-
1
-
-
0024406857
-
A novel genetic system to detect protein-protein interactions
-
DOI 10.1038/340245a0
-
Fields, S. & Song, O. A novel genetic system to detect protein-protein interactions. Nature 340, 245-246 (1989). (Pubitemid 19171591)
-
(1989)
Nature
, vol.340
, Issue.6230
, pp. 245-246
-
-
Fields, S.1
Song, O.-K.2
-
2
-
-
24944591864
-
Imaging in situ protein-DNA interactions in the cell nucleus using FRET-FLIM
-
DOI 10.1016/j.yexcr.2005.06.007, PII S0014482705002715
-
Cremazy, F. G. et al. Imaging in situ protein-DNA interactions in the cell nucleus using FRET-FLIM. Exp. Cell. Res. 309, 390-396 (2005). (Pubitemid 41317362)
-
(2005)
Experimental Cell Research
, vol.309
, Issue.2
, pp. 390-396
-
-
Cremazy, F.G.E.1
Manders, E.M.M.2
Bastiaens, P.I.H.3
Kramer, G.4
Hager, G.L.5
Van Munster, E.B.6
Verschure, P.J.7
Gadella Jr., T.W.J.8
Van Driel, R.9
-
3
-
-
84872555339
-
A fluorescent-based high-throughput screening assay for small molecules that inhibit the interaction of MdmX with p53
-
Tsuganezawa, K. et al. A fluorescent-based high-throughput screening assay for small molecules that inhibit the interaction of MdmX with p53. J. Biomol. Screen. 18, 191-198 (2013).
-
(2013)
J. Biomol. Screen
, vol.18
, pp. 191-198
-
-
Tsuganezawa, K.1
-
4
-
-
77449102676
-
Modulation of protein properties in living cells using nanobodies
-
Kirchhofer, A. et al. Modulation of protein properties in living cells using nanobodies. Nat. Struct. Mol. Biol. 17, 133-138 (2010).
-
(2010)
Nat. Struct. Mol. Biol
, vol.17
, pp. 133-138
-
-
Kirchhofer, A.1
-
5
-
-
0028823020
-
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
-
Montes de Oca Luna, R.,Wagner, D. S. & Lozano, G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378, 203-206 (1995).
-
(1995)
Nature
, vol.378
, pp. 203-206
-
-
De Oca Luna, M.1
Wagner, D.S.R.2
Lozano, G.3
-
6
-
-
0028834902
-
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
-
Jones, S. N., Roe, A. E., Donehower, L. A. & Bradley, A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378, 206-208 (1995).
-
(1995)
Nature
, vol.378
, pp. 206-208
-
-
Jones, S.N.1
Roe, A.E.2
Donehower, L.A.3
Bradley, A.4
-
7
-
-
0035499826
-
How cells choose to die
-
Lane, D. How cells choose to die. Nature 414, 27 (2001).
-
(2001)
Nature
, vol.414
, pp. 27
-
-
Lane, D.1
-
8
-
-
84886656374
-
Activation of the p53 tumor suppressor protein
-
Vousden, K. H. Activation of the p53 tumor suppressor protein. Biochim. Biophys. Acta. 160247-59, 2002.
-
(2002)
Biochim. Biophys. Acta
, pp. 160247-160259
-
-
Vousden, K.H.1
-
9
-
-
0032145989
-
The MDM2 gene amplification database
-
DOI 10.1093/nar/26.15.3453
-
Momand, J., Jung, D., Wilczynski, S. & Niland, J. The MDM2 gene amplification database. Nucleic Acids Res. 26, 3453-3459 (1998). (Pubitemid 28347214)
-
(1998)
Nucleic Acids Research
, vol.26
, Issue.15
, pp. 3453-3459
-
-
Momand, J.1
Jung, D.2
Wilczynski, S.3
Niland, J.4
-
10
-
-
8844278362
-
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
-
DOI 10.1016/j.cell.2004.11.022, PII S0092867404010517
-
Bond, G. L. et al. A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell 119, 591-602 (2004). (Pubitemid 39535748)
-
(2004)
Cell
, vol.119
, Issue.5
, pp. 591-602
-
-
Bond, G.L.1
Hu, W.2
Bond, E.E.3
Robins, H.4
Lutzker, S.G.5
Arva, N.C.6
Bargonetti, J.7
Bartel, F.8
Taubert, H.9
Wuerl, P.10
Onel, K.11
Yip, L.12
Hwang, S.-J.13
Strong, L.C.14
Lozano, G.15
Levine, A.J.16
-
11
-
-
0026740449
-
Amplification of a gene encoding a p53-associated protein in human sarcomas
-
Oliner, J. D., Kinzler, K. W., Meltzer, P. S., George, D. L. & Vogelstein, B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358, 80-83 (1992).
-
(1992)
Nature
, vol.358
, pp. 80-83
-
-
Oliner, J.D.1
Kinzler, K.W.2
Meltzer, P.S.3
George, D.L.4
Vogelstein, B.5
-
12
-
-
0033959324
-
Incidence and prognostic significance of MDM2 oncoprotein overexpression in relapsed childhood acute lymphoblastic leukemia
-
Zhou, M. et al. Incidence and prognostic significance of MDM2 oncoprotein overexpression in relapsed childhood acute lymphoblastic leukemia. Leukemia 14, 61-67 (2000). (Pubitemid 30068374)
-
(2000)
Leukemia
, vol.14
, Issue.1
, pp. 61-67
-
-
Zhou, M.1
Gu, L.2
Abshire, T.C.3
Homans, A.4
Billett, A.L.5
Yeager, A.M.6
Findley, H.W.7
Findley, H.8
-
13
-
-
33744529601
-
Phase I/II adenoviral p53 gene therapy for chemoradiation resistant advanced esophageal squamous cell carcinoma
-
DOI 10.1111/j.1349-7006.2006.00206.x
-
Shimada, H. et al. Phase I/II adenoviral p53 gene therapy for chemoradiation resistant advanced esophageal squamous cell carcinoma. Cancer Sci. 97, 554-561 (2006). (Pubitemid 43811599)
-
(2006)
Cancer Science
, vol.97
, Issue.6
, pp. 554-561
-
-
Shimada, H.1
Matsubara, H.2
Shiratori, T.3
Shimizu, T.4
Miyazaki, S.5
Okazumi, S.6
Nabeya, Y.7
Shuto, K.8
Hayashi, H.9
Tanizawa, T.10
Nakatani, Y.11
Nakasa, H.12
Kitada, M.13
Ochiai, T.14
-
14
-
-
85028113437
-
Translating p53 into the clinic
-
Cheok, C. F., Verma, C. S., Baselga, J. & Lane, D. P. Translating p53 into the clinic. Nat. Rev. Clin. Oncol. 8, 25-37 (2011).
-
(2011)
Nat. Rev. Clin. Oncol
, vol.8
, pp. 25-37
-
-
Cheok, C.F.1
Verma, C.S.2
Baselga, J.3
Lane, D.P.4
-
15
-
-
0033672197
-
Visualization of gene activity in living cells
-
Tsukamoto, T. et al. Visualization of gene activity in living cells. Nat. Cell. Biol. 2, 871-878 (2000).
-
(2000)
Nat. Cell. Biol
, vol.2
, pp. 871-878
-
-
Tsukamoto, T.1
-
16
-
-
3142781225
-
Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
-
Arkin, M. R. & Wells, J. A. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat. Rev. Drug. Discov. 3, 301-317 (2004). (Pubitemid 38499758)
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, Issue.4
, pp. 301-317
-
-
Arkin, M.R.1
Wells, J.A.2
-
17
-
-
10744221485
-
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
-
DOI 10.1126/science.1092472
-
Vassilev, L. T. et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844-848 (2004). (Pubitemid 38174664)
-
(2004)
Science
, vol.303
, Issue.5659
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammlott, U.8
Lukacs, C.9
Klein, C.10
Fotouhi, N.11
Liu, E.A.12
-
18
-
-
11144315535
-
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
-
DOI 10.1038/nm1146
-
Issaeva, N. et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat. Med. 10, 1321-1328 (2004). (Pubitemid 40022713)
-
(2004)
Nature Medicine
, vol.10
, Issue.12
, pp. 1321-1328
-
-
Issaeva, N.1
Bozko, P.2
Enge, M.3
Protopopova, M.4
Verhoef, L.G.G.C.5
Masucci, M.6
Pramanik, A.7
Selivanova, G.8
-
19
-
-
30744449974
-
NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro [1]
-
DOI 10.1038/nm1105-1135, PII NM11051135
-
Krajewski, M., Ozdowy, P., DSilva, L., Rothweiler, U. & Holak, T. A. NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro. Nat. Med. 11, 1135-1136 (2005). (Pubitemid 43093648)
-
(2005)
Nature Medicine
, vol.11
, Issue.11
, pp. 1135-1136
-
-
Krajewski, M.1
Ozdowy, P.2
D'Silva, L.3
Rothweiler, U.4
Holak, T.A.5
-
20
-
-
0033531252
-
Comparative study of the p53-mdm2 and p53-MDMX interfaces
-
DOI 10.1038/sj.onc.1202281
-
Bottger, V. et al. Comparative study of the p53-mdm2 and p53-MDMX interfaces. Oncogene 18, 189-199 (1999). (Pubitemid 29060593)
-
(1999)
Oncogene
, vol.18
, Issue.1
, pp. 189-199
-
-
Bottger, V.1
Bottger, A.2
Garcia-Echeverria, C.3
Ramos, Y.F.M.4
Van Der Eb, A.J.5
Jochemsen, A.G.6
Lane, D.P.7
-
21
-
-
77951766329
-
Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions
-
Li, C. et al. Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions. J. Mol. Biol. 398, 200-213 (2010).
-
(2010)
J. Mol. Biol
, vol.398
, pp. 200-213
-
-
Li, C.1
-
22
-
-
33845256980
-
MDMX overexpression prevents p53 activation by the MDM2 inhibitor nutlin
-
DOI 10.1074/jbc.C600147200
-
Hu, B., Gilkes, D. M., Farooqi, B., Sebti, S. M. & Chen, J. MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin. J. Biol. Chem. 281, 33030-33035 (2006). (Pubitemid 46036685)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.44
, pp. 33030-33035
-
-
Hu, B.1
Gilkes, D.M.2
Farooqi, B.3
Sebti, S.M.4
Chen, J.5
-
23
-
-
33748648777
-
Cargo-dependent mode of uptake and bioavailability of TAT-containing proteins and peptides in living cells
-
Tunnemann, G. et al. Cargo-dependent mode of uptake and bioavailability of TAT-containing proteins and peptides in living cells. FASEB J. 20, 1775-178 (2006).
-
(2006)
FASEB J
, vol.20
, pp. 1775-2178
-
-
Tunnemann, G.1
-
24
-
-
38049156027
-
Molecular dynamics simulations suggest a mechanism for translocation of the HIV-1 TAT peptide across lipid membranes
-
Herce, H. D. & Garcia, A. E. Molecular dynamics simulations suggest a mechanism for translocation of the HIV-1 TAT peptide across lipid membranes. Proc. Natl Acad. Sci. USA 104, 20805-20810 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 20805-20810
-
-
Herce, H.D.1
Garcia, A.E.2
-
25
-
-
70350023192
-
Arginine-rich peptides destabilize the plasma membrane, consistent with a pore formation translocation mechanism of cell-penetrating peptides
-
Herce, H. D. et al. Arginine-rich peptides destabilize the plasma membrane, consistent with a pore formation translocation mechanism of cell-penetrating peptides. Biophys. J. 97, 1917-1925 (2009).
-
(2009)
Biophys. J
, vol.97
, pp. 1917-1925
-
-
Herce, H.D.1
-
26
-
-
63649127300
-
Cell entry of arginine-rich peptides is independent of endocytosis
-
Ter-Avetisyan, G. et al. Cell entry of arginine-rich peptides is independent of endocytosis. J. Biol. Chem. 284, 3370-3378 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, pp. 3370-3378
-
-
Ter-Avetisyan, G.1
-
27
-
-
84877755819
-
Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides
-
Lattig-Tunnemann, G. et al. Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides. Nat. Commun. 2, 453 (2011).
-
(2011)
Nat. Commun
, vol.2
, pp. 453
-
-
Lattig-Tunnemann, G.1
-
28
-
-
0342437491
-
MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
-
DOI 10.1016/S0092-8674(00)81887-5
-
Nan, X., Campoy, F. J. & Bird, A. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell 88, 471-481 (1997). (Pubitemid 27154412)
-
(1997)
Cell
, vol.88
, Issue.4
, pp. 471-481
-
-
Xinsheng, N.1
Campoy, F.J.2
Bird, A.3
-
29
-
-
22344441631
-
Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation
-
DOI 10.1083/jcb.200502062
-
Brero, A. et al. Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation. J. Cell. Biol. 169, 733-743 (2005). (Pubitemid 41002879)
-
(2005)
Journal of Cell Biology
, vol.169
, Issue.5
, pp. 733-743
-
-
Brero, A.1
Easwaran, H.P.2
Nowak, D.3
Grunewald, I.4
Cremer, T.5
Leonhardt, H.6
Cardoso, M.C.7
-
30
-
-
0024289037
-
Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons
-
Karas, M. & Hillenkamp, F. Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. Anal. Chem. 60, 2299-2301 (1988).
-
(1988)
Anal. Chem
, vol.60
, pp. 2299-2301
-
-
Karas, M.1
Hillenkamp, F.2
-
31
-
-
39749193861
-
A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins
-
DOI 10.1074/mcp.M700342-MCP200
-
Rothbauer, U. et al. A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins. Mol. Cell. Proteomics. 7, 282-289 (2008). (Pubitemid 351298442)
-
(2008)
Molecular and Cellular Proteomics
, vol.7
, Issue.2
, pp. 282-289
-
-
Rothbauer, U.1
Zolghadr, K.2
Muyldermans, S.3
Schepers, A.4
Cardoso, M.C.5
Leonhardt, H.6
-
32
-
-
33750328972
-
Targeting and tracing antigens in live cells with fluorescent nanobodies
-
DOI 10.1038/nmeth953, PII NMETH953
-
Rothbauer, U. et al. Targeting and tracing antigens in live cells with fluorescent nanobodies. Nat. Methods 3, 887-889 (2006). (Pubitemid 44614722)
-
(2006)
Nature Methods
, vol.3
, Issue.11
, pp. 887-889
-
-
Rothbauer, U.1
Zolghadr, K.2
Tillib, S.3
Nowak, D.4
Schermelleh, L.5
Gahl, A.6
Backmann, N.7
Conrath, K.8
Muyldermans, S.9
Cardoso, M.C.10
Leonhardt, H.11
-
33
-
-
0034282102
-
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53
-
Boyd, S. D., Tsai, K. Y. & Jacks, T. An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nat. Cell. Biol. 2, 563-568 (2000).
-
(2000)
Nat. Cell. Biol
, vol.2
, pp. 563-568
-
-
Boyd, S.D.1
Tsai, K.Y.2
Jacks, T.3
-
34
-
-
57049168200
-
A fluorescent two-hybrid assay for direct visualization of protein interactions in living cells
-
Zolghadr, K. et al. A fluorescent two-hybrid assay for direct visualization of protein interactions in living cells. Mol. Cell. Proteom. 7, 2279-2287 (2008).
-
(2008)
Mol. Cell. Proteom
, vol.7
, pp. 2279-2287
-
-
Zolghadr, K.1
-
35
-
-
0017759258
-
Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle
-
Yaffe, D. & Saxel, O. Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle. Nature 270, 725-727 (1977). (Pubitemid 8239246)
-
(1977)
Nature
, vol.270
, Issue.5639
, pp. 725-727
-
-
Yaffe, D.1
Saxel, O.2
-
36
-
-
0014206483
-
Two established in vitro cell lines from human mesenchymal tumours
-
Ponten, J. & Saksela, E. Two established in vitro cell lines from human mesenchymal tumours. Int. J. Cancer. 2, 434-447 (1967).
-
(1967)
Int. J. Cancer
, vol.2
, pp. 434-447
-
-
Ponten, J.1
Saksela, E.2
-
37
-
-
85025402749
-
Studies on the propagation in vitro of poliomyelitis viruses. IV. Viral multiplication in a stable strain of human malignant epithelial cells (strain HeLa) derived from an epidermoid carcinoma of the cervix
-
Scherer, W. F., Syverton, J. T. & Gey, G. O. Studies on the propagation in vitro of poliomyelitis viruses. IV. Viral multiplication in a stable strain of human malignant epithelial cells (strain HeLa) derived from an epidermoid carcinoma of the cervix. J. Exp. Med. 97, 695-710 (1953).
-
(1953)
J. Exp. Med
, vol.97
, pp. 695-710
-
-
Scherer, W.F.1
Syverton, J.T.2
Gey, G.O.3
|