Urothelial carcinoma associated 1 is a hypoxia-inducible factor-1α-targeted long noncoding RNA that enhances hypoxic bladder cancer cell proliferation, migration, and invasion

Tumor Biology

Volumn 35, Issue 7, 2014, Pages 6901-6912

  Xue, Mei ^a   Li, Xu ^a   Li, Zhengkun ^a   Chen, Wei ^b  

^a THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

^b MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Bladder cancer; HIF 1 ; Hypoxia; Long noncoding RNA; UCA1

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; LONG UNTRANSLATED RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UROTHELIAL CARCINOMA ASSOCIATED 1;

APOPTOSIS; ARTICLE; BLADDER CANCER CELL LINE; BLADDER CARCINOMA; CANCER CELL; CANCER DIAGNOSIS; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HYPOXIC CELL; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR INVASION; TUMOR MICROENVIRONMENT; UPREGULATION;

APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOPLASM INVASIVENESS; PROMOTER REGIONS, GENETIC; RESPONSE ELEMENTS; RNA, LONG NONCODING; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; URINARY BLADDER NEOPLASMS;

EID: 84905039941     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-1925-x     Document Type: Article

References (35)

1. Ruan K, Song G, Ouyang G. Role of hypoxia in the hallmarks of human cancer. J Cell Biochem. 2009;107(6):1053-62. doi:10.1002/jcb.22214.
2. 2 tension. Proc Natl Acad Sci U S A. 1995;92(12):5510-4.
3. 2-regulated prolyl hydroxylation. Science. 2001;292(5516):468-72. doi:10.1126/science.1059796.
4. 2, and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell. 2001;107(1):1-3.
5. Majmundar AJ, Wong WJ, Simon MC. Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell. 2010;40(2):294-309. doi:10.1016/j.molcel. 2010.09.022.
6. Keith B, Simon MC. Hypoxia-inducible factors, stem cells, and cancer. Cell. 2007;129(3):465-72. doi:10.1016/j.cell.2007.04.019. (Pubitemid 46660978)
7. Jacobs BL, Lee CT, Montie JE. Bladder cancer in 2010: how far have we come? CA Cancer J Clin. 2010;60(4):244-72. doi:10.3322/caac.20077.
8. Gospodarowicz M. Combination therapy: hypoxia modification with radiotherapy for bladder cancer. Nat Rev Clin Oncol. 2011;8(3):129-30. doi:10.1038/nrclinonc.2011.5.
9. Theodoropoulos VE, Lazaris A, Sofras F, Gerzelis I, Tsoukala V, Ghikonti I, et al. Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer. Eur Urol. 2004;46(2):200-8. doi:10.1016/j.eururo.2004.04.008. (Pubitemid 38902737)
10. Chen MC, Lee CF, Huang WH, Chou TC. Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1alpha/VEGF signaling pathway in human bladder cancer cells. Biochem Pharmacol. 2013;85(9):1278-87. doi:10.1016/j.bcp.2013.02.009.
11. Orom UA, Derrien T, Beringer M, Gumireddy K, Gardini A, Bussotti G, et al. Long noncoding RNAs with enhancer-like function in human cells. Cell. 2010;143(1):46-58.
12. Lee JT. Epigenetic regulation by long noncoding RNAs. Science. 2012;338(6113):1435-9.
13. Gutschner T, Diederichs S. The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol. 2012;9(6):703-19. doi:10.4161/rna.20481.
14. Panzitt K, Tschernatsch MM, Guelly C, Moustafa T, Stradner M, Strohmaier HM, et al. Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. Gastroenterology. 2007;132(1):330-42. doi:10.1053/j.gastro.2006.08.026. (Pubitemid 46108730)
15. Wang F, Li X, Xie X, Zhao L, Chen W. UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. FEBS Lett. 2008;582(13):1919-27. doi:10.1016/j.febslet.2008. 05.012.
16. Chen G, Wang Z, Wang D, Qiu C, Liu M, Chen X, et al. LncRNADisease: a database for long-non-coding RNA-associated diseases. Nucleic Acids Res. 2013;41(Database issue):D983-6. doi: 10.1093/nar/gks1099.
17. Zhang Q, Su M, Lu G, Wang J. The complexity of bladder cancer: long noncoding RNAs are on the stage. Mol Cancer. 2013;12(1):101. doi:10.1186/1476-4598-12-101.
18. Loscalzo J. The cellular response to hypoxia: tuning the system with microRNAs. J Clin Invest. 2010;120(11):3815-7. doi:10.1172/JCI45105.
19. Yang C, Li X, Wang Y, Zhao L, Chen W. Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells. Gene. 2012;496(1): 8-16. doi:10.1016/j.gene.2012.01.012.
20. Wu W, Zhang S, Li X, Xue M, Cao S, Chen W. Ets-2 regulates cell apoptosis via the Akt pathway, through the regulation of urothelial cancer associated 1, a long non-coding RNA, in bladder cancer cells. PLoS ONE. 2013;8(9):e73920. doi:10.1371/journal.pone.0073920.
21. Cartharius K, Frech K, Grote K, Klocke B, Haltmeier M, Klingenhoff A, et al. MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics. 2005;21(13): 2933-42. doi:10.1093/bioinformatics/ bti473. (Pubitemid 40916416)
22. Portales-Casamar E, Thongjuea S, Kwon AT, Arenillas D, Zhao X, Valen E, et al. JASPAR 2010: the greatly expanded open-access database of transcription factor binding profiles. Nucleic Acids Res. 2010;38(Database issue):D105-10. doi:10.1093/nar/gkp950.
23. Ching CB, Hansel DE. Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway. Lab Invest. 2010;90(10):1406-14. doi:10.1038/labinvest. 2010.133.
24. Calderaro J, Rebouissou S, de Koning L, Masmoudi A, Herault A, Dubois T, et al. PI3K/AKT pathway activation in bladder carcinogenesis. Int J Cancer. 2014;134(8):1776-84. doi:10.1002/ijc.28518.
25. Maddika S, Ande SR, Panigrahi S, Paranjothy T, Weglarczyk K, Zuse A, et al. Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy. Drug Resist Updat. 2007;10(1-2):13-29. doi:10.1016/j.drup.2007.01.003. (Pubitemid 46636381)
26. Matouk IJ, DeGroot N, Mezan S, Ayesh S, Abu-lail R, Hochberg A, et al. The H19 non-coding RNA is essential for human tumor growth. PLoS ONE. 2007;2(9):e845. doi:10.1371/journal.pone.0000845.
27. Matouk IJ, Mezan S, Mizrahi A, Ohana P, Abu-Lail R, Fellig Y, et al. The oncofetal H19 RNA connection: hypoxia, p53 and cancer. Biochim Biophys Acta. 2010;1803(4):443-51. doi:10.1016/j.bbamcr.2010.01.010.
28. Yang F, Huo XS, Yuan SX, Zhang L, Zhou WP, Wang F, et al. Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. Mol Cell. 2013;49(6): 1083-96. doi:10.1016/j. molcel.2013.01.010.
29. Yang F, Zhang H, Mei Y, Wu M. Reciprocal regulation of HIF-1alpha and lincRNA-p21 modulates the Warburg effect. Mol Cell. 2014;53(1):88-100. doi:10.1016/j.molcel.2013.11.004.
30. Rankin EB, Giaccia AJ. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ. 2008;15(4):678-85. doi:10.1038/cdd.2008.21. (Pubitemid 351405072)
31. Fazilaty H, Gardaneh M, Bahrami T, Salmaninejad A, Behnam B. Crosstalk between breast cancer stem cells and metastatic niche: emerging molecular metastasis pathway? Tumour Biol. 2013;34(4): 2019-30. doi:10.1007/s13277-013- 0831-y.
32. Semenza GL. Cancer-stromal cell interactions mediated by hypoxiainducible factors promote angiogenesis, lymphangiogenesis, andmetastasis. Oncogene. 2013;32(35):4057-63. doi:10.1038/onc.2012. 578.
33. Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003;3(10):721-32. doi:10.1038/nrc1187. (Pubitemid 37328811)
34. Zhang T, Fan J, Wu K, Zeng J, Sun K, Guan Z, et al. Roles of HIF-1alpha in a novel optical orthotopic spontaneous metastatic bladder cancer animalmodel. Urol Oncol. 2012;30(6):928-35. doi:10.1016/j.urolonc.2012.01.003.
35. Li Y, Zhao X, Tang H, Zhong Z, Zhang L, Xu R, et al. Effects of YC-1 on hypoxia-inducible factor 1 alpha in hypoxic human bladder transitional carcinoma cell line T24 cells. Urol Int. 2012;88(1):95-101. doi:10.1159/000331881.