An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

Science

Volumn 346, Issue 6215, 2014, Pages 1373-1377

  Mansour, Marc R ^a,b   Abraham, Brian J ^c   Anders, Lars ^c   Berezovskaya, Alla ^a   Gutierrez, Alejandro ^a,d   Durbin, Adam D ^a   Etchin, Julia ^a   Lee, Lawton ^c   Sallan, Stephen E ^a,d   Silverman, Lewis B ^a,d   Loh, Mignon L ^e   Hunger, Stephen P ^f   Sanda, Takaomi ^g   Young, Richard A ^c,h   Look, A Thomas ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^g NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^h MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; GENOMIC DNA; HISTONE H3; LYSINE; PROTEIN MYB; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR TAL1; HISTONE; ONCOPROTEIN; PROTEIN C MYB; SPACER DNA; TAL1 PROTEIN, HUMAN;

CANCER; GENE EXPRESSION; MUTATION; PROTEIN; PUBLIC HEALTH; TUMOR;

3' UNTRANSLATED REGION; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BINDING SITE; CHROMATIN; CHROMOSOME TRANSLOCATION; GENE EXPRESSION; HISTONE ACETYLATION; HUMAN; INDEL MUTATION; JURKAT CELL LINE; ONCOGENE; SEQUENCE ALIGNMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; TRANSCRIPTION INITIATION SITE; ACETYLATION; ENHANCER REGION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; TUMOR CELL LINE;

ACETYLATION; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; CELL LINE, TUMOR; DNA, INTERGENIC; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONES; HUMANS; INDEL MUTATION; MOLECULAR SEQUENCE DATA; MUTATION; ONCOGENES; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYB;

EID: 84917710235     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1259037     Document Type: Article

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