Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival

Oncogene

Volumn 34, Issue 34, 2015, Pages 4482-4490

  Choudhry, H ^a,b   Albukhari, A ^a,c   Morotti, M ^c   Haider, S ^c   Moralli, D ^b   Smythies, J ^d   Schodel J ^e   Green, C M ^b   Camps, C ^b   Buffa, F ^f   Ratcliffe, P ^d   Ragoussis, J ^b,g,h   Harris, A L ^c   Mole, D R ^d  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g MCGILL UNIVERSITY   (Canada)

^h BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; BEVACIZUMAB; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INOSINE; JUNCTIONAL ADHESION MOLECULE A; LONG UNTRANSLATED RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NEAT1; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; F11R PROTEIN, HUMAN; NEAT1 LONG NON-CODING RNA, HUMAN;

ADVERSE OUTCOME; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL; CANCER PROGNOSIS; CANCER SURVIVAL; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; GENE CONTROL; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HYPOXIA; MCF 7 CELL LINE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROMOTER REGION; RNA EDITING; STRUCTURE ANALYSIS; TRANSCRIPTION INITIATION; TUMOR HYPOXIA; TUMOR MICROENVIRONMENT; ANIMAL; BREAST TUMOR; CELL HYPOXIA; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BREAST NEOPLASMS; CELL ADHESION MOLECULES; CELL HYPOXIA; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; HUMANS; MICE; RECEPTORS, CELL SURFACE; RNA, LONG NONCODING; TRANSCRIPTIONAL ACTIVATION;

EID: 84939778620     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.378     Document Type: Article

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