메뉴 건너뛰기




Volumn 15, Issue 3, 2016, Pages 174-185

Hypoxic regulation of the noncoding genome and NEAT

Author keywords

Cancer; HIF; Hypoxia; Noncoding RNA

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; LONG UNTRANSLATED RNA; METASTASIS ASSOCIATED LUNG ADENOCARCINOMA TRANSCRIPT 1; MICRORNA; NUCLEAR ENRICHED ABUNDANT TRANSCRIPT 1 PROTEIN; PIWI INTERACTING RNA; PROTEIN; SMALL NUCLEOLAR RNA; TRANSCRIPTOME; UNCLASSIFIED DRUG; UNTRANSLATED RNA; NEAT1 LONG NON-CODING RNA, HUMAN;

EID: 84979073180     PISSN: 20412649     EISSN: 20412657     Source Type: Journal    
DOI: 10.1093/bfgp/elv050     Document Type: Article
Times cited : (48)

References (140)
  • 2
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA, et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995;92:5510-14.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3
  • 3
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 1997;11:72-82.
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 4
    • 0031733828 scopus 로고    scopus 로고
    • Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha
    • Gu YZ, Moran SM, Hogenesch JB, et al. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr 1998;7:205-13.
    • (1998) Gene Expr , vol.7 , pp. 205-213
    • Gu, Y.Z.1    Moran, S.M.2    Hogenesch, J.B.3
  • 5
    • 33744954065 scopus 로고    scopus 로고
    • Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways
    • Elvidge GP, Glenny L, Appelhoff RJ, et al. Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. J Biol Chem 2006;281:15215-26.
    • (2006) J Biol Chem , vol.281 , pp. 15215-15226
    • Elvidge, G.P.1    Glenny, L.2    Appelhoff, R.J.3
  • 6
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    • Hu CJ, Wang LY, Chodosh LA, et al. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 2003;23:9361-74.
    • (2003) Mol Cell Biol , vol.23 , pp. 9361-9374
    • Hu, C.J.1    Wang, L.Y.2    Chodosh, L.A.3
  • 7
    • 17144416530 scopus 로고    scopus 로고
    • Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells
    • Wang V, Davis DA, Haque M, et al. Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells. Cancer Res 2005;65:3299-306.
    • (2005) Cancer Res , vol.65 , pp. 3299-3306
    • Wang, V.1    Davis, D.A.2    Haque, M.3
  • 8
    • 20744445650 scopus 로고    scopus 로고
    • Contrasting properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von hippellindau-associated renal cell carcinoma
    • Raval RR, Lau KW, Tran MG, et al. Contrasting properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von hippellindau-associated renal cell carcinoma. Mol Cell Biol 2005;25:5675-86.
    • (2005) Mol Cell Biol , vol.25 , pp. 5675-5686
    • Raval, R.R.1    Lau, K.W.2    Tran, M.G.3
  • 9
    • 77952300971 scopus 로고    scopus 로고
    • Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction
    • Ortiz-Barahona A, Villar D, Pescador N, et al. Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction. Nucleic Acids Res 2010;38:2332-45.
    • (2010) Nucleic Acids Res , vol.38 , pp. 2332-2345
    • Ortiz-Barahona, A.1    Villar, D.2    Pescador, N.3
  • 10
    • 84655161946 scopus 로고    scopus 로고
    • HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression
    • Keith B, Johnson RS, Simon MC. HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 2012;12:9-22.
    • (2012) Nat Rev Cancer , vol.12 , pp. 9-22
    • Keith, B.1    Johnson, R.S.2    Simon, M.C.3
  • 11
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell 2012;148:399-408.
    • (2012) Cell , vol.148 , pp. 399-408
    • Semenza, G.L.1
  • 12
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
    • Kaelin WG, Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 2008;30:393-402.
    • (2008) Mol Cell , vol.30 , pp. 393-402
    • Kaelin, W.G.1    Ratcliffe, P.J.2
  • 13
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 1999;59:5830-5.
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3
  • 14
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumorassociated macrophages
    • Talks KL, Turley H, Gatter KC, et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumorassociated macrophages. Am J Pathol 2000;157:411-21.
    • (2000) Am J Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3
  • 15
    • 1642565876 scopus 로고    scopus 로고
    • Tumor hypoxia and malignant progression
    • Vaupel P, Mayer A, Hockel M. Tumor hypoxia and malignant progression. Methods Enzymol 2004;381:335-54.
    • (2004) Methods Enzymol , vol.381 , pp. 335-354
    • Vaupel, P.1    Mayer, A.2    Hockel, M.3
  • 16
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 2010;29:625-34.
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 17
    • 84859445000 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
    • Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci 2012;33:207-14.
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 207-214
    • Semenza, G.L.1
  • 18
    • 58149478525 scopus 로고    scopus 로고
    • HIF-1alpha and HIF-2alpha have divergent roles in colon cancer
    • Imamura T, Kikuchi H, Herraiz MT, et al. HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int J Cancer 2009;124:763-71.
    • (2009) Int J Cancer , vol.124 , pp. 763-771
    • Imamura, T.1    Kikuchi, H.2    Herraiz, M.T.3
  • 19
    • 70149106164 scopus 로고    scopus 로고
    • HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
    • Bertout JA, Majmundar AJ, Gordan JD, et al. HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc Natl Acad Sci USA 2009;106:14391-6.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14391-14396
    • Bertout, J.A.1    Majmundar, A.J.2    Gordan, J.D.3
  • 20
    • 7944224442 scopus 로고    scopus 로고
    • Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
    • Tang N, Wang L, Esko J, et al. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 2004;6:485-95.
    • (2004) Cancer Cell , vol.6 , pp. 485-495
    • Tang, N.1    Wang, L.2    Esko, J.3
  • 21
    • 0027954044 scopus 로고
    • Mutations of the VHL tumour suppressor gene in renal carcinoma
    • Gnarra JR, Tory K, Weng Y, et al. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet 1994;7:85-90.
    • (1994) Nat Genet , vol.7 , pp. 85-90
    • Gnarra, J.R.1    Tory, K.2    Weng, Y.3
  • 22
    • 0028072991 scopus 로고
    • Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
    • Herman JG, Latif F, Weng Y, et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 1994;91:9700-4.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9700-9704
    • Herman, J.G.1    Latif, F.2    Weng, Y.3
  • 23
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell PH, Wiesener MS, Chang GW, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999;399:271-5.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3
  • 24
    • 0034682783 scopus 로고    scopus 로고
    • Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
    • Cockman ME, Masson N, Mole DR, et al. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J Biol Chem 2000;275:25733-41.
    • (2000) J Biol Chem , vol.275 , pp. 25733-25741
    • Cockman, M.E.1    Masson, N.2    Mole, D.R.3
  • 25
    • 0033776536 scopus 로고    scopus 로고
    • Ubiquitination of hypoxiainducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
    • Ohh M, Park CW, Ivan M, et al. Ubiquitination of hypoxiainducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2000;2:423-7.
    • (2000) Nat Cell Biol , vol.2 , pp. 423-427
    • Ohh, M.1    Park, C.W.2    Ivan, M.3
  • 26
    • 0034663894 scopus 로고    scopus 로고
    • Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein
    • Tanimoto K, Makino Y, Pereira T, et al. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J 2000;19:4298-309.
    • (2000) EMBO J , vol.19 , pp. 4298-4309
    • Tanimoto, K.1    Makino, Y.2    Pereira, T.3
  • 27
    • 0034641615 scopus 로고    scopus 로고
    • Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
    • Kamura T, Sato S, Iwai K, et al. Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci USA 2000;97:10430-5.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10430-10435
    • Kamura, T.1    Sato, S.2    Iwai, K.3
  • 28
    • 17944375360 scopus 로고    scopus 로고
    • C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    • Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001;107:43-54.
    • (2001) Cell , vol.107 , pp. 43-54
    • Epstein, A.C.1    Gleadle, J.M.2    McNeill, L.A.3
  • 29
    • 0035917808 scopus 로고    scopus 로고
    • Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    • Jaakkola P, Mole DR, Tian YM, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001;292:468-72.
    • (2001) Science , vol.292 , pp. 468-472
    • Jaakkola, P.1    Mole, D.R.2    Tian, Y.M.3
  • 30
    • 0035917313 scopus 로고    scopus 로고
    • HIFalpha targeted for VHLmediated destruction by proline hydroxylation: implications for O2 sensing
    • Ivan M, Kondo K, Yang H, et al. HIFalpha targeted for VHLmediated destruction by proline hydroxylation: implications for O2 sensing. Science 2001;292:464-8.
    • (2001) Science , vol.292 , pp. 464-468
    • Ivan, M.1    Kondo, K.2    Yang, H.3
  • 31
    • 18444368709 scopus 로고    scopus 로고
    • Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL
    • Hon WC, Wilson MI, Harlos K, et al. Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature 2002;417:975-8.
    • (2002) Nature , vol.417 , pp. 975-978
    • Hon, W.C.1    Wilson, M.I.2    Harlos, K.3
  • 32
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
    • Mahon PC, Hirota K, Semenza GL. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 2001;15:2675-86.
    • (2001) Genes Dev , vol.15 , pp. 2675-2686
    • Mahon, P.C.1    Hirota, K.2    Semenza, G.L.3
  • 33
    • 18544386401 scopus 로고    scopus 로고
    • Hypoxiainducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
    • Hewitson KS, McNeill LA, Riordan MV, et al. Hypoxiainducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J Biol Chem 2002;277:26351-5.
    • (2002) J Biol Chem , vol.277 , pp. 26351-26355
    • Hewitson, K.S.1    McNeill, L.A.2    Riordan, M.V.3
  • 34
    • 0037097861 scopus 로고    scopus 로고
    • FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
    • Lando D, Peet DJ, Gorman JJ, et al. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 2002;16:1466-71.
    • (2002) Genes Dev , vol.16 , pp. 1466-1471
    • Lando, D.1    Peet, D.J.2    Gorman, J.J.3
  • 35
    • 0036469038 scopus 로고    scopus 로고
    • Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
    • Lando D, Peet DJ, Whelan DA, et al. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 2002;295:858-61.
    • (2002) Science , vol.295 , pp. 858-861
    • Lando, D.1    Peet, D.J.2    Whelan, D.A.3
  • 36
    • 0037117479 scopus 로고    scopus 로고
    • Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha
    • Freedman SJ, Sun ZY, Poy F, et al. Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc Natl Acad Sci USA 2002;99:5367-72.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 5367-5372
    • Freedman, S.J.1    Sun, Z.Y.2    Poy, F.3
  • 37
    • 0037117486 scopus 로고    scopus 로고
    • Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response
    • Dames SA, Martinez-Yamout M, De Guzman RN, et al. Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response. Proc Natl Acad Sci USA 2002;99:5271-6.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 5271-5276
    • Dames, S.A.1    Martinez-Yamout, M.2    De Guzman, R.N.3
  • 38
    • 0033593219 scopus 로고    scopus 로고
    • Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha
    • O'Rourke JF, Tian YM, Ratcliffe PJ, et al. Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha. J Biol Chem 1999;274:2060-71.
    • (1999) J Biol Chem , vol.274 , pp. 2060-2071
    • O'Rourke, J.F.1    Tian, Y.M.2    Ratcliffe, P.J.3
  • 39
    • 0030937718 scopus 로고    scopus 로고
    • Activation of hypoxiainducible factor-1; definition of regulatory domains within the alpha subunit
    • Pugh CW, O'Rourke JF, Nagao M, et al. Activation of hypoxiainducible factor-1; definition of regulatory domains within the alpha subunit. J Biol Chem 1997;272:11205-14.
    • (1997) J Biol Chem , vol.272 , pp. 11205-11214
    • Pugh, C.W.1    O'Rourke, J.F.2    Nagao, M.3
  • 40
    • 5644240828 scopus 로고    scopus 로고
    • Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected]
    • Stolze IP, Tian YM, Appelhoff RJ, et al. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected]. J Biol Chem 2004;279:42719-25.
    • (2004) J Biol Chem , vol.279 , pp. 42719-42725
    • Stolze, I.P.1    Tian, Y.M.2    Appelhoff, R.J.3
  • 41
    • 79953205531 scopus 로고    scopus 로고
    • Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1alpha-mediated apoptosis
    • Khan MN, Bhattacharyya T, Andrikopoulos P, et al. Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1alpha-mediated apoptosis. Br J Cancer 2011;104:1151-9.
    • (2011) Br J Cancer , vol.104 , pp. 1151-1159
    • Khan, M.N.1    Bhattacharyya, T.2    Andrikopoulos, P.3
  • 42
    • 77955284188 scopus 로고    scopus 로고
    • The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism
    • Zhang N, Fu Z, Linke S, et al. The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab 2010;11:364-78.
    • (2010) Cell Metab , vol.11 , pp. 364-378
    • Zhang, N.1    Fu, Z.2    Linke, S.3
  • 43
    • 31444444162 scopus 로고    scopus 로고
    • Integration of oxygen signaling at the consensus HRE
    • Wenger RH, Stiehl DP, Camenisch G. Integration of oxygen signaling at the consensus HRE. Sci STKE 2005;2005:re12.
    • (2005) Sci STKE , vol.2005
    • Wenger, R.H.1    Stiehl, D.P.2    Camenisch, G.3
  • 44
    • 84894260794 scopus 로고    scopus 로고
    • Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2
    • Choudhry H, Schodel J, Oikonomopoulos S, et al. Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2 EMBO Rep 2014;15:70-6.
    • (2014) EMBO Rep , vol.15 , pp. 70-76
    • Choudhry, H.1    Schodel, J.2    Oikonomopoulos, S.3
  • 45
    • 79959450883 scopus 로고    scopus 로고
    • High-resolution genome-wide mapping of HIF-binding sites by ChIPseq
    • Schodel J, Oikonomopoulos S, Ragoussis J, et al. High-resolution genome-wide mapping of HIF-binding sites by ChIPseq. Blood 2010;117:e207-17.
    • (2010) Blood , vol.117 , pp. e207-e217
    • Schodel, J.1    Oikonomopoulos, S.2    Ragoussis, J.3
  • 46
    • 67650531089 scopus 로고    scopus 로고
    • Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts
    • Mole DR, Blancher C, Copley RR, et al. Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts. J Biol Chem 2009;284:16767-75.
    • (2009) J Biol Chem , vol.284 , pp. 16767-16775
    • Mole, D.R.1    Blancher, C.2    Copley, R.R.3
  • 47
    • 75349114759 scopus 로고    scopus 로고
    • Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia
    • Xia X, Kung AL. Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia. Genome Biol 2009;10:R113.
    • (2009) Genome Biol , vol.10
    • Xia, X.1    Kung, A.L.2
  • 48
    • 63449103705 scopus 로고    scopus 로고
    • Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
    • Xia X, Lemieux ME, Li W, et al. Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc Natl Acad Sci USA 2009;106:4260-5.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 4260-4265
    • Xia, X.1    Lemieux, M.E.2    Li, W.3
  • 49
    • 84911915221 scopus 로고    scopus 로고
    • Genome-wide identification of hypoxia-inducible factor-1 and -2 binding sites in hypoxic human macrophages alternatively activated by IL-10
    • Tausendschon M, Rehli M, Dehne N, et al. Genome-wide identification of hypoxia-inducible factor-1 and -2 binding sites in hypoxic human macrophages alternatively activated by IL-10. Biochim Biophys Acta 2015;1849:10-22.
    • (2015) Biochim Biophys Acta , vol.1849 , pp. 10-22
    • Tausendschon, M.1    Rehli, M.2    Dehne, N.3
  • 50
    • 84865757142 scopus 로고    scopus 로고
    • Landscape of transcription in human cells
    • Djebali S, Davis CA, Merkel A, et al. Landscape of transcription in human cells. Nature 2012;489:101-8.
    • (2012) Nature , vol.489 , pp. 101-108
    • Djebali, S.1    Davis, C.A.2    Merkel, A.3
  • 51
    • 20544465985 scopus 로고    scopus 로고
    • Regulation of transcription and translation by hypoxia
    • Liu L, Simon MC. Regulation of transcription and translation by hypoxia. Cancer Biol Ther 2004;3:492-7.
    • (2004) Cancer Biol Ther , vol.3 , pp. 492-497
    • Liu, L.1    Simon, M.C.2
  • 52
    • 83255192187 scopus 로고    scopus 로고
    • Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2
    • Wu C, So J, Davis-Dusenbery BN, et al. Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2. Mol Cell Biol 2011;31:4760-74.
    • (2011) Mol Cell Biol , vol.31 , pp. 4760-4774
    • Wu, C.1    So, J.2    Davis-Dusenbery, B.N.3
  • 53
    • 84893667824 scopus 로고    scopus 로고
    • Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia
    • Camps C, Saini HK, Mole DR, et al. Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia. Mol Cancer 2014;13:13-28.
    • (2014) Mol Cancer , vol.13 , pp. 13-28
    • Camps, C.1    Saini, H.K.2    Mole, D.R.3
  • 54
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.
    • Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993;75:843-54.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 55
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005;120:15-20.
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 56
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: small RNAs with a big role in gene regulation
    • He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004;5:522-31.
    • (2004) Nat Rev Genet , vol.5 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 57
    • 64649083602 scopus 로고    scopus 로고
    • Correlation of microRNA levels during hypoxia with predicted target mRNAs through genome-wide microarray analysis
    • Guimbellot JS, Erickson SW, Mehta T, et al. Correlation of microRNA levels during hypoxia with predicted target mRNAs through genome-wide microarray analysis. BMC Med Genomics 2009;2:15.
    • (2009) BMC Med Genomics , vol.2 , pp. 15
    • Guimbellot, J.S.1    Erickson, S.W.2    Mehta, T.3
  • 58
    • 33846941188 scopus 로고    scopus 로고
    • High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma
    • Hebert C, Norris K, Scheper MA, et al. High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma. Mol Cancer 2007;6:5.
    • (2007) Mol Cancer , vol.6 , pp. 5
    • Hebert, C.1    Norris, K.2    Scheper, M.A.3
  • 59
    • 84865213578 scopus 로고    scopus 로고
    • Functional importance of Dicer protein in the adaptive cellular response to hypoxia
    • Ho JJ, Metcalf JL, Yan MS, et al. Functional importance of Dicer protein in the adaptive cellular response to hypoxia. J Biol Chem 2012;287:29003-20.
    • (2012) J Biol Chem , vol.287 , pp. 29003-29020
    • Ho, J.J.1    Metcalf, J.L.2    Yan, M.S.3
  • 60
    • 54949154476 scopus 로고    scopus 로고
    • MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia
    • Hua Z, Lv Q, Ye W, et al. MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS One 2006;1:e116.
    • (2006) PLoS One , vol.1
    • Hua, Z.1    Lv, Q.2    Ye, W.3
  • 62
    • 45549086958 scopus 로고    scopus 로고
    • Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210
    • Pulkkinen K, Malm T, Turunen M, et al. Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210. FEBS Lett 2008;582:2397-401.
    • (2008) FEBS Lett , vol.582 , pp. 2397-2401
    • Pulkkinen, K.1    Malm, T.2    Turunen, M.3
  • 63
    • 80053597754 scopus 로고    scopus 로고
    • MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia
    • Bruning U, Cerone L, Neufeld Z, et al. MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia. Mol Cell Biol 2011;31:4087-96.
    • (2011) Mol Cell Biol , vol.31 , pp. 4087-4096
    • Bruning, U.1    Cerone, L.2    Neufeld, Z.3
  • 64
    • 79955045666 scopus 로고    scopus 로고
    • Microarray-based analysis: identification of hypoxia-regulated microRNAs in retinoblastoma cells
    • Xu X, Jia R, Zhou Y, et al. Microarray-based analysis: identification of hypoxia-regulated microRNAs in retinoblastoma cells. Int J Oncol 2011;38:1385-93.
    • (2011) Int J Oncol , vol.38 , pp. 1385-1393
    • Xu, X.1    Jia, R.2    Zhou, Y.3
  • 65
    • 34147116217 scopus 로고    scopus 로고
    • The expression of Argonaute2 and related microRNA biogenesis proteins in normal and hypoxic trophoblasts
    • Donker RB, Mouillet JF, Nelson DM, et al. The expression of Argonaute2 and related microRNA biogenesis proteins in normal and hypoxic trophoblasts. Mol Hum Reprod 2007;13:273-9.
    • (2007) Mol Hum Reprod , vol.13 , pp. 273-279
    • Donker, R.B.1    Mouillet, J.F.2    Nelson, D.M.3
  • 66
    • 84857420013 scopus 로고    scopus 로고
    • Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs
    • Voellenkle C, Rooij J, Guffanti A, et al. Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs. RNA 2012;18:472-84.
    • (2012) RNA , vol.18 , pp. 472-484
    • Voellenkle, C.1    Rooij, J.2    Guffanti, A.3
  • 67
    • 84907369198 scopus 로고    scopus 로고
    • HypoxamiRs and cancer: from biology to targeted therapy
    • Gee HE, Ivan C, Calin GA, et al. HypoxamiRs and cancer: from biology to targeted therapy. Antioxid Redox Signal 2014;21:1220-38.
    • (2014) Antioxid Redox Signal , vol.21 , pp. 1220-1238
    • Gee, H.E.1    Ivan, C.2    Calin, G.A.3
  • 69
    • 84897584716 scopus 로고    scopus 로고
    • Emerging roles of miR-210 and other noncoding RNAs in the hypoxic response
    • Huang X, Zuo J. Emerging roles of miR-210 and other noncoding RNAs in the hypoxic response. Acta Biochim Biophys Sin (Shanghai) 2014;46:220-32.
    • (2014) Acta Biochim Biophys Sin (Shanghai) , vol.46 , pp. 220-232
    • Huang, X.1    Zuo, J.2
  • 70
    • 42549092314 scopus 로고    scopus 로고
    • miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer
    • Giannakakis A, Sandaltzopoulos R, Greshock J, et al. miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer. Cancer Biol Ther 2008;7:255-64.
    • (2008) Cancer Biol Ther , vol.7 , pp. 255-264
    • Giannakakis, A.1    Sandaltzopoulos, R.2    Greshock, J.3
  • 71
    • 69749107748 scopus 로고    scopus 로고
    • MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT
    • Zhang Z, Sun H, Dai H, et al. MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT. Cell Cycle 2009;8:2756-68.
    • (2009) Cell Cycle , vol.8 , pp. 2756-2768
    • Zhang, Z.1    Sun, H.2    Dai, H.3
  • 72
    • 78650944900 scopus 로고    scopus 로고
    • MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1)
    • Tsuchiya S, Fujiwara T, Sato F, et al. MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1). J Biol Chem 2011;286:420-8.
    • (2011) J Biol Chem , vol.286 , pp. 420-428
    • Tsuchiya, S.1    Fujiwara, T.2    Sato, F.3
  • 73
    • 84871768966 scopus 로고    scopus 로고
    • MiR-210 disturbs mitotic progression through regulating a group of mitosis-related genes
    • He J, Wu J, Xu N, et al. MiR-210 disturbs mitotic progression through regulating a group of mitosis-related genes. Nucleic Acids Res 2013;41:498-508.
    • (2013) Nucleic Acids Res , vol.41 , pp. 498-508
    • He, J.1    Wu, J.2    Xu, N.3
  • 74
    • 47049119934 scopus 로고    scopus 로고
    • MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3
    • Fasanaro P, D'Alessandra Y, Di Stefano V, et al. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. J Biol Chem 2008;283:15878-83.
    • (2008) J Biol Chem , vol.283 , pp. 15878-15883
    • Fasanaro, P.1    D'Alessandra, Y.2    Di Stefano, V.3
  • 75
    • 77957243894 scopus 로고    scopus 로고
    • MicroRNA-210 as a novel therapy for treatment of ischemic heart disease
    • Hu S, Huang M, Li Z, et al. MicroRNA-210 as a novel therapy for treatment of ischemic heart disease. Circulation 2010;122:S124-31.
    • (2010) Circulation , vol.122 , pp. S124-S131
    • Hu, S.1    Huang, M.2    Li, Z.3
  • 76
    • 84875414244 scopus 로고    scopus 로고
    • miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis
    • McCormick RI, Blick C, Ragoussis J, et al. miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis. Br J Cancer 2013;108:1133-42.
    • (2013) Br J Cancer , vol.108 , pp. 1133-1142
    • McCormick, R.I.1    Blick, C.2    Ragoussis, J.3
  • 77
    • 59149091637 scopus 로고    scopus 로고
    • MicroRNA regulation of DNA repair gene expression in hypoxic stress
    • Crosby ME, Kulshreshtha R, Ivan M, et al. MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res 2009;69:1221-9.
    • (2009) Cancer Res , vol.69 , pp. 1221-1229
    • Crosby, M.E.1    Kulshreshtha, R.2    Ivan, M.3
  • 78
    • 84865413307 scopus 로고    scopus 로고
    • Concomitant activation of miR-107/PDCD10 and hypoxamir-210/Casp8ap2 and their role in cytoprotection during ischemic preconditioning of stem cells
    • Kim HW, Mallick F, Durrani S, et al. Concomitant activation of miR-107/PDCD10 and hypoxamir-210/Casp8ap2 and their role in cytoprotection during ischemic preconditioning of stem cells. Antioxid Redox Signal 2012;17:1053-65.
    • (2012) Antioxid Redox Signal , vol.17 , pp. 1053-1065
    • Kim, H.W.1    Mallick, F.2    Durrani, S.3
  • 79
    • 84857147817 scopus 로고    scopus 로고
    • Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells
    • Du R, Sun W, Xia L, et al. Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells. PLoS One 2012;7:e30771.
    • (2012) PLoS One , vol.7
    • Du, R.1    Sun, W.2    Xia, L.3
  • 80
    • 81355142141 scopus 로고    scopus 로고
    • Non-coding RNAs in human disease
    • Esteller M. Non-coding RNAs in human disease. Nat Rev Genet 2011;12:861-74.
    • (2011) Nat Rev Genet , vol.12 , pp. 861-874
    • Esteller, M.1
  • 81
    • 84928556152 scopus 로고    scopus 로고
    • piRNA involvement in genome stability and human cancer
    • Moyano M, Stefani G. piRNA involvement in genome stability and human cancer. J Hematol Oncol 2015;8:38.
    • (2015) J Hematol Oncol , vol.8 , pp. 38
    • Moyano, M.1    Stefani, G.2
  • 83
    • 84879684791 scopus 로고    scopus 로고
    • Long noncoding RNAs and the genetics of cancer
    • Cheetham SW, Gruhl F, Mattick JS, et al. Long noncoding RNAs and the genetics of cancer. Br J Cancer 2013;108:2419-25.
    • (2013) Br J Cancer , vol.108 , pp. 2419-2425
    • Cheetham, S.W.1    Gruhl, F.2    Mattick, J.S.3
  • 84
    • 84917705502 scopus 로고    scopus 로고
    • A pathophysiological view of the long non-coding RNA world
    • Di Gesualdo F, Capaccioli S, Lulli M. A pathophysiological view of the long non-coding RNA world. Oncotarget 2014;5:10976-96.
    • (2014) Oncotarget , vol.5 , pp. 10976-10996
    • Di Gesualdo, F.1    Capaccioli, S.2    Lulli, M.3
  • 85
    • 84926686903 scopus 로고    scopus 로고
    • HOTAIR: an oncogenic long noncoding RNA in different cancers
    • Hajjari M, Salavaty A. HOTAIR: an oncogenic long noncoding RNA in different cancers. Cancer Biol Med 2015;12:1-9.
    • (2015) Cancer Biol Med , vol.12 , pp. 1-9
    • Hajjari, M.1    Salavaty, A.2
  • 86
    • 84940104547 scopus 로고    scopus 로고
    • Long non-coding RNA SOX2OT: expression signature, splicing patterns, and emerging roles in pluripotency and tumorigenesis
    • Shahryari A, Jazi MS, Samaei NM, et al. Long non-coding RNA SOX2OT: expression signature, splicing patterns, and emerging roles in pluripotency and tumorigenesis. Front Genet 2015;6:196.
    • (2015) Front Genet , vol.6 , pp. 196
    • Shahryari, A.1    Jazi, M.S.2    Samaei, N.M.3
  • 87
    • 84908671045 scopus 로고    scopus 로고
    • A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer
    • Hu X, Feng Y, Zhang D, et al. A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer. Cancer Cell 2014;26:344-57.
    • (2014) Cancer Cell , vol.26 , pp. 344-357
    • Hu, X.1    Feng, Y.2    Zhang, D.3
  • 88
    • 84879582903 scopus 로고    scopus 로고
    • Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines
    • Pickard MR, Mourtada-Maarabouni M, Williams GT. Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines. Biochim Biophys Acta 2013;1832:1613-23.
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 1613-1623
    • Pickard, M.R.1    Mourtada-Maarabouni, M.2    Williams, G.T.3
  • 89
    • 84897993537 scopus 로고    scopus 로고
    • Regulation of metabolism by long, non-coding RNAs
    • Kornfeld JW, Bruning JC. Regulation of metabolism by long, non-coding RNAs. Front Genet 2014;5:57.
    • (2014) Front Genet , vol.5 , pp. 57
    • Kornfeld, J.W.1    Bruning, J.C.2
  • 90
    • 84899543782 scopus 로고    scopus 로고
    • Oncofetal H19 RNA promotes tumor metastasis
    • Matouk IJ, Raveh E, Abu-lail R, et al. Oncofetal H19 RNA promotes tumor metastasis. Biochim Biophys Acta 2014;1843:1414-26.
    • (2014) Biochim Biophys Acta , vol.1843 , pp. 1414-1426
    • Matouk, I.J.1    Raveh, E.2    Abu-lail, R.3
  • 91
    • 84880154515 scopus 로고    scopus 로고
    • Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer
    • Du Z, Fei T, Verhaak RG, et al. Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Nat Struct Mol Biol 2013;20:908-13.
    • (2013) Nat Struct Mol Biol , vol.20 , pp. 908-913
    • Du, Z.1    Fei, T.2    Verhaak, R.G.3
  • 92
    • 77950370221 scopus 로고    scopus 로고
    • The oncofetal H19 RNA connection: hypoxia, p53 and cancer
    • Matouk IJ, Mezan S, Mizrahi A, et al. The oncofetal H19 RNA connection: hypoxia, p53 and cancer. Biochim Biophys Acta 2010;1803:443-51.
    • (2010) Biochim Biophys Acta , vol.1803 , pp. 443-451
    • Matouk, I.J.1    Mezan, S.2    Mizrahi, A.3
  • 93
    • 37149033830 scopus 로고    scopus 로고
    • The H19 non-coding RNA is essential for human tumor growth
    • Matouk IJ, DeGroot N, Mezan S, et al. The H19 non-coding RNA is essential for human tumor growth. PLoS One 2007;2:e845.
    • (2007) PLoS One , vol.2
    • Matouk, I.J.1    DeGroot, N.2    Mezan, S.3
  • 94
    • 84892364858 scopus 로고    scopus 로고
    • Reciprocal regulation of HIF-1alpha and lincRNA-p21 modulates the Warburg effect
    • Yang F, Zhang H, Mei Y, et al. Reciprocal regulation of HIF-1alpha and lincRNA-p21 modulates the Warburg effect. Mol Cell 2014;53:88-100.
    • (2014) Mol Cell , vol.53 , pp. 88-100
    • Yang, F.1    Zhang, H.2    Mei, Y.3
  • 95
    • 85003292750 scopus 로고    scopus 로고
    • Hypoxia-inducible lncRNAAK058003 promotes gastric cancer metastasis by targeting gamma-synuclein
    • Wang Y, Liu X, Zhang H, et al. Hypoxia-inducible lncRNAAK058003 promotes gastric cancer metastasis by targeting gamma-synuclein. Neoplasia 2014;16:1094-106.
    • (2014) Neoplasia , vol.16 , pp. 1094-1106
    • Wang, Y.1    Liu, X.2    Zhang, H.3
  • 96
    • 84905039941 scopus 로고    scopus 로고
    • Urothelial carcinoma associated 1 is a hypoxia-inducible factor-1alpha-targeted long noncoding RNA that enhances hypoxic bladder cancer cell proliferation, migration, and invasion
    • Xue M, Li X, Li Z, et al. Urothelial carcinoma associated 1 is a hypoxia-inducible factor-1alpha-targeted long noncoding RNA that enhances hypoxic bladder cancer cell proliferation, migration, and invasion. Tumour Biol 2014;35:6901-12.
    • (2014) Tumour Biol , vol.35 , pp. 6901-6912
    • Xue, M.1    Li, X.2    Li, Z.3
  • 97
    • 84887620047 scopus 로고    scopus 로고
    • HINCUTs in cancer: hypoxiainduced noncoding ultraconserved transcripts
    • Ferdin J, Nishida N, Wu X, et al. HINCUTs in cancer: hypoxiainduced noncoding ultraconserved transcripts. Cell Death Differ 2013;20:1675-87.
    • (2013) Cell Death Differ , vol.20 , pp. 1675-1687
    • Ferdin, J.1    Nishida, N.2    Wu, X.3
  • 98
    • 84952876224 scopus 로고    scopus 로고
    • Long noncoding RNA HOTAIR, a hypoxia-inducible factor-1alpha activated driver of malignancy, enhances hypoxic cancer cell proliferation, migration, and invasion in non-small cell lung cancer
    • Zhou C, Ye L, Jiang C, et al. Long noncoding RNA HOTAIR, a hypoxia-inducible factor-1alpha activated driver of malignancy, enhances hypoxic cancer cell proliferation, migration, and invasion in non-small cell lung cancer. Tumour Biol 2015;36:9179-88.
    • (2015) Tumour Biol , vol.36 , pp. 9179-9188
    • Zhou, C.1    Ye, L.2    Jiang, C.3
  • 99
    • 84938068832 scopus 로고    scopus 로고
    • EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination
    • Gomez-Maldonado L, Tiana M, Roche O, et al. EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination. Oncogene 2015;34:2609-20.
    • (2015) Oncogene , vol.34 , pp. 2609-2620
    • Gomez-Maldonado, L.1    Tiana, M.2    Roche, O.3
  • 100
    • 84875810883 scopus 로고    scopus 로고
    • Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis
    • Yang F, Huo XS, Yuan SX, et al. Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. Mol Cell 2013;49:1083-96.
    • (2013) Mol Cell , vol.49 , pp. 1083-1096
    • Yang, F.1    Huo, X.S.2    Yuan, S.X.3
  • 101
    • 84897438456 scopus 로고    scopus 로고
    • Modulation of hypoxiasignaling pathways by extracellular linc-RoR
    • Takahashi K, Yan IK, Haga H, et al. Modulation of hypoxiasignaling pathways by extracellular linc-RoR. J Cell Sci 2014;127:1585-94.
    • (2014) J Cell Sci , vol.127 , pp. 1585-1594
    • Takahashi, K.1    Yan, I.K.2    Haga, H.3
  • 102
    • 84863389964 scopus 로고    scopus 로고
    • Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling
    • Wollenick K, Hu J, Kristiansen G, et al. Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling. Nucleic Acids Res 2012;40:1928-43.
    • (2012) Nucleic Acids Res , vol.40 , pp. 1928-1943
    • Wollenick, K.1    Hu, J.2    Kristiansen, G.3
  • 103
    • 84990024206 scopus 로고    scopus 로고
    • induction of long noncoding rna MalaT1 in hypoxic mice
    • Lelli A, Nolan KA, Santambrogio S, et al. induction of long noncoding rna MalaT1 in hypoxic mice. Hypoxia 2015;3:45-52.
    • (2015) Hypoxia , vol.3 , pp. 45-52
    • Lelli, A.1    Nolan, K.A.2    Santambrogio, S.3
  • 104
    • 84855956560 scopus 로고    scopus 로고
    • Long non-coding RNAs in nuclear bodies
    • Ip JY, Nakagawa S. Long non-coding RNAs in nuclear bodies. Dev Growth Differ 2012;54:44-54.
    • (2012) Dev Growth Differ , vol.54 , pp. 44-54
    • Ip, J.Y.1    Nakagawa, S.2
  • 105
    • 84864033675 scopus 로고    scopus 로고
    • Malat1 is not an essential component of nuclear speckles in mice
    • Nakagawa S, Ip JY, Shioi G, et al. Malat1 is not an essential component of nuclear speckles in mice. RNA 2012;18:1487-99.
    • (2012) RNA , vol.18 , pp. 1487-1499
    • Nakagawa, S.1    Ip, J.Y.2    Shioi, G.3
  • 106
    • 77956927823 scopus 로고    scopus 로고
    • The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation
    • Tripathi V, Ellis JD, Shen Z, et al. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell 2010;39:925-38.
    • (2010) Mol Cell , vol.39 , pp. 925-938
    • Tripathi, V.1    Ellis, J.D.2    Shen, Z.3
  • 107
    • 81755161347 scopus 로고    scopus 로고
    • The long noncoding MALAT-1 RNA indicates a poor prognosis in nonsmall cell lung cancer and induces migration and tumor growth
    • Schmidt LH, Spieker T, Koschmieder S, et al. The long noncoding MALAT-1 RNA indicates a poor prognosis in nonsmall cell lung cancer and induces migration and tumor growth. J Thorac Oncol 2011;6:1984-92.
    • (2011) J Thorac Oncol , vol.6 , pp. 1984-1992
    • Schmidt, L.H.1    Spieker, T.2    Koschmieder, S.3
  • 108
    • 84899993786 scopus 로고    scopus 로고
    • Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth
    • Michalik KM, You X, Manavski Y, et al. Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth. Circ Res 2014;114:1389-97.
    • (2014) Circ Res , vol.114 , pp. 1389-1397
    • Michalik, K.M.1    You, X.2    Manavski, Y.3
  • 109
    • 0030762226 scopus 로고    scopus 로고
    • A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus
    • Guru SC, Agarwal SK, Manickam P, et al. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. Genome Res 1997;7:725-35.
    • (1997) Genome Res , vol.7 , pp. 725-735
    • Guru, S.C.1    Agarwal, S.K.2    Manickam, P.3
  • 110
    • 84867575580 scopus 로고    scopus 로고
    • Alternative 3'-end processing of long noncoding RNA initiates construction of nuclear paraspeckles
    • Naganuma T, Nakagawa S, Tanigawa A, et al. Alternative 3'-end processing of long noncoding RNA initiates construction of nuclear paraspeckles. Embo J 2012;31:4020-34.
    • (2012) Embo J , vol.31 , pp. 4020-4034
    • Naganuma, T.1    Nakagawa, S.2    Tanigawa, A.3
  • 111
    • 61849113891 scopus 로고    scopus 로고
    • MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles
    • Sunwoo H, Dinger ME, Wilusz JE, et al. MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. Genome Res 2009;19:347-59.
    • (2009) Genome Res , vol.19 , pp. 347-359
    • Sunwoo, H.1    Dinger, M.E.2    Wilusz, J.E.3
  • 112
    • 84939778620 scopus 로고    scopus 로고
    • Tumor hypoxia induces nuclear paraspeckle formation through HIF-2alpha dependent transcriptional activation of NEAT1 leading to cancer cell survival
    • Choudhry H, Albukhari A, Morotti M, et al. Tumor hypoxia induces nuclear paraspeckle formation through HIF-2alpha dependent transcriptional activation of NEAT1 leading to cancer cell survival. Oncogene 2015;34:4482-90.
    • (2015) Oncogene , vol.34 , pp. 4482-4490
    • Choudhry, H.1    Albukhari, A.2    Morotti, M.3
  • 113
    • 68949212914 scopus 로고    scopus 로고
    • Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA
    • Chen LL, Carmichael GG. Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA. Mol Cell 2009;35:467-78.
    • (2009) Mol Cell , vol.35 , pp. 467-478
    • Chen, L.L.1    Carmichael, G.G.2
  • 114
    • 62549117314 scopus 로고    scopus 로고
    • An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles
    • Clemson CM, Hutchinson JN, Sara SA, et al. An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. Mol Cell 2009;33:717-26.
    • (2009) Mol Cell , vol.33 , pp. 717-726
    • Clemson, C.M.1    Hutchinson, J.N.2    Sara, S.A.3
  • 115
    • 62449319486 scopus 로고    scopus 로고
    • MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspeckles
    • Sasaki YT, Ideue T, Sano M, et al. MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspeckles. Proc Natl Acad Sci USA 2009;106:2525-30.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2525-2530
    • Sasaki, Y.T.1    Ideue, T.2    Sano, M.3
  • 116
    • 84891800602 scopus 로고    scopus 로고
    • NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies
    • Hirose T, Virnicchi G, Tanigawa A, et al. NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies. Mol Biol Cell 2014;25:169-83.
    • (2014) Mol Biol Cell , vol.25 , pp. 169-183
    • Hirose, T.1    Virnicchi, G.2    Tanigawa, A.3
  • 117
    • 84893452948 scopus 로고    scopus 로고
    • Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli.
    • Imamura K, Imamachi N, Akizuki G, et al. Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli. Mol Cell 2014;53:393-406
    • (2014) Mol Cell , vol.53 , pp. 393-406
    • Imamura, K.1    Imamachi, N.2    Akizuki, G.3
  • 118
    • 26844440157 scopus 로고    scopus 로고
    • Regulating gene expression through RNA nuclear retention
    • Prasanth KV, Prasanth SG, Xuan Z, et al. Regulating gene expression through RNA nuclear retention. Cell 2005;123:249-63.
    • (2005) Cell , vol.123 , pp. 249-263
    • Prasanth, K.V.1    Prasanth, S.G.2    Xuan, Z.3
  • 119
  • 120
    • 84885780577 scopus 로고    scopus 로고
    • F11R expression upon hypoxia is regulated by RNA editing
    • Ben-Zvi M, Amariglio N, Paret G, et al. F11R expression upon hypoxia is regulated by RNA editing. PLoS One 2013;8:e77702.
    • (2013) PLoS One , vol.8
    • Ben-Zvi, M.1    Amariglio, N.2    Paret, G.3
  • 121
    • 84922311751 scopus 로고    scopus 로고
    • Neighboring gene regulation by antisense long non-coding RNAs
    • Villegas VE, Zaphiropoulos PG. Neighboring gene regulation by antisense long non-coding RNAs. Int J Mol Sci 2015;16:3251-66.
    • (2015) Int J Mol Sci , vol.16 , pp. 3251-3266
    • Villegas, V.E.1    Zaphiropoulos, P.G.2
  • 122
    • 34447543034 scopus 로고    scopus 로고
    • Hypoxia-inducible expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase
    • Fish JE, Matouk CC, Yeboah E, et al. Hypoxia-inducible expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase. J Biol Chem 2007;282:15652-66.
    • (2007) J Biol Chem , vol.282 , pp. 15652-15666
    • Fish, J.E.1    Matouk, C.C.2    Yeboah, E.3
  • 123
    • 84925743457 scopus 로고    scopus 로고
    • Hypoxia-sensitive epigenetic regulation of an antisense-oriented lncRNA controls WT1 expression in myeloid leukemia cells
    • McCarty G, Loeb DM. Hypoxia-sensitive epigenetic regulation of an antisense-oriented lncRNA controls WT1 expression in myeloid leukemia cells. PLoS One 2015;10:e0119837.
    • (2015) PLoS One , vol.10
    • McCarty, G.1    Loeb, D.M.2
  • 124
    • 84930382752 scopus 로고    scopus 로고
    • Antisense long noncoding RNA HIF1A-AS2 is upregulated in gastric cancer and associated with poor Prognosis
    • Chen WM, Huang MD, Kong R, et al. Antisense long noncoding RNA HIF1A-AS2 is upregulated in gastric cancer and associated with poor Prognosis. Dig Dis Sci 2015;60: 1655-62.
    • (2015) Dig Dis Sci , vol.60 , pp. 1655-1662
    • Chen, W.M.1    Huang, M.D.2    Kong, R.3
  • 125
    • 80052885284 scopus 로고    scopus 로고
    • Characterization of novel antisense HIF-1alpha transcripts in human cancers
    • Bertozzi D, Iurlaro R, Sordet O, et al. Characterization of novel antisense HIF-1alpha transcripts in human cancers. Cell Cycle 2011;10:3189-97.
    • (2011) Cell Cycle , vol.10 , pp. 3189-3197
    • Bertozzi, D.1    Iurlaro, R.2    Sordet, O.3
  • 126
    • 0033585496 scopus 로고    scopus 로고
    • aHIF: a natural antisense transcript overexpressed in human renal cancer and during hypoxia
    • Thrash-Bingham CA, Tartof KD. aHIF: a natural antisense transcript overexpressed in human renal cancer and during hypoxia. J Natl Cancer Inst 1999;91:143-51.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 143-151
    • Thrash-Bingham, C.A.1    Tartof, K.D.2
  • 127
    • 84921344556 scopus 로고    scopus 로고
    • A novel long non-coding RNA, hypoxia-inducible factor-2alpha promoter upstream transcript, functions as an inhibitor of osteosarcoma stem cells in vitro
    • Wang Y, Yao J, Meng H, et al. A novel long non-coding RNA, hypoxia-inducible factor-2alpha promoter upstream transcript, functions as an inhibitor of osteosarcoma stem cells in vitro. Mol Med Rep 2015;11:2534-40.
    • (2015) Mol Med Rep , vol.11 , pp. 2534-2540
    • Wang, Y.1    Yao, J.2    Meng, H.3
  • 128
    • 84927175069 scopus 로고    scopus 로고
    • A novel long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1alpha in pancreatic ductal adenocarcinoma
    • Sun YW, Chen YF, Li J, et al. A novel long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1alpha in pancreatic ductal adenocarcinoma. Br J Cancer 2014;111:2131-41.
    • (2014) Br J Cancer , vol.111 , pp. 2131-2141
    • Sun, Y.W.1    Chen, Y.F.2    Li, J.3
  • 129
    • 48649102010 scopus 로고    scopus 로고
    • Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster
    • Taguchi A, Yanagisawa K, Tanaka M, et al. Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster. Cancer Res 2008;68:5540-5.
    • (2008) Cancer Res , vol.68 , pp. 5540-5545
    • Taguchi, A.1    Yanagisawa, K.2    Tanaka, M.3
  • 130
    • 84878830070 scopus 로고    scopus 로고
    • MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1alpha
    • Yeh YM, Chuang CM, Chao KC, et al. MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1alpha. Int J Cancer 2013;133:867-78.
    • (2013) Int J Cancer , vol.133 , pp. 867-878
    • Yeh, Y.M.1    Chuang, C.M.2    Chao, K.C.3
  • 131
    • 65249185780 scopus 로고    scopus 로고
    • Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes
    • Rane S, He M, Sayed D, et al. Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res 2009;104:879-86.
    • (2009) Circ Res , vol.104 , pp. 879-886
    • Rane, S.1    He, M.2    Sayed, D.3
  • 132
    • 77956533696 scopus 로고    scopus 로고
    • MicroRNAs are dynamically regulated in hypertrophic hearts, and miR-199a is essential for the maintenance of cell size in cardiomyocytes
    • Song XW, Li Q, Lin L, et al. MicroRNAs are dynamically regulated in hypertrophic hearts, and miR-199a is essential for the maintenance of cell size in cardiomyocytes. J Cell Physiol 2010;225:437-43.
    • (2010) J Cell Physiol , vol.225 , pp. 437-443
    • Song, X.W.1    Li, Q.2    Lin, L.3
  • 133
    • 77952507643 scopus 로고    scopus 로고
    • miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells
    • Cascio S, D'Andrea A, Ferla R, et al. miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells. J Cell Physiol 2010;224:242-9.
    • (2010) J Cell Physiol , vol.224 , pp. 242-249
    • Cascio, S.1    D'Andrea, A.2    Ferla, R.3
  • 134
    • 70449602451 scopus 로고    scopus 로고
    • Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration
    • Lei Z, Li B, Yang Z, et al. Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration. PLoS One 2009;4:e7629.
    • (2009) PLoS One , vol.4
    • Lei, Z.1    Li, B.2    Yang, Z.3
  • 135
    • 77950799838 scopus 로고    scopus 로고
    • MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis
    • Cha ST, Chen PS, Johansson G, et al. MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis. Cancer Res 2010;70:2675-85.
    • (2010) Cancer Res , vol.70 , pp. 2675-2685
    • Cha, S.T.1    Chen, P.S.2    Johansson, G.3
  • 136
    • 77950905821 scopus 로고    scopus 로고
    • P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
    • Yamakuchi M, Lotterman CD, Bao C, et al. P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Proc Natl Acad Sci USA 2010;107:6334-9.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 6334-6339
    • Yamakuchi, M.1    Lotterman, C.D.2    Bao, C.3
  • 137
    • 84871712505 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: the role of microRNA
    • Madanecki P, Kapoor N, Bebok Z, et al. Regulation of angiogenesis by hypoxia: the role of microRNA. Cell Mol Biol Lett 2013;18:47-57.
    • (2013) Cell Mol Biol Lett , vol.18 , pp. 47-57
    • Madanecki, P.1    Kapoor, N.2    Bebok, Z.3
  • 138
    • 76749131605 scopus 로고    scopus 로고
    • miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma
    • Liu CJ, Tsai MM, Hung PS, et al. miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma. Cancer Res 2010;70:1635-44.
    • (2010) Cancer Res , vol.70 , pp. 1635-1644
    • Liu, C.J.1    Tsai, M.M.2    Hung, P.S.3
  • 139
    • 78049424494 scopus 로고    scopus 로고
    • Hypoxiainduced microRNA-424 expression in human endothelial cells regulates HIF-alpha isoforms and promotes angiogenesis
    • Ghosh G, Subramanian IV, Adhikari N, et al. Hypoxiainduced microRNA-424 expression in human endothelial cells regulates HIF-alpha isoforms and promotes angiogenesis. J Clin Invest 2010;120:4141-54.
    • (2010) J Clin Invest , vol.120 , pp. 4141-4154
    • Ghosh, G.1    Subramanian, I.V.2    Adhikari, N.3
  • 140
    • 79959425207 scopus 로고    scopus 로고
    • A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like
    • Kelly TJ, Souza AL, Clish CB, et al. A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like. Mol Cell Biol 2011;31:2696-706.
    • (2011) Mol Cell Biol , vol.31 , pp. 2696-2706
    • Kelly, T.J.1    Souza, A.L.2    Clish, C.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.