The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth

Journal of Thoracic Oncology

Volumn 6, Issue 12, 2011, Pages 1984-1992

  Schmidt, Lars Henning ^a   Spieker, Tilmann ^a   Koschmieder, Steffen ^a   Humberg, Julia ^a   Jungen, Dominik ^a   Bulk, Etmar ^a   Hascher, Antje ^a   Wittmer, Danielle ^a   Marra, Alessandro ^b   Hillejan, Ludger ^b   Wiebe, Karsten ^a   Berdel, Wolfgang E ^a   Wiewrodt, Rainer ^a   Muller Tidow, Carsten ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b Niels Stensen Kliniken   (Germany)

Author keywords

MALAT 1; NSCLC; RNA interference; Tumor biology

Indexed keywords

METASTASIS ASSOCIATED IN LUNG ADENOCARCINOMA TRANSCRIPT 1; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN 3T3; CLONOGENESIS; CONTROLLED STUDY; DOWN REGULATION; FEEDBACK SYSTEM; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; GENETIC ASSOCIATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOREGULATION; IN SITU HYBRIDIZATION; INTRACELLULAR SIGNALING; LUNG ADENOCARCINOMA; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; RNA INTERFERENCE; RNA PROBE; TUMOR XENOGRAFT;

EID: 81755161347     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e3182307eac     Document Type: Article

References (33)

1. Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74-108.
2. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2007. CA Cancer J Clin 2007;57:43-66.
3. Fidler IJ. Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. Cancer Res 1990;50:6130-6138. (Pubitemid 20323663)
4. Langley RR, Fidler IJ. Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis. Endocr Rev 2007;28:297-321. (Pubitemid 46984829)
5. Ji H, Ramsey MR, Hayes DN, et al. LKB1 modulates lung cancer differentiation and metastasis. Nature 2007;448:807-810. (Pubitemid 47266337)
6. Karnoub AE, Dash AB, Vo AP, et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007;449:557-563. (Pubitemid 47525152)
7. Nguyen DX, Massague J. Genetic determinants of cancer metastasis. Nat Rev Genet 2007;8:341-352. (Pubitemid 46625811)
8. Eddy SR. Non-coding RNA genes and the modern RNA world. Nat Rev Genet 2001;2:919-929. (Pubitemid 33691089)
9. Birney E, Stamatoyannopoulos JA, Dutta A, et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 2007;447:799-816. (Pubitemid 46920138)
10. Kapranov P, Cheng J, Dike S, et al. RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science 2007;316: 1484-1488. (Pubitemid 46906616)
11. Wilusz JE, Freier SM, Spector DL. 3' end processing of a long nuclearretained noncoding RNA yields a tRNA-like cytoplasmic RNA. Cell 2008;135:919-932.
12. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006;6:857-866. (Pubitemid 44629897)
13. Costa FF. Non-coding RNAs: new players in eukaryotic biology. Gene 2005;357:83-94. (Pubitemid 41297574)
14. Bartels CL, Tsongalis GJ. MicroRNAs: novel biomarkers for human cancer. Clin Chem 2009;55:623-631.
15. Carthew RW, Sontheimer EJ. Origins and mechanisms of miRNAs and siRNAs. Cell 2009;136:642-655.
16. Hutchinson JN, Ensminger AW, Clemson CM, et al. A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains. BMC Genomics 2007;8:39.
17. Ji P, Diederichs S, Wang W, et al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage nonsmall cell lung cancer. Oncogene 2003;22:8031-8041. (Pubitemid 37175867)
18. Bekri S, Adelaide J, Merscher S, et al. Detailed map of a region commonly amplified at 11q13-q14 in human breast carcinoma. Cytogenet Cell Genet 1997;79:125-131. (Pubitemid 28107833)
19. Chakrabarti R, Srivatsan ES, Wood TF, et al. Deletion mapping of endocrine tumors localizes a second tumor suppressor gene on chromosome band 11q13. Genes Chromosomes Cancer 1998;22:130-137. (Pubitemid 28208805)
20. Lin R, Maeda S, Liu C, et al. A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene 2007;26:851-858.
21. Tseng JJ, Hsieh YT, Hsu SL, et al. Metastasis associated lung adenocarcinoma transcript 1 is up-regulated in placenta previa increta/percreta and strongly associated with trophoblast-like cell invasion in vitro. Mol Hum Reprod 2009;15:725-731.
22. Lamond AI, Spector DL. Nuclear speckles: a model for nuclear organelles. Nat Rev Mol Cell Biol 2003;4:605-612. (Pubitemid 36934962)
23. Lieber M, Smith B, Szakal A, et al. A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int J Cancer 1976;17:62-70.
24. Morita S, Kojima T, Kitamura T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther 2000;7:1063-1066. (Pubitemid 30398356)
25. Magnani E, Bartling L, Hake S. From Gateway to MultiSite Gateway in one recombination event. BMC Mol Biol 2006;7:46.
26. Grignani F, Kinsella T, Mencarelli A, et al. High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein. Cancer Res 1998;58:14-19. (Pubitemid 28027708)
27. Mountain CF. Revisions in the International System for Staging Lung Cancer. Chest 1997;111:1710-1717. (Pubitemid 27260107)
28. Sobin LH, Fleming ID. TNM Classification of Malignant Tumors, fifth edition (1997). Union Internationale Contre le Cancer and the American Joint Committee on Cancer. Cancer 1997;80:1803-1804.
29. Travis WD, Colby TV, Corrin B, et al. Histological Typing of Lung and Pleural Tumours, 3rd Ed. Berlin, Heidelberg, New York: Springer Verlag Berlin Heidelberg, 1999.
30. Tanner M, Gancberg D, Di LA, et al. Chromogenic in situ hybridization: a practical alternative for fluorescence in situ hybridization to detect HER-2/neu oncogene amplification in archival breast cancer samples. Am J Pathol 2000;157:1467-1472.
31. Mattick JS, Makunin IV. Non-coding RNA. Hum Mol Genet 2006; 15(Spec No 1):R17-R29.
32. Panzitt K, Tschernatsch MM, Guelly C, et al. Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. Gastroenterology 2007;132:330-342. (Pubitemid 46108730)
33. Tripathi V, Ellis JD, Shen Z, et al. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell 2010;39:925-938.