröer, S. (1998) Discrimination of two amino acid transport activities in 4F2 heavy chain expressing Xenopus laevis oocytes. Biochem J. 333, 549-554
    • (1998) Biochem J. , vol.333 , pp. 549-554
    • Bröer, A.1    Hamprecht, B.2    Bröer, S.3
  • 5
    • 0032508585 scopus 로고    scopus 로고
    • Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)
    • 5 Kanai, Y., Segawa, H., Miyamoto, K., Uchino, H., Takeda, E. and Endou, H. (1998) Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J. Biol. Chem. 273, 23629-23632
    • (1998) J. Biol. Chem. , vol.273 , pp. 23629-23632
    • Kanai, Y.1    Segawa, H.2    Miyamoto, K.3    Uchino, H.4    Takeda, E.5    Endou, H.6
  • 6
    • 0032514944 scopus 로고    scopus 로고
    • Functional heterodimeric amino acid transporters lacking cysteine residues involved in disulfide bond
    • 6 Pfeiffer, R., Spindler, B., Loffing, J., Skelly, P., Shoemaker, C. B. and Verrey, F. (1998) Functional heterodimeric amino acid transporters lacking cysteine residues involved in disulfide bond. FEBS Lett. 439, 157-162
    • (1998) FEBS Lett. , vol.439 , pp. 157-162
    • Pfeiffer, R.1    Spindler, B.2    Loffing, J.3    Skelly, P.4    Shoemaker, C.B.5    Verrey, F.6
  • 7
    • 0033613960 scopus 로고    scopus 로고
    • 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer
    • 7 Nakamura, E., Sato, M., Yang, H., Miyagawa, F., Harasaki, M., Tomita, K., Matsuoka, S., Noma, A., Iwai, K. and Minato, N. (1999) 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer. J. Biol. Chem. 274, 3009-3016
    • (1999) J. Biol. Chem. , vol.274 , pp. 3009-3016
    • Nakamura, E.1    Sato, M.2    Yang, H.3    Miyagawa, F.4    Harasaki, M.5    Tomita, K.6    Matsuoka, S.7    Noma, A.8    Iwai, K.9    Minato, N.10
  • 8
    • 0033521614 scopus 로고    scopus 로고
    • +L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family
    • +L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family. EMBO J. 18, 49-57
    • (1999) EMBO J. , vol.18 , pp. 49-57
    • Pfeiffer, R.1    Rossier, G.2    Spindler, B.3    Meier, C.4    Kühn, L.5    Verrey, F.6
  • 10
    • 0040610689 scopus 로고    scopus 로고
    • Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids
    • 10 Pineda, M., Fernandez, E., Torrents, D., Estevez, R., Lopez, C., Camps, M., Lloberas, J., Zorzano, A. and Palacin, M. (1999) Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J. Biol. Chem. 274, 19738-19744
    • (1999) J. Biol. Chem. , vol.274 , pp. 19738-19744
    • Pineda, M.1    Fernandez, E.2    Torrents, D.3    Estevez, R.4    Lopez, C.5    Camps, M.6    Lloberas, J.7    Zorzano, A.8    Palacin, M.9
  • 12
    • 0033597349 scopus 로고    scopus 로고
    • Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins
    • 12 Sato, H., Tamba, M., Ishii, T. and Bannai, S. (1999) Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. J. Biol. Chem 274, 11455-11458
    • (1999) J. Biol. Chem , vol.274 , pp. 11455-11458
    • Sato, H.1    Tamba, M.2    Ishii, T.3    Bannai, S.4
  • 13
    • 0025095302 scopus 로고
    • Role of amino acid transport and countertransport in nutrition and metabolism
    • 13 Christensen, H. N. (1990) Role of amino acid transport and countertransport in nutrition and metabolism. Physiol Rev. 70, 43-77
    • (1990) Physiol Rev. , vol.70 , pp. 43-77
    • Christensen, H.N.1
  • 14
    • 0008412457 scopus 로고    scopus 로고
    • Transport systems involved in the metabolic traffic between brain cells
    • 14 Bröer, S. (1998) Transport systems involved in the metabolic traffic between brain cells. Nova Acta Leopoldina 306, 79-91
    • (1998) Nova Acta Leopoldina , vol.306 , pp. 79-91
    • Bröer, S.1
  • 15
    • 0033520913 scopus 로고    scopus 로고
    • LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine
    • 15 Rossier, G., Meier, C., Bauch, C., Summa, V., Sorda, B., Verrey, F. and Kühn, L. C. (1999) LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. J. Biol. Chem 274, 34948-34954
    • (1999) J. Biol. Chem , vol.274 , pp. 34948-34954
    • Rossier, G.1    Meier, C.2    Bauch, C.3    Summa, V.4    Sorda, B.5    Verrey, F.6    Kühn, L.C.7
  • 16
    • 0030774069 scopus 로고    scopus 로고
    • Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes
    • 16 Bröer, S., Rahman, B., Pellegri, G., Pellerin, L., Martin, J. L., Verleysdonk, S., Hamprecht, B. and Magistretti, P. J. (1997) Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes. J. Biol. Chem. 272, 30096-30102
    • (1997) J. Biol. Chem. , vol.272 , pp. 30096-30102
    • Bröer, S.1    Rahman, B.2    Pellegri, G.3    Pellerin, L.4    Martin, J.L.5    Verleysdonk, S.6    Hamprecht, B.7    Magistretti, P.J.8
  • 17
    • 0031239010 scopus 로고    scopus 로고
    • Brain metabolism of branched-chain amino acids
    • 17 Yudkoff, M. (1997) Brain metabolism of branched-chain amino acids. Glia 21, 92-98
    • (1997) Glia , vol.21 , pp. 92-98
    • Yudkoff, M.1
  • 18
    • 0033598956 scopus 로고    scopus 로고
    • Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission
    • 18 Chaudry, F. A., Reimer, R. J., Krizaj, D., Barber, D., Storm-Mathiesen, J., Copenhagen, D. R. and Edwards, R. H. (1999) Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. Cell 99, 769-780
    • (1999) Cell , vol.99 , pp. 769-780
    • Chaudry, F.A.1    Reimer, R.J.2    Krizaj, D.3    Barber, D.4    Storm-Mathiesen, J.5    Copenhagen, D.R.6    Edwards, R.H.7
  • 20
    • 0030033642 scopus 로고    scopus 로고
    • Astrocyte leucine metabolism: Significance of branched-chain amino acid transamination
    • 20 Yudkoff, M., Daikhin, Y., Nelson, D., Nissim, I. and Erecinska, M. (1996) Astrocyte leucine metabolism: significance of branched-chain amino acid transamination. J. Neurochem. 66, 378-385
    • (1996) J. Neurochem. , vol.66 , pp. 378-385
    • Yudkoff, M.1    Daikhin, Y.2    Nelson, D.3    Nissim, I.4    Erecinska, M.5
  • 21
    • 0028284186 scopus 로고
    • Synaptosomal high affinity transport systems for essential amino acids in rat brain cortex
    • 21 Rao, K. V. R. and Murthy, C. R. K. (1994) Synaptosomal high affinity transport systems for essential amino acids in rat brain cortex. Neurosci. Lett. 175, 103-106
    • (1994) Neurosci. Lett. , vol.175 , pp. 103-106
    • Rao, K.V.R.1    Murthy, C.R.K.2
  • 22
    • 0030005938 scopus 로고    scopus 로고
    • Glutamine transport in mouse cerebral astrocytes
    • 22 Nagaraja, T. N. and Brookes, N. (1996) Glutamine transport in mouse cerebral astrocytes. J. Neurochem. 66, 1665-1674
    • (1996) J. Neurochem. , vol.66 , pp. 1665-1674
    • Nagaraja, T.N.1    Brookes, N.2
  • 24
    • 0031916983 scopus 로고    scopus 로고
    • Transporters for cationic amino acids in animal cells: Discovery, structure, and function
    • 24 Deves, R. and Boyd, C. A. R. (1998) Transporters for cationic amino acids in animal cells: discovery, structure, and function. Physiol. Rev. 78, 487-545
    • (1998) Physiol. Rev. , vol.78 , pp. 487-545
    • Deves, R.1    Boyd, C.A.R.2
  • 25
    • 0031007025 scopus 로고    scopus 로고
    • Expression of the surface antigen 4F2hc affects system L-like neutral amino acid transport in mammalian cells
    • 25 Bröer, S., Bröer, A. and Hamprecht, B. (1997) Expression of the surface antigen 4F2hc affects system L-like neutral amino acid transport in mammalian cells. Biochem. J. 324, 535-541
    • (1997) Biochem. J. , vol.324 , pp. 535-541
    • Bröer, S.1    Bröer, A.2    Hamprecht, B.3
  • 26
    • 0030608273 scopus 로고    scopus 로고
    • Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain
    • 26 Nagase, T., Seki, N., Ishikawa, K., Ohira, M., Kawarabayasi, Y., Ohara, O., Tanaka, A., Kotani, H., Miyajima, N. and Nomura, N. (1996) Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. DNA Res. 3, 321-329
    • (1996) DNA Res. , vol.3 , pp. 321-329
    • Nagase, T.1    Seki, N.2    Ishikawa, K.3    Ohira, M.4    Kawarabayasi, Y.5    Ohara, O.6    Tanaka, A.7    Kotani, H.8    Miyajima, N.9    Nomura, N.10
  • 27
    • 0028232065 scopus 로고
    • +-independent isoleucine transport activity from rat brain in Xenopus laevis oocytes
    • +-independent isoleucine transport activity from rat brain in Xenopus laevis oocytes. Biochim. Biophys. Acta 1192, 95-100
    • (1994) Biochim. Biophys. Acta , vol.1192 , pp. 95-100
    • Bröer, S.1    Bröer, A.2    Hamprecht, B.3
  • 28
    • 0021893839 scopus 로고
    • Primary glial cultures as a model for studying hormone action
    • 28 Hamprecht, B. and Löffler, F. (1985) Primary glial cultures as a model for studying hormone action. Methods Enzymol. 109, 341-345
    • (1985) Methods Enzymol. , vol.109 , pp. 341-345
    • Hamprecht, B.1    Löffler, F.2
  • 29
    • 0022649760 scopus 로고
    • Immunocytochemical characterization of neuron-rich primary cultures of embryonal rat brain cells established by neuronal and glial markers and by monospecific antisera against cyclic-nucleotide-dependent protein kinases and the synaptic vesicle protein synapsin I
    • 29 Löffler, F., Lohmann, S. M., Walkhoff, B., Walter, U. and Hamprecht, B. (1986) Immunocytochemical characterization of neuron-rich primary cultures of embryonal rat brain cells established by neuronal and glial markers and by monospecific antisera against cyclic-nucleotide-dependent protein kinases and the synaptic vesicle protein synapsin I. Brain Res. 363, 205-211
    • (1986) Brain Res. , vol.363 , pp. 205-211
    • Löffler, F.1    Lohmann, S.M.2    Walkhoff, B.3    Walter, U.4    Hamprecht, B.5
  • 30
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • 30 Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 31
    • 0343244634 scopus 로고    scopus 로고
    • The heterodimeric amino acid transporter 4F2hc/LAT1 is associated in Xenopus oocytes with a non-selective cation channel that is regulated by the serine/threonine kinase sgk-1
    • 31 Wagner, C. A., Bröer, A., Albers, A., Gamper, N., Lang, F. and Bröer, S. (2000) The heterodimeric amino acid transporter 4F2hc/LAT1 is associated in Xenopus oocytes with a non-selective cation channel that is regulated by the serine/threonine kinase sgk-1. J. Physiol. (London) 526, 35-46
    • (2000) J. Physiol. (London) , vol.526 , pp. 35-46
    • Wagner, C.A.1    Bröer, A.2    Albers, A.3    Gamper, N.4    Lang, F.5    Bröer, S.6
  • 32
    • 0000721116 scopus 로고    scopus 로고
    • Amino-acid-dependent modulation of amino acid transport in Xenopus laevis oocytes
    • 32 Taylor, P. M., Kaur, S., MacKenzie, B. and Peter, G. J. (1996) Amino-acid-dependent modulation of amino acid transport in Xenopus laevis oocytes. J. Exp. Biol 199, 923-931
    • (1996) J. Exp. Biol , vol.199 , pp. 923-931
    • Taylor, P.M.1    Kaur, S.2    MacKenzie, B.3    Peter, G.J.4
  • 33
    • 0032402262 scopus 로고    scopus 로고
    • Argininosuccinate synthetase: Localization in astrocytes and role in the production of glial nitric oxide
    • 33 Schmidlin, A. and Wiesinger, H. (1998) Argininosuccinate synthetase: localization in astrocytes and role in the production of glial nitric oxide. Glia 24, 428-436
    • (1998) Glia , vol.24 , pp. 428-436
    • Schmidlin, A.1    Wiesinger, H.2
  • 34
    • 0032533159 scopus 로고    scopus 로고
    • Arginine metabolism: Nitric oxide and beyond
    • 34 Wu, G. and Morris, S. M. (1998) Arginine metabolism: nitric oxide and beyond. Biochem. J. 336, 1-17
    • (1998) Biochem. J. , vol.336 , pp. 1-17
    • Wu, G.1    Morris, S.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.