The ToxTracker assay: Novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals

Toxicological Sciences

Volumn 125, Issue 1, 2012, Pages 285-298

  Hendriks, Giel ^a   Atallah, Mirna ^a   Morolli, Bruno ^a   Calléja, Fabienne ^a   Ras Verloop, Nienke ^a   Huijskens, Ilse ^b   Raamsman, Martine ^b   van de Water, Bob ^b   Vrieling, Harry ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

DNA replication stress; Genetic toxicology; Genotoxicity; High throughput screening; Mode of action; Oxidative stress; Toxtracker

Indexed keywords

4 CHLOROANILINE; 4 HYDROXYNONENAL; AMITROLE; ARSENITE SODIUM; BLEOMYCIN; CADMIUM CHLORIDE; CAMPTOTHECIN; CARBAMIC ACID METHYL ESTER; CHEMICAL COMPOUND; CISPLATIN; COPPER SULFATE; CYCLOHEXANONE; CYTARABINE; DIETHANOLAMINE; DOXORUBICIN; ERYTHROMYCIN STEARATE; ETOPOSIDE; FLAVOPIRIDOL; GALLIC ACID PROPYL ESTER; GREEN FLUORESCENT PROTEIN; HEXACHLOROETHANE; HYBRID PROTEIN; HYDROGEN PEROXIDE; MESYLIC ACID METHYL ESTER; MITOMYCIN C; PACLITAXEL; PHENFORMIN; POTASSIUM BROMATE; PYRIDINE; TERT BUTYL HYDROPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASSAY; ATAXIA TELANGIECTASIA; BACTERIAL ARTIFICIAL CHROMOSOME; CONTROLLED STUDY; DNA FINGERPRINTING; DNA REPLICATION; EMBRYONIC STEM CELL; GENETIC TRANSCRIPTION; GENOTOXICITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; REPORTER GENE; SIGNAL TRANSDUCTION; TOXICOLOGICAL PARAMETERS; TOXTRACKER ASSAY; TRANSCRIPTION REGULATION;

ATAXIA TELANGIECTASIA; BACTERIA (MICROORGANISMS); LONCHOCARPUS GLAUCIFOLIUS;

EID: 84555188954     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr281     Document Type: Article

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