Universal strategies in research and drug discovery based on protein-fragment complementation assays

Nature Reviews Drug Discovery

Volumn 6, Issue 7, 2007, Pages 569-582

  Michnick, Stephen W ^a   Ear, Po Hien ^a   Manderson, Emily N ^a   Remy, Ingrid ^a   Stefan, Eduard ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ANTIDIABETIC AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; CARDIOVASCULAR AGENT; CENTRAL NERVOUS SYSTEM AGENTS; CHAPERONE; CYAN FLUORESCENT PROTEIN; CYTOSKELETON PROTEIN; DESIGNED ANKYRIN REPEAT PROTEIN; ERYTHROPOIETIN RECEPTOR; G PROTEIN COUPLED RECEPTOR; GREEN FLUORESCENT PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LEUCINE ZIPPER PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE INHIBITOR; SCAFFOLD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

CLUSTER ANALYSIS; DRUG MECHANISM; DRUG RESEARCH; DRUG SCREENING; DRUG TARGETING; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE LIBRARY; GENETIC MANIPULATION; HIGH THROUGHPUT SCREENING; MICROARRAY ANALYSIS; MOLECULAR DYNAMICS; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FRAGMENT COMPLEMENTATION ASSAY; PROTEIN PROTEIN INTERACTION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; DRUG DESIGN; GENES; GENETIC COMPLEMENTATION TEST; HUMANS; PEPTIDE FRAGMENTS; PROTEIN FOLDING; PROTEIN INTERACTION MAPPING;

EID: 34347374044     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd2311     Document Type: Review

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