-
1
-
-
84934954629
-
-
Sittampalam GS, Coussens NP, Nelson H, Arkin M, Auld D, Austin C, et al. (eds.), Assay Guidance Manual. Bethesda, MD
-
Arkin MR, Glicksman MA, Fu H, Havel JJ, Du Y. 2004. Inhibition of protein-protein interactions: non-cellular assay formats. In Sittampalam GS, Coussens NP, Nelson H, Arkin M, Auld D, Austin C, et al. (eds.). Assay Guidance Manual. Bethesda, MD.
-
(2004)
Inhibition of Protein-Protein Interactions: Non-Cellular Assay Formats
-
-
Arkin, M.R.1
Glicksman, M.A.2
Fu, H.3
Havel, J.J.4
Du, Y.5
-
2
-
-
3142781225
-
Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
-
Arkin MR, Wells JA. 2004. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat. Rev. Drug Discov. 3: 301-317.
-
(2004)
Nat. Rev. Drug Discov
, vol.3
, pp. 301-317
-
-
Arkin, M.R.1
Wells, J.A.2
-
5
-
-
4344668661
-
Drug repositioning: Identifying and developing new uses for existing drugs
-
Ashburn TT, Thor KB. 2004. Drug repositioning: identifying and developing new uses for existing drugs. Nat. Rev. Drug. Discov. 3: 673-683.
-
(2004)
Nat. Rev. Drug. Discov
, vol.3
, pp. 673-683
-
-
Ashburn, T.T.1
Thor, K.B.2
-
6
-
-
84934437420
-
A review of novel optical imaging strategies of the stroke pathology and stem cell therapy in stroke
-
Aswendt M, Adamczak J, Tennstaedt A. 2014. A review of novel optical imaging strategies of the stroke pathology and stem cell therapy in stroke. Front. Cell. Neurosci. 8: 226.
-
(2014)
Front. Cell. Neurosci
, vol.8
, pp. 226
-
-
Aswendt, M.1
Adamczak, J.2
Tennstaedt, A.3
-
7
-
-
84930503842
-
Advances in CRISPR-Cas9 genome engineering: Lessons learned from RNA interference
-
Barrangou R, Birmingham A, Wiemann S, Beijersbergen RL, Hornung V, Smith A. 2015. Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference. Nucleic Acids Res. 43: 3407-3419.
-
(2015)
Nucleic Acids Res
, vol.43
, pp. 3407-3419
-
-
Barrangou, R.1
Birmingham, A.2
Wiemann, S.3
Beijersbergen, R.L.4
Hornung, V.5
Smith, A.6
-
8
-
-
0036139314
-
A neural network classifier capable of recognizing the patterns of all major subcellular structures in fluorescence microscope images of HeLa cells
-
Boland MV, Murphy RF. 2001. A neural network classifier capable of recognizing the patterns of all major subcellular structures in fluorescence microscope images of HeLa cells. Bioinformatics 17: 1213-1223.
-
(2001)
Bioinformatics
, vol.17
, pp. 1213-1223
-
-
Boland, M.V.1
Murphy, R.F.2
-
9
-
-
45549089565
-
The art and design of genet ic screens: RNA interference
-
Boutros M, Ahringer J. 2008. The art and design of genet ic screens: RNA interference. Nat. Rev. Genet. 9: 554-566.
-
(2008)
Nat. Rev. Genet
, vol.9
, pp. 554-566
-
-
Boutros, M.1
Ahringer, J.2
-
10
-
-
0028365276
-
Chemiluminescent and bioluminescent reporter gene assays
-
Bronstein I, Fortin J, Stanley PE, Stewart GS, Kricka LJ. 1994. Chemiluminescent and bioluminescent reporter gene assays. Anal. Biochem. 219: 169-181.
-
(1994)
Anal. Biochem
, vol.219
, pp. 169-181
-
-
Bronstein, I.1
Fortin, J.2
Stanley, P.E.3
Stewart, G.S.4
Kricka, L.J.5
-
11
-
-
80051866149
-
RNA interference in mammals: Behind the screen
-
Campeau E, Gobeil S. 2011. RNA interference in mammals: Behind the screen. Brief. Funct. Genomics 10: 215-226.
-
(2011)
Brief. Funct. Genomics
, vol.10
, pp. 215-226
-
-
Campeau, E.1
Gobeil, S.2
-
12
-
-
77955351178
-
D evelopment of a 3D human in vitro skin co-culture model for detecting irritants in real-time
-
Canton I, Cole DM, Kemp EH, Watson PF, Chunthapong J, Ryan AJ, et al. 2010. D evelopment of a 3D human in vitro skin co-culture model for detecting irritants in real-time. Biotechnol. Bioeng. 106: 794-803.
-
(2010)
Biotechnol. Bioeng
, vol.106
, pp. 794-803
-
-
Canton, I.1
Cole, D.M.2
Kemp, E.H.3
Watson, P.F.4
Chunthapong, J.5
Ryan, A.J.6
-
13
-
-
84892697565
-
An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models
-
Celli JP, Rizvi I, Blanden AR, Massodi I, Glidden MD, Pogue BW, Hasan T. 2014. An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models. Sci. Rep. 4: 3751.
-
(2014)
Sci. Rep
, vol.4
, pp. 3751
-
-
Celli, J.P.1
Rizvi, I.2
Blanden, A.R.3
Massodi, I.4
Glidden, M.D.5
Pogue, B.W.6
Hasan, T.7
-
14
-
-
17844406856
-
Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
-
Chen L, Feany MB. 2005. Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat. Neurosci. 8: 657-663.
-
(2005)
Nat. Neurosci
, vol.8
, pp. 657-663
-
-
Chen, L.1
Feany, M.B.2
-
15
-
-
34547770279
-
New uses for old drugs
-
Chong CR, Sullivan DJ Jr. 2007. New uses for old drugs. Nature 448: 645-646.
-
(2007)
Nature
, vol.448
, pp. 645-646
-
-
Chong, C.R.1
Sullivan, D.J.2
-
16
-
-
2942616604
-
Complex phenotypic assays in highthroughput screening
-
Clemons PA. 2004. Complex phenotypic assays in highthroughput screening. Curr. Opin. Chem. Biol. 8: 334-338.
-
(2004)
Curr. Opin. Chem. Biol
, vol.8
, pp. 334-338
-
-
Clemons, P.A.1
-
17
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong L, Ran FA, Cox D, Lin S, Barret to R, Habib N, et al. 2013. Multiplex genome engineering using CRISPR/Cas systems. Science 339: 819-823.
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
Ran, F.A.2
Cox, D.3
Lin, S.4
Barret To, R.5
Habib, N.6
-
18
-
-
3042565868
-
Automatic identification of subcellular phenotypes on human cell arrays
-
Conrad C, Erfle H, Warnat P, Daigle N, Lorch T, Ellenberg J, et al. 2004. Automatic identification of subcellular phenotypes on human cell arrays. Genome Res. 14: 1130-1136.
-
(2004)
Genome Res
, vol.14
, pp. 1130-1136
-
-
Conrad, C.1
Erfle, H.2
Warnat, P.3
Daigle, N.4
Lorch, T.5
Ellenberg, J.6
-
19
-
-
77149130553
-
Automated microscopy for high-content RNAi screening
-
Conrad C, Gerlich DW. 2010. Automated microscopy for high-content RNAi screening. J. Cell Biol. 188: 453-461.
-
(2010)
J. Cell Biol
, vol.188
, pp. 453-461
-
-
Conrad, C.1
Gerlich, D.W.2
-
20
-
-
34547697192
-
-
Crisman TJ, Parker CN, Jenkins JL, Scheiber J, Thoma M, Kang ZB, et al. 2007. Underst anding false p osit ives i n reporter gene assays: In silico chemogenomics approaches to prioritize cell-based HTS data. J. Chem. Inf. Model. 47: 1319-1327.
-
(2007)
J. Chem. Inf. Model
, vol.47
, pp. 1319-1327
-
-
Crisman, T.J.1
Parker, C.N.2
Jenkins, J.L.3
Scheiber, J.4
Thoma, M.5
Kang, Z.B.6
-
22
-
-
34247217907
-
Chemical genetics reveals a complex functional ground state of neural stem cells
-
Diamandis P, Wildenhain J, Clarke ID, Sacher AG, Graham J, Bellows DS, et al. 2007. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat. Chem. Biol. 3: 268-273.
-
(2007)
Nat. Chem. Biol
, vol.3
, pp. 268-273
-
-
Diamandis, P.1
Wildenhain, J.2
Clarke, I.D.3
Sacher, A.G.4
Graham, J.5
Bellows, D.S.6
-
23
-
-
84911909507
-
Cellular reporter systems for high-throughput screening of interactions between bioactive matrices and human mesenchymal stromal cells
-
Duryagina R, Anastassiadis K, Maitz MF, Gramm S, Schneider S, Wobus M, et al. 2014. Cellular reporter systems for high-throughput screening of interactions between bioactive matrices and human mesenchymal stromal cells. Tissue Eng. Part C Methods 20: 828-837.
-
(2014)
Tissue Eng. Part C Methods
, vol.20
, pp. 828-837
-
-
Duryagina, R.1
Anastassiadis, K.2
Maitz, M.F.3
Gramm, S.4
Schneider, S.5
Wobus, M.6
-
24
-
-
33646187810
-
High-throughput RNAi screening in cultured cells: A user’s guide
-
Echeverri CJ, Perrimon N. 2006. High-throughput RNAi screening in cultured cells: A user’s guide. Nat. Rev. Genet. 7: 373-384.
-
(2006)
Nat. Rev. Genet
, vol.7
, pp. 373-384
-
-
Echeverri, C.J.1
Perrimon, N.2
-
25
-
-
84931448067
-
Flow cytometry: Impact on early drug discovery
-
Edwards BS, Sklar LA. 2015. Flow cytometry: Impact on early drug discovery. J. Biomol. Screen. 20: 689-707.
-
(2015)
J. Biomol. Screen
, vol.20
, pp. 689-707
-
-
Edwards, B.S.1
Sklar, L.A.2
-
26
-
-
82355175128
-
NKX2-5(EGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes
-
Elliot tD A, B raam S R, K out iss K, N g ES, Jenny R, Lagerqvist EL, et al. 2011. NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes. Nat. Methods 8: 1037-1040.
-
(2011)
Nat. Methods
, vol.8
, pp. 1037-1040
-
-
Elliot, T.A.1
B Raam, S.R.2
K Out Iss, K.3
N G, E.S.4
Jenny, R.5
Lagerqvist, E.L.6
-
27
-
-
84940054630
-
Viral and transgenic reporters and genetic analysis of adult neurogenesis. Cold Spring Harb
-
Enikolopov G, Overstreet-Wadiche L, Ge S. 2015. Viral and transgenic reporters and genetic analysis of adult neurogenesis. Cold Spring Harb. Perspect. Biol. 7: a018804.
-
(2015)
Perspect. Biol
, vol.7
-
-
Enikolopov, G.1
Overstreet-Wadiche, L.2
Ge, S.3
-
28
-
-
34347220153
-
Reverse transfection on cell arrays for high content screening microscopy
-
Erfle H, Neumann B, Liebel U, Rogers P, Held M, Walter T, et al. 2007. Reverse transfection on cell arrays for high content screening microscopy. Nat. Protoc. 2: 392-399.
-
(2007)
Nat. Protoc
, vol.2
, pp. 392-399
-
-
Erfle, H.1
Neumann, B.2
Liebel, U.3
Rogers, P.4
Held, M.5
Walter, T.6
-
29
-
-
49249126411
-
Work flow for multiplexing siRNA assays by solid-phase reverse transfection in multiwell plates
-
Erfle H, Neumann B, Rogers P, Bulkescher J, Ellenberg J, Pepperkok R. 2008. Work flow for multiplexing siRNA assays by solid-phase reverse transfection in multiwell plates. J. Biomol. Screen. 13: 575-580.
-
(2008)
J. Biomol. Screen
, vol.13
, pp. 575-580
-
-
Erfle, H.1
Neumann, B.2
Rogers, P.3
Bulkescher, J.4
Ellenberg, J.5
Pepperkok, R.6
-
30
-
-
4444290116
-
SiRNA cell arrays for high-content screening microscopy
-
Erfle H, Simpson JC, Bastiaens PI, Pepperkok R. 2004. siRNA cell arrays for high-content screening microscopy. Biotechniques 37: 454-458, 460, 462.
-
(2004)
Biotechniques
, vol.37
, pp. 454-458
-
-
Erfle, H.1
Simpson, J.C.2
Bastiaens, P.I.3
Pepperkok, R.4
-
31
-
-
84878872860
-
High-content multiplexed tissue imaging and quantification for cancer drug discovery
-
Falcon BL, Stewart J, Ezell S, Hanson J, Wijsman J, Ye X, et al. 2013. High-content multiplexed tissue imaging and quantification for cancer drug discovery. Drug Discov. Today 18: 510-522.
-
(2013)
Drug Discov. Today
, vol.18
, pp. 510-522
-
-
Falcon, B.L.1
Stewart, J.2
Ezell, S.3
Hanson, J.4
Wijsman, J.5
Ye, X.6
-
32
-
-
67650070045
-
Multi-parameter phenotypic profiling: Using cellular effects to characterize small-molecule compounds
-
Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA. 2009. Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat. Rev. Drug Discov. 8: 567-578.
-
(2009)
Nat. Rev. Drug Discov
, vol.8
, pp. 567-578
-
-
Feng, Y.1
Mitchison, T.J.2
Bender, A.3
Young, D.W.4
Tallarico, J.A.5
-
33
-
-
65549112285
-
High-throughput cellular microarray platforms: Applications in drug discovery, toxicology and stem cell research
-
Fernandes TG, Diogo MM, Clark DS, Dordick JS, Cabral JM. 2009. High-throughput cellular microarray platforms: Applications in drug discovery, toxicology and stem cell research. Trends Biotechnol. 27: 342-349.
-
(2009)
Trends Biotechnol
, vol.27
, pp. 342-349
-
-
Fernandes, T.G.1
Diogo, M.M.2
Clark, D.S.3
Dordick, J.S.4
Cabral, J.M.5
-
34
-
-
51549106300
-
On-chip, cell-based microarray immunofluorescence assay for high-throughput analysis of target proteins
-
Fernandes TG, Kwon SJ, Lee MY, Clark DS, Cabral JM, Dordick JS. 2008. On-chip, cell-based microarray immunofluorescence assay for high-throughput analysis of target proteins. Anal. Chem. 80: 6633-6639.
-
(2008)
Anal. Chem
, vol.80
, pp. 6633-6639
-
-
Fernandes, T.G.1
Kwon, S.J.2
Lee, M.Y.3
Clark, D.S.4
Cabral, J.M.5
Dordick, J.S.6
-
35
-
-
0024406857
-
A novel genetic system to detect protein-protein interactions
-
Fields S, Song O. 1989. A novel genetic system to detect protein-protein interactions. Nature 340: 245-246.
-
(1989)
Nature
, vol.340
, pp. 245-246
-
-
Fields, S.1
Song, O.2
-
36
-
-
25644454404
-
P harmaceuticals: A n ew grammar for drug discovery
-
Fishman MC, P ort er JA. 2 005. P harmaceuticals: a n ew grammar for drug discovery. Nature 437: 491-493.
-
Nature
, vol.437
, pp. 491-493
-
-
Fishman, M.C.1
P Ort Er, J.A.2
-
37
-
-
0035984722
-
Beta-lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein-protein interactions
-
Galarneau A, Primeau M, Trudeau LE, Michnick SW. 2002. Beta-lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein-protein interactions. Nat. Biotechnol. 20: 619-622.
-
(2002)
Nat. Biotechnol
, vol.20
, pp. 619-622
-
-
Galarneau, A.1
Primeau, M.2
Trudeau, L.E.3
Michnick, S.W.4
-
38
-
-
58149142955
-
Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells
-
Ganesan AK, Ho H, Bodemann B, Petersen S, Aruri J, Koshy S, et al. 2008. Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. PLoS Genet. 4: e1000298.
-
(2008)
Plos Genet
, vol.4
-
-
Ganesan, A.K.1
Ho, H.2
Bodemann, B.3
Petersen, S.4
Aruri, J.5
Koshy, S.6
-
39
-
-
85058906649
-
I mage-based h igh-cont ent reporter assays: Limitations and advantages
-
Gasparri F, G alvani A. 2010. I mage-based h igh-cont ent reporter assays: limitations and advantages. Drug Discov. Today Technol. 7: e1-e94.
-
(2010)
Drug Discov. Today Technol
, vol.7
-
-
Gasparri, F.1
G Alvani, A.2
-
40
-
-
80053490751
-
Automated genome-widevisualprofiling of cellular proteins involved in HIV infection
-
Genovesio A, Kwon YJ, Windisch MP, Kim NY, Choi SY, Kim HC, et al. 2011. Automated genome-widevisualprofiling of cellular proteins involved in HIV infection. J. Biomol. Screen. 16: 945-958.
-
(2011)
J. Biomol. Screen
, vol.16
, pp. 945-958
-
-
Genovesio, A.1
Kwon, Y.J.2
Windisch, M.P.3
Kim, N.Y.4
Choi, S.Y.5
Kim, H.C.6
-
41
-
-
0034647238
-
Antiparallel leucine zipper-directed protein reassembly: Application to the green fluorescent protein
-
Ghosh I, Hamilton AD, Regan L. 2000. Antiparallel leucine zipper-directed protein reassembly: Application to the green fluorescent protein. J. Am. Chem. Soc. 122: 5658-5659.
-
(2000)
J. Am. Chem. Soc
, vol.122
, pp. 5658-5659
-
-
Ghosh, I.1
Hamilton, A.D.2
Regan, L.3
-
42
-
-
38649084032
-
The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease
-
Gorbatyuk OS, Li S, Sullivan LF, Chen W, Kondrikova G, Manfredsson FP, et al. 2008. The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. Proc. Natl. Acad. Sci. USA 105: 763-768.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 763-768
-
-
Gorbatyuk, O.S.1
Li, S.2
Sullivan, L.F.3
Chen, W.4
Kondrikova, G.5
Manfredsson, F.P.6
-
43
-
-
84856511126
-
Yeast two-hybrid methods and their applications in drug discovery
-
Hamdi A, Colas P. 2012. Yeast two-hybrid methods and their applications in drug discovery. Trends Pharmacol. Sci. 33: 109-118.
-
(2012)
Trends Pharmacol. Sci
, vol.33
, pp. 109-118
-
-
Hamdi, A.1
Colas, P.2
-
44
-
-
84892153139
-
Clinical development success rates for investigational drugs
-
Hay M, Thomas DW, Craighead JL, Economides C, Rosenthal J. 2014. Clinical development success rates for investigational drugs. Nat. Biotechnol. 32: 40-51.
-
(2014)
Nat. Biotechnol
, vol.32
, pp. 40-51
-
-
Hay, M.1
Thomas, D.W.2
Craighead, J.L.3
Economides, C.4
Rosenthal, J.5
-
45
-
-
79952196976
-
3D cell culture: A review of current approaches and techniques
-
Haycock JW. 2011. 3D cell culture: a review of current approaches and techniques. Methods Mol. Biol. 695: 1-15.
-
(2011)
Methods Mol. Biol
, vol.695
, pp. 1-15
-
-
Haycock, J.W.1
-
46
-
-
84555188954
-
The ToxTracker assay: Novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals
-
Hendriks G, Atallah M, Morolli B, Calleja F, Ras-Verloop N, Huijskens I, et al. 2012. The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals. Toxicol. Sci. 125: 285-298.
-
(2012)
Toxicol. Sci
, vol.125
, pp. 285-298
-
-
Hendriks, G.1
Atallah, M.2
Morolli, B.3
Calleja, F.4
Ras-Verloop, N.5
Huijskens, I.6
-
48
-
-
84886668282
-
Visualization and targeted disruption of protein interactions in living cells
-
Herce HD, Deng W, Helma J, Leonhardt H, Cardoso MC. 2013. Visualization and targeted disruption of protein interactions in living cells. Nat. Commun. 4: 2660.
-
(2013)
Nat. Commun
, vol.4
, pp. 2660
-
-
Herce, H.D.1
Deng, W.2
Helma, J.3
Leonhardt, H.4
Cardoso, M.C.5
-
49
-
-
80052397500
-
Screening of siRNA nanoparticles for delivery to airway epithelial cells using high-content analysis
-
Hibbitts A, Lieggi N, McCabe O, Thomas W, Barlow J, O’Brien F, Cryan SA. 2011. Screening of siRNA nanoparticles for delivery to airway epithelial cells using high-content analysis. Ther. Deliv. 2: 987-999.
-
(2011)
Ther. Deliv
, vol.2
, pp. 987-999
-
-
Hibbitts, A.1
Lieggi, N.2
McCabe, O.3
Thomas, W.4
Barlow, J.5
O’Brien, F.6
Cryan, S.A.7
-
50
-
-
3242761757
-
Immunohistochemistry
-
Chapter 21: Unit 21.4
-
Hofman F. 2002. Immunohistochemistry. Curr. Protoc. Immunol. Chapter 21: Unit 21.4.
-
(2002)
Curr. Protoc. Immunol.
-
-
Hofman, F.1
-
51
-
-
74249095519
-
CRISPR/Cas, the immune system of bacteria and archaea
-
Horvath P, Barrangou R. 2010. CRISPR/Cas, the immune system of bacteria and archaea. Science 327: 167-170.
-
(2010)
Science
, vol.327
, pp. 167-170
-
-
Horvath, P.1
Barrangou, R.2
-
52
-
-
84884165315
-
DNA targeting specificity of RNAguided Cas9 nucleases
-
Hsu PD, Scott DA, Weinstein JA, Ran FA, Konermann S, Agarwala V, et al. 2013. DNA targeting specificity of RNAguided Cas9 nucleases. Nat. Biotechnol. 31: 827-832.
-
(2013)
Nat. Biotechnol
, vol.31
, pp. 827-832
-
-
Hsu, P.D.1
Scott, D.A.2
Weinstein, J.A.3
Ran, F.A.4
Konermann, S.5
Agarwala, V.6
-
54
-
-
84874875145
-
Concise review: The relevance of human stem cell-derived organoid models for epithelial translational medicine
-
Hynds RE, Giangreco A. 2013. Concise review: the relevance of human stem cell-derived organoid models for epithelial translational medicine. Stem Cells 31: 417-422.
-
(2013)
Stem Cells
, vol.31
, pp. 417-422
-
-
Hynds, R.E.1
Giangreco, A.2
-
55
-
-
34447538141
-
High-throughput screening assays for t he ident ification o f chemical p robes
-
Inglese J, Johnson RL, Simeonov A, Xia M, Zheng W, Austin CP, Auld DS. 2007. High-throughput screening assays for t he ident ification o f chemical p robes. Nat. Chem. Biol. 3: 466-479.
-
(2007)
Nat. Chem. Biol
, vol.3
, pp. 466-479
-
-
Inglese, J.1
Johnson, R.L.2
Simeonov, A.3
Xia, M.4
Zheng, W.5
Austin, C.P.6
Auld, D.S.7
-
56
-
-
33745612464
-
Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity
-
Jackson AL, Burchard J, Schelter J, Chau BN, Cleary M, Lim L, Linsley PS. 2006. Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity. RNA 12: 1179-1187.
-
(2006)
RNA
, vol.12
, pp. 1179-1187
-
-
Jackson, A.L.1
Burchard, J.2
Schelter, J.3
Chau, B.N.4
Cleary, M.5
Lim, L.6
Linsley, P.S.7
-
57
-
-
84865070369
-
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
-
Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E. 2012. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337: 816-821.
-
(2012)
Science
, vol.337
, pp. 816-821
-
-
Jinek, M.1
Chylinski, K.2
Fonfara, I.3
Hauer, M.4
Doudna, J.A.5
Charpentier, E.6
-
58
-
-
0028080090
-
Split ubiquitin as a sensor of protein interactions in vivo
-
Johnsson N, Varshavsky A. 1994. Split ubiquitin as a sensor of protein interactions in vivo. Proc. Natl. Acad. Sci. USA 91: 10340-10344.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 10340-10344
-
-
Johnsson, N.1
Varshavsky, A.2
-
59
-
-
84908148990
-
Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines
-
Karlsson HL, Gliga AR, Calleja FM, Goncalves CS, Wallinder IO, Vrieling H, et al. 2014. Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines. Part. Fibre Toxicol. 11: 41.
-
(2014)
Part. Fibre Toxicol
, vol.11
, pp. 41
-
-
Karlsson, H.L.1
Gliga, A.R.2
Calleja, F.M.3
Goncalves, C.S.4
Wallinder, I.O.5
Vrieling, H.6
-
60
-
-
35348858911
-
Cell-based high-content screening of small-molecule libraries
-
Korn K, Krausz E. 2007. Cell-based high-content screening of small-molecule libraries. Curr. Opin. Chem. Biol. 11: 503-510.
-
(2007)
Curr. Opin. Chem. Biol
, vol.11
, pp. 503-510
-
-
Korn, K.1
Krausz, E.2
-
61
-
-
33947395259
-
High-content siRNA screening
-
Krausz E. 2007. High-content siRNA screening. Mol. Biosyst. 3: 232-240.
-
(2007)
Mol. Biosyst
, vol.3
, pp. 232-240
-
-
Krausz, E.1
-
62
-
-
44649106998
-
High-cont ent siRNA screening for target identification and validation
-
Krausz E, Korn K. 2008. High-cont ent siRNA screening for target identification and validation. Expert Opin. Drug Discov. 3: 551-564.
-
(2008)
Expert Opin. Drug Discov
, vol.3
, pp. 551-564
-
-
Krausz, E.1
Korn, K.2
-
63
-
-
0142092529
-
High-throughput selection of effective RNAi probes for gene silencing
-
Kumar R, Conklin DS, Mittal V. 2003. High-throughput selection of effective RNAi probes for gene silencing. Genome Res. 13: 2333-2340.
-
(2003)
Genome Res
, vol.13
, pp. 2333-2340
-
-
Kumar, R.1
Conklin, D.S.2
Mittal, V.3
-
64
-
-
84899998196
-
High-throughput and combinatorial gene expression on a chip for metabolism-induced toxicology screening
-
Kwon SJ, Lee DW, Shah DA, Ku B, Jeon SY, Solanki K, et al. 2014. High-throughput and combinatorial gene expression on a chip for metabolism-induced toxicology screening. Nat. Commun. 5: 3739.
-
(2014)
Nat. Commun
, vol.5
, pp. 3739
-
-
Kwon, S.J.1
Lee, D.W.2
Shah, D.A.3
Ku, B.4
Jeon, S.Y.5
Solanki, K.6
-
65
-
-
80053352042
-
Translational research: 4 ways to fix the clinical trial
-
Ledford H. 2011. Translational research: 4 ways to fix the clinical trial. Nature 477: 526-528.
-
(2011)
Nature
, vol.477
, pp. 526-528
-
-
Ledford, H.1
-
66
-
-
0032567339
-
Generation of destabilized green fluorescent protein as a transcription reporter
-
Li X, Zhao X, Fang Y, Jiang X, Duong T, Fan C, et al. 1998. Generation of destabilized green fluorescent protein as a transcription reporter. J. Biol. Chem. 273: 34970-34975.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 34970-34975
-
-
Li, X.1
Zhao, X.2
Fang, Y.3
Jiang, X.4
Duong, T.5
Fan, C.6
-
67
-
-
34250216344
-
Image-based multivariate profiling of drug responses from single cells
-
Loo LH, Wu LF, Altschuler SJ. 2007. Image-based multivariate profiling of drug responses from single cells. Nat. Methods 4: 445-453.
-
(2007)
Nat. Methods
, vol.4
, pp. 445-453
-
-
Loo, L.H.1
Wu, L.F.2
Altschuler, S.J.3
-
68
-
-
69549137879
-
Multiplexing of pathway-specific beta-lactamase reporter gene assays by optical coding with Qtracker nanocrystals
-
Machleidt T, Whitney P, Bi K. 2009. Multiplexing of pathway-specific beta-lactamase reporter gene assays by optical coding with Qtracker nanocrystals. J. Biomol. Screen. 14: 845-852.
-
(2009)
J. Biomol. Screen
, vol.14
, pp. 845-852
-
-
Machleidt, T.1
Whitney, P.2
Bi, K.3
-
69
-
-
84884856342
-
Cas9 as a versatile tool for engineering biology
-
Mali P, Esvelt KM, Church GM. 2013. Cas9 as a versatile tool for engineering biology. Nat. Methods 10: 957-963.
-
(2013)
Nat. Methods
, vol.10
, pp. 957-963
-
-
Mali, P.1
Esvelt, K.M.2
Church, G.M.3
-
70
-
-
84873734105
-
RNA-guided human genome engineering via Cas 9
-
Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, et al. 2013. RNA-guided human genome engineering via Cas 9. Science 339: 823-826.
-
(2013)
Science
, vol.339
, pp. 823-826
-
-
Mali, P.1
Yang, L.2
Esvelt, K.M.3
Aach, J.4
Guell, M.5
Dicarlo, J.E.6
-
71
-
-
33644876958
-
TRANSFAC and i t s module TRANSCompel: Transcriptional gene regulation in eukaryotes
-
Matys V, Kel-Margoulis OV, Fricke E, Liebich I, Land S, Barre-Dirrie A, et al. 2006. TRANSFAC and i t s module TRANSCompel: Transcriptional gene regulation in eukaryotes. Nucleic Acids Res. 34: D108-D110.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. D108-D110
-
-
Matys, V.1
Kel-Margoulis, O.V.2
Fricke, E.3
Liebich, I.4
Land, S.5
Barre-Dirrie, A.6
-
72
-
-
84884377472
-
Tumour heterogeneity and cancer cell plasticity
-
Meacham CE, Morrison SJ. 2013. Tumour heterogeneity and cancer cell plasticity. Nature 501: 328-337.
-
(2013)
Nature
, vol.501
, pp. 328-337
-
-
Meacham, C.E.1
Morrison, S.J.2
-
73
-
-
84899847797
-
Three-dimensional cellular microarray platform for human neural stem cell differentiation and toxicology
-
Meli L, Barbosa HS, Hickey AM, Gasimli L, Nierode G, Diogo MM, et al. 2014. Three-dimensional cellular microarray platform for human neural stem cell differentiation and toxicology. Stem Cell Res. 13: 36-47.
-
(2014)
Stem Cell Res
, vol.13
, pp. 36-47
-
-
Meli, L.1
Barbosa, H.S.2
Hickey, A.M.3
Gasimli, L.4
Nierode, G.5
Diogo, M.M.6
-
74
-
-
77956048943
-
A toolkit of protein-fragment complementation assays for studying and dissecting large-scale and dynamic protein-protein interactions in living cells
-
Michnick SW, Ear PH, Landry C, Malleshaiah MK, Messier V. 2010. A toolkit of protein-fragment complementation assays for studying and dissecting large-scale and dynamic protein-protein interactions in living cells. Methods Enzymol. 470: 335-368.
-
(2010)
Methods Enzymol
, vol.470
, pp. 335-368
-
-
Michnick, S.W.1
Ear, P.H.2
Landry, C.3
Malleshaiah, M.K.4
Messier, V.5
-
75
-
-
34347374044
-
Universal strategies in research and drug discovery based on protein-fragment complementation assays
-
Michnick SW, Ear PH, Manderson EN, Remy I, Stefan E. 2007. Universal strategies in research and drug discovery based on protein-fragment complementation assays. Nat. Rev. Drug Discov. 6: 569-582.
-
(2007)
Nat. Rev. Drug Discov
, vol.6
, pp. 569-582
-
-
Michnick, S.W.1
Ear, P.H.2
Manderson, E.N.3
Remy, I.4
Stefan, E.5
-
76
-
-
0033741370
-
Detection of protein-protein interactions by protein fragment complementation strategies
-
Michnick SW, Remy I, Campbell-Valois FX, Vallee-Belisle A, Pelletier JN. 2000. Detection of protein-protein interactions by protein fragment complementation strategies. Methods Enzymol. 328: 208-230.
-
(2000)
Methods Enzymol
, vol.328
, pp. 208-230
-
-
Michnick, S.W.1
Remy, I.2
Campbell-Valois, F.X.3
Vallee-Belisle, A.4
Pelletier, J.N.5
-
77
-
-
84867594876
-
RNAi screening: New approaches, understandings, and organisms
-
Mohr SE, Perrimon N. 2012. RNAi screening: new approaches, understandings, and organisms. Wiley Interdiscip. Rev. RNA 3: 145-158.
-
(2012)
Wiley Interdiscip. Rev. RNA
, vol.3
, pp. 145-158
-
-
Mohr, S.E.1
Perrimon, N.2
-
78
-
-
84906702408
-
RNAi screening comes of age: Improved techniques and complementary approaches
-
Mohr SE, Smith JA, Shamu CE, Neumuller RA, Perrimon N. 2014. RNAi screening comes of age: improved techniques and complementary approaches. Nat. Rev. Mol. Cell Biol. 15: 591-600.
-
(2014)
Nat. Rev. Mol. Cell Biol
, vol.15
, pp. 591-600
-
-
Mohr, S.E.1
Smith, J.A.2
Shamu, C.E.3
Neumuller, R.A.4
Perrimon, N.5
-
79
-
-
79251539547
-
Bacterial artificial chromosome mutagenesis using recombineering
-
2011
-
Narayanan K, Chen Q. 2011. Bacterial artificial chromosome mutagenesis using recombineering. J. Biomed. Biotechnol. 2011: 971296.
-
(2011)
J. Biomed. Biotechnol
-
-
Narayanan, K.1
Chen, Q.2
-
80
-
-
0032810113
-
Reporter gene technology: The future looks bright
-
Naylor LH. 1999. Reporter gene technology: The future looks bright. Biochem. Pharmacol. 58: 749-757.
-
(1999)
Biochem. Pharmacol
, vol.58
, pp. 749-757
-
-
Naylor, L.H.1
-
81
-
-
33646057010
-
High-throughput RNAi screening by time-lapse imaging of live human cells
-
Neumann B, Held M, Liebel U, Erfle H, Rogers P, Pepperkok R, Ellenberg J. 2006. High-throughput RNAi screening by time-lapse imaging of live human cells. Nat. Methods 3: 385-390.
-
(2006)
Nat. Methods
, vol.3
, pp. 385-390
-
-
Neumann, B.1
Held, M.2
Liebel, U.3
Erfle, H.4
Rogers, P.5
Pepperkok, R.6
Ellenberg, J.7
-
82
-
-
65549106068
-
Recombinant DNA technologies for construction of precisely designed transgene constructs
-
Ohtsuka M, Kimura M, Tanaka M, Inoko H. 2009. Recombinant DNA technologies for construction of precisely designed transgene constructs. Curr. Pharm. Biotechnol. 10: 244-251.
-
(2009)
Curr. Pharm. Biotechnol
, vol.10
, pp. 244-251
-
-
Ohtsuka, M.1
Kimura, M.2
Tanaka, M.3
Inoko, H.4
-
83
-
-
34648834682
-
The third dimension bridges the gap between cell culture and live tissue
-
Pampaloni F, Reynaud EG, Stelzer EH. 2007. The third dimension bridges the gap between cell culture and live tissue. Nat. Rev. Mol. Cell Biol. 8: 839-845.
-
(2007)
Nat. Rev. Mol. Cell Biol
, vol.8
, pp. 839-845
-
-
Pampaloni, F.1
Reynaud, E.G.2
Stelzer, E.H.3
-
84
-
-
77649234756
-
H ow t o improve R&D productivity: The pharmaceutical industry’s grand challenge
-
Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg S R, S chacht AL. 2010. H ow t o improve R&D productivity: the pharmaceutical industry’s grand challenge. Nat. Rev. Drug Discov. 9: 203-214.
-
(2010)
Nat. Rev. Drug Discov
, vol.9
, pp. 203-214
-
-
Paul, S.M.1
Mytelka, D.S.2
Dunwiddie, C.T.3
Persinger, C.C.4
Munos, B.H.5
Lindborg, S.R.6
S Chacht, A.L.7
-
85
-
-
0034193568
-
Protein-protein interactions define specificity in signal transduction
-
Pawson T, Nash P. 2000. Protein-protein interactions define specificity in signal transduction. Genes Dev. 14: 1027-1047.
-
(2000)
Genes Dev
, vol.14
, pp. 1027-1047
-
-
Pawson, T.1
Nash, P.2
-
86
-
-
21844440569
-
Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis
-
Pelkmans L, Fava E, Grabner H, Hannus M, Habermann B, Krausz E, Zerial M. 2005. Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Nature 436: 78-86.
-
(2005)
Nature
, vol.436
, pp. 78-86
-
-
Pelkmans, L.1
Fava, E.2
Grabner, H.3
Hannus, M.4
Habermann, B.5
Krausz, E.6
Zerial, M.7
-
87
-
-
0032514623
-
Oligomerization domain-directed reassembly of active dihydrofolate reductase from rationally designed fragments
-
Pelletier JN, Campbell-Valois FX, Michnick SW. 1998. Oligomerization domain-directed reassembly of active dihydrofolate reductase from rationally designed fragments. Proc. Natl. Acad. Sci. USA 95: 12141-12146.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 12141-12146
-
-
Pelletier, J.N.1
Campbell-Valois, F.X.2
Michnick, S.W.3
-
89
-
-
8444223104
-
Multidimensional drug profiling by automated microscopy
-
Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. 2004. Multidimensional drug profiling by automated microscopy. Science 306: 1194-1198.
-
(2004)
Science
, vol.306
, pp. 1194-1198
-
-
Perlman, Z.E.1
Slack, M.D.2
Feng, Y.3
Mitchison, T.J.4
Wu, L.F.5
Altschuler, S.J.6
-
91
-
-
33751208345
-
A highly sensitive proteinprotein interaction assay based on Gaussia luciferase
-
Remy I, Michnick SW. 2006. A highly sensitive proteinprotein interaction assay based on Gaussia luciferase. Nat. Methods 3: 977-979.
-
(2006)
Nat. Methods
, vol.3
, pp. 977-979
-
-
Remy, I.1
Michnick, S.W.2
-
92
-
-
0033548048
-
Erythropoietin receptor activation by a ligand-induced conformation change
-
Remy I, Wilson IA, Michnick SW. 1999. Erythropoietin receptor activation by a ligand-induced conformation change. Science 283: 990-993.
-
(1999)
Science
, vol.283
, pp. 990-993
-
-
Remy, I.1
Wilson, I.A.2
Michnick, S.W.3
-
93
-
-
84924371138
-
A dual-reporter system for real-time monitoring and high-throughput CRISPR/Cas9 library screening of the hepatitis C virus
-
Ren Q, Li C, Yuan P, Cai C, Zhang L, Luo GG, Wei W. 2015. A dual-reporter system for real-time monitoring and high-throughput CRISPR/Cas9 library screening of the hepatitis C virus. Sci. Rep. 5: 8865.
-
(2015)
Sci. Rep
, vol.5
, pp. 8865
-
-
Ren, Q.1
Li, C.2
Yuan, P.3
Cai, C.4
Zhang, L.5
Luo, G.G.6
Wei, W.7
-
94
-
-
23044496736
-
Protein-protein interactions in human disease
-
Ryan DP, Matthews JM. 2005. Protein-protein interactions in human disease. Curr. Opin. Struct. Biol. 15: 441-446.
-
(2005)
Curr. Opin. Struct. Biol
, vol.15
, pp. 441-446
-
-
Ryan, D.P.1
Matthews, J.M.2
-
95
-
-
84887498634
-
Imaging flow cytomet ry for morphologic and phenotypic characterization of rare circulating endothelial cells
-
Samsel L, Dagur PK, Raghavachari N, Seamon C, Kato GJ, McCoy JP Jr. 2013. Imaging flow cytomet ry for morphologic and phenotypic characterization of rare circulating endothelial cells. Cytometry B Clin. Cytom. 84: 379-389.
-
(2013)
Cytometry B Clin. Cytom
, vol.84
, pp. 379-389
-
-
Samsel, L.1
Dagur, P.K.2
Raghavachari, N.3
Seamon, C.4
Kato, G.J.5
McCoy, J.P.6
-
96
-
-
33947361161
-
Genetically encoded fluorescent indicators to visualize protein phosphorylation by extracellular signal-regulated kinase in single living cells
-
Sato M, Kawai Y, Umezawa Y. 2007. Genetically encoded fluorescent indicators to visualize protein phosphorylation by extracellular signal-regulated kinase in single living cells. Anal. Chem. 79: 2570-2575.
-
(2007)
Anal. Chem
, vol.79
, pp. 2570-2575
-
-
Sato, M.1
Kawai, Y.2
Umezawa, Y.3
-
97
-
-
0036196296
-
Fluorescent indicators for imaging protein phosphorylation in single living cells
-
Sato M, Ozawa T, Inukai K, Asano T, Umezawa Y. 2002. Fluorescent indicators for imaging protein phosphorylation in single living cells. Nat. Biotechnol. 20: 287-294.
-
(2002)
Nat. Biotechnol
, vol.20
, pp. 287-294
-
-
Sato, M.1
Ozawa, T.2
Inukai, K.3
Asano, T.4
Umezawa, Y.5
-
98
-
-
84892765883
-
Genome-scale CRISPR-Cas9 knockout screening in human cells
-
Shalem O, S anjana N E, H artenian E, S hi X, Scot t DA, Mikkelsen TS, et al. 2014. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science 343: 84-87.
-
(2014)
Science
, vol.343
, pp. 84-87
-
-
Shalem, O.1
S Anjana, N.E.2
H Artenian, E.3
S Hi, X.4
Scot T, D.A.5
Mikkelsen, T.S.6
-
99
-
-
84928205754
-
High-throughput functional genomics using CRISPR-Cas 9
-
Shalem O, Sanjana NE, Zhang F. 2015. High-throughput functional genomics using CRISPR-Cas 9. Nat. Rev. Genet. 16: 299-311.
-
(2015)
Nat. Rev. Genet
, vol.16
, pp. 299-311
-
-
Shalem, O.1
Sanjana, N.E.2
Zhang, F.3
-
100
-
-
11144267737
-
Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma s p. Red f luorescent protein
-
Shaner NC, Campbell RE, Steinbach PA, Giepmans BN, Palmer AE, Tsien RY. 2004. Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma s p. red f luorescent protein. Nat. Biotechnol. 22: 1567-1572.
-
(2004)
Nat. Biotechnol
, vol.22
, pp. 1567-1572
-
-
Shaner, N.C.1
Campbell, R.E.2
Steinbach, P.A.3
Giepmans, B.N.4
Palmer, A.E.5
Tsien, R.Y.6
-
101
-
-
2342513372
-
RNA interference microarrays: High-throughput loss-offunction genetics in mammalian cells
-
Silva JM, Mizuno H, Brady A, Lucito R, Hannon GJ. 2004. RNA interference microarrays: high-throughput loss-offunction genetics in mammalian cells. Proc. Natl. Acad. Sci. USA 101: 6548-6552.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 6548-6552
-
-
Silva, J.M.1
Mizuno, H.2
Brady, A.3
Lucito, R.4
Hannon, G.J.5
-
102
-
-
33751252292
-
Direct observation of individual endogenous protein complexes in situ by proximity ligation
-
Soderberg O, Gullberg M, Jarvius M, Ridderstrale K, Leuchowius KJ, Jarvius J, et al. 2006. Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat. Methods 3: 995-1000.
-
(2006)
Nat. Methods
, vol.3
, pp. 995-1000
-
-
Soderberg, O.1
Gullberg, M.2
Jarvius, M.3
Ridderstrale, K.4
Leuchowius, K.J.5
Jarvius, J.6
-
103
-
-
15844431376
-
Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans
-
Sonnichsen B, Koski LB, Walsh A, Marschall P, Neumann B, Brehm M, et al. 2005. Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature 434: 462-469.
-
(2005)
Nature
, vol.434
, pp. 462-469
-
-
Sonnichsen, B.1
Koski, L.B.2
Walsh, A.3
Marschall, P.4
Neumann, B.5
Brehm, M.6
-
104
-
-
0037117550
-
A DNA vector-based RNAi technology to suppress gene expression in mammalian cells
-
Sui G, Soohoo C, Affar el B, Gay F, Shi Y, Forrester WC. 2002. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc. Natl. Acad. Sci. USA 99: 5515-5520.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 5515-5520
-
-
Sui, G.1
Soohoo, C.2
Affar El, B.3
Gay, F.4
Shi, Y.5
Forrester, W.C.6
-
106
-
-
21744448078
-
An unbiased cell morphology-based screen for new, biologically active small molecules
-
Tanaka M, Bateman R, Rauh D, Vaisberg E, Ramachandani S, Zhang C, et al. 2005. An unbiased cell morphology-based screen for new, biologically active small molecules. PLoS Biol. 3: e128.
-
(2005)
Plos Biol
, vol.3
-
-
Tanaka, M.1
Bateman, R.2
Rauh, D.3
Vaisberg, E.4
Ramachandani, S.5
Zhang, C.6
-
107
-
-
0035909994
-
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells
-
Ting AY, Kain KH, Klemke RL, Tsien RY. 2001. Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proc. Natl. Acad. Sci. USA 98: 15003-15008.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
-
-
Ting, A.Y.1
Kain, K.H.2
Klemke, R.L.3
Tsien, R.Y.4
-
108
-
-
78751560396
-
High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array
-
Tung YC, Hsiao AY, Allen SG, Torisawa YS, Ho M, Takayama S. 2011. High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array. Analyst 136: 473-478.
-
(2011)
Analyst
, vol.136
, pp. 473-478
-
-
Tung, Y.C.1
Hsiao, A.Y.2
Allen, S.G.3
Torisawa, Y.S.4
Ho, M.5
Takayama, S.6
-
109
-
-
84939783278
-
High-throughput silencing using the CRISPR-Cas9 system: A review of the benefits and challenges
-
Wade M. 2015. High-throughput silencing using the CRISPR-Cas9 system: a review of the benefits and challenges. J. Biomol. Screen. 20: 1027-1039.
-
(2015)
J. Biomol. Screen
, vol.20
, pp. 1027-1039
-
-
Wade, M.1
-
110
-
-
33745726644
-
Chemical genetics
-
Walsh DP, Chang YT. 2006. Chemical genetics. Chem. Rev. 106: 2476-2530.
-
(2006)
Chem. Rev
, vol.106
, pp. 2476-2530
-
-
Walsh, D.P.1
Chang, Y.T.2
-
111
-
-
84898849001
-
Adenovirus-mediated efficient gene transfer into cultured three-dimensional organoids
-
Wang N, Zhang H, Zhang BQ, Liu W, Zhang Z, Qiao M, et al. 2014. Adenovirus-mediated efficient gene transfer into cultured three-dimensional organoids. PLoS One 9: e93608.
-
(2014)
Plos One
, vol.9
-
-
Wang, N.1
Zhang, H.2
Zhang, B.Q.3
Liu, W.4
Zhang, Z.5
Qiao, M.6
-
112
-
-
37249004920
-
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
-
Wells JA, McClendon CL. 2007. Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 450: 1001-1009.
-
(2007)
Nature
, vol.450
, pp. 1001-1009
-
-
Wells, J.A.1
McClendon, C.L.2
-
113
-
-
0035967967
-
Signal transduction: Signaling specificity - A complex affair
-
Weston CR, Davis RJ. 2001. Signal transduction: Signaling specificity - a complex affair. Science 292: 2439-2440.
-
(2001)
Science
, vol.292
, pp. 2439-2440
-
-
Weston, C.R.1
Davis, R.J.2
-
114
-
-
84857097177
-
RNAguided genetic silencing systems in bacteria and archaea
-
Wiedenheft B, Sternberg SH, Doudna JA. 2012. RNAguided genetic silencing systems in bacteria and archaea. Nature 482: 331-338.
-
(2012)
Nature
, vol.482
, pp. 331-338
-
-
Wiedenheft, B.1
Sternberg, S.H.2
Doudna, J.A.3
-
116
-
-
84896355899
-
Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment
-
Wink S, Hiemstra S, Huppelschoten S, Danen E, Niemeijer M, Hendriks G, et al. 2014. Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment. Chem. Res. Toxicol. 27: 338-355.
-
(2014)
Chem. Res. Toxicol
, vol.27
, pp. 338-355
-
-
Wink, S.1
Hiemstra, S.2
Huppelschoten, S.3
Danen, E.4
Niemeijer, M.5
Hendriks, G.6
-
117
-
-
84884289608
-
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering
-
Yang H, Wang H, Shivalila CS, Cheng AW, Shi L, Jaenisch R. 2013. One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell 154: 1370-1379.
-
(2013)
Cell
, vol.154
, pp. 1370-1379
-
-
Yang, H.1
Wang, H.2
Shivalila, C.S.3
Cheng, A.W.4
Shi, L.5
Jaenisch, R.6
-
119
-
-
84900861730
-
High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells
-
Zhou Y, Zhu S, Cai C, Yuan P, Li C, Huang Y, Wei W. 2014. High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells. Nature 509: 487-491.
-
(2014)
Nature
, vol.509
, pp. 487-491
-
-
Zhou, Y.1
Zhu, S.2
Cai, C.3
Yuan, P.4
Li, C.5
Huang, Y.6
Wei, W.7
-
120
-
-
0035799654
-
Microarrays of cells expressing defined cDNAs
-
Ziauddin J, Sabatini DM. 2001. Microarrays of cells expressing defined cDNAs. Nature 411: 107-110.
-
(2001)
Nature
, vol.411
, pp. 107-110
-
-
Ziauddin, J.1
Sabatini, D.M.2
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