Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines

Particle and Fibre Toxicology

Volumn 11, Issue 1, 2014, Pages

  Karlsson, Hanna L ^a   Gliga, Anda R ^a   Calléja, Fabienne M G R ^b   Gonçalves, Cátia S A G ^b   Wallinder, Inger O ^c   Vrieling, Harry ^b   Fadeel, Bengt ^a   Hendriks, Giel ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

Author keywords

Genotoxicity; High throughput screening; Metal oxide nanoparticles; Nanomaterials; Oxidative stress; Reporter cells; ToxTracker

Indexed keywords

CARBON NANOTUBE; COPPER OXIDE NANOPARTICLE; DIESEL FUEL; DNA; GREEN FLUORESCENT PROTEIN; HISTONE H2AX; METAL OXIDE NANOPARTICLE; NANOPARTICLE; NICKLE OXIDE NANOPARTICLE; PROTEIN P53; RAD51 PROTEIN; REACTIVE OXYGEN METABOLITE; SILICON DIOXIDE; SILVER NANOPARTICLE; UNCLASSIFIED DRUG; ZINC OXIDE NANOPARTICLE; BIOLOGICAL MARKER; GASOLINE; METAL NANOPARTICLE; OXIDE; SILVER;

ANIMAL CELL; ARTICLE; ATOMIC EMISSION SPECTROMETRY; CARCINOGENICITY; CELL ASSAY; CELL LINE; CELL TRANSPORT; CELLULAR STRESS RESPONSE; COMET ASSAY; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DNA BINDING; DNA DAMAGE; DNA REPLICATION; EMBRYONIC STEM CELL; FLOW CYTOMETRY; GENOTOXICITY; HAZARD ASSESSMENT; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PHOTON CROSS CORRELATION SPECTROSCOPY; SPECTROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ANIMAL; BIOSYNTHESIS; CELL SURVIVAL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; EVALUATION STUDY; GENETICS; HIGH THROUGHPUT SCREENING; METABOLISM; MUTAGEN TESTING; PATHOLOGY; PROCEDURES; REPORTER GENE; RISK ASSESSMENT; SOLUBILITY;

ANIMALS; BIOLOGICAL MARKERS; CELL LINE; CELL SURVIVAL; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC STEM CELLS; GASOLINE; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HIGH-THROUGHPUT SCREENING ASSAYS; METAL NANOPARTICLES; MICE; MUTAGENICITY TESTS; NANOTUBES, CARBON; OXIDATIVE STRESS; OXIDES; PARTICLE SIZE; QUARTZ; REACTIVE OXYGEN SPECIES; RISK ASSESSMENT; SILVER; SOLUBILITY;

EID: 84908148990     PISSN: 17438977     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/s12989-014-0041-9     Document Type: Article

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