-
1
-
-
0035863097
-
RNA interference is mediated by 21- and 22-nucleotide RNAs
-
DOI 10.1101/gad.862301
-
Elbashir SM, Lendeckel W, Tuschl T. RNA interference is mediated by 21-and 22-nucleotide RNAs. Genes Dev. 15(2), 188-200 (2001). (Pubitemid 32107664)
-
(2001)
Genes and Development
, vol.15
, Issue.2
, pp. 188-200
-
-
Elbashir, S.M.1
Lendeckel, W.2
Tuschl, T.3
-
2
-
-
0035858332
-
Recent progress in gene delivery using non-viral transfer complexes
-
DOI 10.1016/S0168-3659(01)00267-X, PII S016836590100267X
-
Godbey WT, Mikos AG. Recent progress in gene delivery using non-viral transfer complexes. J. Control. Release 72(1-3), 115-125 (2001). (Pubitemid 32522349)
-
(2001)
Journal of Controlled Release
, vol.72
, Issue.1-3
, pp. 115-125
-
-
Godbey, W.T.1
Mikos, A.G.2
-
3
-
-
0030715323
-
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
-
Li P, Nijhawan D, Budihardjo I et al. Cytochrome C and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91(4), 479-489 (1997). (Pubitemid 27508237)
-
(1997)
Cell
, vol.91
, Issue.4
, pp. 479-489
-
-
Li, P.1
Nijhawan, D.2
Budihardjo, I.3
Srinivasula, S.M.4
Ahmad, M.5
Alnemri, E.S.6
Wang, X.7
-
4
-
-
0032575752
-
Mitochondria and apoptosis
-
Green DR, Reed JC. Mitochondria and apoptosis. Science 281(5381), 1309-1312 (1998). (Pubitemid 28406816)
-
(1998)
Science
, vol.281
, Issue.5381
, pp. 1309-1312
-
-
Green, D.R.1
Reed, J.C.2
-
5
-
-
33749681890
-
Delivery of RNA interference
-
Li CX, Parker A, Menocal E, Xiang S, Borodyansky L, Fruehauf JH. Delivery of RNA interference. Cell Cycle 5(18), 2103-2109 (2006). (Pubitemid 44553744)
-
(2006)
Cell Cycle
, vol.5
, Issue.18
, pp. 2103-2109
-
-
Li, C.X.1
Parker, A.2
Menocal, E.3
Xiang, S.4
Borodyansky, L.5
Fruehauf, J.H.6
-
6
-
-
4344651353
-
Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells
-
DOI 10.1016/j.chembiol.2004.06.006, PII S1074552104001930
-
Chiu YL, Ali A, Chu CY, Cao H, Rana TM. Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells. Chem. Biol. 11(8), 1165-1175 (2004). (Pubitemid 39138769)
-
(2004)
Chemistry and Biology
, vol.11
, Issue.8
, pp. 1165-1175
-
-
Chiu, Y.-L.1
Ali, A.2
Chu, C.-Y.3
Cao, H.4
Rana, T.M.5
-
7
-
-
31544448890
-
Comparative evaluation of target-specific GFP gene silencing efficiencies for antisense ODN, synthetic siRNA, and siRNA plasmid complexed with PEI-PEG-FOL conjugate
-
DOI 10.1021/bc050289f
-
Kim SH, Mok H, Jeong JH, Kim SW, Park TG. Comparative evaluation of target-specifc GFP gene silencing effciencies for antisense ODN, synthetic siRNA, and siRNA plasmid complexed with PEI-PEG-FOL conjugate. Bioconjug. Chem. 17(1), 241-244 (2006). (Pubitemid 43157607)
-
(2006)
Bioconjugate Chemistry
, vol.17
, Issue.1
, pp. 241-244
-
-
Kim, S.H.1
Mok, H.2
Jeong, J.H.3
Kim, S.W.4
Park, T.G.5
-
8
-
-
20144389695
-
Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7
-
DOI 10.1038/nm1191
-
Hornung V, Guenthner-Biller M, Bourquin C et al. Sequence-specifc potent induction of IFN-a by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat. Med. 11(3), 263-270 (2005). (Pubitemid 40460553)
-
(2005)
Nature Medicine
, vol.11
, Issue.3
, pp. 263-270
-
-
Hornung, V.1
Guenthner-Biller, M.2
Bourquin, C.3
Ablasser, A.4
Schlee, M.5
Uematsu, S.6
Noronha, A.7
Manoharan, M.8
Akira, S.9
De Fougerolles, A.10
Endres, S.11
Hartmann, G.12
-
9
-
-
44649091252
-
SiRNA and the lung: Research tool or therapeutic drug?
-
De Fougerolles A, Novobrantseva T. siRNA and the lung: research tool or therapeutic drug? Curr. Opin. Pharmacol. 8(3), 280-285 (2008).
-
(2008)
Curr. Opin. Pharmacol.
, vol.8
, Issue.3
, pp. 280-285
-
-
De Fougerolles, A.1
Novobrantseva, T.2
-
10
-
-
36649027868
-
Pulmonary delivery of nucleic acids
-
DOI 10.1517/17425247.4.6.575
-
Birchall J. Pulmonary delivery of nucleic acids. Expert Opin. Drug Deliv. 4(6), 575-578 (2007). (Pubitemid 350193396)
-
(2007)
Expert Opinion on Drug Delivery
, vol.4
, Issue.6
, pp. 575-578
-
-
Birchall, J.1
-
11
-
-
1542425280
-
Delivery of DNA to lung airway epithelium
-
Weiss DJ. Delivery of DNA to lung airway epithelium. Methods Mol. Biol. 246, 53-68 (2004).
-
(2004)
Methods Mol. Biol.
, vol.246
, pp. 53-68
-
-
Weiss, D.J.1
-
12
-
-
60149103022
-
Extracellular barriers in respiratory gene therapy
-
Sanders N, Rudolph C, Braeckmans K, De Smedt SC, Demeester J. Extracellular barriers in respiratory gene therapy. Adv. Drug Deliv. Rev. 61(2), 115-127 (2009).
-
(2009)
Adv. Drug Deliv. Rev.
, vol.61
, Issue.2
, pp. 115-127
-
-
Sanders, N.1
Rudolph, C.2
Braeckmans, K.3
De Smedt, S.C.4
Demeester, J.5
-
14
-
-
23144461838
-
Inflammatory pathway analysis using a high content screening platform
-
DOI 10.1089/adt.2005.3.261
-
Bertelsen M, Sanfridson A. Infammatory pathway ana lysis using a high-content screening platform. Assay Drug Dev. Technol. 3(3), 261-271 (2005). (Pubitemid 41079124)
-
(2005)
Assay and Drug Development Technologies
, vol.3
, Issue.3
, pp. 261-271
-
-
Bertelsen, M.1
Sanfridson, A.2
-
15
-
-
77950668281
-
High-throughput RNAi screening to dissect cellular pathways. A how-to guide
-
Falschlehner C, Steinbrink S, Erdmann G, Boutros M. High-throughput RNAi screening to dissect cellular pathways. A how-to guide. Biotechnol. J. 5(4), 368-376 (2010).
-
(2010)
Biotechnol. J.
, vol.5
, Issue.4
, pp. 368-376
-
-
Falschlehner, C.1
Steinbrink, S.2
Erdmann, G.3
Boutros, M.4
-
16
-
-
54249170562
-
A novel high-throughput assay for the quantitative assessment of receptor traffcking
-
Grimsey NL, Narayan PJ, Dragunow M, Glass M. A novel high-throughput assay for the quantitative assessment of receptor traffcking. Clin. Exp. Pharmacol. Physiol. 35(11), 1377-1382 (2008).
-
(2008)
Clin. Exp. Pharmacol. Physiol.
, vol.35
, Issue.11
, pp. 1377-1382
-
-
Grimsey, N.L.1
Narayan, P.J.2
Dragunow, M.3
Glass, M.4
-
17
-
-
77955278701
-
High content ana lysis of cytotoxic effects of pDMAEMA on human intestinal epithelial and monocyte cultures
-
Rawlinson LA, O'brien PJ, Brayden DJ. High content ana lysis of cytotoxic effects of pDMAEMA on human intestinal epithelial and monocyte cultures. J. Control. Release 146(1), 84-92
-
J. Control. Release
, vol.146
, Issue.1
, pp. 84-92
-
-
Rawlinson, L.A.1
O'Brien, P.J.2
Brayden, D.J.3
-
18
-
-
33747084103
-
High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening
-
DOI 10.1007/s00204-006-0091-3
-
O'brien PJ, Irwin W, Diaz D et al. High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high-content screening. Arch. Toxicol. 80(9), 580-604 (2006). (Pubitemid 44214526)
-
(2006)
Archives of Toxicology
, vol.80
, Issue.9
, pp. 580-604
-
-
O'Brien, P.J.1
Irwin, W.2
Diaz, D.3
Howard-Cofield, E.4
Krejsa, C.M.5
Slaughter, M.R.6
Gao, B.7
Kaludercic, N.8
Angeline, A.9
Bernardi, P.10
Brain, P.11
Hougham, C.12
-
19
-
-
52449135231
-
Transfection effciency and toxicity of polyethylenimine in differentiated Calu-3 and nondifferentiated COS-1 cell cultures
-
Florea BI, Meaney C, Junginger HE, Borchard G. Transfection effciency and toxicity of polyethylenimine in differentiated Calu-3 and nondifferentiated COS-1 cell cultures. AAPS PharmSci. 4(3), E12 (2002).
-
(2002)
AAPS PharmSci.
, vol.4
, Issue.3
-
-
Florea, B.I.1
Meaney, C.2
Junginger, H.E.3
Borchard, G.4
-
20
-
-
0034786764
-
Chitosan as a nonviral gene delivery system. Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo
-
DOI 10.1038/sj.gt.3301492
-
Koping-Hoggard M, Tubulekas I, Guan H et al. Chitosan as a nonviral gene delivery system. Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo. Gene Ther. 8(14), 1108-1121 (2001). (Pubitemid 32962708)
-
(2001)
Gene Therapy
, vol.8
, Issue.14
, pp. 1108-1121
-
-
Koping-Hoggard, M.1
Tubulekas, I.2
Guan, H.3
Edwards, K.4
Nilsson, M.5
Varum, K.M.6
Artursson, P.7
-
21
-
-
84881194089
-
PEGylation of nanoparticles improves their cytoplasmic transport
-
Suh J, Choy KL, Lai SK et al. PEGylation of nanoparticles improves their cytoplasmic transport. Int. J. Nanomed. 2(4), 735-741 (2007).
-
(2007)
Int. J. Nanomed.
, vol.2
, Issue.4
, pp. 735-741
-
-
Suh, J.1
Choy, K.L.2
Lai, S.K.3
-
22
-
-
73349140554
-
Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier
-
Tang Bc, Dawson M, Lai Sk et al. Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier. Proc. Natl Acad. Sci. USA 106(46), 19268-19273 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, Issue.46
, pp. 19268-19273
-
-
Bc, T.1
Dawson, M.2
Sk, L.3
-
23
-
-
71049193822
-
PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application. Structure-function relationships
-
Beyerle A, Merkel O, Stoeger T, Kissel T. PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application. Structure-function relationships. Toxicol. Appl. Pharmacol. 242(2), 146-154 (2010).
-
(2010)
Toxicol. Appl. Pharmacol.
, vol.242
, Issue.2
, pp. 146-154
-
-
Beyerle, A.1
Merkel, O.2
Stoeger, T.3
Kissel, T.4
-
24
-
-
33745630072
-
Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier
-
DOI 10.1007/s11095-006-0255-0
-
Grainger CI, Greenwell LL, Lockley DJ, Martin GP, Forbes B. Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier. Pharm. Res. 23(7), 1482-1490 (2006). (Pubitemid 43993811)
-
(2006)
Pharmaceutical Research
, vol.23
, Issue.7
, pp. 1482-1490
-
-
Grainger, C.I.1
Greenwell, L.L.2
Lockley, D.J.3
Martin, G.P.4
Forbes, B.5
-
25
-
-
0027133866
-
Reverse transcription polymerase chain reaction (RT-PCR) phenotypic analysis of cell cultures of human tracheal epithelium, tracheobronchial glands, and lung carcinomas
-
Finkbeiner WE, Carrier SD, Teresi CE. Reverse transcription-polymerase chain reaction (RT-PCR) phenotypic ana lysis of cell cultures of human tracheal epithelium, tracheobronchial glands, and lung carcinomas. Am. J. Respir. Cell Mol. Biol. 9(5), 547-556 (1993). (Pubitemid 2007529)
-
(1993)
Am. J. Respir. Cell Mol. Biol.
, vol.9
, Issue.5
, pp. 547-556
-
-
Finkbeiner, W.E.1
Carrier, S.D.2
Teresi, C.E.3
-
26
-
-
0037458930
-
Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3
-
DOI 10.1016/S0168-3659(02)00356-5
-
Florea BI, Cassara ML, Junginger HE, Borchard G. Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3. J. Control. Release 87(1-3), 131-138 (2003). (Pubitemid 36255450)
-
(2003)
Journal of Controlled Release
, vol.87
, Issue.1-3
, pp. 131-138
-
-
Florea, B.I.1
Cassara, M.L.2
Junginger, H.E.3
Borchard, G.4
-
27
-
-
77957227472
-
Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction
-
Johnson-Lyles DN, Peifey K, Lockett S et al. Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction. Toxicol. Appl. Pharmacol. 248(3), 249-258
-
Toxicol. Appl. Pharmacol.
, vol.248
, Issue.3
, pp. 249-258
-
-
Johnson-Lyles, D.N.1
Peifey, K.2
Lockett, S.3
-
28
-
-
33644606491
-
Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes
-
Rodriguez-Enriquez S, Kim I, Currin RT, Lemasters JJ. Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy 2(1), 39-46 (2006).
-
(2006)
Autophagy
, vol.2
, Issue.1
, pp. 39-46
-
-
Rodriguez-Enriquez, S.1
Kim, I.2
Currin, R.T.3
Lemasters, J.J.4
-
29
-
-
14844303045
-
Enhancing transfection efficiency using polyethylene glycol grafted polyethylenimine and fusogenic peptide
-
Lee H, Jeong J, Lee J, Park T. Enhancing transfection effciency using polyethylene glycol grafted polyethylenimine and fusogenic peptide. Biotechnol. Bioprocess Engin. 6(4), 269-273 (2001). (Pubitemid 33811612)
-
(2001)
Biotechnology and Bioprocess Engineering
, vol.6
, Issue.4
, pp. 269-273
-
-
Lee, H.1
Jeong, J.H.2
Lee, J.H.3
Park, T.G.4
-
30
-
-
33746871883
-
Biophysical and structural characterization of polyethylenimine-mediated siRNA delivery in vitro
-
DOI 10.1007/s11095-006-9009-2
-
Grayson AC, Doody AM, Putnam D. Biophysical and structural characterization of polyethylenimine-mediated siRNA delivery in vitro. Pharm. Res. 23(8), 1868-1876 (2006). (Pubitemid 44200551)
-
(2006)
Pharmaceutical Research
, vol.23
, Issue.8
, pp. 1868-1876
-
-
Grayson, A.C.1
Doody, A.M.2
Putnam, D.3
-
31
-
-
67651202350
-
Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by fuorescence fuctuation spectroscopy and single photon emission computed tomography (SPECT) imaging
-
Merkel OM, Librizzi D, Pfestroff A et al. Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: effects on pharmacokinetics and biodistribution measured by fuorescence fuctuation spectroscopy and single photon emission computed tomography (SPECT) imaging. J. Control. Release 138(2), 148-159 (2009).
-
(2009)
J. Control. Release
, vol.138
, Issue.2
, pp. 148-159
-
-
Merkel, O.M.1
Librizzi, D.2
Pfestroff, A.3
-
32
-
-
33748994569
-
Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes
-
DOI 10.1021/bc060129j
-
Mao S, Neu M, Germershaus O et al. Infuence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/siRNA polyplexes. Bioconjug. Chem. 17(5), 1209-1218 (2006). (Pubitemid 44455329)
-
(2006)
Bioconjugate Chemistry
, vol.17
, Issue.5
, pp. 1209-1218
-
-
Mao, S.1
Neu, M.2
Germershaus, O.3
Merkel, O.4
Sitterberg, J.5
Bakowsky, U.6
Kissel, T.7
-
33
-
-
0033490399
-
Poly(ethylene glycol)-induced DNA condensation in aqueous/methanol containing low-molecular-weight electrolyte solutions: Part I. Theoretical considerations
-
DOI 10.1016/S0032-3861(98)00643-0, PII S0032386198006430
-
Kleideiter G, Nordmeier E. Poly(ethylene glycol)-induced DNA condensation in aqueous/methanol containing low-molecular-weight electrolyte solutions. Theoretical considerations. Polymer 40(14), 4013-4023 (1999). (Pubitemid 30122491)
-
(1999)
Polymer
, vol.40
, Issue.14
, pp. 4013-4023
-
-
Kleideiter, G.1
Nordmeier, E.2
-
34
-
-
0036077937
-
Polyethylenimine-graft-poly(ethylene glycol) copolymers: Influence of copolymer block structure on DNA complexation and biological activities as gene delivery system
-
DOI 10.1021/bc025529v
-
Petersen H, Fechner PM, Martin AL et al. Polyethylenimine-graft- poly(ethylene glycol) copolymers. infuence of copolymer block structure on DNA complexation and biological activities as gene delivery system. Bioconjug. Chem. 13(4), 845-854 (2002). (Pubitemid 34801128)
-
(2002)
Bioconjugate Chemistry
, vol.13
, Issue.4
, pp. 845-854
-
-
Petersen, H.1
Fechner, P.M.2
Martin, A.L.3
Kunath, K.4
Stolnik, S.5
Roberts, C.J.6
Fischer, D.7
Davies, M.C.8
Kissel, T.9
-
35
-
-
79952317711
-
Polyethylenimines for RNAi-mediated gene targeting in vivo and siRNA delivery to the lung
-
Gunther M, Lipka J, Malek A, Gutsch D, Kreyling W, Aigner A. Polyethylenimines for RNAi-mediated gene targeting in vivo and siRNA delivery to the lung. Eur. J. Pharm. Biopharm. 77(3), 438-449
-
Eur. J. Pharm. Biopharm.
, vol.77
, Issue.3
, pp. 438-449
-
-
Gunther, M.1
Lipka, J.2
Malek, A.3
Gutsch, D.4
Kreyling, W.5
Aigner, A.6
-
36
-
-
68249122805
-
Nonviral siRNA delivery to the lung. investigation of PEG-PEI polyplexes and their in vivo performance
-
Merkel OM, Beyerle A, Librizzi D et al. Nonviral siRNA delivery to the lung. investigation of PEG-PEI polyplexes and their in vivo performance. Mol. Pharm. 6(4), 1246-1260 (2009).
-
(2009)
Mol. Pharm.
, vol.6
, Issue.4
, pp. 1246-1260
-
-
Merkel, O.M.1
Beyerle, A.2
Librizzi, D.3
-
37
-
-
79955468361
-
Comparative in vivo study of poly(ethylene imine)/siRNA complexes for pulmonary delivery in mice
-
Beyerle A, Braun A, Merkel O, Koch F, Stoeger T, Kissel T. Comparative in vivo study of poly(ethylene imine)/siRNA complexes for pulmonary delivery in mice. J. Control. Release 151(1), 51-56 (2011).
-
(2011)
J. Control. Release
, vol.151
, Issue.1
, pp. 51-56
-
-
Beyerle, A.1
Braun, A.2
Merkel, O.3
Koch, F.4
Stoeger, T.5
Kissel, T.6
-
38
-
-
34547650971
-
Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance
-
DOI 10.1523/JNEUROSCI.1984-07.2007
-
Ward MW, Huber HJ, Weisova P, Dussmann H, Nicholls DG, Prehn JH. Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance. J. Neurosci. 27(31), 8238-8249 (2007). (Pubitemid 47219629)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.31
, pp. 8238-8249
-
-
Ward, M.W.1
Huber, H.J.2
Weisova, P.3
Dussmann, H.4
Nicholls, D.G.5
Prehn, J.H.M.6
-
39
-
-
37549027163
-
Performance of the vibrating membrane aerosol generation device: Aeroneb micropump nebulizer
-
Zhang G, David A, Wiedmann TS. Performance of the vibrating membrane aerosol generation device: Aeroneb micropump nebulizer. J. Aerosol Med. 20(4), 408-416 (2007).
-
(2007)
J. Aerosol Med.
, vol.20
, Issue.4
, pp. 408-416
-
-
Zhang, G.1
David, A.2
Wiedmann, T.S.3
|