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Volumn 17, Issue 9, 2016, Pages 597-604

Applying CRISPR-Cas9 tools to identify and characterize transcriptional enhancers

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATIN; CRISPR CAS SYSTEM; CRISPR CAS9 SYSTEM; ENHANCER REGION; EPIGENETICS; GENE ACTIVATION; GENETIC MANIPULATION; GENETIC SCREENING; GENETIC TRANSCRIPTION; HIGH THROUGHPUT SCREENING; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; GENE EDITING; GENETIC EPIGENESIS; PROCEDURES;

EID: 84977156544     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm.2016.79     Document Type: Review
Times cited : (55)

References (101)
  • 1
    • 0019811465 scopus 로고
    • Expression of a β-globin gene is enhanced by remote SV40 DNA sequences
    • Banerji, J., Rusconi, S. & Schaffner, W. Expression of a β-globin gene is enhanced by remote SV40 DNA sequences. Cell 27, 299-308 (1981).
    • (1981) Cell , vol.27 , pp. 299-308
    • Banerji, J.1    Rusconi, S.2    Schaffner, W.3
  • 2
    • 77149139820 scopus 로고    scopus 로고
    • Enhancers: The abundance and function of regulatory sequences beyond promoters
    • Bulger, M. & Groudine, M. Enhancers: the abundance and function of regulatory sequences beyond promoters. Dev. Biol. 339, 250-257 (2010).
    • (2010) Dev. Biol. , vol.339 , pp. 250-257
    • Bulger, M.1    Groudine, M.2
  • 3
    • 84885620722 scopus 로고    scopus 로고
    • An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level
    • Bauer, D. E. et al. An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science 342, 253-257 (2013).
    • (2013) Science , vol.342 , pp. 253-257
    • Bauer, D.E.1
  • 4
    • 79951473520 scopus 로고    scopus 로고
    • 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response
    • Harismendy, O. et al. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature 470, 264-268 (2011).
    • (2011) Nature , vol.470 , pp. 264-268
    • Harismendy, O.1
  • 5
    • 84917710235 scopus 로고    scopus 로고
    • An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element
    • Mansour, M. R. et al. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science 346, 1373-1377 (2014).
    • (2014) Science , vol.346 , pp. 1373-1377
    • Mansour, M.R.1
  • 6
    • 84865822182 scopus 로고    scopus 로고
    • Systematic localization of common disease-associated variation in regulatory DNA
    • Maurano, M. T. et al. Systematic localization of common disease-associated variation in regulatory DNA. Science 337, 1190-1195 (2012).
    • (2012) Science , vol.337 , pp. 1190-1195
    • Maurano, M.T.1
  • 7
    • 77955499945 scopus 로고    scopus 로고
    • From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
    • Musunuru, K. et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature 466, 714-719 (2010).
    • (2010) Nature , vol.466 , pp. 714-719
    • Musunuru, K.1
  • 8
    • 84951189190 scopus 로고    scopus 로고
    • Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism
    • Oldridge, D. A. et al. Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism. Nature 528, 418-421 (2015).
    • (2015) Nature , vol.528 , pp. 418-421
    • Oldridge, D.A.1
  • 9
    • 84897459814 scopus 로고    scopus 로고
    • An atlas of active enhancers across human cell types and tissues
    • Andersson, R. et al. An atlas of active enhancers across human cell types and tissues. Nature 507, 455-461 (2014).
    • (2014) Nature , vol.507 , pp. 455-461
    • Andersson, R.1
  • 10
    • 84865755978 scopus 로고    scopus 로고
    • The accessible chromatin landscape of the human genome
    • Thurman, R. E. et al. The accessible chromatin landscape of the human genome. Nature 489, 75-82 (2012).
    • (2012) Nature , vol.489 , pp. 75-82
    • Thurman, R.E.1
  • 11
    • 70249088327 scopus 로고    scopus 로고
    • Genomic views of distant-acting enhancers
    • Visel, A., Rubin, E. M. & Pennacchio, L. A. Genomic views of distant-acting enhancers. Nature 461, 199-205 (2009).
    • (2009) Nature , vol.461 , pp. 199-205
    • Visel, A.1    Rubin, E.M.2    Pennacchio, L.A.3
  • 12
    • 84873729095 scopus 로고    scopus 로고
    • Multiplex genome engineering using CRISPR/Cas systems
    • Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823 (2013).
    • (2013) Science , vol.339 , pp. 819-823
    • Cong, L.1
  • 13
    • 84876567971 scopus 로고    scopus 로고
    • RNA-programmed genome editing in human cells
    • Jinek, M. et al. RNA-programmed genome editing in human cells. eLife 2, e00471 (2013).
    • (2013) ELife , vol.2 , pp. e00471
    • Jinek, M.1
  • 14
    • 84873734105 scopus 로고    scopus 로고
    • RNA-guided human genome engineering via Cas9
    • Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823-826 (2013).
    • (2013) Science , vol.339 , pp. 823-826
    • Mali, P.1
  • 15
    • 84874624936 scopus 로고    scopus 로고
    • Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
    • Cho, S. W., Kim, S., Kim, J. M. & Kim, J. S. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat. Biotechnol. 31, 230-232 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 230-232
    • Cho, S.W.1    Kim, S.2    Kim, J.M.3    Kim, J.S.4
  • 16
    • 84880571335 scopus 로고    scopus 로고
    • CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes
    • Gilbert, L. A. et al. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell 154, 442-451 (2013).
    • (2013) Cell , vol.154 , pp. 442-451
    • Gilbert, L.A.1
  • 17
    • 84908352138 scopus 로고    scopus 로고
    • Genome-scale CRISPR-mediated control of gene repression and activation
    • Gilbert, L. A. et al. Genome-scale CRISPR-mediated control of gene repression and activation. Cell 159, 647-661 (2014).
    • (2014) Cell , vol.159 , pp. 647-661
    • Gilbert, L.A.1
  • 18
    • 84946925193 scopus 로고    scopus 로고
    • BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
    • Canver, M. C. et al. BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis. Nature 527, 192-197 (2015).
    • (2015) Nature , vol.527 , pp. 192-197
    • Canver, M.C.1
  • 19
    • 84957590341 scopus 로고    scopus 로고
    • Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9
    • Korkmaz, G. et al. Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9. Nat. Biotechnol. 34, 192-198 (2016).
    • (2016) Nat. Biotechnol. , vol.34 , pp. 192-198
    • Korkmaz, G.1
  • 20
    • 84890048526 scopus 로고    scopus 로고
    • Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins
    • Maeder, M. L. et al. Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. Nat. Biotechnol. 31, 1137-1142 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 1137-1142
    • Maeder, M.L.1
  • 21
    • 84884906690 scopus 로고    scopus 로고
    • RNA-guided gene activation by CRISPR-Cas9-based transcription factors
    • Perez-Pinera, P. et al. RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nat. Methods 10, 973-976 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 973-976
    • Perez-Pinera, P.1
  • 22
    • 84884907424 scopus 로고    scopus 로고
    • CRISPR RNA-guided activation of endogenous human genes
    • Maeder, M. L. et al. CRISPR RNA-guided activation of endogenous human genes. Nat. Methods 10, 977-979 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 977-979
    • Maeder, M.L.1
  • 23
    • 84923096541 scopus 로고    scopus 로고
    • Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
    • Konermann, S. et al. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature 517, 583-588 (2015).
    • (2015) Nature , vol.517 , pp. 583-588
    • Konermann, S.1
  • 24
    • 84908328232 scopus 로고    scopus 로고
    • A protein-tagging system for signal amplification in gene expression and fluorescence imaging
    • Tanenbaum, M. E., Gilbert, L. A., Qi, L. S., Weissman, J. S. & Vale, R. D. A protein-tagging system for signal amplification in gene expression and fluorescence imaging. Cell 159, 635-646 (2014).
    • (2014) Cell , vol.159 , pp. 635-646
    • Tanenbaum, M.E.1    Gilbert, L.A.2    Qi, L.S.3    Weissman, J.S.4    Vale, R.D.5
  • 25
    • 0027772890 scopus 로고
    • Eukaryotic activators function during multiple steps of preinitiation complex assembly
    • Choy, B. & Green, M. R. Eukaryotic activators function during multiple steps of preinitiation complex assembly. Nature 366, 531-536 (1993).
    • (1993) Nature , vol.366 , pp. 531-536
    • Choy, B.1    Green, M.R.2
  • 26
    • 0037314175 scopus 로고    scopus 로고
    • Sequential recruitment of HAT and SWI/SNF components to condensed chromatin by VP16
    • Memedula, S. & Belmont, A. S. Sequential recruitment of HAT and SWI/SNF components to condensed chromatin by VP16. Curr. Biol. 13, 241-246 (2003).
    • (2003) Curr. Biol. , vol.13 , pp. 241-246
    • Memedula, S.1    Belmont, A.S.2
  • 27
    • 84964313405 scopus 로고    scopus 로고
    • Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers
    • Gao, X. et al. Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers. Nucleic Acids Res. 42, e155 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. e155
    • Gao, X.1
  • 28
    • 84929135130 scopus 로고    scopus 로고
    • Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
    • Hilton, I. B. et al. Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. Nat. Biotechnol. 33, 510-517 (2015).
    • (2015) Nat. Biotechnol. , vol.33 , pp. 510-517
    • Hilton, I.B.1
  • 29
    • 84874687019 scopus 로고    scopus 로고
    • Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
    • Qi, L. S. et al. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 152, 1173-1183 (2013).
    • (2013) Cell , vol.152 , pp. 1173-1183
    • Qi, L.S.1
  • 30
    • 84894063115 scopus 로고    scopus 로고
    • Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system
    • Chen, B. et al. Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell 155, 1479-1491 (2013).
    • (2013) Cell , vol.155 , pp. 1479-1491
    • Chen, B.1
  • 31
    • 84881449454 scopus 로고    scopus 로고
    • TALE-mediated modulation of≈transcriptional enhancers in vivo
    • Crocker, J. & Stern, D. L. TALE-mediated modulation of≈transcriptional enhancers in vivo. Nat. Methods 10, 762-767 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 762-767
    • Crocker, J.1    Stern, D.L.2
  • 32
    • 84949100864 scopus 로고    scopus 로고
    • Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
    • Thakore, P. I. et al. Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. Nat. Methods 12, 1143-1149 (2015).
    • (2015) Nat. Methods , vol.12 , pp. 1143-1149
    • Thakore, P.I.1
  • 33
    • 84956634373 scopus 로고    scopus 로고
    • Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers
    • Zhang, X. et al. Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers. Nat. Genet. 48, 176-182 (2016).
    • (2016) Nat. Genet. , vol.48 , pp. 176-182
    • Zhang, X.1
  • 34
    • 84928924333 scopus 로고    scopus 로고
    • Functional annotation of native enhancers with a Cas9-histone demethylase fusion
    • Kearns, N. A. et al. Functional annotation of native enhancers with a Cas9-histone demethylase fusion. Nat. Methods 12, 401-403 (2015).
    • (2015) Nat. Methods , vol.12 , pp. 401-403
    • Kearns, N.A.1
  • 35
    • 77950421703 scopus 로고    scopus 로고
    • KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading
    • Groner, A. C. et al. KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading. PLoS Genet. 6, e1000869 (2010).
    • (2010) PLoS Genet. , vol.6 , pp. e1000869
    • Groner, A.C.1
  • 37
    • 84898025687 scopus 로고    scopus 로고
    • Hormone-responsive enhancer-activity maps reveal predictive motifs, indirect repression, and targeting of closed chromatin
    • Shlyueva, D. et al. Hormone-responsive enhancer-activity maps reveal predictive motifs, indirect repression, and targeting of closed chromatin. Mol. Cell 54, 180-192 (2014).
    • (2014) Mol. Cell , vol.54 , pp. 180-192
    • Shlyueva, D.1
  • 38
    • 11144332565 scopus 로고    scopus 로고
    • Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    • Shi, Y. et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119, 941-953 (2004).
    • (2004) Cell , vol.119 , pp. 941-953
    • Shi, Y.1
  • 39
    • 84876216563 scopus 로고    scopus 로고
    • Master transcription factors and mediator establish super-enhancers at key cell identity genes
    • Whyte, W. A. et al. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell 153, 307-319 (2013).
    • (2013) Cell , vol.153 , pp. 307-319
    • Whyte, W.A.1
  • 40
    • 84898494315 scopus 로고    scopus 로고
    • A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia
    • Groschel, S. et al. A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia. Cell 157, 369-381 (2014).
    • (2014) Cell , vol.157 , pp. 369-381
    • Groschel, S.1
  • 41
    • 84918551761 scopus 로고    scopus 로고
    • A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential
    • Zhou, H. Y. et al. A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential. Genes Dev. 28, 2699-2711 (2014).
    • (2014) Genes Dev. , vol.28 , pp. 2699-2711
    • Zhou, H.Y.1
  • 42
    • 84915816838 scopus 로고    scopus 로고
    • CRISPR reveals a distal super-enhancer required for Sox2 expression in mouse embryonic stem cells
    • Li, Y. et al. CRISPR reveals a distal super-enhancer required for Sox2 expression in mouse embryonic stem cells. PLoS ONE 9, e114485 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e114485
    • Li, Y.1
  • 43
    • 84928207423 scopus 로고    scopus 로고
    • Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers
    • Hnisz, D. et al. Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers. Mol. Cell 58, 362-370 (2015).
    • (2015) Mol. Cell , vol.58 , pp. 362-370
    • Hnisz, D.1
  • 44
    • 84905388288 scopus 로고    scopus 로고
    • Characterization of genomic deletion efficiency mediated by clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells
    • Canver, M. C. et al. Characterization of genomic deletion efficiency mediated by clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. J. Biol. Chem. 289, 21312-21324 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 21312-21324
    • Canver, M.C.1
  • 45
    • 84957602988 scopus 로고    scopus 로고
    • High-throughput mapping of regulatory DNA
    • Rajagopal, N. et al. High-throughput mapping of regulatory DNA. Nat. Biotechnol. 34, 167-174 (2016).
    • (2016) Nat. Biotechnol. , vol.34 , pp. 167-174
    • Rajagopal, N.1
  • 46
    • 84960387483 scopus 로고    scopus 로고
    • A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening
    • Diao, Y. et al. A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening. Genome Res. 26, 397-405 (2016).
    • (2016) Genome Res. , vol.26 , pp. 397-405
    • Diao, Y.1
  • 47
    • 84887104139 scopus 로고    scopus 로고
    • Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
    • Esvelt, K. M. et al. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nat. Methods 10, 1116-1121 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 1116-1121
    • Esvelt, K.M.1
  • 48
    • 84949791988 scopus 로고    scopus 로고
    • Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
    • Kleinstiver, B. P. et al. Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition. Nat. Biotechnol. 33, 1293-1298 (2015).
    • (2015) Nat. Biotechnol. , vol.33 , pp. 1293-1298
    • Kleinstiver, B.P.1
  • 49
    • 84937908208 scopus 로고    scopus 로고
    • Engineered CRISPR-Cas9 nucleases with altered PAM specificities
    • Kleinstiver, B. P. et al. Engineered CRISPR-Cas9 nucleases with altered PAM specificities. Nature 523, 481-485 (2015).
    • (2015) Nature , vol.523 , pp. 481-485
    • Kleinstiver, B.P.1
  • 50
    • 84927514894 scopus 로고    scopus 로고
    • In vivo genome editing using Staphylococcus aureus Cas9
    • Ran, F. A. et al. In vivo genome editing using Staphylococcus aureus Cas9. Nature 520, 186-191 (2015).
    • (2015) Nature , vol.520 , pp. 186-191
    • Ran, F.A.1
  • 51
    • 84907257107 scopus 로고    scopus 로고
    • Saturation editing of genomic regions by multiplex homology-directed repair
    • Findlay, G. M., Boyle, E. A., Hause, R. J., Klein, J. C. & Shendure, J. Saturation editing of genomic regions by multiplex homology-directed repair. Nature 513, 120-123 (2014).
    • (2014) Nature , vol.513 , pp. 120-123
    • Findlay, G.M.1    Boyle, E.A.2    Hause, R.J.3    Klein, J.C.4    Shendure, J.5
  • 52
    • 84884165315 scopus 로고    scopus 로고
    • DNA targeting specificity of RNA-guided Cas9 nucleases
    • Hsu, P. D. et al. DNA targeting specificity of RNA-guided Cas9 nucleases. Nat. Biotechnol. 31, 827-832 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 827-832
    • Hsu, P.D.1
  • 53
    • 84884160273 scopus 로고    scopus 로고
    • CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
    • Mali, P. et al. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat. Biotechnol. 31, 833-838 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 833-838
    • Mali, P.1
  • 54
    • 84892749369 scopus 로고    scopus 로고
    • Genetic screens in human cells using the CRISPR-Cas9 system
    • Wang, T., Wei, J. J., Sabatini, D. M. & Lander, E. S. Genetic screens in human cells using the CRISPR-Cas9 system. Science 343, 80-84 (2014).
    • (2014) Science , vol.343 , pp. 80-84
    • Wang, T.1    Wei, J.J.2    Sabatini, D.M.3    Lander, E.S.4
  • 55
    • 84877707375 scopus 로고    scopus 로고
    • One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
    • Wang, H. et al. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 153, 910-918 (2013).
    • (2013) Cell , vol.153 , pp. 910-918
    • Wang, H.1
  • 56
    • 84898665052 scopus 로고    scopus 로고
    • Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
    • Koike-Yusa, H., Li, Y., Tan, E. P., Velasco-Herrera Mdel, C. & Yusa, K. Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library. Nat. Biotechnol. 32, 267-273 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , pp. 267-273
    • Koike-Yusa, H.1    Li, Y.2    Tan, E.P.3    Velasco-Herrera Mdel, C.4    Yusa, K.5
  • 57
    • 84892765883 scopus 로고    scopus 로고
    • Genome-scale CRISPR-Cas9 knockout screening in human cells
    • Shalem, O. et al. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science 343, 84-87 (2014).
    • (2014) Science , vol.343 , pp. 84-87
    • Shalem, O.1
  • 58
    • 84928205754 scopus 로고    scopus 로고
    • High-throughput functional genomics using CRISPR-Cas9
    • Shalem, O., Sanjana, N. E. & Zhang, F. High-throughput functional genomics using CRISPR-Cas9. Nat. Rev. Genet. 16, 299-311 (2015).
    • (2015) Nat. Rev. Genet. , vol.16 , pp. 299-311
    • Shalem, O.1    Sanjana, N.E.2    Zhang, F.3
  • 59
    • 84939603800 scopus 로고    scopus 로고
    • Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries
    • Vidigal, J. A. & Ventura, A. Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries. Nat. Commun. 6, 8083 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 8083
    • Vidigal, J.A.1    Ventura, A.2
  • 60
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • Consortium, E. P. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74 (2012).
    • (2012) Nature , vol.489 , pp. 57-74
    • Consortium, E.P.1
  • 61
    • 84882976110 scopus 로고    scopus 로고
    • Optical control of mammalian endogenous transcription and epigenetic states
    • Konermann, S. et al. Optical control of mammalian endogenous transcription and epigenetic states. Nature 500, 472-476 (2013).
    • (2013) Nature , vol.500 , pp. 472-476
    • Konermann, S.1
  • 62
    • 84942793975 scopus 로고    scopus 로고
    • Photoactivatable CRISPR-Cas9 for optogenetic genome editing
    • Nihongaki, Y., Kawano, F., Nakajima, T. & Sato, M. Photoactivatable CRISPR-Cas9 for optogenetic genome editing. Nat. Biotechnol. 33, 755-760 (2015).
    • (2015) Nat. Biotechnol. , vol.33 , pp. 755-760
    • Nihongaki, Y.1    Kawano, F.2    Nakajima, T.3    Sato, M.4
  • 63
  • 64
    • 84925534357 scopus 로고    scopus 로고
    • A light-inducible CRISPR-Cas9 system for control of endogenous gene activation
    • Polstein, L. R. & Gersbach, C. A. A light-inducible CRISPR-Cas9 system for control of endogenous gene activation. Nat. Chem. Biol. 11, 198-200 (2015).
    • (2015) Nat. Chem. Biol. , vol.11 , pp. 198-200
    • Polstein, L.R.1    Gersbach, C.A.2
  • 65
    • 84922735816 scopus 로고    scopus 로고
    • In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
    • Maddalo, D. et al. In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system. Nature 516, 423-427 (2014).
    • (2014) Nature , vol.516 , pp. 423-427
    • Maddalo, D.1
  • 66
    • 84880507665 scopus 로고    scopus 로고
    • Mutational heterogeneity in cancer and the search for new cancer-associated genes
    • Lawrence, M. S. et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 499, 214-218 (2013).
    • (2013) Nature , vol.499 , pp. 214-218
    • Lawrence, M.S.1
  • 67
    • 84923771297 scopus 로고    scopus 로고
    • CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation
    • Narendra, V. et al. CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation. Science 347, 1017-1021 (2015).
    • (2015) Science , vol.347 , pp. 1017-1021
    • Narendra, V.1
  • 68
    • 84960171833 scopus 로고    scopus 로고
    • Activation of proto-oncogenes by disruption of chromosome neighborhoods
    • Hnisz, D. et al. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science 351, 1454-1458 (2016).
    • (2016) Science , vol.351 , pp. 1454-1458
    • Hnisz, D.1
  • 69
    • 84861964135 scopus 로고    scopus 로고
    • Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor
    • Deng, W. et al. Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell 149, 1233-1244 (2012).
    • (2012) Cell , vol.149 , pp. 1233-1244
    • Deng, W.1
  • 70
    • 84908439526 scopus 로고    scopus 로고
    • Reactivation of developmentally silenced globin genes by forced chromatin looping
    • Deng, W. et al. Reactivation of developmentally silenced globin genes by forced chromatin looping. Cell 158, 849-860 (2014).
    • (2014) Cell , vol.158 , pp. 849-860
    • Deng, W.1
  • 71
    • 84920992414 scopus 로고    scopus 로고
    • Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds
    • Zalatan, J. G. et al. Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell 160, 339-350 (2015).
    • (2015) Cell , vol.160 , pp. 339-350
    • Zalatan, J.G.1
  • 72
    • 34250159524 scopus 로고    scopus 로고
    • Genome-wide mapping of in vivo protein-DNA interactions
    • Johnson, D. S., Mortazavi, A., Myers, R. M. & Wold, B. Genome-wide mapping of in vivo protein-DNA interactions. Science 316, 1497-1502 (2007).
    • (2007) Science , vol.316 , pp. 1497-1502
    • Johnson, D.S.1    Mortazavi, A.2    Myers, R.M.3    Wold, B.4
  • 73
    • 60149091656 scopus 로고    scopus 로고
    • ChIP-seq accurately predicts tissue-specific activity of enhancers
    • Visel, A. et al. ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature 457, 854-858 (2009).
    • (2009) Nature , vol.457 , pp. 854-858
    • Visel, A.1
  • 74
    • 79955583542 scopus 로고    scopus 로고
    • Mapping and analysis of chromatin state dynamics in nine human cell types
    • Ernst, J. et al. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 473, 43-49 (2011).
    • (2011) Nature , vol.473 , pp. 43-49
    • Ernst, J.1
  • 75
    • 38649099445 scopus 로고    scopus 로고
    • High-resolution mapping and characterization of open chromatin across the genome
    • Boyle, A. P. et al. High-resolution mapping and characterization of open chromatin across the genome. Cell 132, 311-322 (2008).
    • (2008) Cell , vol.132 , pp. 311-322
    • Boyle, A.P.1
  • 76
    • 0037083376 scopus 로고    scopus 로고
    • Capturing chromosome conformation
    • Dekker, J., Rippe, K., Dekker, M. & Kleckner, N. Capturing chromosome conformation. Science 295, 1306-1311 (2002).
    • (2002) Science , vol.295 , pp. 1306-1311
    • Dekker, J.1    Rippe, K.2    Dekker, M.3    Kleckner, N.4
  • 77
    • 70349873824 scopus 로고    scopus 로고
    • Comprehensive mapping of long-range interactions reveals folding principles of the human genome
    • Lieberman-Aiden, E. et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 326, 289-293 (2009).
    • (2009) Science , vol.326 , pp. 289-293
    • Lieberman-Aiden, E.1
  • 78
    • 70449103609 scopus 로고    scopus 로고
    • An oestrogen-receptor-α-bound human chromatin interactome
    • Fullwood, M. J. et al. An oestrogen-receptor-α-bound human chromatin interactome. Nature 462, 58-64 (2009).
    • (2009) Nature , vol.462 , pp. 58-64
    • Fullwood, M.J.1
  • 79
    • 77952367798 scopus 로고    scopus 로고
    • Widespread transcription at neuronal activity-regulated enhancers
    • Kim, T. K. et al. Widespread transcription at neuronal activity-regulated enhancers. Nature 465, 182-187 (2010).
    • (2010) Nature , vol.465 , pp. 182-187
    • Kim, T.K.1
  • 80
    • 57849109058 scopus 로고    scopus 로고
    • Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters
    • Core, L. J., Waterfall, J. J. & Lis, J. T. Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science 322, 1845-1848 (2008).
    • (2008) Science , vol.322 , pp. 1845-1848
    • Core, L.J.1    Waterfall, J.J.2    Lis, J.T.3
  • 81
    • 84863229330 scopus 로고    scopus 로고
    • Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay
    • Melnikov, A. et al. Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay. Nat. Biotechnol. 30, 271-277 (2012).
    • (2012) Nat. Biotechnol. , vol.30 , pp. 271-277
    • Melnikov, A.1
  • 82
    • 84863230316 scopus 로고    scopus 로고
    • Massively parallel functional dissection of mammalian enhancers in vivo
    • Patwardhan, R. P. et al. Massively parallel functional dissection of mammalian enhancers in vivo. Nat. Biotechnol. 30, 265-270 (2012).
    • (2012) Nat. Biotechnol. , vol.30 , pp. 265-270
    • Patwardhan, R.P.1
  • 83
    • 84874381107 scopus 로고    scopus 로고
    • Genome-wide quantitative enhancer activity maps identified by STARR-seq
    • Arnold, C. D. et al. Genome-wide quantitative enhancer activity maps identified by STARR-seq. Science 339, 1074-1077 (2013).
    • (2013) Science , vol.339 , pp. 1074-1077
    • Arnold, C.D.1
  • 84
    • 84876836223 scopus 로고    scopus 로고
    • Modification of enhancer chromatin: What, how, and why?
    • Calo, E. & Wysocka, J. Modification of enhancer chromatin: what, how, and why? Mol. Cell 49, 825-837 (2013).
    • (2013) Mol. Cell , vol.49 , pp. 825-837
    • Calo, E.1    Wysocka, J.2
  • 85
    • 84899450857 scopus 로고    scopus 로고
    • Transcriptional enhancers: From properties to genome-wide predictions
    • Shlyueva, D., Stampfel, G. & Stark, A. Transcriptional enhancers: from properties to genome-wide predictions. Nat. Rev. Genet. 15, 272-286 (2014).
    • (2014) Nat. Rev. Genet. , vol.15 , pp. 272-286
    • Shlyueva, D.1    Stampfel, G.2    Stark, A.3
  • 86
    • 84884829249 scopus 로고    scopus 로고
    • Mapping human epigenomes
    • Rivera, C. M. & Ren, B. Mapping human epigenomes. Cell 155, 39-55 (2013).
    • (2013) Cell , vol.155 , pp. 39-55
    • Rivera, C.M.1    Ren, B.2
  • 87
    • 84881171344 scopus 로고    scopus 로고
    • Enhancer transcripts mark active estrogen receptor binding sites
    • Hah, N., Murakami, S., Nagari, A., Danko, C. G. & Kraus, W. L. Enhancer transcripts mark active estrogen receptor binding sites. Genome Res. 23, 1210-1223 (2013).
    • (2013) Genome Res. , vol.23 , pp. 1210-1223
    • Hah, N.1    Murakami, S.2    Nagari, A.3    Danko, C.G.4    Kraus, W.L.5
  • 88
    • 84923796255 scopus 로고    scopus 로고
    • Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells
    • Arner, E. et al. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science 347, 1010-1014 (2015).
    • (2015) Science , vol.347 , pp. 1010-1014
    • Arner, E.1
  • 89
    • 84865070369 scopus 로고    scopus 로고
    • A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
    • Jinek, M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816-821 (2012).
    • (2012) Science , vol.337 , pp. 816-821
    • Jinek, M.1
  • 90
    • 84952639685 scopus 로고    scopus 로고
    • Beyond editing: Repurposing CRISPR-Cas9 for precision genome regulation and interrogation
    • Dominguez, A. A., Lim, W. A. & Qi, L. S. Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation. Nat. Rev. Mol. Cell Biol. 17, 5-15 (2016).
    • (2016) Nat. Rev. Mol. Cell Biol. , vol.17 , pp. 5-15
    • Dominguez, A.A.1    Lim, W.A.2    Qi, L.S.3
  • 91
    • 84902095352 scopus 로고    scopus 로고
    • Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
    • Wu, X. et al. Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nat. Biotechnol. 32, 670-676 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , pp. 670-676
    • Wu, X.1
  • 92
    • 84921540377 scopus 로고    scopus 로고
    • Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation
    • Doench, J. G. et al. Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation. Nat. Biotechnol. 32, 1262-1267 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , pp. 1262-1267
    • Doench, J.G.1
  • 93
    • 84903516238 scopus 로고    scopus 로고
    • Microhomology-based choice of Cas9 nuclease target sites
    • Bae, S., Kweon, J., Kim, H. S. & Kim, J. S. Microhomology-based choice of Cas9 nuclease target sites. Nat. Methods 11, 705-706 (2014).
    • (2014) Nat. Methods , vol.11 , pp. 705-706
    • Bae, S.1    Kweon, J.2    Kim, H.S.3    Kim, J.S.4
  • 94
    • 84880570576 scopus 로고    scopus 로고
    • High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
    • Fu, Y. et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat. Biotechnol. 31, 822-826 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 822-826
    • Fu, Y.1
  • 95
    • 84884155038 scopus 로고    scopus 로고
    • High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
    • Pattanayak, V. et al. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nat. Biotechnol. 31, 839-843 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 839-843
    • Pattanayak, V.1
  • 96
    • 84903545084 scopus 로고    scopus 로고
    • Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
    • Kuscu, C., Arslan, S., Singh, R., Thorpe, J. & Adli, M. Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease. Nat. Biotechnol. 32, 677-683 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , pp. 677-683
    • Kuscu, C.1    Arslan, S.2    Singh, R.3    Thorpe, J.4    Adli, M.5
  • 97
    • 84895871173 scopus 로고    scopus 로고
    • DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
    • Sternberg, S. H., Redding, S., Jinek, M., Greene, E. C. & Doudna, J. A. DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature 507, 62-67 (2014).
    • (2014) Nature , vol.507 , pp. 62-67
    • Sternberg, S.H.1    Redding, S.2    Jinek, M.3    Greene, E.C.4    Doudna, J.A.5
  • 98
    • 84884288934 scopus 로고    scopus 로고
    • Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
    • Ran, F. A. et al. Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell 154, 1380-1389 (2013).
    • (2013) Cell , vol.154 , pp. 1380-1389
    • Ran, F.A.1
  • 99
    • 84896929630 scopus 로고    scopus 로고
    • Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
    • Fu, Y., Sander, J. D., Reyon, D., Cascio, V. M. & Joung, J. K. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nat. Biotechnol. 32, 279-284 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , pp. 279-284
    • Fu, Y.1    Sander, J.D.2    Reyon, D.3    Cascio, V.M.4    Joung, J.K.5
  • 100
    • 84963941043 scopus 로고    scopus 로고
    • High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
    • Kleinstiver, B. P. et al. High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Nature 529, 490-495 (2016).
    • (2016) Nature , vol.529 , pp. 490-495
    • Kleinstiver, B.P.1
  • 101
    • 84952943845 scopus 로고    scopus 로고
    • Rationally engineered Cas9 nucleases with improved specificity
    • Slaymaker, I. M. et al. Rationally engineered Cas9 nucleases with improved specificity. Science 351, 84-88 (2016).
    • (2016) Science , vol.351 , pp. 84-88
    • Slaymaker, I.M.1


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