메뉴 건너뛰기




Volumn 23, Issue 6, 2016, Pages 980-989

The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; SOMATOMEDIN C;

EID: 84975451703     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.05.014     Document Type: Review
Times cited : (104)

References (117)
  • 1
    • 80052860823 scopus 로고    scopus 로고
    • The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium
    • A. Abbas, H. Imrie, H. Viswambharan, P. Sukumar, A. Rajwani, R.M. Cubbon, M. Gage, J. Smith, S. Galloway, N. Yuldeshava, and et al. The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium Diabetes 60 2011 2169 2178
    • (2011) Diabetes , vol.60 , pp. 2169-2178
    • Abbas, A.1    Imrie, H.2    Viswambharan, H.3    Sukumar, P.4    Rajwani, A.5    Cubbon, R.M.6    Gage, M.7    Smith, J.8    Galloway, S.9    Yuldeshava, N.10
  • 2
    • 68149141237 scopus 로고    scopus 로고
    • Insulinlike growth factor-1, insulinlike growth factor binding protein-1, and cognitive function in older men and women
    • W.K. Al-Delaimy, D. von Muhlen, and E. Barrett-Connor Insulinlike growth factor-1, insulinlike growth factor binding protein-1, and cognitive function in older men and women J. Am. Geriatr. Soc. 57 2009 1441 1446
    • (2009) J. Am. Geriatr. Soc. , vol.57 , pp. 1441-1446
    • Al-Delaimy, W.K.1    Von Muhlen, D.2    Barrett-Connor, E.3
  • 3
    • 12344335482 scopus 로고    scopus 로고
    • Long-lived growth hormone receptor knockout mice: Interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction
    • K.A. Al-Regaiey, M.M. Masternak, M. Bonkowski, L. Sun, and A. Bartke Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction Endocrinology 146 2005 851 860
    • (2005) Endocrinology , vol.146 , pp. 851-860
    • Al-Regaiey, K.A.1    Masternak, M.M.2    Bonkowski, M.3    Sun, L.4    Bartke, A.5
  • 4
    • 84859051249 scopus 로고    scopus 로고
    • Health span approximates life span among many supercentenarians: Compression of morbidity at the approximate limit of life span
    • S.L. Andersen, P. Sebastiani, D.A. Dworkis, L. Feldman, and T.T. Perls Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span J. Gerontol. A Biol. Sci. Med. Sci. 67 2012 395 405
    • (2012) J. Gerontol. A Biol. Sci. Med. Sci. , vol.67 , pp. 395-405
    • Andersen, S.L.1    Sebastiani, P.2    Dworkis, D.A.3    Feldman, L.4    Perls, T.T.5
  • 6
    • 44849114351 scopus 로고    scopus 로고
    • Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression
    • M. Anzo, L.J. Cobb, D.L. Hwang, H. Mehta, J.W. Said, S. Yakar, D. LeRoith, and P. Cohen Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression Cancer Res. 68 2008 3342 3349
    • (2008) Cancer Res. , vol.68 , pp. 3342-3349
    • Anzo, M.1    Cobb, L.J.2    Hwang, D.L.3    Mehta, H.4    Said, J.W.5    Yakar, S.6    LeRoith, D.7    Cohen, P.8
  • 10
    • 0030693249 scopus 로고    scopus 로고
    • Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: Quantification of individual receptor species by selective immunoprecipitation and immunoblotting
    • E.M. Bailyes, B.T. Navé, M.A. Soos, S.R. Orr, A.C. Hayward, and K. Siddle Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting Biochem. J. 327 1997 209 215
    • (1997) Biochem. J. , vol.327 , pp. 209-215
    • Bailyes, E.M.1    Navé, B.T.2    Soos, M.A.3    Orr, S.R.4    Hayward, A.C.5    Siddle, K.6
  • 11
    • 84922385920 scopus 로고    scopus 로고
    • Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants
    • A. Bansal, L.J. Zhu, K. Yen, and H.A. Tissenbaum Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants Proc. Natl. Acad. Sci. USA 112 2015 E277 E286
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. E277-E286
    • Bansal, A.1    Zhu, L.J.2    Yen, K.3    Tissenbaum, H.A.4
  • 12
    • 0033920612 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-binding proteins: Interactions with IGFs and intrinsic bioactivities
    • R.C. Baxter Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities Am. J. Physiol. Endocrinol. Metab. 278 2000 E967 E976
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.278 , pp. E967-E976
    • Baxter, R.C.1
  • 13
    • 84877874915 scopus 로고    scopus 로고
    • Insulin-like growth factor 2 in development and disease: A mini-review
    • D. Bergman, M. Halje, M. Nordin, and W. Engström Insulin-like growth factor 2 in development and disease: a mini-review Gerontology 59 2013 240 249
    • (2013) Gerontology , vol.59 , pp. 240-249
    • Bergman, D.1    Halje, M.2    Nordin, M.3    Engström, W.4
  • 14
    • 84990033491 scopus 로고    scopus 로고
    • Management of endocrine disease: Acromegaly and Cancer: An old debate revisited
    • Published online April 18, 2016
    • C.L. Boguszewski, and J. Ayuk Management of endocrine disease: Acromegaly and Cancer: an old debate revisited Eur. J. Endocrinol. 2016 10.1530/EJE-16-0178 Published online April 18, 2016
    • (2016) Eur. J. Endocrinol.
    • Boguszewski, C.L.1    Ayuk, J.2
  • 17
    • 0025933857 scopus 로고
    • Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins
    • C.R. Breese, R.L. Ingram, and W.E. Sonntag Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins J. Gerontol. 46 1991 B180 B187
    • (1991) J. Gerontol. , vol.46 , pp. B180-B187
    • Breese, C.R.1    Ingram, R.L.2    Sonntag, W.E.3
  • 21
    • 84869741103 scopus 로고    scopus 로고
    • Association between circulating levels of IGF-1 and IGFBP-3 and lung cancer risk: A meta-analysis
    • H. Cao, G. Wang, L. Meng, H. Shen, Z. Feng, Q. Liu, and J. Du Association between circulating levels of IGF-1 and IGFBP-3 and lung cancer risk: a meta-analysis PLoS ONE 7 2012 e49884
    • (2012) PLoS ONE , vol.7 , pp. e49884
    • Cao, H.1    Wang, G.2    Meng, L.3    Shen, H.4    Feng, Z.5    Liu, Q.6    Du, J.7
  • 23
    • 0021867948 scopus 로고
    • Regulation of growth hormone release from cultured human pituitary adenomas by somatomedins and insulin
    • G.P. Ceda, A.R. Hoffman, G.D. Silverberg, D.M. Wilson, and R.G. Rosenfeld Regulation of growth hormone release from cultured human pituitary adenomas by somatomedins and insulin J. Clin. Endocrinol. Metab. 60 1985 1204 1209
    • (1985) J. Clin. Endocrinol. Metab. , vol.60 , pp. 1204-1209
    • Ceda, G.P.1    Hoffman, A.R.2    Silverberg, G.D.3    Wilson, D.M.4    Rosenfeld, R.G.5
  • 24
    • 84940895562 scopus 로고    scopus 로고
    • Suppression of IGF-I signals in neural stem cells enhances neurogenesis and olfactory function during aging
    • Z. Chaker, S. Aïd, H. Berry, and M. Holzenberger Suppression of IGF-I signals in neural stem cells enhances neurogenesis and olfactory function during aging Aging Cell 14 2015 847 856
    • (2015) Aging Cell , vol.14 , pp. 847-856
    • Chaker, Z.1    Aïd, S.2    Berry, H.3    Holzenberger, M.4
  • 25
    • 70349766917 scopus 로고    scopus 로고
    • Enhancing the apoptotic potential of insulin-like growth factor-binding protein-3 in prostate cancer by modulation of CK2 phosphorylation
    • L.J. Cobb, H. Mehta, and P. Cohen Enhancing the apoptotic potential of insulin-like growth factor-binding protein-3 in prostate cancer by modulation of CK2 phosphorylation Mol. Endocrinol. 23 2009 1624 1633
    • (2009) Mol. Endocrinol. , vol.23 , pp. 1624-1633
    • Cobb, L.J.1    Mehta, H.2    Cohen, P.3
  • 28
  • 29
    • 84876496436 scopus 로고    scopus 로고
    • Targeting IGF-IR with ganitumab inhibits tumorigenesis and increases durability of response to androgen-deprivation therapy in VCaP prostate cancer xenografts
    • C.D. Fahrenholtz, P.J. Beltran, and K.L. Burnstein Targeting IGF-IR with ganitumab inhibits tumorigenesis and increases durability of response to androgen-deprivation therapy in VCaP prostate cancer xenografts Mol. Cancer Ther. 12 2013 394 404
    • (2013) Mol. Cancer Ther. , vol.12 , pp. 394-404
    • Fahrenholtz, C.D.1    Beltran, P.J.2    Burnstein, K.L.3
  • 30
    • 84858631674 scopus 로고    scopus 로고
    • The many faces of insulin-like peptide signalling in the brain
    • A.M. Fernandez, and I. Torres-Alemán The many faces of insulin-like peptide signalling in the brain Nat. Rev. Neurosci. 13 2012 225 239
    • (2012) Nat. Rev. Neurosci. , vol.13 , pp. 225-239
    • Fernandez, A.M.1    Torres-Alemán, I.2
  • 31
  • 34
    • 84929083437 scopus 로고    scopus 로고
    • A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: The GAMMA trial
    • C.S. Fuchs, S. Azevedo, T. Okusaka, J.L. Van Laethem, L.R. Lipton, H. Riess, C. Szczylik, M.J. Moore, M. Peeters, G. Bodoky, and et al. A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: the GAMMA trial Ann. Oncol. 26 2015 921 927
    • (2015) Ann. Oncol. , vol.26 , pp. 921-927
    • Fuchs, C.S.1    Azevedo, S.2    Okusaka, T.3    Van Laethem, J.L.4    Lipton, L.R.5    Riess, H.6    Szczylik, C.7    Moore, M.J.8    Peeters, M.9    Bodoky, G.10
  • 38
    • 84939824081 scopus 로고    scopus 로고
    • Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance
    • G. Gontier, C. George, Z. Chaker, M. Holzenberger, and S. Aïd Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance J. Neurosci. 35 2015 11500 11513
    • (2015) J. Neurosci. , vol.35 , pp. 11500-11513
    • Gontier, G.1    George, C.2    Chaker, Z.3    Holzenberger, M.4    Aïd, S.5
  • 39
    • 84941731159 scopus 로고    scopus 로고
    • The role of IGF-I, IGF-II, and IGFBP-3 in male cognitive aging and dementia risk: The Caerphilly Prospective Study
    • C.J. Green, J.M. Holly, A. Bayer, M. Fish, S. Ebrahim, J. Gallacher, and Y. Ben-Shlomo The role of IGF-I, IGF-II, and IGFBP-3 in male cognitive aging and dementia risk: the Caerphilly Prospective Study J. Alzheimers Dis. 41 2014 867 875
    • (2014) J. Alzheimers Dis. , vol.41 , pp. 867-875
    • Green, C.J.1    Holly, J.M.2    Bayer, A.3    Fish, M.4    Ebrahim, S.5    Gallacher, J.6    Ben-Shlomo, Y.7
  • 41
    • 0141755327 scopus 로고    scopus 로고
    • Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: Relative roles of growth hormone and IGF-1 in insulin resistance
    • M. Haluzik, S. Yakar, O. Gavrilova, J. Setser, Y. Boisclair, and D. LeRoith Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance Diabetes 52 2003 2483 2489
    • (2003) Diabetes , vol.52 , pp. 2483-2489
    • Haluzik, M.1    Yakar, S.2    Gavrilova, O.3    Setser, J.4    Boisclair, Y.5    LeRoith, D.6
  • 42
    • 0029860211 scopus 로고    scopus 로고
    • Increased hexosamine availability similarly impairs the action of insulin and IGF-1 on glucose disposal
    • M. Hawkins, N. Barzilai, W. Chen, I. Angelov, M. Hu, P. Cohen, and L. Rossetti Increased hexosamine availability similarly impairs the action of insulin and IGF-1 on glucose disposal Diabetes 45 1996 1734 1743
    • (1996) Diabetes , vol.45 , pp. 1734-1743
    • Hawkins, M.1    Barzilai, N.2    Chen, W.3    Angelov, I.4    Hu, M.5    Cohen, P.6    Rossetti, L.7
  • 43
    • 84920273003 scopus 로고    scopus 로고
    • Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism with longevity in Chinese nonagenarians and centenarians
    • Y.H. He, X. Lu, L.Q. Yang, L.Y. Xu, and Q.P. Kong Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism with longevity in Chinese nonagenarians and centenarians Aging (Albany, N.Y.) 6 2014 944 956
    • (2014) Aging (Albany, N.Y.) , vol.6 , pp. 944-956
    • He, Y.H.1    Lu, X.2    Yang, L.Q.3    Xu, L.Y.4    Kong, Q.P.5
  • 45
    • 84861982317 scopus 로고    scopus 로고
    • Insulin-like growth factor physiology: What we have learned from human studies
    • v
    • J.M. Holly, and C.M. Perks Insulin-like growth factor physiology: what we have learned from human studies Endocrinol. Metab. Clin. North Am. 41 2012 249 263, v
    • (2012) Endocrinol. Metab. Clin. North Am. , vol.41 , pp. 249-263
    • Holly, J.M.1    Perks, C.M.2
  • 47
    • 33846422735 scopus 로고    scopus 로고
    • Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intake
    • D.M. Huffman, M.S. Johnson, A. Watts, A. Elgavish, I.A. Eltoum, and T.R. Nagy Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intake Cancer Res. 67 2007 417 424
    • (2007) Cancer Res. , vol.67 , pp. 417-424
    • Huffman, D.M.1    Johnson, M.S.2    Watts, A.3    Elgavish, A.4    Eltoum, I.A.5    Nagy, T.R.6
  • 48
    • 84955190089 scopus 로고    scopus 로고
    • Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline
    • D.M. Huffman, G. Farias Quipildor, K. Mao, X. Zhang, J. Wan, P. Apontes, P. Cohen, and N. Barzilai Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline Aging Cell 15 2016 181 186
    • (2016) Aging Cell , vol.15 , pp. 181-186
    • Huffman, D.M.1    Farias Quipildor, G.2    Mao, K.3    Zhang, X.4    Wan, J.5    Apontes, P.6    Cohen, P.7    Barzilai, N.8
  • 49
    • 0027324846 scopus 로고
    • The growth hormone: Insulin-like growth factor 1 axis is a mediator of diet restriction-induced inhibition of mononuclear cell leukemia in Fischer rats
    • S.D. Hursting, B.R. Switzer, J.E. French, and F.W. Kari The growth hormone: insulin-like growth factor 1 axis is a mediator of diet restriction-induced inhibition of mononuclear cell leukemia in Fischer rats Cancer Res. 53 1993 2750 2757
    • (1993) Cancer Res. , vol.53 , pp. 2750-2757
    • Hursting, S.D.1    Switzer, B.R.2    French, J.E.3    Kari, F.W.4
  • 50
    • 0345237923 scopus 로고    scopus 로고
    • Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: Correlation to extended longevity
    • Y. Ikeno, R.T. Bronson, G.B. Hubbard, S. Lee, and A. Bartke Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity J. Gerontol. A Biol. Sci. Med. Sci. 58 2003 291 296
    • (2003) J. Gerontol. A Biol. Sci. Med. Sci. , vol.58 , pp. 291-296
    • Ikeno, Y.1    Bronson, R.T.2    Hubbard, G.B.3    Lee, S.4    Bartke, A.5
  • 52
    • 84969794953 scopus 로고    scopus 로고
    • Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis while Maintaining Normal Cardiac Performance in Adult Male Mice
    • A. Jara, X. Liu, D. Sim, C.M. Benner, S. Duran-Ortiz, Y. Qian, E.O. List, D.E. Berryman, J.K. Kim, and J.J. Kopchick Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis While Maintaining Normal Cardiac Performance in Adult Male Mice Endocrinology 157 2016 1929 1941
    • (2016) Endocrinology , vol.157 , pp. 1929-1941
    • Jara, A.1    Liu, X.2    Sim, D.3    Benner, C.M.4    Duran-Ortiz, S.5    Qian, Y.6    List, E.O.7    Berryman, D.E.8    Kim, J.K.9    Kopchick, J.J.10
  • 53
    • 0037143639 scopus 로고    scopus 로고
    • Low serum insulin-like growth factor i is associated with increased risk of ischemic heart disease: A population-based case-control study
    • A. Juul, T. Scheike, M. Davidsen, J. Gyllenborg, and T. Jørgensen Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study Circulation 106 2002 939 944
    • (2002) Circulation , vol.106 , pp. 939-944
    • Juul, A.1    Scheike, T.2    Davidsen, M.3    Gyllenborg, J.4    Jørgensen, T.5
  • 54
    • 34147183436 scopus 로고    scopus 로고
    • Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke
    • R.C. Kaplan, A.P. McGinn, M.N. Pollak, L.H. Kuller, H.D. Strickler, T.E. Rohan, A.R. Cappola, X. Xue, and B.M. Psaty Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke J. Clin. Endocrinol. Metab. 92 2007 1319 1325
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 1319-1325
    • Kaplan, R.C.1    McGinn, A.P.2    Pollak, M.N.3    Kuller, L.H.4    Strickler, H.D.5    Rohan, T.E.6    Cappola, A.R.7    Xue, X.8    Psaty, B.M.9
  • 56
    • 0027771804 scopus 로고
    • A C. Elegans mutant that lives twice as long as wild type
    • C. Kenyon, J. Chang, E. Gensch, A. Rudner, and R. Tabtiang A C. Elegans mutant that lives twice as long as wild type Nature 366 1993 461 464
    • (1993) Nature , vol.366 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.5
  • 57
    • 77953536809 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: Pooled individual data analysis of 17 prospective studies
    • T.J. Key, P.N. Appleby, G.K. Reeves, A.W. Roddam Endogenous Hormones and Breast Cancer Collaborative Group Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies Lancet Oncol. 11 2010 530 542
    • (2010) Lancet Oncol. , vol.11 , pp. 530-542
    • Key, T.J.1    Appleby, P.N.2    Reeves, G.K.3    Roddam, A.W.4
  • 58
    • 33846436784 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo
    • H.S. Kim, O. Ali, M. Shim, K.W. Lee, P. Vuguin, R. Muzumdar, N. Barzilai, and P. Cohen Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo Pediatr. Res. 61 2007 159 164
    • (2007) Pediatr. Res. , vol.61 , pp. 159-164
    • Kim, H.S.1    Ali, O.2    Shim, M.3    Lee, K.W.4    Vuguin, P.5    Muzumdar, R.6    Barzilai, N.7    Cohen, P.8
  • 59
    • 0031732891 scopus 로고    scopus 로고
    • Normal intelligence with severe insulin-like growth factor i deficiency due to growth hormone receptor deficiency: A controlled study in a genetically homogeneous population
    • J.H. Kranzler, A.L. Rosenbloom, V. Martinez, and J. Guevara-Aguirre Normal intelligence with severe insulin-like growth factor I deficiency due to growth hormone receptor deficiency: a controlled study in a genetically homogeneous population J. Clin. Endocrinol. Metab. 83 1998 1953 1958
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 1953-1958
    • Kranzler, J.H.1    Rosenbloom, A.L.2    Martinez, V.3    Guevara-Aguirre, J.4
  • 60
    • 0032452531 scopus 로고    scopus 로고
    • Association between insulin-like growth factor i and bone mineral density in older women and men: The Framingham Heart Study
    • J.A. Langlois, C.J. Rosen, M. Visser, M.T. Hannan, T. Harris, P.W. Wilson, and D.P. Kiel Association between insulin-like growth factor I and bone mineral density in older women and men: the Framingham Heart Study J. Clin. Endocrinol. Metab. 83 1998 4257 4262
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 4257-4262
    • Langlois, J.A.1    Rosen, C.J.2    Visser, M.3    Hannan, M.T.4    Harris, T.5    Wilson, P.W.6    Kiel, D.P.7
  • 61
    • 0842291511 scopus 로고    scopus 로고
    • The prospective association of serum insulin-like growth factor i (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: The Rancho Bernardo Study
    • G.A. Laughlin, E. Barrett-Connor, M.H. Criqui, and D. Kritz-Silverstein The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study J. Clin. Endocrinol. Metab. 89 2004 114 120
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 114-120
    • Laughlin, G.A.1    Barrett-Connor, E.2    Criqui, M.H.3    Kritz-Silverstein, D.4
  • 62
    • 0034489210 scopus 로고    scopus 로고
    • Insulin regulation of human hepatic growth hormone receptors: Divergent effects on biosynthesis and surface translocation
    • K.C. Leung, N. Doyle, M. Ballesteros, M.J. Waters, and K.K. Ho Insulin regulation of human hepatic growth hormone receptors: divergent effects on biosynthesis and surface translocation J. Clin. Endocrinol. Metab. 85 2000 4712 4720
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 4712-4720
    • Leung, K.C.1    Doyle, N.2    Ballesteros, M.3    Waters, M.J.4    Ho, K.K.5
  • 64
    • 50449083011 scopus 로고    scopus 로고
    • Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction
    • Q. Li, A.F. Ceylan-Isik, J. Li, and J. Ren Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction Rejuvenation Res. 11 2008 725 733
    • (2008) Rejuvenation Res. , vol.11 , pp. 725-733
    • Li, Q.1    Ceylan-Isik, A.F.2    Li, J.3    Ren, J.4
  • 65
    • 0035965708 scopus 로고    scopus 로고
    • Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis
    • R.J. Lichtenwalner, M.E. Forbes, S.A. Bennett, C.D. Lynch, W.E. Sonntag, and D.R. Riddle Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis Neuroscience 107 2001 603 613
    • (2001) Neuroscience , vol.107 , pp. 603-613
    • Lichtenwalner, R.J.1    Forbes, M.E.2    Bennett, S.A.3    Lynch, C.D.4    Sonntag, W.E.5    Riddle, D.R.6
  • 67
    • 70449380772 scopus 로고    scopus 로고
    • Type 1 insulin-like growth factor receptor signaling is essential for the development of the hippocampal formation and dentate gyrus
    • W. Liu, P. Ye, J.R. O'Kusky, and A.J. D'Ercole Type 1 insulin-like growth factor receptor signaling is essential for the development of the hippocampal formation and dentate gyrus J. Neurosci. Res. 87 2009 2821 2832
    • (2009) J. Neurosci. Res. , vol.87 , pp. 2821-2832
    • Liu, W.1    Ye, P.2    O'Kusky, J.R.3    D'Ercole, A.J.4
  • 68
    • 84960323599 scopus 로고    scopus 로고
    • Does the GH/IGF-1 axis contribute to skeletal sexual dimorphism? Evidence from mouse studies
    • Z. Liu, S. Mohan, and S. Yakar Does the GH/IGF-1 axis contribute to skeletal sexual dimorphism? Evidence from mouse studies Growth Horm. IGF Res. 27 2016 7 17
    • (2016) Growth Horm. IGF Res. , vol.27 , pp. 7-17
    • Liu, Z.1    Mohan, S.2    Yakar, S.3
  • 71
    • 84905045240 scopus 로고    scopus 로고
    • Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity
    • S. Milman, G. Atzmon, D.M. Huffman, J. Wan, J.P. Crandall, P. Cohen, and N. Barzilai Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity Aging Cell 13 2014 769 771
    • (2014) Aging Cell , vol.13 , pp. 769-771
    • Milman, S.1    Atzmon, G.2    Huffman, D.M.3    Wan, J.4    Crandall, J.P.5    Cohen, P.6    Barzilai, N.7
  • 75
    • 84861022498 scopus 로고    scopus 로고
    • Insulin-like growth factors and insulin: At the crossroad between tumor development and longevity
    • R. Novosyadlyy, and D. Leroith Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity J. Gerontol. A Biol. Sci. Med. Sci. 67 2012 640 651
    • (2012) J. Gerontol. A Biol. Sci. Med. Sci. , vol.67 , pp. 640-651
    • Novosyadlyy, R.1    Leroith, D.2
  • 79
    • 0035980421 scopus 로고    scopus 로고
    • Effects of HRT on serum levels of IGF-I in postmenopausal women
    • C. Posaci, S. Altunyurt, H. Islekel, and A. Onvural Effects of HRT on serum levels of IGF-I in postmenopausal women Maturitas 40 2001 69 74
    • (2001) Maturitas , vol.40 , pp. 69-74
    • Posaci, C.1    Altunyurt, S.2    Islekel, H.3    Onvural, A.4
  • 80
    • 0031442972 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding proteins in serum and other biological fluids: Regulation and functions
    • S. Rajaram, D.J. Baylink, and S. Mohan Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions Endocr. Rev. 18 1997 801 831
    • (1997) Endocr. Rev. , vol.18 , pp. 801-831
    • Rajaram, S.1    Baylink, D.J.2    Mohan, S.3
  • 82
    • 0023110391 scopus 로고
    • Effect of restricted caloric intake on azoxymethane-induced colon tumor incidence in male F344 rats
    • B.S. Reddy, C.X. Wang, and H. Maruyama Effect of restricted caloric intake on azoxymethane-induced colon tumor incidence in male F344 rats Cancer Res. 47 1987 1226 1228
    • (1987) Cancer Res. , vol.47 , pp. 1226-1228
    • Reddy, B.S.1    Wang, C.X.2    Maruyama, H.3
  • 83
    • 1942436958 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: Systematic review and meta-regression analysis
    • A.G. Renehan, M. Zwahlen, C. Minder, S.T. O'Dwyer, S.M. Shalet, and M. Egger Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis Lancet 363 2004 1346 1353
    • (2004) Lancet , vol.363 , pp. 1346-1353
    • Renehan, A.G.1    Zwahlen, M.2    Minder, C.3    O'Dwyer, S.T.4    Shalet, S.M.5    Egger, M.6
  • 84
    • 80052583050 scopus 로고    scopus 로고
    • Prospective study of insulin-like growth factor-I, insulin-like growth factor-binding protein 3, genetic variants in the IGF1 and IGFBP3 genes and risk of coronary artery disease
    • S.L. Ricketts, K.L. Rensing, J.M. Holly, L. Chen, E.H. Young, R. Luben, S. Ashford, K. Song, X. Yuan, A. Dehghan, et al. GEMS Investigators Prospective study of insulin-like growth factor-I, insulin-like growth factor-binding protein 3, genetic variants in the IGF1 and IGFBP3 genes and risk of coronary artery disease Int. J. Mol. Epidemiol. Genet. 2 2011 261 285
    • (2011) Int. J. Mol. Epidemiol. Genet. , vol.2 , pp. 261-285
    • Ricketts, S.L.1    Rensing, K.L.2    Holly, J.M.3    Chen, L.4    Young, E.H.5    Luben, R.6    Ashford, S.7    Song, K.8    Yuan, X.9    Dehghan, A.10
  • 86
    • 84875257995 scopus 로고    scopus 로고
    • Ganitumab with either exemestane or fulvestrant for postmenopausal women with advanced, hormone-receptor-positive breast cancer: A randomised, controlled, double-blind, phase 2 trial
    • J.F. Robertson, J.M. Ferrero, H. Bourgeois, H. Kennecke, R.H. de Boer, W. Jacot, J. McGreivy, S. Suzuki, M. Zhu, I. McCaffery, and et al. Ganitumab with either exemestane or fulvestrant for postmenopausal women with advanced, hormone-receptor-positive breast cancer: a randomised, controlled, double-blind, phase 2 trial Lancet Oncol. 14 2013 228 235
    • (2013) Lancet Oncol. , vol.14 , pp. 228-235
    • Robertson, J.F.1    Ferrero, J.M.2    Bourgeois, H.3    Kennecke, H.4    De Boer, R.H.5    Jacot, W.6    McGreivy, J.7    Suzuki, S.8    Zhu, M.9    McCaffery, I.10
  • 88
    • 64249111139 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor peptides and prostate cancer risk: A systematic review and meta-analysis
    • M.A. Rowlands, D. Gunnell, R. Harris, L.J. Vatten, J.M. Holly, and R.M. Martin Circulating insulin-like growth factor peptides and prostate cancer risk: a systematic review and meta-analysis Int. J. Cancer 124 2009 2416 2429
    • (2009) Int. J. Cancer , vol.124 , pp. 2416-2429
    • Rowlands, M.A.1    Gunnell, D.2    Harris, R.3    Vatten, L.J.4    Holly, J.M.5    Martin, R.M.6
  • 89
    • 0019423888 scopus 로고
    • Impaired growth hormone secretion in the adult population: Relation to age and adiposity
    • D. Rudman, M.H. Kutner, C.M. Rogers, M.F. Lubin, G.A. Fleming, and R.P. Bain Impaired growth hormone secretion in the adult population: relation to age and adiposity J. Clin. Invest. 67 1981 1361 1369
    • (1981) J. Clin. Invest. , vol.67 , pp. 1361-1369
    • Rudman, D.1    Kutner, M.H.2    Rogers, C.M.3    Lubin, M.F.4    Fleming, G.A.5    Bain, R.P.6
  • 91
    • 0037129721 scopus 로고    scopus 로고
    • Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: A prospective observational study
    • M.S. Sandhu, A.H. Heald, J.M. Gibson, J.K. Cruickshank, D.B. Dunger, and N.J. Wareham Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study Lancet 359 2002 1740 1745
    • (2002) Lancet , vol.359 , pp. 1740-1745
    • Sandhu, M.S.1    Heald, A.H.2    Gibson, J.M.3    Cruickshank, J.K.4    Dunger, D.B.5    Wareham, N.J.6
  • 92
    • 34548015443 scopus 로고    scopus 로고
    • Insulin-like growth factors and subsequent risk of mortality in the United States
    • S. Saydah, B. Graubard, R. Ballard-Barbash, and D. Berrigan Insulin-like growth factors and subsequent risk of mortality in the United States Am. J. Epidemiol. 166 2007 518 526
    • (2007) Am. J. Epidemiol. , vol.166 , pp. 518-526
    • Saydah, S.1    Graubard, B.2    Ballard-Barbash, R.3    Berrigan, D.4
  • 93
    • 23444432499 scopus 로고    scopus 로고
    • Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging
    • W.E. Sonntag, M. Ramsey, and C.S. Carter Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging Ageing Res. Rev. 4 2005 195 212
    • (2005) Ageing Res. Rev. , vol.4 , pp. 195-212
    • Sonntag, W.E.1    Ramsey, M.2    Carter, C.S.3
  • 94
    • 79953221503 scopus 로고    scopus 로고
    • Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies
    • R. Steuerman, O. Shevah, and Z. Laron Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies Eur. J. Endocrinol. 164 2011 485 489
    • (2011) Eur. J. Endocrinol. , vol.164 , pp. 485-489
    • Steuerman, R.1    Shevah, O.2    Laron, Z.3
  • 95
    • 0029973924 scopus 로고    scopus 로고
    • Growth, differentiation, and survival: Multiple physiological functions for insulin-like growth factors
    • C.E. Stewart, and P. Rotwein Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors Physiol. Rev. 76 1996 1005 1026
    • (1996) Physiol. Rev. , vol.76 , pp. 1005-1026
    • Stewart, C.E.1    Rotwein, P.2
  • 97
    • 13844277026 scopus 로고    scopus 로고
    • Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice
    • L.Y. Sun, K. Al-Regaiey, M.M. Masternak, J. Wang, and A. Bartke Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice Neurobiol. Aging 26 2005 929 937
    • (2005) Neurobiol. Aging , vol.26 , pp. 929-937
    • Sun, L.Y.1    Al-Regaiey, K.2    Masternak, M.M.3    Wang, J.4    Bartke, A.5
  • 98
    • 84887431034 scopus 로고    scopus 로고
    • Human metastatic melanoma cell lines express high levels of growth hormone receptor and respond to GH treatment
    • E.G. Sustarsic, R.K. Junnila, and J.J. Kopchick Human metastatic melanoma cell lines express high levels of growth hormone receptor and respond to GH treatment Biochem. Biophys. Res. Commun. 441 2013 144 150
    • (2013) Biochem. Biophys. Res. Commun. , vol.441 , pp. 144-150
    • Sustarsic, E.G.1    Junnila, R.K.2    Kopchick, J.J.3
  • 100
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: Insights into insulin action
    • C.M. Taniguchi, B. Emanuelli, and C.R. Kahn Critical nodes in signalling pathways: insights into insulin action Nat. Rev. Mol. Cell Biol. 7 2006 85 96
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 101
    • 79956016645 scopus 로고    scopus 로고
    • Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles
    • C. Tazearslan, J. Huang, N. Barzilai, and Y. Suh Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles Aging Cell 10 2011 551 554
    • (2011) Aging Cell , vol.10 , pp. 551-554
    • Tazearslan, C.1    Huang, J.2    Barzilai, N.3    Suh, Y.4
  • 103
    • 84977485778 scopus 로고    scopus 로고
    • Association between Cognition and Serum Insulin-Like Growth Factor-1 in Middle-Aged & Older Men: An 8 Year Follow-Up Study
    • S. Tumati, H. Burger, S. Martens, Y.T. van der Schouw, and A. Aleman Association between Cognition and Serum Insulin-Like Growth Factor-1 in Middle-Aged & Older Men: An 8 Year Follow-Up Study PLoS ONE 11 2016 e0154450
    • (2016) PLoS ONE , vol.11 , pp. e0154450
    • Tumati, S.1    Burger, H.2    Martens, S.3    Van Der Schouw, Y.T.4    Aleman, A.5
  • 104
    • 84861087862 scopus 로고    scopus 로고
    • The emerging role of IGF-1 deficiency in cardiovascular aging: Recent advances
    • Z. Ungvari, and A. Csiszar The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances J. Gerontol. A Biol. Sci. Med. Sci. 67 2012 599 610
    • (2012) J. Gerontol. A Biol. Sci. Med. Sci. , vol.67 , pp. 599-610
    • Ungvari, Z.1    Csiszar, A.2
  • 105
    • 77957801613 scopus 로고    scopus 로고
    • The association of serum insulin-like growth factor-I with mortality, cardiovascular disease, and cancer in the elderly: A population-based study
    • C.C. van Bunderen, I.C. van Nieuwpoort, N.M. van Schoor, D.J. Deeg, P. Lips, and M.L. Drent The association of serum insulin-like growth factor-I with mortality, cardiovascular disease, and cancer in the elderly: a population-based study J. Clin. Endocrinol. Metab. 95 2010 4616 4624
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 4616-4624
    • Van Bunderen, C.C.1    Van Nieuwpoort, I.C.2    Van Schoor, N.M.3    Deeg, D.J.4    Lips, P.5    Drent, M.L.6
  • 108
    • 84958596629 scopus 로고    scopus 로고
    • Gender-Specific Associations of Serum Insulin-Like Growth Factor-1 with Bone Health and Fractures in Older Persons
    • N.C. van Varsseveld, E. Sohl, M.L. Drent, and P. Lips Gender-Specific Associations of Serum Insulin-Like Growth Factor-1 With Bone Health and Fractures in Older Persons J. Clin. Endocrinol. Metab. 100 2015 4272 4281
    • (2015) J. Clin. Endocrinol. Metab. , vol.100 , pp. 4272-4281
    • Van Varsseveld, N.C.1    Sohl, E.2    Drent, M.L.3    Lips, P.4
  • 109
    • 0142056143 scopus 로고    scopus 로고
    • Serum insulin-like growth factor i and risk for heart failure in elderly individuals without a previous myocardial infarction: The Framingham Heart Study
    • R.S. Vasan, L.M. Sullivan, R.B. D'Agostino, R. Roubenoff, T. Harris, D.B. Sawyer, D. Levy, and P.W. Wilson Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham Heart Study Ann. Intern. Med. 139 2003 642 648
    • (2003) Ann. Intern. Med. , vol.139 , pp. 642-648
    • Vasan, R.S.1    Sullivan, L.M.2    D'Agostino, R.B.3    Roubenoff, R.4    Harris, T.5    Sawyer, D.B.6    Levy, D.7    Wilson, P.W.8
  • 110
    • 84864008371 scopus 로고    scopus 로고
    • Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress
    • M. Wang, and R.A. Miller Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress Aging Cell 11 2012 668 674
    • (2012) Aging Cell , vol.11 , pp. 668-674
    • Wang, M.1    Miller, R.A.2
  • 114
    • 84892530622 scopus 로고    scopus 로고
    • Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation
    • J. Xu, G. Gontier, Z. Chaker, P. Lacube, J. Dupont, and M. Holzenberger Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation Aging Cell 13 2014 19 28
    • (2014) Aging Cell , vol.13 , pp. 19-28
    • Xu, J.1    Gontier, G.2    Chaker, Z.3    Lacube, P.4    Dupont, J.5    Holzenberger, M.6
  • 115
    • 30844451581 scopus 로고    scopus 로고
    • Serum levels of insulin-like growth factor (IGF); IGF-binding proteins-3, -4, and -5; And their relationships to bone mineral density and the risk of vertebral fractures in postmenopausal women
    • T. Yamaguchi, M. Kanatani, M. Yamauchi, H. Kaji, T. Sugishita, D.J. Baylink, S. Mohan, K. Chihara, and T. Sugimoto Serum levels of insulin-like growth factor (IGF); IGF-binding proteins-3, -4, and -5; and their relationships to bone mineral density and the risk of vertebral fractures in postmenopausal women Calcif. Tissue Int. 78 2006 18 24
    • (2006) Calcif. Tissue Int. , vol.78 , pp. 18-24
    • Yamaguchi, T.1    Kanatani, M.2    Yamauchi, M.3    Kaji, H.4    Sugishita, T.5    Baylink, D.J.6    Mohan, S.7    Chihara, K.8    Sugimoto, T.9
  • 116
    • 0025764087 scopus 로고
    • Effects of aging and sex on plasma insulin-like growth factor i (IGF-I) levels in normal adults
    • H. Yamamoto, M. Sohmiya, N. Oka, and Y. Kato Effects of aging and sex on plasma insulin-like growth factor I (IGF-I) levels in normal adults Acta Endocrinol. 124 1991 497 500
    • (1991) Acta Endocrinol. , vol.124 , pp. 497-500
    • Yamamoto, H.1    Sohmiya, M.2    Oka, N.3    Kato, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.