-
1
-
-
0019811465
-
Expression of a β-globin gene is enhanced by remote SV40 DNA sequences
-
Banerji, J., Rusconi, S. & Schaffner, W. Expression of a β-globin gene is enhanced by remote SV40 DNA sequences. Cell 27, 299-308 (1981).
-
(1981)
Cell
, vol.27
, pp. 299-308
-
-
Banerji, J.1
Rusconi, S.2
Schaffner, W.3
-
2
-
-
77149139820
-
Enhancers: The abundance and function of regulatory sequences beyond promoters
-
Bulger, M. & Groudine, M. Enhancers: the abundance and function of regulatory sequences beyond promoters. Dev. Biol. 339, 250-257 (2010).
-
(2010)
Dev. Biol.
, vol.339
, pp. 250-257
-
-
Bulger, M.1
Groudine, M.2
-
3
-
-
84885620722
-
An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level
-
Bauer, D. E. et al. An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science 342, 253-257 (2013).
-
(2013)
Science
, vol.342
, pp. 253-257
-
-
Bauer, D.E.1
-
4
-
-
79951473520
-
9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response
-
Harismendy, O. et al. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature 470, 264-268 (2011).
-
(2011)
Nature
, vol.470
, pp. 264-268
-
-
Harismendy, O.1
-
5
-
-
84917710235
-
An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element
-
Mansour, M. R. et al. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science 346, 1373-1377 (2014).
-
(2014)
Science
, vol.346
, pp. 1373-1377
-
-
Mansour, M.R.1
-
6
-
-
84865822182
-
Systematic localization of common disease-associated variation in regulatory DNA
-
Maurano, M. T. et al. Systematic localization of common disease-associated variation in regulatory DNA. Science 337, 1190-1195 (2012).
-
(2012)
Science
, vol.337
, pp. 1190-1195
-
-
Maurano, M.T.1
-
7
-
-
77955499945
-
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
-
Musunuru, K. et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature 466, 714-719 (2010).
-
(2010)
Nature
, vol.466
, pp. 714-719
-
-
Musunuru, K.1
-
8
-
-
84951189190
-
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism
-
Oldridge, D. A. et al. Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism. Nature 528, 418-421 (2015).
-
(2015)
Nature
, vol.528
, pp. 418-421
-
-
Oldridge, D.A.1
-
9
-
-
84897459814
-
An atlas of active enhancers across human cell types and tissues
-
Andersson, R. et al. An atlas of active enhancers across human cell types and tissues. Nature 507, 455-461 (2014).
-
(2014)
Nature
, vol.507
, pp. 455-461
-
-
Andersson, R.1
-
10
-
-
84865755978
-
The accessible chromatin landscape of the human genome
-
Thurman, R. E. et al. The accessible chromatin landscape of the human genome. Nature 489, 75-82 (2012).
-
(2012)
Nature
, vol.489
, pp. 75-82
-
-
Thurman, R.E.1
-
11
-
-
70249088327
-
Genomic views of distant-acting enhancers
-
Visel, A., Rubin, E. M. & Pennacchio, L. A. Genomic views of distant-acting enhancers. Nature 461, 199-205 (2009).
-
(2009)
Nature
, vol.461
, pp. 199-205
-
-
Visel, A.1
Rubin, E.M.2
Pennacchio, L.A.3
-
12
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823 (2013).
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
-
13
-
-
84876567971
-
RNA-programmed genome editing in human cells
-
Jinek, M. et al. RNA-programmed genome editing in human cells. eLife 2, e00471 (2013).
-
(2013)
ELife
, vol.2
, pp. e00471
-
-
Jinek, M.1
-
14
-
-
84873734105
-
RNA-guided human genome engineering via Cas9
-
Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823-826 (2013).
-
(2013)
Science
, vol.339
, pp. 823-826
-
-
Mali, P.1
-
15
-
-
84874624936
-
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
-
Cho, S. W., Kim, S., Kim, J. M. & Kim, J. S. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat. Biotechnol. 31, 230-232 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 230-232
-
-
Cho, S.W.1
Kim, S.2
Kim, J.M.3
Kim, J.S.4
-
16
-
-
84880571335
-
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes
-
Gilbert, L. A. et al. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell 154, 442-451 (2013).
-
(2013)
Cell
, vol.154
, pp. 442-451
-
-
Gilbert, L.A.1
-
17
-
-
84908352138
-
Genome-scale CRISPR-mediated control of gene repression and activation
-
Gilbert, L. A. et al. Genome-scale CRISPR-mediated control of gene repression and activation. Cell 159, 647-661 (2014).
-
(2014)
Cell
, vol.159
, pp. 647-661
-
-
Gilbert, L.A.1
-
18
-
-
84946925193
-
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
-
Canver, M. C. et al. BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis. Nature 527, 192-197 (2015).
-
(2015)
Nature
, vol.527
, pp. 192-197
-
-
Canver, M.C.1
-
19
-
-
84957590341
-
Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9
-
Korkmaz, G. et al. Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9. Nat. Biotechnol. 34, 192-198 (2016).
-
(2016)
Nat. Biotechnol.
, vol.34
, pp. 192-198
-
-
Korkmaz, G.1
-
20
-
-
84890048526
-
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins
-
Maeder, M. L. et al. Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. Nat. Biotechnol. 31, 1137-1142 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 1137-1142
-
-
Maeder, M.L.1
-
21
-
-
84884906690
-
RNA-guided gene activation by CRISPR-Cas9-based transcription factors
-
Perez-Pinera, P. et al. RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nat. Methods 10, 973-976 (2013).
-
(2013)
Nat. Methods
, vol.10
, pp. 973-976
-
-
Perez-Pinera, P.1
-
22
-
-
84884907424
-
CRISPR RNA-guided activation of endogenous human genes
-
Maeder, M. L. et al. CRISPR RNA-guided activation of endogenous human genes. Nat. Methods 10, 977-979 (2013).
-
(2013)
Nat. Methods
, vol.10
, pp. 977-979
-
-
Maeder, M.L.1
-
23
-
-
84923096541
-
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
-
Konermann, S. et al. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature 517, 583-588 (2015).
-
(2015)
Nature
, vol.517
, pp. 583-588
-
-
Konermann, S.1
-
24
-
-
84908328232
-
A protein-tagging system for signal amplification in gene expression and fluorescence imaging
-
Tanenbaum, M. E., Gilbert, L. A., Qi, L. S., Weissman, J. S. & Vale, R. D. A protein-tagging system for signal amplification in gene expression and fluorescence imaging. Cell 159, 635-646 (2014).
-
(2014)
Cell
, vol.159
, pp. 635-646
-
-
Tanenbaum, M.E.1
Gilbert, L.A.2
Qi, L.S.3
Weissman, J.S.4
Vale, R.D.5
-
25
-
-
0027772890
-
Eukaryotic activators function during multiple steps of preinitiation complex assembly
-
Choy, B. & Green, M. R. Eukaryotic activators function during multiple steps of preinitiation complex assembly. Nature 366, 531-536 (1993).
-
(1993)
Nature
, vol.366
, pp. 531-536
-
-
Choy, B.1
Green, M.R.2
-
26
-
-
0037314175
-
Sequential recruitment of HAT and SWI/SNF components to condensed chromatin by VP16
-
Memedula, S. & Belmont, A. S. Sequential recruitment of HAT and SWI/SNF components to condensed chromatin by VP16. Curr. Biol. 13, 241-246 (2003).
-
(2003)
Curr. Biol.
, vol.13
, pp. 241-246
-
-
Memedula, S.1
Belmont, A.S.2
-
27
-
-
84964313405
-
Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers
-
Gao, X. et al. Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers. Nucleic Acids Res. 42, e155 (2014).
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. e155
-
-
Gao, X.1
-
28
-
-
84929135130
-
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
-
Hilton, I. B. et al. Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. Nat. Biotechnol. 33, 510-517 (2015).
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 510-517
-
-
Hilton, I.B.1
-
29
-
-
84874687019
-
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
-
Qi, L. S. et al. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 152, 1173-1183 (2013).
-
(2013)
Cell
, vol.152
, pp. 1173-1183
-
-
Qi, L.S.1
-
30
-
-
84894063115
-
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system
-
Chen, B. et al. Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell 155, 1479-1491 (2013).
-
(2013)
Cell
, vol.155
, pp. 1479-1491
-
-
Chen, B.1
-
31
-
-
84881449454
-
TALE-mediated modulation of≈transcriptional enhancers in vivo
-
Crocker, J. & Stern, D. L. TALE-mediated modulation of≈transcriptional enhancers in vivo. Nat. Methods 10, 762-767 (2013).
-
(2013)
Nat. Methods
, vol.10
, pp. 762-767
-
-
Crocker, J.1
Stern, D.L.2
-
32
-
-
84949100864
-
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
-
Thakore, P. I. et al. Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. Nat. Methods 12, 1143-1149 (2015).
-
(2015)
Nat. Methods
, vol.12
, pp. 1143-1149
-
-
Thakore, P.I.1
-
33
-
-
84956634373
-
Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers
-
Zhang, X. et al. Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers. Nat. Genet. 48, 176-182 (2016).
-
(2016)
Nat. Genet.
, vol.48
, pp. 176-182
-
-
Zhang, X.1
-
34
-
-
84928924333
-
Functional annotation of native enhancers with a Cas9-histone demethylase fusion
-
Kearns, N. A. et al. Functional annotation of native enhancers with a Cas9-histone demethylase fusion. Nat. Methods 12, 401-403 (2015).
-
(2015)
Nat. Methods
, vol.12
, pp. 401-403
-
-
Kearns, N.A.1
-
35
-
-
77950421703
-
KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading
-
Groner, A. C. et al. KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading. PLoS Genet. 6, e1000869 (2010).
-
(2010)
PLoS Genet.
, vol.6
, pp. e1000869
-
-
Groner, A.C.1
-
36
-
-
84923786414
-
The selection and function of cell type-specific enhancers
-
Heinz, S., Romanoski, C. E., Benner, C. & Glass, C. K. The selection and function of cell type-specific enhancers. Nat. Rev. Mol. Cell Biol. 16, 144-154 (2015).
-
(2015)
Nat. Rev. Mol. Cell Biol.
, vol.16
, pp. 144-154
-
-
Heinz, S.1
Romanoski, C.E.2
Benner, C.3
Glass, C.K.4
-
37
-
-
84898025687
-
Hormone-responsive enhancer-activity maps reveal predictive motifs, indirect repression, and targeting of closed chromatin
-
Shlyueva, D. et al. Hormone-responsive enhancer-activity maps reveal predictive motifs, indirect repression, and targeting of closed chromatin. Mol. Cell 54, 180-192 (2014).
-
(2014)
Mol. Cell
, vol.54
, pp. 180-192
-
-
Shlyueva, D.1
-
38
-
-
11144332565
-
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
-
Shi, Y. et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119, 941-953 (2004).
-
(2004)
Cell
, vol.119
, pp. 941-953
-
-
Shi, Y.1
-
39
-
-
84876216563
-
Master transcription factors and mediator establish super-enhancers at key cell identity genes
-
Whyte, W. A. et al. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell 153, 307-319 (2013).
-
(2013)
Cell
, vol.153
, pp. 307-319
-
-
Whyte, W.A.1
-
40
-
-
84898494315
-
A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia
-
Groschel, S. et al. A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia. Cell 157, 369-381 (2014).
-
(2014)
Cell
, vol.157
, pp. 369-381
-
-
Groschel, S.1
-
41
-
-
84918551761
-
A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential
-
Zhou, H. Y. et al. A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential. Genes Dev. 28, 2699-2711 (2014).
-
(2014)
Genes Dev.
, vol.28
, pp. 2699-2711
-
-
Zhou, H.Y.1
-
42
-
-
84915816838
-
CRISPR reveals a distal super-enhancer required for Sox2 expression in mouse embryonic stem cells
-
Li, Y. et al. CRISPR reveals a distal super-enhancer required for Sox2 expression in mouse embryonic stem cells. PLoS ONE 9, e114485 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e114485
-
-
Li, Y.1
-
43
-
-
84928207423
-
Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers
-
Hnisz, D. et al. Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers. Mol. Cell 58, 362-370 (2015).
-
(2015)
Mol. Cell
, vol.58
, pp. 362-370
-
-
Hnisz, D.1
-
44
-
-
84905388288
-
Characterization of genomic deletion efficiency mediated by clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells
-
Canver, M. C. et al. Characterization of genomic deletion efficiency mediated by clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. J. Biol. Chem. 289, 21312-21324 (2014).
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 21312-21324
-
-
Canver, M.C.1
-
45
-
-
84957602988
-
High-throughput mapping of regulatory DNA
-
Rajagopal, N. et al. High-throughput mapping of regulatory DNA. Nat. Biotechnol. 34, 167-174 (2016).
-
(2016)
Nat. Biotechnol.
, vol.34
, pp. 167-174
-
-
Rajagopal, N.1
-
46
-
-
84960387483
-
A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening
-
Diao, Y. et al. A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening. Genome Res. 26, 397-405 (2016).
-
(2016)
Genome Res.
, vol.26
, pp. 397-405
-
-
Diao, Y.1
-
47
-
-
84887104139
-
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
-
Esvelt, K. M. et al. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nat. Methods 10, 1116-1121 (2013).
-
(2013)
Nat. Methods
, vol.10
, pp. 1116-1121
-
-
Esvelt, K.M.1
-
48
-
-
84949791988
-
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
-
Kleinstiver, B. P. et al. Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition. Nat. Biotechnol. 33, 1293-1298 (2015).
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 1293-1298
-
-
Kleinstiver, B.P.1
-
49
-
-
84937908208
-
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
-
Kleinstiver, B. P. et al. Engineered CRISPR-Cas9 nucleases with altered PAM specificities. Nature 523, 481-485 (2015).
-
(2015)
Nature
, vol.523
, pp. 481-485
-
-
Kleinstiver, B.P.1
-
50
-
-
84927514894
-
In vivo genome editing using Staphylococcus aureus Cas9
-
Ran, F. A. et al. In vivo genome editing using Staphylococcus aureus Cas9. Nature 520, 186-191 (2015).
-
(2015)
Nature
, vol.520
, pp. 186-191
-
-
Ran, F.A.1
-
51
-
-
84907257107
-
Saturation editing of genomic regions by multiplex homology-directed repair
-
Findlay, G. M., Boyle, E. A., Hause, R. J., Klein, J. C. & Shendure, J. Saturation editing of genomic regions by multiplex homology-directed repair. Nature 513, 120-123 (2014).
-
(2014)
Nature
, vol.513
, pp. 120-123
-
-
Findlay, G.M.1
Boyle, E.A.2
Hause, R.J.3
Klein, J.C.4
Shendure, J.5
-
52
-
-
84884165315
-
DNA targeting specificity of RNA-guided Cas9 nucleases
-
Hsu, P. D. et al. DNA targeting specificity of RNA-guided Cas9 nucleases. Nat. Biotechnol. 31, 827-832 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 827-832
-
-
Hsu, P.D.1
-
53
-
-
84884160273
-
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
-
Mali, P. et al. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat. Biotechnol. 31, 833-838 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 833-838
-
-
Mali, P.1
-
54
-
-
84892749369
-
Genetic screens in human cells using the CRISPR-Cas9 system
-
Wang, T., Wei, J. J., Sabatini, D. M. & Lander, E. S. Genetic screens in human cells using the CRISPR-Cas9 system. Science 343, 80-84 (2014).
-
(2014)
Science
, vol.343
, pp. 80-84
-
-
Wang, T.1
Wei, J.J.2
Sabatini, D.M.3
Lander, E.S.4
-
55
-
-
84877707375
-
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
-
Wang, H. et al. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 153, 910-918 (2013).
-
(2013)
Cell
, vol.153
, pp. 910-918
-
-
Wang, H.1
-
56
-
-
84898665052
-
Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
-
Koike-Yusa, H., Li, Y., Tan, E. P., Velasco-Herrera Mdel, C. & Yusa, K. Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library. Nat. Biotechnol. 32, 267-273 (2014).
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 267-273
-
-
Koike-Yusa, H.1
Li, Y.2
Tan, E.P.3
Velasco-Herrera Mdel, C.4
Yusa, K.5
-
57
-
-
84892765883
-
Genome-scale CRISPR-Cas9 knockout screening in human cells
-
Shalem, O. et al. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science 343, 84-87 (2014).
-
(2014)
Science
, vol.343
, pp. 84-87
-
-
Shalem, O.1
-
58
-
-
84928205754
-
High-throughput functional genomics using CRISPR-Cas9
-
Shalem, O., Sanjana, N. E. & Zhang, F. High-throughput functional genomics using CRISPR-Cas9. Nat. Rev. Genet. 16, 299-311 (2015).
-
(2015)
Nat. Rev. Genet.
, vol.16
, pp. 299-311
-
-
Shalem, O.1
Sanjana, N.E.2
Zhang, F.3
-
59
-
-
84939603800
-
Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries
-
Vidigal, J. A. & Ventura, A. Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries. Nat. Commun. 6, 8083 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 8083
-
-
Vidigal, J.A.1
Ventura, A.2
-
60
-
-
84865790047
-
An integrated encyclopedia of DNA elements in the human genome
-
Consortium, E. P. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74 (2012).
-
(2012)
Nature
, vol.489
, pp. 57-74
-
-
Consortium, E.P.1
-
61
-
-
84882976110
-
Optical control of mammalian endogenous transcription and epigenetic states
-
Konermann, S. et al. Optical control of mammalian endogenous transcription and epigenetic states. Nature 500, 472-476 (2013).
-
(2013)
Nature
, vol.500
, pp. 472-476
-
-
Konermann, S.1
-
62
-
-
84942793975
-
Photoactivatable CRISPR-Cas9 for optogenetic genome editing
-
Nihongaki, Y., Kawano, F., Nakajima, T. & Sato, M. Photoactivatable CRISPR-Cas9 for optogenetic genome editing. Nat. Biotechnol. 33, 755-760 (2015).
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 755-760
-
-
Nihongaki, Y.1
Kawano, F.2
Nakajima, T.3
Sato, M.4
-
63
-
-
84923141668
-
CRISPR-Cas9-based photoactivatable transcription system
-
Nihongaki, Y., Yamamoto, S., Kawano, F., Suzuki, H. & Sato, M. CRISPR-Cas9-based photoactivatable transcription system. Chem. Biol. 22, 169-174 (2015).
-
(2015)
Chem. Biol.
, vol.22
, pp. 169-174
-
-
Nihongaki, Y.1
Yamamoto, S.2
Kawano, F.3
Suzuki, H.4
Sato, M.5
-
64
-
-
84925534357
-
A light-inducible CRISPR-Cas9 system for control of endogenous gene activation
-
Polstein, L. R. & Gersbach, C. A. A light-inducible CRISPR-Cas9 system for control of endogenous gene activation. Nat. Chem. Biol. 11, 198-200 (2015).
-
(2015)
Nat. Chem. Biol.
, vol.11
, pp. 198-200
-
-
Polstein, L.R.1
Gersbach, C.A.2
-
65
-
-
84922735816
-
In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
-
Maddalo, D. et al. In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system. Nature 516, 423-427 (2014).
-
(2014)
Nature
, vol.516
, pp. 423-427
-
-
Maddalo, D.1
-
66
-
-
84880507665
-
Mutational heterogeneity in cancer and the search for new cancer-associated genes
-
Lawrence, M. S. et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 499, 214-218 (2013).
-
(2013)
Nature
, vol.499
, pp. 214-218
-
-
Lawrence, M.S.1
-
67
-
-
84923771297
-
CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation
-
Narendra, V. et al. CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation. Science 347, 1017-1021 (2015).
-
(2015)
Science
, vol.347
, pp. 1017-1021
-
-
Narendra, V.1
-
68
-
-
84960171833
-
Activation of proto-oncogenes by disruption of chromosome neighborhoods
-
Hnisz, D. et al. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science 351, 1454-1458 (2016).
-
(2016)
Science
, vol.351
, pp. 1454-1458
-
-
Hnisz, D.1
-
69
-
-
84861964135
-
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor
-
Deng, W. et al. Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell 149, 1233-1244 (2012).
-
(2012)
Cell
, vol.149
, pp. 1233-1244
-
-
Deng, W.1
-
70
-
-
84908439526
-
Reactivation of developmentally silenced globin genes by forced chromatin looping
-
Deng, W. et al. Reactivation of developmentally silenced globin genes by forced chromatin looping. Cell 158, 849-860 (2014).
-
(2014)
Cell
, vol.158
, pp. 849-860
-
-
Deng, W.1
-
71
-
-
84920992414
-
Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds
-
Zalatan, J. G. et al. Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell 160, 339-350 (2015).
-
(2015)
Cell
, vol.160
, pp. 339-350
-
-
Zalatan, J.G.1
-
72
-
-
34250159524
-
Genome-wide mapping of in vivo protein-DNA interactions
-
Johnson, D. S., Mortazavi, A., Myers, R. M. & Wold, B. Genome-wide mapping of in vivo protein-DNA interactions. Science 316, 1497-1502 (2007).
-
(2007)
Science
, vol.316
, pp. 1497-1502
-
-
Johnson, D.S.1
Mortazavi, A.2
Myers, R.M.3
Wold, B.4
-
73
-
-
60149091656
-
ChIP-seq accurately predicts tissue-specific activity of enhancers
-
Visel, A. et al. ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature 457, 854-858 (2009).
-
(2009)
Nature
, vol.457
, pp. 854-858
-
-
Visel, A.1
-
74
-
-
79955583542
-
Mapping and analysis of chromatin state dynamics in nine human cell types
-
Ernst, J. et al. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 473, 43-49 (2011).
-
(2011)
Nature
, vol.473
, pp. 43-49
-
-
Ernst, J.1
-
75
-
-
38649099445
-
High-resolution mapping and characterization of open chromatin across the genome
-
Boyle, A. P. et al. High-resolution mapping and characterization of open chromatin across the genome. Cell 132, 311-322 (2008).
-
(2008)
Cell
, vol.132
, pp. 311-322
-
-
Boyle, A.P.1
-
76
-
-
0037083376
-
Capturing chromosome conformation
-
Dekker, J., Rippe, K., Dekker, M. & Kleckner, N. Capturing chromosome conformation. Science 295, 1306-1311 (2002).
-
(2002)
Science
, vol.295
, pp. 1306-1311
-
-
Dekker, J.1
Rippe, K.2
Dekker, M.3
Kleckner, N.4
-
77
-
-
70349873824
-
Comprehensive mapping of long-range interactions reveals folding principles of the human genome
-
Lieberman-Aiden, E. et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 326, 289-293 (2009).
-
(2009)
Science
, vol.326
, pp. 289-293
-
-
Lieberman-Aiden, E.1
-
78
-
-
70449103609
-
An oestrogen-receptor-α-bound human chromatin interactome
-
Fullwood, M. J. et al. An oestrogen-receptor-α-bound human chromatin interactome. Nature 462, 58-64 (2009).
-
(2009)
Nature
, vol.462
, pp. 58-64
-
-
Fullwood, M.J.1
-
79
-
-
77952367798
-
Widespread transcription at neuronal activity-regulated enhancers
-
Kim, T. K. et al. Widespread transcription at neuronal activity-regulated enhancers. Nature 465, 182-187 (2010).
-
(2010)
Nature
, vol.465
, pp. 182-187
-
-
Kim, T.K.1
-
80
-
-
57849109058
-
Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters
-
Core, L. J., Waterfall, J. J. & Lis, J. T. Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science 322, 1845-1848 (2008).
-
(2008)
Science
, vol.322
, pp. 1845-1848
-
-
Core, L.J.1
Waterfall, J.J.2
Lis, J.T.3
-
81
-
-
84863229330
-
Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay
-
Melnikov, A. et al. Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay. Nat. Biotechnol. 30, 271-277 (2012).
-
(2012)
Nat. Biotechnol.
, vol.30
, pp. 271-277
-
-
Melnikov, A.1
-
82
-
-
84863230316
-
Massively parallel functional dissection of mammalian enhancers in vivo
-
Patwardhan, R. P. et al. Massively parallel functional dissection of mammalian enhancers in vivo. Nat. Biotechnol. 30, 265-270 (2012).
-
(2012)
Nat. Biotechnol.
, vol.30
, pp. 265-270
-
-
Patwardhan, R.P.1
-
83
-
-
84874381107
-
Genome-wide quantitative enhancer activity maps identified by STARR-seq
-
Arnold, C. D. et al. Genome-wide quantitative enhancer activity maps identified by STARR-seq. Science 339, 1074-1077 (2013).
-
(2013)
Science
, vol.339
, pp. 1074-1077
-
-
Arnold, C.D.1
-
84
-
-
84876836223
-
Modification of enhancer chromatin: What, how, and why?
-
Calo, E. & Wysocka, J. Modification of enhancer chromatin: what, how, and why? Mol. Cell 49, 825-837 (2013).
-
(2013)
Mol. Cell
, vol.49
, pp. 825-837
-
-
Calo, E.1
Wysocka, J.2
-
85
-
-
84899450857
-
Transcriptional enhancers: From properties to genome-wide predictions
-
Shlyueva, D., Stampfel, G. & Stark, A. Transcriptional enhancers: from properties to genome-wide predictions. Nat. Rev. Genet. 15, 272-286 (2014).
-
(2014)
Nat. Rev. Genet.
, vol.15
, pp. 272-286
-
-
Shlyueva, D.1
Stampfel, G.2
Stark, A.3
-
86
-
-
84884829249
-
Mapping human epigenomes
-
Rivera, C. M. & Ren, B. Mapping human epigenomes. Cell 155, 39-55 (2013).
-
(2013)
Cell
, vol.155
, pp. 39-55
-
-
Rivera, C.M.1
Ren, B.2
-
87
-
-
84881171344
-
Enhancer transcripts mark active estrogen receptor binding sites
-
Hah, N., Murakami, S., Nagari, A., Danko, C. G. & Kraus, W. L. Enhancer transcripts mark active estrogen receptor binding sites. Genome Res. 23, 1210-1223 (2013).
-
(2013)
Genome Res.
, vol.23
, pp. 1210-1223
-
-
Hah, N.1
Murakami, S.2
Nagari, A.3
Danko, C.G.4
Kraus, W.L.5
-
88
-
-
84923796255
-
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells
-
Arner, E. et al. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science 347, 1010-1014 (2015).
-
(2015)
Science
, vol.347
, pp. 1010-1014
-
-
Arner, E.1
-
89
-
-
84865070369
-
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
-
Jinek, M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816-821 (2012).
-
(2012)
Science
, vol.337
, pp. 816-821
-
-
Jinek, M.1
-
90
-
-
84952639685
-
Beyond editing: Repurposing CRISPR-Cas9 for precision genome regulation and interrogation
-
Dominguez, A. A., Lim, W. A. & Qi, L. S. Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation. Nat. Rev. Mol. Cell Biol. 17, 5-15 (2016).
-
(2016)
Nat. Rev. Mol. Cell Biol.
, vol.17
, pp. 5-15
-
-
Dominguez, A.A.1
Lim, W.A.2
Qi, L.S.3
-
91
-
-
84902095352
-
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
-
Wu, X. et al. Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nat. Biotechnol. 32, 670-676 (2014).
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 670-676
-
-
Wu, X.1
-
92
-
-
84921540377
-
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation
-
Doench, J. G. et al. Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation. Nat. Biotechnol. 32, 1262-1267 (2014).
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 1262-1267
-
-
Doench, J.G.1
-
93
-
-
84903516238
-
Microhomology-based choice of Cas9 nuclease target sites
-
Bae, S., Kweon, J., Kim, H. S. & Kim, J. S. Microhomology-based choice of Cas9 nuclease target sites. Nat. Methods 11, 705-706 (2014).
-
(2014)
Nat. Methods
, vol.11
, pp. 705-706
-
-
Bae, S.1
Kweon, J.2
Kim, H.S.3
Kim, J.S.4
-
94
-
-
84880570576
-
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
-
Fu, Y. et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat. Biotechnol. 31, 822-826 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 822-826
-
-
Fu, Y.1
-
95
-
-
84884155038
-
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
-
Pattanayak, V. et al. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nat. Biotechnol. 31, 839-843 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 839-843
-
-
Pattanayak, V.1
-
96
-
-
84903545084
-
Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
-
Kuscu, C., Arslan, S., Singh, R., Thorpe, J. & Adli, M. Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease. Nat. Biotechnol. 32, 677-683 (2014).
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 677-683
-
-
Kuscu, C.1
Arslan, S.2
Singh, R.3
Thorpe, J.4
Adli, M.5
-
97
-
-
84895871173
-
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
-
Sternberg, S. H., Redding, S., Jinek, M., Greene, E. C. & Doudna, J. A. DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature 507, 62-67 (2014).
-
(2014)
Nature
, vol.507
, pp. 62-67
-
-
Sternberg, S.H.1
Redding, S.2
Jinek, M.3
Greene, E.C.4
Doudna, J.A.5
-
98
-
-
84884288934
-
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
-
Ran, F. A. et al. Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell 154, 1380-1389 (2013).
-
(2013)
Cell
, vol.154
, pp. 1380-1389
-
-
Ran, F.A.1
-
99
-
-
84896929630
-
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
-
Fu, Y., Sander, J. D., Reyon, D., Cascio, V. M. & Joung, J. K. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nat. Biotechnol. 32, 279-284 (2014).
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 279-284
-
-
Fu, Y.1
Sander, J.D.2
Reyon, D.3
Cascio, V.M.4
Joung, J.K.5
-
100
-
-
84963941043
-
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
-
Kleinstiver, B. P. et al. High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Nature 529, 490-495 (2016).
-
(2016)
Nature
, vol.529
, pp. 490-495
-
-
Kleinstiver, B.P.1
-
101
-
-
84952943845
-
Rationally engineered Cas9 nucleases with improved specificity
-
Slaymaker, I. M. et al. Rationally engineered Cas9 nucleases with improved specificity. Science 351, 84-88 (2016).
-
(2016)
Science
, vol.351
, pp. 84-88
-
-
Slaymaker, I.M.1
|